Fundamentals of radiation biology:
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| Main Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
New Jersey ; London ; Singapore
World Scientific
[2023]
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xiv, 384 Seiten Illustrationen, Diagramme |
| ISBN: | 9789811258916 9811258910 9789811257650 9811257655 |
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| adam_text | Ni Contents xiii Preface Chapter 1 The Origins of Radiation 1 1.1. Introduction 1 1.2. Radiation Produced by Radionuclides 1 1.2.1. Nuclear Structure 1 1.2.2. Binding Energy 2 1.2.3. Radioactive Decay 4 1.2.4. Decay Energy, Q 9 1.2.5. Particle Kinetic Energy, T 1.3. Machine-Produced Radiation Chapter 2 15 16 1.3.1. History 16 1.3.2. Diagnostic X-ray Machines 17 1.3.3. Therapeutic X-ray Machines 17 1.3.4. Heavy Particle Therapy Machines 20 1.4 Summary 22 1.5. Problems 23 1.6. Bibliography 24 Interactions Between Radiation and Absorbing Materials 27 2.1. Introduction 27 2.2. The Structure of Matter 27 2.3. Interactions Involving Neutral Particles 28 2.3.1 Massless Neutral Particles 2.Յ.1.1. Macroscopic implicationsfor massless particles 2.3.2 . Massive Neutral Particles — Neutrons 28 37 39 2.4. Interactions Involving Charged Particles 42 2.5. Energy Transfer 43 2.5.1. Massless Neutral Particles 43 2.5.2. Massive Neutral Particles 46 2.5.3. Massive Charged Particles 47
eíí Fundamentals of Radiation Biology 2.6. Kerma, Cerna, and Dose Chapter 3 2.6.1. Kerma 48 2.6.2. Cerna 50 2.6.3. Dose 50 2.7. Stopping Power 50 2.8. Summary 57 2.9. Problems 58 2.10. Bibliography 59 Radiation Chemistry 61 3.1. Introduction 61 3.2. Radiolysis of Water 61 3.3. The Structure of DNA 64 3.4. Indirect Damage of DNA 66 3.5. Direct Damage of DNA 68 3.6. Summary 71 3.7. Problems 73 3.8. Bibliography 74 Chapter 4 The Biochemistry of DNA Repair Chapter 5 48 75 4.1. Introduction 75 4.2. A Brief Review of Molecular Biology 75 4.3. DNA Damage and Repair 82 4.4. Genetic Mutations 86 4.5. Chromosomal Damage 88 4.6. Cell Death 91 4.7. Summary 94 4.8. Problems 96 4.9. Bibliography 99 Higher Order Biology and Radiation Damage 101 5.1. Introduction 101 5.2. Genomic Instability 101 5.3. Epigenetic Mutation 103 5.4. Cell Division 106 5.4.1. Meiosis 106 5.4.2. Cell Cycle Synchronization 109 5.5. Tissue Kinetics 110 5.6. Matters of Scale 113 5.7. Summary 117
Contents Chapter 6 Chapter 7 ІХ 5.8. Problems 118 5.9. Bibliography 119 Modeling Radiation Biology 121 6.1. Introduction 121 6.2. Modeling Cell Survival 122 6.2.1. Lea’s Target Theory 123 6.2.2. Multitarget-Single Hit Model 130 6.2.3. Linear Quadratic Model 132 6.2.4. Boutique Survival Models 138 6.2.4.1. Cybernetic Model 138 6.2.4.2. Repair-Misrepair Model 141 6.2.4.3. Lethal-Potentially Lethal Model 143 6.2.4.4. Threshold Energy Repair Saturation Model 147 6.2.4.5. Giant Loop Binary LesionModel 147 6.3. Summary 150 6.4. Problems 152 6.5. Bibliography 153 Applications of Dose Response Models 155 7.1. Introduction 155 7.2. Interpretation of the Dose Response Curve 155 7.3. Factors Affecting Cell Survival 166 7.3.1. Target Size 166 7.3.2. Repair Capacity 168 7.3.3. Cell Cycle and Synchronization 169 7.3.4. Apoptosis 171 7.3.5. Dose Rate 172 7.4. Fractionated Dose Delivery 174 7.5. Radiation Quality 178 7.5.1. Linear Energy Transfer 179 7.5.2. Radiation Quality and the SurvivalCurve 186 7.6. Relative Biological Effectiveness 189 7.7. Radiation Response Modification 191 7.7.1. Oxygen Enhancement Ratio 192 7.7.2. Chemical Modification [Radioprotectors and Sensitizers] 193 7.8. Summary 195 7.9. Problems 197 7.10. Bibliography 200
