S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Jena
[2022]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 72 Seiten Illustrationen, Diagramme 30 cm |
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| 100 | 1 | |a Weiwei, Yi |d 1988- |e Verfasser |0 (DE-588)1268646970 |4 aut | |
| 245 | 1 | 0 | |a S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |c by Weiwei Yi |
| 264 | 1 | |a Jena |c [2022] | |
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| 502 | |b Dissertation |c Friedrich-Schiller-Universität Jena |d 2022 | ||
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| 700 | 1 | |a Rudolph, Karl Lenhard |d 1969- |0 (DE-588)121126102 |4 dgs | |
| 700 | 1 | |a Kosan, Christian |d 1971- |0 (DE-588)124448607 |4 dgs | |
| 700 | 1 | |a Geiger, Hartmut |0 (DE-588)1117836568 |4 dgs | |
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Record in the Search Index
| _version_ | 1804185194033315840 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
....................................................................................................................................
1
ABBREVIATIONS
........................................................................................................................................
3
ZUSAMMENFASSUNG
................................................................................................................................
7
SUMMARY
................................................................................................................................................
9
1.
INTRODUCTION
.....................................................................................................................................
10
1.1
HEMATOPOIETIC
STEM
CELLS
...................................................................................................
10
1.1.1
HEMATOPOIETIC
HIERARCHY
..........................................................................................
10
1.1.2
IDENTITY
OF
ADULT
HSC
...............................................................................................
11
1.2
RNS
AND
NO
IN
HSC
............................................................................................................
12
................................................................................................................................................................
14
1.3
NO
AND
GSNOR
...................................................................................................................
14
1.4
SNO
AND
PROTEOSTASIS
...........................................................................................................
15
1.5
AIM
OF
RESEARCH
.....................................................................................................................
17
2.
MATERIALS
AND
METHODS
..................................................................................................................
18
2.1
MATERIALS
.................................................................................................................................
18
2.1.1
MATERIALS
AND
EQUIPMENT
........................................................................................
18
2.1.2
REAGENTS
AND
CHEMICALS
...........................................................................................
19
2.1.3
ANTIBODIES
AND
KITS
...................................................................................................
21
2.2
METHODS
..................................................................................................................................
24
2.2.1
MICE
.............................................................................................................................
24
2.2.2
BONE
MARROW
ISOLATION
AND
FLOW
CYTOMETRY
.........................................................
24
2.2.3
ANNEXIN
V
STAINING
AND
CASPASE
3/7
BASED
LUMINESCENCE
ASSAY
........................
25
2.2.4
CELL
CYCLE
STAINING
.....................................................................................................
26
2.2.5
NO
LEVEL
DETECTION
.....................................................................................................
27
2.2.6
PROTEIN
AGGREGATION
ASSAY
.......................................................................................
27
2.2.7
COMPETITIVE
TRANSPLANTATION
ASSAY
........................................................................
27
2.2.8
DNA
EXTRACTION
AND
GENOTYPING
.............................................................................
28
2.2.9
RNA
EXTRACTION
AND
RT-PCR
.................................................................................
28
2.2.10
TREATMENTS
...............................................................................................................
29
2.2.11
MOUSE
EMBRYONIC
FIBROBLAST
CELLS
(MEFS)
ISOLATION
........................................30
2.2.12
CELL
CULTURE
..............................................................................................................
30
2.2.13
PLASMID
CONSTRUCTION
..............................................................................................31
2.2.14
LENTIVIRUS
PRODUCTION
............................................................................................
32
2.2.15
IMMUNO-FLUORESCENCE
ASSAY
...................................................................................33
2.2.16
MASS
SPECTROMETRY
ANALYSIS
OF
S-NITROSYLATION
OF
PROTEINS
..............................
33
2.2.17
STATISTICAL
ANALYSIS
...................................................................................................
35
3.
RESULTS
..............................................................................................................................................
35
3.1
NO
BUT
NOT
ROS
LEVEL
INCREASES
DURING
HSC
REGENERATION
...........................................
35
3.2
PROTEIN
AGGREGATION
ACCUMULATES
IN
HSCS
POST
5-FU
TREATMENT
.................................
38
3.3
GSNOF
7
MICE
SHOW
NORMAL
HEMATOLOGIC
PHENOTYPE
UNDER
HOMEOSTATIC
CONDITION....
