Nanomedicine: panacea or pandora's box
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| Main Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
Boca Raton ; London
CRC Press, Taylor & Francis
2023
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | ix, 163 Seiten |
| ISBN: | 9780367436247 9781032435435 |
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| adam_text | Contents Authors....................................................................................................................... ix Chapter 1 Introduction............................................................................................1 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Chapter 2 What Is Nano?..............................................................................2 The Structure............................................................................... 4 The Place of Novelty in Innovation............................................. 4 The Definition of Nanomedicine................................................. 5 Can the Definition of the Nano (Nanosciences and Nanotechnology) Be Limited to Size?....................................... 5 To Go Further............................................................................ 7 References................................................................................. 7 Nanopharmacy: What Is New With the Nano?...................................... 9 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 The Nanomedical Strategy...................................................... 10 Isn’t Everything Nano?............................................................ 11 Titanium and Other Nano-metals............................................ 13 Nanopharmaceuticals by Design............................................. 13 The Bottom-up Paradigm of Molecular Design Applied to Drugs..................................................................................... 14 From
Empirical Plant-Based Recipes to Industrial Products: Ushering in a New Era of Chemotherapy?.... 15 Paul Ehrlich, Magic Bullets, Receptors, and the Lock and Key Analogy............................................................ 18 Nanopharmacy as Drug Design...............................................21 Vectors and Encapsulation....................................................... 21 Basic Nanomaterials: Chylomicrons, Micelles and Liposomes...................................................................... 22 Man-Made Micelles and Liposomes.......................................22 The First Generation—Liposomal Vectors............................. 23 The Second Generation—PEGylation.....................................24 The Third Generation—Nanomaterials With Specifically Modified Surfaces................................................. 25 2.14.1 Multi-functional Vectors.............................................. 25 2.14.2 Albumin as the New Nanoparticle Standard...............27 Is Nanopharmacy a Medical Revolution?............................... 28 Pharmacy Is Not Always What It Seems.................................29 To Go Further.......................................................................... 30 References............................................................................... 31 v
Contents vi Chapter 3 Theranostics: Toward a New Integrative Horizon...............................33 Theranostics—A Broad Definition........................................... 34 Breast Cancer: Appropriate Treatments for Different Tumors...................................................................................... 36 3.3 Radioligand Therapy—The Dual Functionality of Radioactivity............................................................................. 38 3.4 Remote Guidance and Imaging—The Theranostic Potential of Magnetic Nanoparticles....................................... 39 3.5 The Prostate-Specific Antigen (PSA) and Prostate Cancer....................................................................................... 41 3.6 Transferrin and Biological Barriers. Another Form of Theranostics?............................................................................43 3.7 Visualizing Folate Receptors During Surgery.......................... 44 3.8 Diagnosis and Treatment: The Dawning of a New Era?......... 44 3.9 Theranostics and Precision Medicine: Refining and Individualizing Treatment........................................................ 46 3.10 Genetics and Cancer.................................................................. 48 3.11 To Go Further............................................................................ 50 3.12 References................................................................................. 50 3.1 3.2 Chapter 4 Health Under Surveillance................................................................. 53 4.1 4.2 4.3