Fundamentals of Radiation Biology X Chapter 8 Chapter 9 In vivo Radiation Response 201 8.1. Introduction 201 8.2. Scaling Up from In Vitro Dose Response 201 8.2.1. Colony Forming Unit Assays 202 8.2.2. Functional Assays and Fractionation Studies 205 8.2.3. Addressing Tissue Kinetics 208 8.3. Organ Radiation Sensitivity 210 8.4. The Brain and Radiation Response 212 8.5. Another Organ-Like System: Tumors 217 8.5.1. Tumor Kinetics 217 8.5.2. Tumor Radiation Sensitivity Assays 218 8.5.3. Hypoxia and Anoxia 221 8.6. Radiation Biology of the Organism 224 8.7. Summary 227 8.8. Problems 228 8.9. Bibliography 231 Radiation and Cancer Biology 233 9.1. Introduction 233 9.2. Transformation 233 9.3. Initiation of Cancer 236 9.3.1. Origin Theories 237 9.3.2. Genetic Mutation 238 9.3.3. Epigenetic Mutation 240 9.3.4. miRNA Gene Activation 242 9.3.5. Carcinogenesis by Viral Infection 242 9.4. Progression to Neoplasia 244 9.4.1. Genomic Instability 247 9.4.2. Latency 250 9.5. Cancer Biology 9.5.1. Cancer in situ 253 254 9.5.1.1. The hallmarks of cancer 255 9.5.1.2. The Cancer Microenvironment 261 9.5.1.Յ. Supportive Physiology 262 9.5.1.4. The Macroenvironment — Nature vs Nurture 265 9.6. Radiation-Induced Carcinogenesis 266 9.6.1. Initial Transformation Events 267 9.6.2. Early and Persistent Neoplastic Transformation Events 269
Contents Xі 9.6.3. Late Neoplastic Transformation Events 270 9.6.4. High LET Radiation-Induced Transformation and Carcinogenesis 272 9.7. Summary 279 9.8. Problems 282 9.9. Bibliography 284 Chapter 10 Radiation Therapy 287 10.1. Introduction 287 10.2. The Therapeutic Ratio 288 10.3. Dose-Limiting Techniques for Normal Tissue 293 10.3.1. External Beam X-Ray Radiation Volume-Limiting Techniques 293 10.3.2. External Beam Charged Particle Radiation 296 10.3.2.1. Volume Limiting Techniques 296 10.3.2.2. RBEandNTCP 296 10.3.3. Brachytherapy: Volume-Limiting Techniques 298 10.4. Dose Protraction in Brachytherapy 301 10.5. Fractionation and Biological Equivalence 304 10.5.1. Isodose, BED, and EQD 305 10.6. FLASH Radiotherapy 314 10.7. Cancer Recurrence 315 10.8. Summary 316 10.9. Problems 317 10.10. Bibliography 318 Chapter 11 Radiation Safety 321 11.1. Introduction 321 11.2. Radiation Protection 321 11.2.1. Radiation Protection in Radiotherapy 322 11.2.2. Patient Radiation Protection in Radiology 324 Internalized Radioactivity 328 11.3.1. Distribution of Internalized Radioactivity 330 11.3.2. Determining Dose 333 Health Physics — The Evaluation of Risk 338 11.4.1. Lethal Radiation Syndromes 340 11.4.2. Increased Cancer Risk 343 11.4.3. Heritable Radiation Risk 348 11.4.4. Fetal Detriment 350 11.3. 11.4. 11.4.4.1. Preimplantation 350 11.4.4.2. Embryogenesis 350
X¡ j Fundamentals of Radiation Biology 11.4.4.3. Fetal Growth 352 11.4.5. Health Physics Regulations 353 Mass Radiation Exposure Events 354 11.5.1. Chernobyl Nuclear Reactor 354 11.5.2. Fukushima Daiichi Nuclear Power Plant 356 11.5.3. Additional Mass Radiation Exposure Events 357 11.6. Environmental Risk Remediation 359 11.7. Radiation Protection and Exposure Remediation 363 11.8. Nuclear Terrorism 365 11.9. Summary 371 11.10. Problems 374 11.11. Bibliography 375 11.5. Appendix A Answers to Selected Problems 377 Index 381
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| adam_txt |
