Genetische Prädisposition für unilaterale Vestibularisschwannome:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
Freiburg im Breisgau
[2022]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 68 Seiten Illustrationen, Diagramme 30 cm |
Staff View
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Record in the Search Index
| _version_ | 1804185112030478336 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
INHALTSVERZEICHNIS
.....................................................................................................................................
II
ABKUERZUNGSVERZEICHNIS
.............................................................................................................................
1
ABBILDUNGSVERZEICHNIS
.............................................................................................................................
2
T
ABELLENVERZEICHNIS
..................................................................................................................................
3
1.
ZIELSETZUNG
...........................................................................................................................................
4
2.
EINLEITUNG
..............................................................................................................................................
5
2.1
VESTIBULARISSCHWANNOM
..................................................................................................................
5
2.1.1
EPIDEMIOLOGIE
.............................................................................................................................
6
2.1.2
PATHOGENESE
UND
LOKALISATION
.....................................................................................................
6
2.1.3
KLINIK
..........................................................................................................................................
7
2.1.4
DIAGNOSTIK
...................................................................................................................................
8
2.1.5
AETIOLOGIE
......................................................................................................................................
9
2.1.6
THERAPIE
......................................................................................................................................
10
2.1.6.1
CHIRURGISCHE
THERAPIE
........................................................................................................
10
2.1.6.2
STRAHLENTHERAPIE
..................................................................................................................
11
2.1.6.3
VERLAUFSKONTROLLE
................................................................................................................
12
2.2
GENETIK
UND
MOLEKULARE
MECHANISMEN
........................................................................................
13
2.2.1
MMPS/MATRIX
METALLOPROTEINASEN
.........................................................................................
13
2.2.2
TISSUE
INHIBITOR
OF
METALLOPROTEINASE
3
/
TIMP3
..................................................................
14
2.2.3
CAVEOLIN
1/
CAVI
.................................................................................................................
16
2.2.4
LOH
ANALYSEN
.......................................................................................................................
18
3.
MATERIAL
UND
METHODEN
......................................................................................................................
19
3.1
MATERIAL
.........................................................................................................................................
19
3.1.1
PROBEN
...................................................................................................................................
19
3.1.2
PRIMER
....................................................................................................................................
19
3.1.3
LOSS
OF
HETEROZYGOSITY-MARKER
............................................................................................
21
3.1.4
INTRON/EXON-STRUKTUR
.............................................................................................................
23
3.1.5
CHEMIKALIEN
UND
REAGENZIEN
...............................................................................................
24
3.1.6
KITS
.........................................................................................................................................
24
3.2.7
GERAETE
.....................................................................................................................................
25
3.2.8
PROGRAMME
UND
FEATURES
.......................................................................................................
25
3.2
METHODEN
......................................................................................................................................
25
3.2.1
DNA-PRAEPARATION
...................................................................................................................
25
3.2.2
PHOTOMETRIE
...........................................................................................................................
26
3.2.3
PCR
ZUR
FRAGMENTVERVIELFAELTIGUNG
........................................................................................
26
3.2.4
GELELEKTROPHORESE
..................................................................................................................
27
3.2.5
REINIGUNG
DES
PCR-PRODUKTS
................................................................................................
28
3.2.6
SEQUENZIERUNG
DER
DNA-FRAGMENTE
......................................................................................
28
3.2.7
SEQUENZABGLEICH
UND
PATHOGENITAETSPRUEFUNG
.........................................................................
30
3.2.8
PATHOGENITAETSPRUEFUNG
.............................................................................................................
30
3.2.9
STATITISCHE
METHODEN
.............................................................................................................
30
4.
ERGEBNISSE
...........................................................................................................................................
32
4.1
PATIENTENKOLLEKTIV
.........................................................................................................................
32
4.2
KLINISCHE
DATEN
............................................................................................................................
32
4.3
DNA-SEQUENZIERUNG
....................................................................................................................
33
4.3.1
CAVEOLIN
1
.............................................................................................................................
33
4.3.2
TIMP3
....................................................................................................................................
33
4.4
LOH-ANALYSEN
.............................................................................................................................
38
4.4.1
TUMORGROESSE
...........................................................................................................................
38
4.4.2
DIAGNOSEALTER
.........................................................................................................................
39
4.4.3
KLINISCHE
SYMPTOME:
HOERMINDERUNG,
TINNITUS
UND
SCHWINDEL
...........................................
40
4.4.4
THERAPIE
.................................................................................................................................
43
5.
DISKUSSION
...........................................................................................................................................
45
5.1
SEQUENZIERUNG
..............................................................................................................................
45
5.1.1
CAVEOLIN
1
.............................................................................................................................
45
5.1.2
TIMP3
...................................................................................................................................
47
5.2
LOSS
OF
HETEROZYGOSITY
......................................................................................................,..........
48
5.2.1
KLINISCHE
DATEN
.....................................................................................................................
49
5.3
ALLGEMEINEN
LIMITATIONEN
............................................................................................................
50
5.4
FAZIT
UND
IMPLIKATIONEN
FUER
THEORIE
UND
PRAXIS
..........................................................................
52
6.
ZUSAMMENFASSUNG
..............................................................................................................................
54
7.
LITERATURVERZEICHNIS
............................................................................................................................
55
8.
LEBENSLAUF
...........................................................................................................................................
65
9.
EIDESSTATTLICHE
VERSICHERUNG
..............................................................................................................
67
10.
DANKSAGUNG
......................................................................................................................................
68
|
| adam_txt |
INHALTSVERZEICHNIS
INHALTSVERZEICHNIS
.
II
ABKUERZUNGSVERZEICHNIS
.
1
ABBILDUNGSVERZEICHNIS
.