39
3.4
GSNOR
DEFICIENCY
IMPAIRS
HSC
REGENERATION
AFTER
5-FU
TREATMENT
.............................
41
3.5
DELETION
OF
GSNOR
IMPAIRS
THE
REPOPULATING
ABILITY
OF
HSCS
........................................
45
3.6
NO
SYNTHESIS
INHIBITION
RESTORES
THE
REGENERATIVE
CAPACITY
OF
GSNOR
DEFICIENT
HSCS
47
3.7
L-NAME
TREATMENT
RESCUES
THE
DEFECT
OF
HSC
RECOVERY
IN
GSNOR
DELETED
MICE
......
50
3.8
CHEMICAL
CHAPERONE
RESCUES
THE
REGENERATION
DEFECT
OF
GSNORHSCS
.......................
52
3.9
CHOP
DELETION
RESCUES
THE
IMPAIRED
FUNCTION
OF
GSNOR
-
HSCS
.....................................
54
4.
DISCUSSION
.........................................................................................................................................60
5.
REFERENCE
..........................................................................................................................................
63
APPENDIX:
1
...........................................................................................................................................
68
ACKNOWLEDGMENTS
.......................................................................................................................68
APPENDIX:
II
.........................................................................................................................................
69
LIST
OF
FIGURES
...............................................................................................................................
69
APPENDIX:
III
........................................................................................................................................
70
LIST
OF
PRIMERS
..............................................................................................................................
70
APPENDIX:
IV
........................................................................................................................................71
LIST
OF
PUBLICATIONS
......................................................................................................................
71
DECLARATION
...........................................................................................................................................
72
2
|
| adam_txt |
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
.
1
ABBREVIATIONS
.
3
ZUSAMMENFASSUNG
.
7
SUMMARY
.
9
1.
INTRODUCTION
.
10
1.1
HEMATOPOIETIC
STEM
CELLS
.
10
1.1.1
HEMATOPOIETIC
HIERARCHY
.
10
1.1.2
IDENTITY
OF
ADULT
HSC
.
11
1.2
RNS
AND
NO
IN
HSC
.
12
.
14
1.3
NO
AND
GSNOR
.
14
1.4
SNO
AND
PROTEOSTASIS
.
15
1.5
AIM
OF
RESEARCH
.
17
2.
MATERIALS
AND
METHODS
.
18
2.1
MATERIALS
.
18
2.1.1
MATERIALS
AND
EQUIPMENT
.
18
2.1.2
REAGENTS
AND
CHEMICALS
.
19
2.1.3
ANTIBODIES
AND
KITS
.
21
2.2
METHODS
.
24
2.2.1
MICE
.
24
2.2.2
BONE
MARROW
ISOLATION
AND
FLOW
CYTOMETRY
.
24
2.2.3
ANNEXIN
V
STAINING
AND
CASPASE
3/7
BASED
LUMINESCENCE
ASSAY
.
25
2.2.4
CELL
CYCLE
STAINING
.
26
2.2.5
NO
LEVEL
DETECTION
.
27
2.2.6
PROTEIN
AGGREGATION
ASSAY
.
27
2.2.7
COMPETITIVE
TRANSPLANTATION
ASSAY
.
27
2.2.8
DNA
EXTRACTION
AND
GENOTYPING
.
28
2.2.9
RNA
EXTRACTION
AND
RT-PCR
.
28
2.2.10
TREATMENTS
.
29
2.2.11
MOUSE
EMBRYONIC
FIBROBLAST
CELLS
(MEFS)
ISOLATION
.30
2.2.12
CELL
CULTURE
.
30
2.2.13
PLASMID
CONSTRUCTION
.31
2.2.14
LENTIVIRUS
PRODUCTION
.
32
2.2.15
IMMUNO-FLUORESCENCE
ASSAY
.33
2.2.16
MASS
SPECTROMETRY
ANALYSIS
OF
S-NITROSYLATION
OF
PROTEINS
.
33
2.2.17
STATISTICAL
ANALYSIS
.
35
3.
RESULTS
.
35
3.1
NO
BUT
NOT
ROS
LEVEL
INCREASES
DURING
HSC
REGENERATION
.
35
3.2
PROTEIN
AGGREGATION
ACCUMULATES
IN
HSCS
POST
5-FU
TREATMENT
.
