Verfügbarkeit: Capillary electrophoresis-mass spectrometry for proteomics and metabolomics

Capillary electrophoresis-mass spectrometry for proteomics and metabolomics: principles and applications

Gespeichert in:

Bibliographische Detailangaben
Weitere Verfasser:	Ramautar, Rawi (HerausgeberIn), Chen, David D.Y (HerausgeberIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Weinheim, Germany Wiley-VCH [2023]
Schlagworte:	Kapillarelektrophorese Metabolomik Massenspektrometrie Proteomanalyse Bioanalytical Chemistry Bioanalytische Chemie Biowissenschaften Chemie Chemistry Genomforschung u. Proteomik Genomics & Proteomics Life Sciences Mass Spectrometry Metabolomics Proteomics CH16: Massenspektrometrie CH1D: Bioanalytische Chemie LS33: Genomforschung u. Proteomik Aufsatzsammlung
Online-Zugang:	http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34921-0/ Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	xiv, 386 Seiten Illustrationen, Diagramme 25 cm, 682 g
ISBN:	9783527349210 3527349219

Internformat

MARC


LEADER	00000nam a2200000 c 4500
001	BV048815966
003	DE-604
005	20230721
007	t
008	230215s2023 gw a\|\|\| \|\|\|\| 00\|\|\| eng d
015			\|a 22,N21 \|2 dnb
015			\|a 23,A06 \|2 dnb
016	7		\|a 1258092069 \|2 DE-101
020			\|a 9783527349210 \|c Festeinband : circa EUR 129.00 (DE) (freier Preis), circa EUR 132.70 (AT) (freier Preis) \|9 978-3-527-34921-0
020			\|a 3527349219 \|9 3-527-34921-9
024	3		\|a 9783527349210
028	5	2	\|a Bestellnummer: 1134921 000
035			\|a (OCoLC)1355329223
035			\|a (DE-599)DNB1258092069
040			\|a DE-604 \|b ger \|e rda
041	0		\|a eng
044			\|a gw \|c XA-DE-BW
049			\|a DE-703 \|a DE-19
082	0	4	\|a 572.636 \|2 23/ger
082	0		\|a 572.5 \|2 23/ger
084			\|a VG 9800 \|0 (DE-625)147244:253 \|2 rvk
084			\|8 3\p \|a 540 \|2 23sdnb
084			\|8 2\p \|a 610 \|2 23sdnb
084			\|8 1\p \|a 570 \|2 23sdnb
245	1	0	\|a Capillary electrophoresis-mass spectrometry for proteomics and metabolomics \|b principles and applications \|c edited by Rawi Ramautar and David D.Y. Chen
264		1	\|a Weinheim, Germany \|b Wiley-VCH \|c [2023]
300			\|a xiv, 386 Seiten \|b Illustrationen, Diagramme \|c 25 cm, 682 g
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
650	0	7	\|a Kapillarelektrophorese \|0 (DE-588)4290002-5 \|2 gnd \|9 rswk-swf
650	0	7	\|a Metabolomik \|0 (DE-588)1138059420 \|2 gnd \|9 rswk-swf
650	0	7	\|a Massenspektrometrie \|0 (DE-588)4037882-2 \|2 gnd \|9 rswk-swf
650	0	7	\|a Proteomanalyse \|0 (DE-588)4596545-6 \|2 gnd \|9 rswk-swf
653			\|a Bioanalytical Chemistry
653			\|a Bioanalytische Chemie
653			\|a Biowissenschaften
653			\|a Chemie
653			\|a Chemistry
653			\|a Genomforschung u. Proteomik
653			\|a Genomics & Proteomics
653			\|a Kapillarelektrophorese
653			\|a Life Sciences
653			\|a Mass Spectrometry
653			\|a Massenspektrometrie
653			\|a Metabolomics
653			\|a Proteomics
653			\|a CH16: Massenspektrometrie
653			\|a CH1D: Bioanalytische Chemie
653			\|a LS33: Genomforschung u. Proteomik
655		7	\|0 (DE-588)4143413-4 \|a Aufsatzsammlung \|2 gnd-content
689	0	0	\|a Proteomanalyse \|0 (DE-588)4596545-6 \|D s
689	0	1	\|a Metabolomik \|0 (DE-588)1138059420 \|D s
689	0	2	\|a Kapillarelektrophorese \|0 (DE-588)4290002-5 \|D s
689	0	3	\|a Massenspektrometrie \|0 (DE-588)4037882-2 \|D s
689	0		\|5 DE-604
700	1		\|a Ramautar, Rawi \|0 (DE-588)116333376X \|4 edt
700	1		\|a Chen, David D.Y. \|4 edt
710	2		\|a Wiley-VCH \|0 (DE-588)16179388-5 \|4 pbl
776	0	8	\|i Erscheint auch als \|n Online-Ausgabe, PDF \|z 978-3-527-83308-5
776	0	8	\|i Erscheint auch als \|n Online-Ausgabe, EPUB \|z 978-3-527-83310-8
776	0	8	\|i Erscheint auch als \|n Online-Ausgabe \|z 978-3-527-83309-2
856	4	2	\|m X:MVB \|u http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34921-0/
856	4	2	\|m B:DE-101 \|q application/pdf \|u https://d-nb.info/1258092069/04 \|3 Inhaltsverzeichnis
856	4	2	\|m DNB Datenaustausch \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034081796&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