Chapter 5 Genetic Nanomedicine...................................................................... 65 5.1 5.2 5.3 Chapter 6 In Vivo, In Vitro, In Silico: The Inversion of Scales in Genetic Analysis............................................................ 54 4.1.1 Probes—A Future Outside the Array?........................ 57 4.1.2 NBIC Convergence and Nanoelectronics................... 59 To Go Further........................................................................... 62 References................................................................................ 63 Using Nanoparticles to Integrate Elements of Nucleic Acids Into Cells........................................................................65 The Use of NPs for Vaccination Against Infectious Diseases........................................................ 68 5.2.1 How Vaccines Fit Into Nanomedicine........................ 73 References................................................................................ 76 Toxicology of Nanomaterials: A New Toxicology?........................... 77 6.1 6.2 6.3 New Methods, New Possibilities, New Investigations............. 77 Entry Into the Body: The Three Principal Routes.....................79 6.2.1 The Skin...................................................................... 80 6.2.2 The Lungs.................................................................... 80 6.2.3 The Intestines.............................................................. 82 The Blood-Brain Barrier: An Inner Frontier............................. 82
vii Contents 6.4 6.5 6.6 6.7 6.8 6.9 6.10 6.11 6.12 6.13 Chapter 7 Organs on Chips, Miniaturization and Medical Specialties: The Different Logics of Nanomedicine............................................... 93 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 7.10 7.11 7.12 7.13 7.14 7.15 Chapter 8 The Distribution of Nanoparticles in the Body........................ 82 6.4.1 The Metabolism of Nanoparticles............................... 83 6.4.2 The Elimination of Nanoparticles............................... 83 Cell Response............................................................................ 83 6.5.1 How Nanoparticles Enter the Cells?........................... 83 6.5.2 Cellular Reactions to Nanoparticles............................ 85 The Paradox of the Dose-Function Relationship With Nanoparticles............................................................................ 86 6.6.1 New Paradigms for the Toxicological Testing of Nanoparticles.......................................................... 86 How to Express Dose?............................................................... 86 Immune Paralysis by Overloading............................................ 87 Biopersistency* and ‘Frustrated Phagocytosis’........................ 88 The Corona of Nanoparticles..................................................... 88 Are Stealthy Nanoparticles a Myth?.......................................... 89 To Go Further............................................................................ 91
References................................................................................. 91 The Goals and Limits of Miniaturization................................. 94 Miniaturizing Organisms and Organs. The Possibilities and the Limits........................................................................... 95 From the Lab(oratory)-on-a֊Chip to the Organ-ona-Chip....................................................................................... 97 The Organ-on֊a-Chip: Is the Future of Metabolic Testing Already Here?.............................................................. 98 Lung Cells................................................................................. 98 Heart Cells................................................................................. 99 Skin............................................................................................ 99 Multiple Organs....................................................................... 100 Organs on Chips and the Nano................................................ 102 Why Do We Need Organs on Chips?...................................... 103 Tumors on Chips...................................................................... 105 Miniaturization and the Nano.................................................. 107 Nanomedicine as a Distributed Approach toMedical Specialties............................................................................... 107 To Go Further.......................................................................... 109
References............................................................................... 110 Regenerative Medicine: Mobilizing the Body’s Own Repair Mechanisms...................................................................................... Ill 8.1 The Potential of the Stem Cells Behind Regenerative Medicine..................................................................... 112