2
T
ABELLENVERZEICHNIS
.
3
1.
ZIELSETZUNG
.
4
2.
EINLEITUNG
.
5
2.1
VESTIBULARISSCHWANNOM
.
5
2.1.1
EPIDEMIOLOGIE
.
6
2.1.2
PATHOGENESE
UND
LOKALISATION
.
6
2.1.3
KLINIK
.
7
2.1.4
DIAGNOSTIK
.
8
2.1.5
AETIOLOGIE
.
9
2.1.6
THERAPIE
.
10
2.1.6.1
CHIRURGISCHE
THERAPIE
.
10
2.1.6.2
STRAHLENTHERAPIE
.
11
2.1.6.3
VERLAUFSKONTROLLE
.
12
2.2
GENETIK
UND
MOLEKULARE
MECHANISMEN
.
13
2.2.1
MMPS/MATRIX
METALLOPROTEINASEN
.
13
2.2.2
TISSUE
INHIBITOR
OF
METALLOPROTEINASE
3
/
TIMP3
.
14
2.2.3
CAVEOLIN
1/
CAVI
.
16
2.2.4
LOH
ANALYSEN
.
18
3.
MATERIAL
UND
METHODEN
.
19
3.1
MATERIAL
.
19
3.1.1
PROBEN
.
19
3.1.2
PRIMER
.
19
3.1.3
LOSS
OF
HETEROZYGOSITY-MARKER
.
21
3.1.4
INTRON/EXON-STRUKTUR
.
23
3.1.5
CHEMIKALIEN
UND
REAGENZIEN
.
24
3.1.6
KITS
.
24
3.2.7
GERAETE
.
25
3.2.8
PROGRAMME
UND
FEATURES
.
25
3.2
METHODEN
.
25
3.2.1
DNA-PRAEPARATION
.
25
3.2.2
PHOTOMETRIE
.
26
3.2.3
PCR
ZUR
FRAGMENTVERVIELFAELTIGUNG
.
26
3.2.4
GELELEKTROPHORESE
.
27
3.2.5
REINIGUNG
DES
PCR-PRODUKTS
.
28
3.2.6
SEQUENZIERUNG
DER
DNA-FRAGMENTE
.
28
3.2.7
SEQUENZABGLEICH
UND
PATHOGENITAETSPRUEFUNG
.
30
3.2.8
PATHOGENITAETSPRUEFUNG
.
30
3.2.9
STATITISCHE
METHODEN
.
30
4.
ERGEBNISSE
.
32
4.1
PATIENTENKOLLEKTIV
.
32
4.2
KLINISCHE
DATEN
.
32
4.3
DNA-SEQUENZIERUNG
.
33
4.3.1
CAVEOLIN
1
.
33
4.3.2
TIMP3
.
33
4.4
LOH-ANALYSEN
.
38
4.4.1
TUMORGROESSE
.
38
4.4.2
DIAGNOSEALTER
.
39
4.4.3
KLINISCHE
SYMPTOME:
HOERMINDERUNG,
TINNITUS
UND
SCHWINDEL
.
40
4.4.4
THERAPIE
.
43
5.
DISKUSSION
.
45
5.1
SEQUENZIERUNG
.
45
5.1.1
CAVEOLIN
1
.
45
5.1.2
TIMP3
.
47
5.2
LOSS
OF
HETEROZYGOSITY
.,.
48
5.2.1
KLINISCHE
DATEN
.
49
5.3
ALLGEMEINEN
LIMITATIONEN
.
50
5.4
FAZIT
UND
IMPLIKATIONEN
FUER
THEORIE
UND
PRAXIS
.
52
6.
ZUSAMMENFASSUNG
.
54
7.
LITERATURVERZEICHNIS
.
55
8.
LEBENSLAUF
.
65
9.
EIDESSTATTLICHE
VERSICHERUNG
.
67
10.
DANKSAGUNG
.
68 |
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| author_GND | (DE-588)1278584080 |
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| index_date | 2024-07-03T21:55:59Z |
| indexdate | 2024-07-10T09:50:03Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034189927 |
| oclc_num | 1362479750 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | 68 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| record_format | marc |
| spelling | Neuhold, Alexander Verfasser (DE-588)1278584080 aut Genetische Prädisposition für unilaterale Vestibularisschwannome vorgelegt von Raimund Alexander Neuhold Freiburg im Breisgau [2022] 68 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2022 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1281026972/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034189927&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,06987 20230222 DE-101 https://d-nb.info/provenance/plan#emakn 2\p dnb 20230302 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Neuhold, Alexander Genetische Prädisposition für unilaterale Vestibularisschwannome |
| subject_GND | (DE-588)4113937-9 |
| title | Genetische Prädisposition für unilaterale Vestibularisschwannome |
| title_auth | Genetische Prädisposition für unilaterale Vestibularisschwannome |
| title_exact_search | Genetische Prädisposition für unilaterale Vestibularisschwannome |
| title_exact_search_txtP | Genetische Prädisposition für unilaterale Vestibularisschwannome |
| title_full | Genetische Prädisposition für unilaterale Vestibularisschwannome vorgelegt von Raimund Alexander Neuhold |
| title_fullStr | Genetische Prädisposition für unilaterale Vestibularisschwannome vorgelegt von Raimund Alexander Neuhold |
| title_full_unstemmed | Genetische Prädisposition für unilaterale Vestibularisschwannome vorgelegt von Raimund Alexander Neuhold |
| title_short | Genetische Prädisposition für unilaterale Vestibularisschwannome |
| title_sort | genetische pradisposition fur unilaterale vestibularisschwannome |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1281026972/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034189927&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT neuholdalexander genetischepradispositionfurunilateralevestibularisschwannome |
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