Ni Contents xiii Preface Chapter 1 The Origins of Radiation 1 1.1. Introduction 1 1.2. Radiation Produced by Radionuclides 1 1.2.1. Nuclear Structure 1 1.2.2. Binding Energy 2 1.2.3. Radioactive Decay 4 1.2.4. Decay Energy, Q 9 1.2.5. Particle Kinetic Energy, T 1.3. Machine-Produced Radiation Chapter 2 15 16 1.3.1. History 16 1.3.2. Diagnostic X-ray Machines 17 1.3.3. Therapeutic X-ray Machines 17 1.3.4. Heavy Particle Therapy Machines 20 1.4 Summary 22 1.5. Problems 23 1.6. Bibliography 24 Interactions Between Radiation and Absorbing Materials 27 2.1. Introduction 27 2.2. The Structure of Matter 27 2.3. Interactions Involving Neutral Particles 28 2.3.1 Massless Neutral Particles 2.Յ.1.1. Macroscopic implicationsfor massless particles 2.3.2 . Massive Neutral Particles — Neutrons 28 37 39 2.4. Interactions Involving Charged Particles 42 2.5. Energy Transfer 43 2.5.1. Massless Neutral Particles 43 2.5.2. Massive Neutral Particles 46 2.5.3. Massive Charged Particles 47
eíí Fundamentals of Radiation Biology 2.6. Kerma, Cerna, and Dose Chapter 3 2.6.1. Kerma 48 2.6.2. Cerna 50 2.6.3. Dose 50 2.7. Stopping Power 50 2.8. Summary 57 2.9. Problems 58 2.10. Bibliography 59 Radiation Chemistry 61 3.1. Introduction 61 3.2. Radiolysis of Water 61 3.3. The Structure of DNA 64 3.4. Indirect Damage of DNA 66 3.5. Direct Damage of DNA 68 3.6. Summary 71 3.7. Problems 73 3.8. Bibliography 74 Chapter 4 The Biochemistry of DNA Repair Chapter 5 48 75 4.1. Introduction 75 4.2. A Brief Review of Molecular Biology 75 4.3. DNA Damage and Repair 82 4.4. Genetic Mutations 86 4.5. Chromosomal Damage 88 4.6. Cell Death 91 4.7. Summary 94 4.8. Problems 96 4.9. Bibliography 99 Higher Order Biology and Radiation Damage 101 5.1. Introduction 101 5.2. Genomic Instability 101 5.3. Epigenetic Mutation 103 5.4. Cell Division 106 5.4.1. Meiosis 106 5.4.2. Cell Cycle Synchronization 109 5.5. Tissue Kinetics 110 5.6. Matters of Scale 113 5.7. Summary 117
Contents Chapter 6 Chapter 7 ІХ 5.8. Problems 118 5.9. Bibliography 119 Modeling Radiation Biology 121 6.1. Introduction 121 6.2. Modeling Cell Survival 122 6.2.1. Lea’s Target Theory 123 6.2.2. Multitarget-Single Hit Model 130 6.2.3. Linear Quadratic Model 132 6.2.4. Boutique Survival Models 138 6.2.4.1. Cybernetic Model 138 6.2.4.2. Repair-Misrepair Model 141 6.2.4.3. Lethal-Potentially Lethal Model 143 6.2.4.4. Threshold Energy Repair Saturation Model 147 6.2.4.5. Giant Loop Binary LesionModel 147 6.3. Summary 150 6.4. Problems 152 6.5. Bibliography 153 Applications of Dose Response Models 155 7.1. Introduction 155 7.2. Interpretation of the Dose Response Curve 155 7.3. Factors Affecting Cell Survival 166 7.3.1. Target Size 166 7.3.2. Repair Capacity 168 7.3.3. Cell Cycle and Synchronization 169 7.3.4. Apoptosis 171 7.3.5. Dose Rate 172 7.4. Fractionated Dose Delivery 174 7.5. Radiation Quality 178 7.5.1. Linear Energy Transfer 179 7.5.2. Radiation Quality and the SurvivalCurve 186 7.6. Relative Biological Effectiveness 189 7.7. Radiation Response Modification 191 7.7.1. Oxygen Enhancement Ratio 192 7.7.2. Chemical Modification [Radioprotectors and Sensitizers] 193 7.8. Summary 195 7.9. Problems 197 7.10. Bibliography 200
Fundamentals of Radiation Biology X Chapter 8 Chapter 9 In vivo Radiation Response 201 8.1. Introduction 201 8.2. Scaling Up from In Vitro Dose Response 201 8.2.1. Colony Forming Unit Assays 202 8.2.2. Functional Assays and Fractionation Studies 205 8.2.3. Addressing Tissue Kinetics 208 8.3. Organ Radiation Sensitivity 210 8.4. The Brain and Radiation Response 212 8.5. Another Organ-Like System: Tumors 217 8.5.1. Tumor Kinetics 217 8.5.2. Tumor Radiation Sensitivity Assays 218 8.5.3. Hypoxia and Anoxia 221 8.6. Radiation Biology of the Organism 224 8.7. Summary 227 8.8. Problems 228 8.9. Bibliography 231 Radiation and Cancer Biology 233 9.1. Introduction 233 9.2. Transformation 233 9.3. Initiation of Cancer 236 9.3.1. Origin Theories 237 9.3.2. Genetic Mutation 238 9.3.3. Epigenetic Mutation 240 9.3.4. miRNA Gene Activation 242 9.3.5. Carcinogenesis by Viral Infection 242 9.4. Progression to Neoplasia 244 9.4.1. Genomic Instability 247 9.4.2. Latency 250 9.5. Cancer Biology 9.5.1. Cancer in situ 253 254 9.5.1.1. The hallmarks of cancer 255 9.5.1.2. The Cancer Microenvironment 261 9.5.1.