999			\|a oai:aleph.bib-bvb.de:BVB01-034081796
883	2		\|8 1\p \|a dnb \|d 20230203 \|q DE-101 \|u https://d-nb.info/provenance/plan#dnb
883	2		\|8 2\p \|a dnb \|d 20230203 \|q DE-101 \|u https://d-nb.info/provenance/plan#dnb
883	2		\|8 3\p \|a dnb \|d 20230203 \|q DE-101 \|u https://d-nb.info/provenance/plan#dnb

Datensatz im Suchindex

_version_	1804184904573911040
adam_text	CONTENTS PREFACE XIII 1 CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY INTERFACING: PRINCIPLES AND RECENT DEVELOPMENTS 1 LUKAS NAUMANN, JASMIN SCHAIRER, ALISA HOCHSMANN, ELAHE NAGHDI, AND CHRISTIAN NEUSILFI 1.1 1.2 1.2.1 1.2.2 1.2.3 1.3 1.3.1 1.3.2 1.4 1.4.1 1.4.2 1.5 1.5.1 1.5.2 1.6 1.7 1.7.1 1.7.2 1.8 INTRODUCTION 1 GENERAL CONSIDERATIONS OF CE-ESI-MS 2 ELECTROSPRAY IONIZATION 3 ELECTRICAL CIRCUIT IN CE-ESI-MS 4 CE MODES AND CONDITIONS IN CE-MS 5 SHEATH LIQUID INTERFACES 5 COAXIAL SHEATH-FLOW ESI-MS INTERFACE 6 NANOFLOW SHEATH LIQUID ESI-MS INTERFACE 9 SHEATHLESS INTERFACES 14 POROUS-TIP INTERFACE 15 OTHER SHEATHLESS INTERFACES 17 OTHER CE-ESI-MS INTERFACES 19 LIQUID JUNCTION 19 INTERFACE-FREE CE-MS 21 MICROCHIP ELECTROPHORESIS-MS INTERFACES 22 ALTERNATIVE IONIZATION TECHNIQUES FOR CE-MS 26 CE AND MCE COMBINED WITH MALDI-MS 26 CE-ICP-MS 27 CONCLUDING REMARKS AND OUTLOOK 27 LIST OF ABBREVIATIONS 28 REFERENCES 28 2 DATA ANALYSIS STRATEGIES IN CE-MS FOR METABOLOMICS 35 NICOLAS DROUIN, JULIEN BOCCARD, SERGE RUDAZ, AND VICTOR GONZALEZ-RUIZ 2.1 2.2 INTRODUCTION 35 THE ANNOTATION CHALLENGE IN CE-MS-BASED UNTARGETED METABOLOMICS 36 VI CONTENTS 2.2.1 2.2.2 2.2.3 2.2.3.1 2.2.3.2 2.2.3.3 2.2.4 2.2.5 2.2.6 2.2.7 2.3 2.3.1 2.3.2 2.3.3 2.4 2.5 PEAK PICKING IN CE-MS METABOLOMICS 37 ALIGNMENT APPROACHES 38 HEF TRANSFORMATION 39 HISTORICAL EVOLUTION AND CURRENT STATE 39 QUANTITATIVE ASPECTS OF THE USE OF MOBILOGRAMS 43 TECHNICAL CONSIDERATIONS OF THE HE# TRANSFORMATION 45 REPRODUCIBILITY AND EXCHANGE OF HEFF INFORMATION USING LIBRARIES 46 INTERLABORATORY REPRODUCIBILITY 49 ROMANCE 51 ION MOBILITY 51 DATA PRETREATMENT 53 AREA NORMALIZATION 54 ANALYTICAL QUALITY MONITORING 54 DATA FILTERING 55 DATA TREATMENT 56 CONCLUDING REMARKS 58 ACKNOWLEDGMENT 58 REFERENCES 59 3 DATA-PROCESSING WORKFLOW FOR RELATIVE QUANTIFICATION FROM LABEL-FREE AND ISOBARIC LABELING-BASED UNTARGETED SHOTGUN PROTEOMICS: FROM DATABASE SEARCH TO DIFFERENTIAL EXPRESSION ANALYSIS 65 JENNY J. ZHONG, GREGG B. MORIN, AND DAVID D. Y. CHEN 3.1 3.2 3.2.1 3.2.1.1 3.2.1.2 3.2.1.3 3.2.1.4 3.2.2 3.2.3 3.2.3.1 3.2.3.2 3.2.3.3 3.2.4 3.3 3.3.1 3.3.2 3.3.2.1 3.3.2.2 3.3.2.3 INTRODUCTION 65 SPECTRA ACQUISITION AND DATABASE SEARCH 68 PARAMETERS AFFECTING SEQUENCE DATABASE SEARCH 69 DATABASE SELECTION 73 ENZYME SPECIFICITY AND MISSED CLEAVAGES 74 POSTTRANSLATIONAL MODIFICATIONS 77 PRECURSOR MASS TOLERANCE 77 TARGET-DECOY SEARCH STRATEGY FOR FALSE DISCOVERY RATE ESTIMATION 81 DATABASE SEARCH ENGINES 83 SEQUEST 83 MASCOT 85 MULTIPLE SEARCH ENGINES 85 PROTEIN INFERENCE 86 RELATIVE PROTEIN QUANTIFICATION 87 FILTERING 87 MISSING VALUE IMPUTATION 87 IMPUTATION METHODS 92 COMPARATIVE STUDIES 93 NORMALIZATION 99 CONTENTS VII 3.3.3 3.3.4 3.4 SUMMARIZATION 104 DIFFERENTIAL EXPRESSION ANALYSIS 104 CONCLUSIONS 107 REFERENCES 108 4 DATA PROCESSING IN METABOLOMICS CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY 121 JIAHUA TAN, ZI-AO HUANG, GREGG B. MORIN, AND DAVID D. Y. CHEN 4.1 4.2 4.2.1 4.2.2 4.2.3 4.2.4 4.3 4.3.1 4.3.2 4.3.3 4.3.4 4.3.5 4.3.6 4.3.7 4.4 DATA EXTRACTION AND THE INTERPRETATION OF THE EXTRACTED DATA 121 DATA PREPROCESSING 123 HANDLING MISSING VALUES 124 NORMALIZATION 124 TRANSFORMATION 127 SCALING 127 STATISTICAL ANALYSIS 128 TWO-SAMPLE T-TEST 128 PRINCIPAL COMPONENT ANALYSIS (PCA) 130 PARTIAL LEAST-SQUARES DISCRIMINANT ANALYSIS (PLS-DA) 132 SUPPORT VECTOR MACHINE 132 LOGISTIC REGRESSION 136 RANDOM FOREST MODEL 137 EVALUATION OF CLASSIFICATION MODELS 138 METABOLITE IDENTIFICATION 142 REFERENCES 142 5 UTILITY AND ADVANCES OF CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY FOR METABOLOMICS 147 WEI ZHANG AND RAWI RAMAUTAR 5.1 5.2 5.2.1 5.2.2 5.2.3 5.2.4 5.2.5 5.3 5.3.1 5.3.2 5.3.3 5.4 INTRODUCTION 147 TECHNOLOGICAL DEVELOPMENTS 148 IMPROVING SENSITIVITY 148 INCREASING METABOLOME COVERAGE 158 INCREASING ANNOTATION CAPACITY 158 TACKLING ANIONIC PROFILING 160 INCREASING SAMPLE THROUGHPUT 162 APPLICATIONS 163 BIOMEDICAL SAMPLES 163 MICROBIAL EXTRACTS 167 PLANTS 169 CONCLUDING REMARKS 171 ACKNOWLEDGMENT 171 CONFLICT OF INTEREST 172 REFERENCES 172 VIII CONTENTS 6 COMPREHENSIVE LIPID PROFILING BY MULTISEGMENT INJECTION-NONAQUEOUS CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY: EXPANDING COVERAGE BEYOND HYDROPHILIC METABOLITES 179 RITCHIE LY, SANDI M. AZAB, MEERA SHANMUGANATHAN, AND PHILIP BRITZ-MCKIBBIN 6.1 6.2 THE EARLY ORIGINS OF LIPIDOMICS 179 MAJOR INSTRUMENTAL PLATFORMS IN LIPIDOMICS: THE ROLE OF SEPARATION SCIENCE 180 6.3 6.4 6.5 6.6 NACE-MS: AN EMERGING SEPARATION PLATFORM FOR LIPIDOMICS? 181 MULTIPLEXED SEPARATIONS FOR FATTY ACIDS BY MSI-NACE-MS 181 COMPREHENSIVE LIPID PROFILING STRATEGIES BY MSI-NACE-MS 186 FUTURE PERSPECTIVES AND SUMMARY 188 REFERENCES 189 7 STRATEGIES FOR IDENTIFICATION OF MODIFIED AMINO ACIDS WITH CE-MS IN METABOLOMICS 195 PAULA CUEVAS-DELGADO, ANA GRADILLAS, AND CORAL BARBAS 7.1 7.1.1 7.1.2 7.2 7.3 INTRODUCTION 195 POST-TRANSLATIONAL MODIFICATIONS AND MODIFIED AMINO ACIDS 195 MODIFIED AMINO ACIDS AS BIOMARKERS OF PATHOLOGIES 197 METHODS FOR THE DETECTION OF MODIFIED AMINO ACIDS 198 CAPILLARY ELECTROPHORESIS COUPLED TO MASS SPECTROMETRY TO ANALYZE MODIFIED AMINO ACIDS 203 7.3.1 7.4 APPLICATIONS OF CE-MS FOR ANALYSIS OF MODIFIED AMINO ACIDS 205 RECENT DEVELOPMENTS TO ENHANCE AND FACILITATE THE ANNOTATION PROCESS IN CE-MS 208 ACKNOWLEDGMENTS 212 REFERENCES 212 8 CE-MS APPROACHES FOR SINGLE-CELL METABOLOMICS 221 TAKAYUKI KAWAI 8.1 8.2 8.2.1 8.2.2 8.2.3 8.3 8.3.1 INTRODUCTION 221 TECHNIQUES FOR SINGLE-CELL METABOLOME ANALYSIS 222 HIGHLY SENSITIVE CE-MS INTERFACING 222 ONLINE SAMPLE PRECONCENTRATION TECHNIQUES 223 ISOLATION OF SINGLE CELLS 224 APPLICATION TO SINGLE-CELL METABOLOME ANALYSIS 225 METABOLOME ANALYSIS OF LARGE SINGLE CELLS WITH HIGHLY SENSITIVE INTERFACE 225 8.3.2 SINGLE-CELL METABOLOME ANALYSIS WITH HIGHLY SENSITIVE INTERFACE AND OSP METHOD 226 8.3.3 SINGLE-CELL METABOLOME ANALYSIS BY ONLINE SAMPLING AND HIGHLY SENSITIVE INTERFACE 229 CONTENTS IX 8.4 CONCLUSIONS 230 REFERENCES 230 9 CE-MS APPROACHES FOR PEPTIDOMICS 235 SILLE STEPANOVA AND VACLAV KASICKA 9.1 9.2 9.3 9.3.1 9.3.2 9.3.3 9.4 9.4.1 9.4.2 9.4.3 9.5 INTRODUCTION 235 SAMPLE PREPARATION 238 CE-MS 240 BASIC CHARACTERIZATION 240 PEPTIDE IDENTIFICATION 242 PEPTIDE QUANTITATION 244 APPLICATIONS 245 SEARCH, IDENTIFICATION, AND DETERMINATION OF BIOMARKERS 245 FOOD PEPTIDOMICS 248 OTHER APPLICATIONS 249 CONCLUSIONS 250 ACKNOWLEDGMENTS 250 LIST OF ABBREVIATIONS 251 REFERENCES 251 10 CAPILLARY ZONE ELECTROPHORESIS-MASS SPECTROMETRY FOR TOP-DOWN PROTEOMICS: TECHNOLOGICAL DEVELOPMENT AND BIOLOGICAL APPLICATIONS 261 LIANGLIANG SUN 10.1 10.2 10.2.1 10.2.2 10.2.3 10.2.4 INTRODUCTION 261 TECHNOLOGICAL DEVELOPMENT 263 CE-MS INTERFACE 263 CAPILLARY COATING 264 SAMPLE LOADING CAPACITY AND SEPARATION WINDOW 265 COUPLING NOVEL GAS-PHASE FRAGMENTATION TECHNIQUES TO CZE-MS/MS FORTDP 267 10.2.5 10.3 10.3.1 ELECTROPHORETIC MOBILITY PREDICTION OF PROTEOFORMS 268 APPLICATIONS OF CZE-MS-BASED TDP 269 DELINEATION OF PROTEOFORMS OF COMPLEX PROTEOMES, DISEASE BIOMARKERS, AND BIOPHARMACEUTICALS 269 10.3.2 10.4 CZE-MS FOR NATIVE TDP 270 CONCLUSIONS AND PERSPECTIVES 272 ACKNOWLEDGMENTS 272 REFERENCES 272 11 CE-MS METHODS FOR THE CHARACTERIZATION OF MONOCLONAL ANTIBODIES 281 TESSA REINERT, ALAIN BECK, PASCAL HOUZE, RABAH GAHOUAL, AND YANNIS FRANCOIS 11.1 11.2 INTRODUCTION 281 MAB CHARACTERIZATION APPROACHES 283 X CONTENTS 11.3 11.3.1 11.3.1.1 11.3.1.2 11.3.1.3 APPLICATIONS 288 PRIMARY STRUCTURE CHARACTERIZATION OF MONOCLONAL ANTIBODIES 288 ANALYTICAL WORKFLOW 288 