38
3.3
GSNOF
7
'
MICE
SHOW
NORMAL
HEMATOLOGIC
PHENOTYPE
UNDER
HOMEOSTATIC
CONDITION.
39
3.4
GSNOR
DEFICIENCY
IMPAIRS
HSC
REGENERATION
AFTER
5-FU
TREATMENT
.
41
3.5
DELETION
OF
GSNOR
IMPAIRS
THE
REPOPULATING
ABILITY
OF
HSCS
.
45
3.6
NO
SYNTHESIS
INHIBITION
RESTORES
THE
REGENERATIVE
CAPACITY
OF
GSNOR
DEFICIENT
HSCS
47
3.7
L-NAME
TREATMENT
RESCUES
THE
DEFECT
OF
HSC
RECOVERY
IN
GSNOR
DELETED
MICE
.
50
3.8
CHEMICAL
CHAPERONE
RESCUES
THE
REGENERATION
DEFECT
OF
GSNORHSCS
.
52
3.9
CHOP
DELETION
RESCUES
THE
IMPAIRED
FUNCTION
OF
GSNOR
-
HSCS
.
54
4.
DISCUSSION
.60
5.
REFERENCE
.
63
APPENDIX:
1
.
68
ACKNOWLEDGMENTS
.68
APPENDIX:
II
.
69
LIST
OF
FIGURES
.
69
APPENDIX:
III
.
70
LIST
OF
PRIMERS
.
70
APPENDIX:
IV
.71
LIST
OF
PUBLICATIONS
.
71
DECLARATION
.
72
2 |
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| author | Weiwei, Yi 1988- |
| author_GND | (DE-588)1268646970 (DE-588)121126102 (DE-588)124448607 (DE-588)1117836568 |
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| author_role | aut |
| author_sort | Weiwei, Yi 1988- |
| author_variant | y w yw |
| building | Verbundindex |
| bvnumber | BV048961585 |
| ctrlnum | (OCoLC)1372142788 (DE-599)KXP1817333003 |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV048961585 |
| illustrated | Illustrated |
| index_date | 2024-07-03T22:00:34Z |
| indexdate | 2024-07-10T09:51:21Z |
| institution | BVB |
| institution_GND | (DE-588)36164-1 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034225336 |
| oclc_num | 1372142788 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 72 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| record_format | marc |
| spelling | Weiwei, Yi 1988- Verfasser (DE-588)1268646970 aut S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration by Weiwei Yi Jena [2022] 72 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Schiller-Universität Jena 2022 (DE-588)4113937-9 Hochschulschrift gnd-content Rudolph, Karl Lenhard 1969- (DE-588)121126102 dgs Kosan, Christian 1971- (DE-588)124448607 dgs Geiger, Hartmut (DE-588)1117836568 dgs Friedrich-Schiller-Universität Jena (DE-588)36164-1 dgg B:DE-101 application/pdf https://d-nb.info/1269995901/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034225336&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,81023 20230213 DE-101 https://d-nb.info/provenance/plan#emakn 2\p dnb 20230217 DE-101 https://d-nb.info/provenance/plan#dnb 3\p dnb 20230217 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Weiwei, Yi 1988- S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| subject_GND | (DE-588)4113937-9 |
| title | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| title_auth | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| title_exact_search | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| title_exact_search_txtP | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| title_full | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration by Weiwei Yi |
| title_fullStr | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration by Weiwei Yi |
| title_full_unstemmed | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration by Weiwei Yi |
| title_short | S-nitrosoglutathione reductase (GSNOR) deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| title_sort | s nitrosoglutathione reductase gsnor deficiency impairs hematopoietic stem cell proteostasis and regeneration |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1269995901/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034225336&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT weiweiyi snitrosoglutathionereductasegsnordeficiencyimpairshematopoieticstemcellproteostasisandregeneration AT rudolphkarllenhard snitrosoglutathionereductasegsnordeficiencyimpairshematopoieticstemcellproteostasisandregeneration AT kosanchristian snitrosoglutathionereductasegsnordeficiencyimpairshematopoieticstemcellproteostasisandregeneration AT geigerhartmut snitrosoglutathionereductasegsnordeficiencyimpairshematopoieticstemcellproteostasisandregeneration AT friedrichschilleruniversitatjena snitrosoglutathionereductasegsnordeficiencyimpairshematopoieticstemcellproteostasisandregeneration |
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