Contents viii 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 Chapter 9 Replacing Missing Bone as a Nano-architectural, Functional Challenge.............................................................. 113 8.2.1 Nanoparticles, Nanotubes and Nanofibers............... 115 8.2.2 Carbon Nanomaterials................................................ 115 8.2.3 Graphene—A Flagship Nano-material....................... 116 8.2.4 Peptide Amphiphiles.................................................. 117 8.2.5 Hydrogels................................................................... 118 8.2.6 Magnetic Scaffolds..................................................... 118 Mesenchymal Stem Cells—The Key toRegenerative Medicine.................................................................................119 8.3.1 Diseases of the Bones and Joints............................... 120 8.3.2 Heart Disease............................................................. 120 Angiogenesis.......................................................................... 121 The Potential of Stem Cells.....................................................121 From Replacement to Enhancement........................................122 Autologous Organ Transplantation.......................................... 122 To Go Further......................................................................... 123 References...............................................................................124 Conclusion........................................................................................ 125 9.1
References...............................................................................128 Glossary........................................................................................................................131 Index 159
The nook s an ntiocuction to nanomedicine informed by a philosophical reflection anom :he cocáin ene recert developments. It is an overview of the field, sketching o_t the mam areas of current investment and research. The authors present some case studies rmstrating the deferent areas of research (nanopharmacy, theranostics ano patient monitoring) as meli as reflecting on the risks that accompany it. such as unanticipatec impacts on human health and environmental toxicity. This introduction то a xast-growmg field in modern medical research is of great interest to researchers working n many dmciolmes as well as the general public. In addition to an overview o; me work currency ongoing. the authors critically assess these projects from an etn.cal ano philosophical perspective. Key Features • Provides an overview of nanomedicine • Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine • Written in an accessible manner intended for a wide audience
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| adam_txt |
Contents Authors. ix Chapter 1 Introduction.1 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Chapter 2 What Is Nano?.2 The Structure. 4 The Place of Novelty in Innovation. 4 The Definition of Nanomedicine. 5 Can the Definition of the Nano (Nanosciences and Nanotechnology) Be Limited to Size?. 5 To Go Further. 7 References. 7 Nanopharmacy: What Is New With the Nano?. 9 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 The Nanomedical Strategy. 10 Isn’t Everything Nano?. 11 Titanium and Other Nano-metals. 13 Nanopharmaceuticals by Design. 13 The Bottom-up Paradigm of Molecular Design Applied to Drugs. 14 From
Empirical Plant-Based Recipes to Industrial Products: Ushering in a New Era of Chemotherapy?. 15 Paul Ehrlich, Magic Bullets, Receptors, and the Lock and Key Analogy. 18 Nanopharmacy as Drug Design.21 Vectors and Encapsulation. 21 Basic Nanomaterials: Chylomicrons, Micelles and Liposomes. 22 Man-Made Micelles and Liposomes.22 The First Generation—Liposomal Vectors. 23 The Second Generation—PEGylation.24 The Third Generation—Nanomaterials With Specifically Modified Surfaces. 25 2.14.1 Multi-functional Vectors. 25 2.14.2 Albumin as the New Nanoparticle Standard.27 Is Nanopharmacy a Medical Revolution?. 28 Pharmacy Is Not Always What It Seems.29 To Go Further. 30 References. 31 v
Contents vi Chapter 3 Theranostics: Toward a New Integrative Horizon.33 Theranostics—A Broad Definition. 34 Breast Cancer: Appropriate Treatments for Different Tumors. 36 3.3 Radioligand Therapy—The Dual Functionality of Radioactivity. 38 3.4 Remote Guidance and Imaging—The Theranostic Potential of Magnetic Nanoparticles. 39 3.5 The Prostate-Specific Antigen (PSA) and Prostate Cancer. 41 3.6 Transferrin and Biological Barriers. Another Form of Theranostics?.43 3.7 Visualizing Folate Receptors During Surgery. 44 3.8 Diagnosis and Treatment: The Dawning of a New Era?. 44 3.9 Theranostics and Precision Medicine: Refining and Individualizing Treatment. 46 3.10 Genetics and Cancer. 48 3.11 To Go Further. 50 3.12 References. 50 3.1 3.2 Chapter 4 Health Under Surveillance. 53 4.1 4.2 4.3
Chapter 5 Genetic Nanomedicine. 65 5.1 5.2 5.3 Chapter 6 In Vivo, In Vitro, In Silico: The Inversion of Scales in Genetic Analysis. 54 4.1.1 Probes—A Future Outside the Array?. 57 4.1.2 NBIC Convergence and Nanoelectronics. 59 To Go Further. 62 References. 63 Using Nanoparticles to Integrate Elements of Nucleic Acids Into Cells.65 The Use of NPs for Vaccination Against Infectious Diseases. 68 5.2.1 How Vaccines Fit Into Nanomedicine. 73 References. 76 Toxicology of Nanomaterials: A New Toxicology?. 77 6.1 6.2 6.3 New Methods, New Possibilities, New Investigations. 77 Entry Into the Body: The Three Principal Routes.79 6.2.1 The Skin. 80 6.2.2 The Lungs. 80 6.2.3 The Intestines. 82 The Blood-Brain Barrier: An Inner Frontier. 82