AMINO ACID SEQUENCE CHARACTERIZATION USING CE-MS(/MS) 290 PTMS CHARACTERIZATION AND RELATIVE QUANTIFICATION USING CE-MS(/MS) 291 11.3.1.4 11.3.2 11.3.2.1 11.3.2.2 11.3.2.3 11.3.3 11.3.3.1 11.3.3.2 11.3.3.3 11.3.4 11.4 GLYCOSYLATION DETERMINATION USING CE-MS(/MS) 294 MIDDLE-UP/MIDDLE-DOWN ANALYSIS 296 ANALYTICAL WORKFLOW 296 MAB ANALYSIS USING MIDDLE-UP STRATEGY 298 MAB ANALYSIS USING MIDDLE-DOWN STRATEGY 299 INTACT ANALYSIS 299 ANALYTICAL WORKFLOW 300 MAB ANALYSIS IN DENATURING CONDITIONS USING CE-MS 300 MAB ANALYSIS IN NATIVE CONDITIONS USING CE-MS 301 AUTOMATION: FUTURE OF CE-MS FOR MAB ANALYSIS 302 CONCLUSION 304 REFERENCES 305 12 CE AND CE-MS APPROACHES FOR GLYCAN ANALYSIS 313 DANIEL SARKOZY AND ANDRAS GUTTMAN 12.1 12.2 12.2.1 12.2.2 12.2.3 12.2.4 12.3 12.3.1 THE IMPORTANCE OF GLYCOSYLATION 313 CAPILLARY ELECTROPHORESIS IN ANALYTICAL GLYCOMICS 314 SAMPLE PREPARATION FOR CE-BASED GLYCAN ANALYSIS 315 ANALYSIS OF OLIGOSACCHARIDES FROM BIOLOGICAL SAMPLES 316 STRUCTURAL ELUCIDATION OF CARBOHYDRATES: THE GU VALUE APPROACH 318 LIF SENSITIVITY AND QUANTIFICATION 321 CE-MS OF OLIGOSACCHARIDES 322 MAJOR PARAMETERS TO SET THE ESI FOR CE-MS OF DERIVATIZED OLIGOSACCHARIDES 322 12.3.2 12.3.3 12.4 CE-MS FOR QUANTITATIVE CARBOHYDRATE ANALYSIS 323 CE-MS FOR GLYCOMIC STUDIES 326 CONCLUSIONS AND FUTURE PROSPECTIVE 328 ACKNOWLEDGMENT 329 REFERENCES 329 13 CE - MS APPROACHES FOR GLYCO(PROTEO)MIC ANALYSIS 335 WEI WANG, WENJUN WANG, AND GUINEVERE S.M. LAGEVEEN-KAMMEIJER 13.1 13.1.1 13.1.2 13.1.3 13.1.4 13.1.5 13.2 INTRODUCTION 335 N LINKED GLYCOSYLATION 336 O-LINKED GLYCOSYLATION 337 GLYCOSYLATION WORKFLOWS 338 ANALYTICAL APPROACHES 340 CE-MS INTERFACES 342 GLYCAN ANALYSIS BY CE-MS 345 CONTENTS XI 13.2.1 13.3 13.3.1 13.3.2 13.3.3 13.4 13.4.1 13.4.2 13.4.3 13.5 GLYCAN DERIVATIZATION STRATEGIES 346 GLYCOPEPTIDE ANALYSIS 349 SAMPLE TREATMENT 350 SEPARATION CONDITIONS 351 APPLICATIONS 353 PROTEIN ANALYSIS 355 SAMPLE TREATMENT 356 SEPARATION CONDITIONS 357 APPLICATIONS 358 CONCLUSIONS AND OUTLOOK 362 ACKNOWLEDGMENTS 363 LIST OF ABBREVIATIONS 363 REFERENCES 365 INDEX 377
adam_txt	CONTENTS PREFACE XIII 1 CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY INTERFACING: PRINCIPLES AND RECENT DEVELOPMENTS 1 LUKAS NAUMANN, JASMIN SCHAIRER, ALISA HOCHSMANN, ELAHE NAGHDI, AND CHRISTIAN NEUSILFI 1.1 1.2 1.2.1 1.2.2 1.2.3 1.3 1.3.1 1.3.2 1.4 1.4.1 1.4.2 1.5 1.5.1 1.5.2 1.6 1.7 1.7.1 1.7.2 1.8 INTRODUCTION 1 GENERAL CONSIDERATIONS OF CE-ESI-MS 2 ELECTROSPRAY IONIZATION 3 ELECTRICAL CIRCUIT IN CE-ESI-MS 4 CE MODES AND CONDITIONS IN CE-MS 5 SHEATH LIQUID INTERFACES 5 COAXIAL SHEATH-FLOW ESI-MS INTERFACE 6 NANOFLOW SHEATH LIQUID ESI-MS INTERFACE 9 SHEATHLESS INTERFACES 14 POROUS-TIP INTERFACE 15 OTHER SHEATHLESS INTERFACES 17 OTHER CE-ESI-MS INTERFACES 19 LIQUID JUNCTION 19 INTERFACE-FREE CE-MS 21 MICROCHIP ELECTROPHORESIS-MS INTERFACES 22 ALTERNATIVE IONIZATION TECHNIQUES FOR CE-MS 26 CE AND MCE COMBINED WITH MALDI-MS 26 CE-ICP-MS 27 CONCLUDING REMARKS AND OUTLOOK 27 LIST OF ABBREVIATIONS 28 REFERENCES 28 2 DATA ANALYSIS STRATEGIES IN CE-MS FOR METABOLOMICS 35 NICOLAS DROUIN, JULIEN BOCCARD, SERGE RUDAZ, AND VICTOR GONZALEZ-RUIZ 2.1 2.2 INTRODUCTION 35 THE ANNOTATION CHALLENGE IN CE-MS-BASED UNTARGETED METABOLOMICS 36 VI CONTENTS 2.2.1 2.2.2 2.2.3 2.2.3.1 2.2.3.2 2.2.3.3 2.2.4 2.2.5 2.2.6 2.2.7 2.3 2.3.1 2.3.2 2.3.3 2.4 2.5 PEAK PICKING IN CE-MS METABOLOMICS 37 ALIGNMENT APPROACHES 38 HEF TRANSFORMATION 39 HISTORICAL EVOLUTION AND CURRENT STATE 39 QUANTITATIVE ASPECTS OF THE USE OF MOBILOGRAMS 43 TECHNICAL CONSIDERATIONS OF THE HE# TRANSFORMATION 45 REPRODUCIBILITY AND EXCHANGE OF HEFF INFORMATION USING LIBRARIES 46 INTERLABORATORY REPRODUCIBILITY 49 ROMANCE 51 ION MOBILITY 51 DATA PRETREATMENT 53 AREA NORMALIZATION 54 ANALYTICAL QUALITY MONITORING 54 DATA FILTERING 55 DATA TREATMENT 56 CONCLUDING REMARKS 58 ACKNOWLEDGMENT 58 REFERENCES 59 3 DATA-PROCESSING WORKFLOW FOR RELATIVE QUANTIFICATION FROM LABEL-FREE AND ISOBARIC