The ontology of physics for biology: semantic modeling of multiscale, multidomain physiological systems
This book introduces semantic representations of multiscale, multidomain physiological systems that link to qualitative reasoning and to quantitative analysis of biophysical processes in health and disease. Two major public health problems, diabetes and hypertension, serve as use-cases to illustrate...
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton ; London ; New York
CRC Press
2024
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| Edition: | First edition |
| Subjects: | |
| Summary: | This book introduces semantic representations of multiscale, multidomain physiological systems that link to qualitative reasoning and to quantitative analysis of biophysical processes in health and disease. Two major public health problems, diabetes and hypertension, serve as use-cases to illustrate the depth and rigor of such representations for logical inference and quantitative analysis. Central to this approach is the Ontology of Physics for Biology (OPB) that formally represents the foundations of classical physics and engineering system dynamics that are the basis for our understanding of biomedical entities, processes, and functional relationships.Furthermore, we introduce OPB-based software for annotating and abstracting available biosimulation models for reuse, recombination, and for archiving of physics-based biomedical knowledge. We have formalized and leveraged physics-based biological knowledge as a working view of physiology and biophysics from three distinct perspectives: (1) biologists and biomedical investigators, (2) biophysicists and bioengineers, and (3) biomedical ontologists and informaticists. We present a logical and intuitive semantics of classical physics as a tool for mediating and translating biophysical knowledge among biomedical domains.Daniel L. Cook, MD, PhDJohn H. Gennari, PhDMaxwell L. Neal, PhD |
| Item Description: | 1. Biomedical Challenges 2. Biomedical Information and Data Resources 3. Biomedical Ontologies 4. Biophysical Systems Analysis 5. System Dynamic Modeling 6. Ontology of Physics for Biology 7. OPB-based Semantic Modeling 8. OPB Review and Possibilities |
| Physical Description: | xix, 220 Seiten Illustrationen 453 gr |
| ISBN: | 9781138598058 9781032533100 |
Staff View
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| spelling | Cook, Daniel L. Verfasser aut The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems Daniel L. Cook, MD, PhD, John H. Gennari, PhD, Maxwell L. Neal, PhD First edition Boca Raton ; London ; New York CRC Press 2024 xix, 220 Seiten Illustrationen 453 gr txt rdacontent n rdamedia nc rdacarrier 1. Biomedical Challenges 2. Biomedical Information and Data Resources 3. Biomedical Ontologies 4. Biophysical Systems Analysis 5. System Dynamic Modeling 6. Ontology of Physics for Biology 7. OPB-based Semantic Modeling 8. OPB Review and Possibilities This book introduces semantic representations of multiscale, multidomain physiological systems that link to qualitative reasoning and to quantitative analysis of biophysical processes in health and disease. Two major public health problems, diabetes and hypertension, serve as use-cases to illustrate the depth and rigor of such representations for logical inference and quantitative analysis. Central to this approach is the Ontology of Physics for Biology (OPB) that formally represents the foundations of classical physics and engineering system dynamics that are the basis for our understanding of biomedical entities, processes, and functional relationships.Furthermore, we introduce OPB-based software for annotating and abstracting available biosimulation models for reuse, recombination, and for archiving of physics-based biomedical knowledge. We have formalized and leveraged physics-based biological knowledge as a working view of physiology and biophysics from three distinct perspectives: (1) biologists and biomedical investigators, (2) biophysicists and bioengineers, and (3) biomedical ontologists and informaticists. We present a logical and intuitive semantics of classical physics as a tool for mediating and translating biophysical knowledge among biomedical domains.Daniel L. Cook, MD, PhDJohn H. Gennari, PhDMaxwell L. Neal, PhD bicssc / Biophysics bisacsh / SCIENCE / Biotechnology bisacsh / SCIENCE / Physics / General Ontologie Wissensverarbeitung (DE-588)4827894-4 gnd rswk-swf Biomedizin (DE-588)4647152-2 gnd rswk-swf Semantische Modellierung (DE-588)4672054-6 gnd rswk-swf Semantische Modellierung (DE-588)4672054-6 s Ontologie Wissensverarbeitung (DE-588)4827894-4 s Biomedizin (DE-588)4647152-2 s DE-604 Gennari, John H. Verfasser aut Neal, Maxwell Lewis Verfasser (DE-588)1207845329 aut Erscheint auch als Online-Ausgabe 9780429469961 |
| spellingShingle | Cook, Daniel L. Gennari, John H. Neal, Maxwell Lewis The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems bicssc / Biophysics bisacsh / SCIENCE / Biotechnology bisacsh / SCIENCE / Physics / General Ontologie Wissensverarbeitung (DE-588)4827894-4 gnd Biomedizin (DE-588)4647152-2 gnd Semantische Modellierung (DE-588)4672054-6 gnd |
| subject_GND | (DE-588)4827894-4 (DE-588)4647152-2 (DE-588)4672054-6 |
| title | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems |
| title_auth | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems |
| title_exact_search | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems |
| title_exact_search_txtP | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems |
| title_full | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems Daniel L. Cook, MD, PhD, John H. Gennari, PhD, Maxwell L. Neal, PhD |
| title_fullStr | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems Daniel L. Cook, MD, PhD, John H. Gennari, PhD, Maxwell L. Neal, PhD |
| title_full_unstemmed | The ontology of physics for biology semantic modeling of multiscale, multidomain physiological systems Daniel L. Cook, MD, PhD, John H. Gennari, PhD, Maxwell L. Neal, PhD |
| title_short | The ontology of physics for biology |
| title_sort | the ontology of physics for biology semantic modeling of multiscale multidomain physiological systems |
| title_sub | semantic modeling of multiscale, multidomain physiological systems |
| topic | bicssc / Biophysics bisacsh / SCIENCE / Biotechnology bisacsh / SCIENCE / Physics / General Ontologie Wissensverarbeitung (DE-588)4827894-4 gnd Biomedizin (DE-588)4647152-2 gnd Semantische Modellierung (DE-588)4672054-6 gnd |
| topic_facet | bicssc / Biophysics bisacsh / SCIENCE / Biotechnology bisacsh / SCIENCE / Physics / General Ontologie Wissensverarbeitung Biomedizin Semantische Modellierung |
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