vii Contents 6.4 6.5 6.6 6.7 6.8 6.9 6.10 6.11 6.12 6.13 Chapter 7 Organs on Chips, Miniaturization and Medical Specialties: The Different Logics of Nanomedicine. 93 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 7.10 7.11 7.12 7.13 7.14 7.15 Chapter 8 The Distribution of Nanoparticles in the Body. 82 6.4.1 The Metabolism of Nanoparticles. 83 6.4.2 The Elimination of Nanoparticles. 83 Cell Response. 83 6.5.1 How Nanoparticles Enter the Cells?. 83 6.5.2 Cellular Reactions to Nanoparticles. 85 The Paradox of the Dose-Function Relationship With Nanoparticles. 86 6.6.1 New Paradigms for the Toxicological Testing of Nanoparticles. 86 How to Express Dose?. 86 Immune Paralysis by Overloading. 87 Biopersistency* and ‘Frustrated Phagocytosis’. 88 The Corona of Nanoparticles. 88 Are Stealthy Nanoparticles a Myth?. 89 To Go Further. 91
References. 91 The Goals and Limits of Miniaturization. 94 Miniaturizing Organisms and Organs. The Possibilities and the Limits. 95 From the Lab(oratory)-on-a֊Chip to the Organ-ona-Chip. 97 The Organ-on֊a-Chip: Is the Future of Metabolic Testing Already Here?. 98 Lung Cells. 98 Heart Cells. 99 Skin. 99 Multiple Organs. 100 Organs on Chips and the Nano. 102 Why Do We Need Organs on Chips?. 103 Tumors on Chips. 105 Miniaturization and the Nano. 107 Nanomedicine as a Distributed Approach toMedical Specialties. 107 To Go Further. 109
References. 110 Regenerative Medicine: Mobilizing the Body’s Own Repair Mechanisms. Ill 8.1 The Potential of the Stem Cells Behind Regenerative Medicine. 112
Contents viii 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 Chapter 9 Replacing Missing Bone as a Nano-architectural, Functional Challenge. 113 8.2.1 Nanoparticles, Nanotubes and Nanofibers. 115 8.2.2 Carbon Nanomaterials. 115 8.2.3 Graphene—A Flagship Nano-material. 116 8.2.4 Peptide Amphiphiles. 117 8.2.5 Hydrogels. 118 8.2.6 Magnetic Scaffolds. 118 Mesenchymal Stem Cells—The Key toRegenerative Medicine.119 8.3.1 Diseases of the Bones and Joints. 120 8.3.2 Heart Disease. 120 Angiogenesis. 121 The Potential of Stem Cells.121 From Replacement to Enhancement.122 Autologous Organ Transplantation. 122 To Go Further. 123 References.124 Conclusion. 125 9.1
References.128 Glossary.131 Index 159
The nook s an ntiocuction to nanomedicine informed by a philosophical reflection anom :he cocáin ene recert developments. It is an overview of the field, sketching o_t the mam areas of current investment and research. The authors present some case studies rmstrating the deferent areas of research (nanopharmacy, theranostics ano patient monitoring) as meli as reflecting on the risks that accompany it. such as unanticipatec impacts on human health and environmental toxicity. This introduction то a xast-growmg field in modern medical research is of great interest to researchers working n many dmciolmes as well as the general public. In addition to an overview o; me work currency ongoing. the authors critically assess these projects from an etn.cal ano philosophical perspective. Key Features • Provides an overview of nanomedicine • Employs a reflective and coherent critical evaluation of the benefits and risks of nanomedicine • Written in an accessible manner intended for a wide audience |
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| spelling | Simon, Jonathan 1964- Verfasser (DE-588)141218312 aut Nanomedicine panacea or pandora's box Jonathan Simon and Bertram H. Rihn Boca Raton ; London CRC Press, Taylor & Francis 2023 ix, 163 Seiten txt rdacontent n rdamedia nc rdacarrier Nanomedizin (DE-588)1067838503 gnd rswk-swf Nanomedizin (DE-588)1067838503 s DE-604 Rihn, Bertram H. Verfasser aut Erscheint auch als Online-Ausgabe 978-1-003-36783-3 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034153976&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034153976&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
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| subject_GND | (DE-588)1067838503 |
| title | Nanomedicine panacea or pandora's box |
| title_auth | Nanomedicine panacea or pandora's box |
| title_exact_search | Nanomedicine panacea or pandora's box |
| title_exact_search_txtP | Nanomedicine panacea or pandora's box |
| title_full | Nanomedicine panacea or pandora's box Jonathan Simon and Bertram H. Rihn |
| title_fullStr | Nanomedicine panacea or pandora's box Jonathan Simon and Bertram H. Rihn |
| title_full_unstemmed | Nanomedicine panacea or pandora's box Jonathan Simon and Bertram H. Rihn |
| title_short | Nanomedicine |
| title_sort | nanomedicine panacea or pandora s box |
| title_sub | panacea or pandora's box |
| topic | Nanomedizin (DE-588)1067838503 gnd |
| topic_facet | Nanomedizin |
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