LABELING-BASED UNTARGETED SHOTGUN PROTEOMICS: FROM DATABASE SEARCH TO DIFFERENTIAL EXPRESSION ANALYSIS 65 JENNY J. ZHONG, GREGG B. MORIN, AND DAVID D. Y. CHEN 3.1 3.2 3.2.1 3.2.1.1 3.2.1.2 3.2.1.3 3.2.1.4 3.2.2 3.2.3 3.2.3.1 3.2.3.2 3.2.3.3 3.2.4 3.3 3.3.1 3.3.2 3.3.2.1 3.3.2.2 3.3.2.3 INTRODUCTION 65 SPECTRA ACQUISITION AND DATABASE SEARCH 68 PARAMETERS AFFECTING SEQUENCE DATABASE SEARCH 69 DATABASE SELECTION 73 ENZYME SPECIFICITY AND MISSED CLEAVAGES 74 POSTTRANSLATIONAL MODIFICATIONS 77 PRECURSOR MASS TOLERANCE 77 TARGET-DECOY SEARCH STRATEGY FOR FALSE DISCOVERY RATE ESTIMATION 81 DATABASE SEARCH ENGINES 83 SEQUEST 83 MASCOT 85 MULTIPLE SEARCH ENGINES 85 PROTEIN INFERENCE 86 RELATIVE PROTEIN QUANTIFICATION 87 FILTERING 87 MISSING VALUE IMPUTATION 87 IMPUTATION METHODS 92 COMPARATIVE STUDIES 93 NORMALIZATION 99 CONTENTS VII 3.3.3 3.3.4 3.4 SUMMARIZATION 104 DIFFERENTIAL EXPRESSION ANALYSIS 104 CONCLUSIONS 107 REFERENCES 108 4 DATA PROCESSING IN METABOLOMICS CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY 121 JIAHUA TAN, ZI-AO HUANG, GREGG B. MORIN, AND DAVID D. Y. CHEN 4.1 4.2 4.2.1 4.2.2 4.2.3 4.2.4 4.3 4.3.1 4.3.2 4.3.3 4.3.4 4.3.5 4.3.6 4.3.7 4.4 DATA EXTRACTION AND THE INTERPRETATION OF THE EXTRACTED DATA 121 DATA PREPROCESSING 123 HANDLING MISSING VALUES 124 NORMALIZATION 124 TRANSFORMATION 127 SCALING 127 STATISTICAL ANALYSIS 128 TWO-SAMPLE T-TEST 128 PRINCIPAL COMPONENT ANALYSIS (PCA) 130 PARTIAL LEAST-SQUARES DISCRIMINANT ANALYSIS (PLS-DA) 132 SUPPORT VECTOR MACHINE 132 LOGISTIC REGRESSION 136 RANDOM FOREST MODEL 137 EVALUATION OF CLASSIFICATION MODELS 138 METABOLITE IDENTIFICATION 142 REFERENCES 142 5 UTILITY AND ADVANCES OF CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY FOR METABOLOMICS 147 WEI ZHANG AND RAWI RAMAUTAR 5.1 5.2 5.2.1 5.2.2 5.2.3 5.2.4 5.2.5 5.3 5.3.1 5.3.2 5.3.3 5.4 INTRODUCTION 147 TECHNOLOGICAL DEVELOPMENTS 148 IMPROVING SENSITIVITY 148 INCREASING METABOLOME COVERAGE 158 INCREASING ANNOTATION CAPACITY 158 TACKLING ANIONIC PROFILING 160 INCREASING SAMPLE THROUGHPUT 162 APPLICATIONS 163 BIOMEDICAL SAMPLES 163 MICROBIAL EXTRACTS 167 PLANTS 169 CONCLUDING REMARKS 171 ACKNOWLEDGMENT 171 CONFLICT OF INTEREST 172 REFERENCES 172 VIII CONTENTS 6 COMPREHENSIVE LIPID PROFILING BY MULTISEGMENT INJECTION-NONAQUEOUS CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY: EXPANDING COVERAGE BEYOND HYDROPHILIC METABOLITES 179 RITCHIE LY, SANDI M. AZAB, MEERA SHANMUGANATHAN, AND PHILIP BRITZ-MCKIBBIN 6.1 6.2 THE EARLY ORIGINS OF LIPIDOMICS 179 MAJOR INSTRUMENTAL PLATFORMS IN LIPIDOMICS: THE ROLE OF SEPARATION SCIENCE 180 6.3 6.4 6.5 6.6 NACE-MS: AN EMERGING SEPARATION PLATFORM FOR LIPIDOMICS? 181 MULTIPLEXED SEPARATIONS FOR FATTY ACIDS BY MSI-NACE-MS 181 COMPREHENSIVE LIPID PROFILING STRATEGIES BY MSI-NACE-MS 186 FUTURE PERSPECTIVES AND SUMMARY 188 REFERENCES 189 7 STRATEGIES FOR IDENTIFICATION OF MODIFIED AMINO ACIDS WITH CE-MS IN METABOLOMICS 195 PAULA CUEVAS-DELGADO, ANA GRADILLAS, AND CORAL BARBAS 7.1 7.1.1 7.1.2 7.2 7.3 INTRODUCTION 195 POST-TRANSLATIONAL MODIFICATIONS AND MODIFIED AMINO ACIDS 195 MODIFIED AMINO ACIDS AS BIOMARKERS OF PATHOLOGIES 197 METHODS FOR THE DETECTION OF MODIFIED AMINO ACIDS 198 CAPILLARY ELECTROPHORESIS COUPLED TO MASS SPECTROMETRY TO ANALYZE MODIFIED AMINO ACIDS 203 7.3.1 7.4 APPLICATIONS OF CE-MS FOR ANALYSIS OF MODIFIED AMINO ACIDS 205 RECENT DEVELOPMENTS TO ENHANCE AND FACILITATE THE ANNOTATION PROCESS IN CE-MS 208 ACKNOWLEDGMENTS 212 REFERENCES 212 8 CE-MS APPROACHES FOR SINGLE-CELL METABOLOMICS 221 TAKAYUKI KAWAI 8.1 8.2 8.2.1 8.2.2 8.2.3 8.3 8.3.1 INTRODUCTION 221 TECHNIQUES FOR SINGLE-CELL METABOLOME ANALYSIS 222 HIGHLY SENSITIVE CE-MS INTERFACING 222 ONLINE SAMPLE PRECONCENTRATION TECHNIQUES 223 ISOLATION OF SINGLE CELLS 224 APPLICATION TO SINGLE-CELL METABOLOME ANALYSIS 225 METABOLOME ANALYSIS OF LARGE SINGLE CELLS WITH HIGHLY SENSITIVE INTERFACE 225 8.3.2 SINGLE-CELL METABOLOME ANALYSIS WITH HIGHLY SENSITIVE INTERFACE AND OSP