Յ. Supportive Physiology 262 9.5.1.4. The Macroenvironment — Nature vs Nurture 265 9.6. Radiation-Induced Carcinogenesis 266 9.6.1. Initial Transformation Events 267 9.6.2. Early and Persistent Neoplastic Transformation Events 269
Contents Xі 9.6.3. Late Neoplastic Transformation Events 270 9.6.4. High LET Radiation-Induced Transformation and Carcinogenesis 272 9.7. Summary 279 9.8. Problems 282 9.9. Bibliography 284 Chapter 10 Radiation Therapy 287 10.1. Introduction 287 10.2. The Therapeutic Ratio 288 10.3. Dose-Limiting Techniques for Normal Tissue 293 10.3.1. External Beam X-Ray Radiation Volume-Limiting Techniques 293 10.3.2. External Beam Charged Particle Radiation 296 10.3.2.1. Volume Limiting Techniques 296 10.3.2.2. RBEandNTCP 296 10.3.3. Brachytherapy: Volume-Limiting Techniques 298 10.4. Dose Protraction in Brachytherapy 301 10.5. Fractionation and Biological Equivalence 304 10.5.1. Isodose, BED, and EQD 305 10.6. FLASH Radiotherapy 314 10.7. Cancer Recurrence 315 10.8. Summary 316 10.9. Problems 317 10.10. Bibliography 318 Chapter 11 Radiation Safety 321 11.1. Introduction 321 11.2. Radiation Protection 321 11.2.1. Radiation Protection in Radiotherapy 322 11.2.2. Patient Radiation Protection in Radiology 324 Internalized Radioactivity 328 11.3.1. Distribution of Internalized Radioactivity 330 11.3.2. Determining Dose 333 Health Physics — The Evaluation of Risk 338 11.4.1. Lethal Radiation Syndromes 340 11.4.2. Increased Cancer Risk 343 11.4.3. Heritable Radiation Risk 348 11.4.4. Fetal Detriment 350 11.3. 11.4. 11.4.4.1. Preimplantation 350 11.4.4.2. Embryogenesis 350
X¡ j Fundamentals of Radiation Biology 11.4.4.3. Fetal Growth 352 11.4.5. Health Physics Regulations 353 Mass Radiation Exposure Events 354 11.5.1. Chernobyl Nuclear Reactor 354 11.5.2. Fukushima Daiichi Nuclear Power Plant 356 11.5.3. Additional Mass Radiation Exposure Events 357 11.6. Environmental Risk Remediation 359 11.7. Radiation Protection and Exposure Remediation 363 11.8. Nuclear Terrorism 365 11.9. Summary 371 11.10. Problems 374 11.11. Bibliography 375 11.5. Appendix A Answers to Selected Problems 377 Index 381 |
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| spelling | Klein, Susan B. Verfasser aut Fundamentals of radiation biology Susan B. Klein (Indiana University, USA), Marc S. Mendonca (Indiana University, USA & Purdue University, USA) New Jersey ; London ; Singapore World Scientific [2023] xiv, 384 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Strahlenbiologie (DE-588)4057819-7 gnd rswk-swf Radiobiology Strahlenbiologie (DE-588)4057819-7 s DE-604 Mendonca, Marc S. Verfasser aut Erscheint auch als Online-Ausgabe 978-981-125-766-7 Erscheint auch als Online-Ausgabe 978-981-125-767-4 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034126413&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title_full | Fundamentals of radiation biology Susan B. Klein (Indiana University, USA), Marc S. Mendonca (Indiana University, USA & Purdue University, USA) |
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