METHOD 226 8.3.3 SINGLE-CELL METABOLOME ANALYSIS BY ONLINE SAMPLING AND HIGHLY SENSITIVE INTERFACE 229 CONTENTS IX 8.4 CONCLUSIONS 230 REFERENCES 230 9 CE-MS APPROACHES FOR PEPTIDOMICS 235 SILLE STEPANOVA AND VACLAV KASICKA 9.1 9.2 9.3 9.3.1 9.3.2 9.3.3 9.4 9.4.1 9.4.2 9.4.3 9.5 INTRODUCTION 235 SAMPLE PREPARATION 238 CE-MS 240 BASIC CHARACTERIZATION 240 PEPTIDE IDENTIFICATION 242 PEPTIDE QUANTITATION 244 APPLICATIONS 245 SEARCH, IDENTIFICATION, AND DETERMINATION OF BIOMARKERS 245 FOOD PEPTIDOMICS 248 OTHER APPLICATIONS 249 CONCLUSIONS 250 ACKNOWLEDGMENTS 250 LIST OF ABBREVIATIONS 251 REFERENCES 251 10 CAPILLARY ZONE ELECTROPHORESIS-MASS SPECTROMETRY FOR TOP-DOWN PROTEOMICS: TECHNOLOGICAL DEVELOPMENT AND BIOLOGICAL APPLICATIONS 261 LIANGLIANG SUN 10.1 10.2 10.2.1 10.2.2 10.2.3 10.2.4 INTRODUCTION 261 TECHNOLOGICAL DEVELOPMENT 263 CE-MS INTERFACE 263 CAPILLARY COATING 264 SAMPLE LOADING CAPACITY AND SEPARATION WINDOW 265 COUPLING NOVEL GAS-PHASE FRAGMENTATION TECHNIQUES TO CZE-MS/MS FORTDP 267 10.2.5 10.3 10.3.1 ELECTROPHORETIC MOBILITY PREDICTION OF PROTEOFORMS 268 APPLICATIONS OF CZE-MS-BASED TDP 269 DELINEATION OF PROTEOFORMS OF COMPLEX PROTEOMES, DISEASE BIOMARKERS, AND BIOPHARMACEUTICALS 269 10.3.2 10.4 CZE-MS FOR NATIVE TDP 270 CONCLUSIONS AND PERSPECTIVES 272 ACKNOWLEDGMENTS 272 REFERENCES 272 11 CE-MS METHODS FOR THE CHARACTERIZATION OF MONOCLONAL ANTIBODIES 281 TESSA REINERT, ALAIN BECK, PASCAL HOUZE, RABAH GAHOUAL, AND YANNIS FRANCOIS 11.1 11.2 INTRODUCTION 281 MAB CHARACTERIZATION APPROACHES 283 X CONTENTS 11.3 11.3.1 11.3.1.1 11.3.1.2 11.3.1.3 APPLICATIONS 288 PRIMARY STRUCTURE CHARACTERIZATION OF MONOCLONAL ANTIBODIES 288 ANALYTICAL WORKFLOW 288 AMINO ACID SEQUENCE CHARACTERIZATION USING CE-MS(/MS) 290 PTMS CHARACTERIZATION AND RELATIVE QUANTIFICATION USING CE-MS(/MS) 291 11.3.1.4 11.3.2 11.3.2.1 11.3.2.2 11.3.2.3 11.3.3 11.3.3.1 11.3.3.2 11.3.3.3 11.3.4 11.4 GLYCOSYLATION DETERMINATION USING CE-MS(/MS) 294 MIDDLE-UP/MIDDLE-DOWN ANALYSIS 296 ANALYTICAL WORKFLOW 296 MAB ANALYSIS USING MIDDLE-UP STRATEGY 298 MAB ANALYSIS USING MIDDLE-DOWN STRATEGY 299 INTACT ANALYSIS 299 ANALYTICAL WORKFLOW 300 MAB ANALYSIS IN DENATURING CONDITIONS USING CE-MS 300 MAB ANALYSIS IN NATIVE CONDITIONS USING CE-MS 301 AUTOMATION: FUTURE OF CE-MS FOR MAB ANALYSIS 302 CONCLUSION 304 REFERENCES 305 12 CE AND CE-MS APPROACHES FOR GLYCAN ANALYSIS 313 DANIEL SARKOZY AND ANDRAS GUTTMAN 12.1 12.2 12.2.1 12.2.2 12.2.3 12.2.4 12.3 12.3.1 THE IMPORTANCE OF GLYCOSYLATION 313 CAPILLARY ELECTROPHORESIS IN ANALYTICAL GLYCOMICS 314 SAMPLE PREPARATION FOR CE-BASED GLYCAN ANALYSIS 315 ANALYSIS OF OLIGOSACCHARIDES FROM BIOLOGICAL SAMPLES 316 STRUCTURAL ELUCIDATION OF CARBOHYDRATES: THE GU VALUE APPROACH 318 LIF SENSITIVITY AND QUANTIFICATION 321 CE-MS OF OLIGOSACCHARIDES 322 MAJOR PARAMETERS TO SET THE ESI FOR CE-MS OF DERIVATIZED OLIGOSACCHARIDES 322 12.3.2 12.3.3 12.4 CE-MS FOR QUANTITATIVE CARBOHYDRATE ANALYSIS 323 CE-MS FOR GLYCOMIC STUDIES 326 CONCLUSIONS AND FUTURE PROSPECTIVE 328 ACKNOWLEDGMENT 329 REFERENCES 329 13 CE - MS APPROACHES FOR GLYCO(PROTEO)MIC ANALYSIS 335 WEI WANG, WENJUN WANG, AND GUINEVERE S.M. LAGEVEEN-KAMMEIJER 13.1 13.1.1 13.1.2 13.1.3 13.1.4 13.1.5 13.2 INTRODUCTION 335 N LINKED GLYCOSYLATION 336 O-LINKED GLYCOSYLATION 337 GLYCOSYLATION WORKFLOWS 338 ANALYTICAL APPROACHES 340 CE-MS INTERFACES 342 GLYCAN ANALYSIS BY CE-MS 345 CONTENTS XI 13.2.1 13.3 13.3.1 13.3.2 13.3.3 13.4 13.4.1 13.4.2 13.4.3 13.5 GLYCAN DERIVATIZATION STRATEGIES 346 GLYCOPEPTIDE ANALYSIS 349 SAMPLE TREATMENT 350 SEPARATION CONDITIONS 351 APPLICATIONS 353 PROTEIN ANALYSIS 355 SAMPLE TREATMENT 356 SEPARATION CONDITIONS 357 APPLICATIONS 358 CONCLUSIONS AND OUTLOOK 362 ACKNOWLEDGMENTS 363 LIST OF ABBREVIATIONS 363 REFERENCES 365 INDEX 377
any_adam_object	1
any_adam_object_boolean	1
author2	Ramautar, Rawi Chen, David D.Y
author2_role	edt edt
author2_variant	r r rr d d c dd ddc
author_GND	(DE-588)116333376X
author_facet	Ramautar, Rawi Chen, David D.Y
building	Verbundindex
bvnumber	BV048815966
classification_rvk	VG 9800
ctrlnum	(OCoLC)1355329223 (DE-599)DNB1258092069
dewey-full	572.636 572.5
dewey-hundreds	500 - Natural sciences and mathematics
dewey-ones	572 - Biochemistry
dewey-raw	572.636 572.5
dewey-search	572.636 572.5
dewey-sort	3572.636
dewey-tens	570 - Biology
discipline	Chemie / Pharmazie Biologie
discipline_str_mv	Chemie / Pharmazie Biologie
format	Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03534nam a2200853 c 4500</leader><controlfield tag="001">BV048815966</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20230721 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">230215s2023 gw a\|\|\| \|\|\|\| 00\|\|\| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">22,N21</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">23,A06</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1258092069</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527349210</subfield><subfield code="c">Festeinband : circa EUR 129.00 (DE) (freier Preis), circa EUR 132.70 (AT) (freier Preis)</subfield><subfield code="9">978-3-527-34921-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527349219</subfield><subfield code="9">3-527-34921-9</subfield></datafield><datafield tag="024" ind1="3" ind2=" "><subfield code="a">9783527349210</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">Bestellnummer: 1134921 000</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1355329223</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1258092069</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BW</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-703</subfield><subfield code="a">DE-19</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">572.636</subfield><subfield code="2">23/ger</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.5</subfield><subfield code="2">23/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VG 9800</subfield><subfield code="0">(DE-625)147244:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="8">3\p</subfield><subfield code="a">540</subfield><subfield code="2">23sdnb</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="8">2\p</subfield><subfield code="a">610</subfield><subfield code="2">23sdnb</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="8">1\p</subfield><subfield code="a">570</subfield><subfield code="2">23sdnb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Capillary electrophoresis-mass spectrometry for proteomics and metabolomics</subfield><subfield code="b">principles and applications</subfield><subfield code="c">edited by Rawi Ramautar and David D.Y. Chen</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Weinheim, Germany</subfield><subfield code="b">Wiley-VCH</subfield><subfield code="c">[2023]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xiv, 386 Seiten</subfield><subfield code="b">Illustrationen, Diagramme</subfield><subfield code="c">25 cm, 682 g</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Kapillarelektrophorese</subfield><subfield code="0">(DE-588)4290002-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Metabolomik</subfield><subfield code="0">(DE-588)1138059420</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Massenspektrometrie</subfield><subfield code="0">(DE-588)4037882-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Proteomanalyse</subfield><subfield code="0">(DE-588)4596545-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Bioanalytical Chemistry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Bioanalytische Chemie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Biowissenschaften</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Chemie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Chemistry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Genomforschung u. Proteomik</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Genomics & Proteomics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Kapillarelektrophorese</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Life Sciences</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Mass Spectrometry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Massenspektrometrie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Metabolomics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Proteomics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CH16: Massenspektrometrie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CH1D: Bioanalytische Chemie</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LS33: Genomforschung u. Proteomik</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Proteomanalyse</subfield><subfield code="0">(DE-588)4596545-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Metabolomik</subfield><subfield code="0">(DE-588)1138059420</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Kapillarelektrophorese</subfield><subfield code="0">(DE-588)4290002-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="3"><subfield code="a">Massenspektrometrie</subfield><subfield code="0">(DE-588)4037882-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ramautar, Rawi</subfield><subfield code="0">(DE-588)116333376X</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, David D.Y.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Wiley-VCH</subfield><subfield code="0">(DE-588)16179388-5</subfield><subfield code="4">pbl</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, PDF</subfield><subfield code="z">978-3-527-83308-5</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe, EPUB</subfield><subfield code="z">978-3-527-83310-8</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="z">978-3-527-83309-2</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">X:MVB</subfield><subfield code="u">http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34921-0/</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">B:DE-101</subfield><subfield code="q">application/pdf</subfield><subfield code="u">https://d-nb.info/1258092069/04</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034081796&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-034081796</subfield></datafield><datafield tag="883" ind1="2" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">dnb</subfield><subfield code="d">20230203</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#dnb</subfield></datafield><datafield tag="883" ind1="2" ind2=" "><subfield code="8">2\p</subfield><subfield code="a">dnb</subfield><subfield code="d">20230203</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#dnb</subfield></datafield><datafield tag="883" ind1="2" ind2=" "><subfield code="8">3\p</subfield><subfield code="a">dnb</subfield><subfield code="d">20230203</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#dnb</subfield></datafield></record></collection>
genre	(DE-588)4143413-4 Aufsatzsammlung gnd-content
genre_facet	Aufsatzsammlung
id	DE-604.BV048815966
illustrated	Illustrated
index_date	2024-07-03T21:31:33Z
indexdate	2024-07-10T09:46:45Z
institution	BVB
institution_GND	(DE-588)16179388-5
isbn	9783527349210 3527349219
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-034081796
oclc_num	1355329223
open_access_boolean
owner	DE-703 DE-19 DE-BY-UBM
owner_facet	DE-703 DE-19 DE-BY-UBM
physical	xiv, 386 Seiten Illustrationen, Diagramme 25 cm, 682 g
publishDate	2023
publishDateSearch	2023
publishDateSort	2023
publisher	Wiley-VCH
record_format	marc
spelling	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications edited by Rawi Ramautar and David D.Y. Chen Weinheim, Germany Wiley-VCH [2023] xiv, 386 Seiten Illustrationen, Diagramme 25 cm, 682 g txt rdacontent n rdamedia nc rdacarrier Kapillarelektrophorese (DE-588)4290002-5 gnd rswk-swf Metabolomik (DE-588)1138059420 gnd rswk-swf Massenspektrometrie (DE-588)4037882-2 gnd rswk-swf Proteomanalyse (DE-588)4596545-6 gnd rswk-swf Bioanalytical Chemistry Bioanalytische Chemie Biowissenschaften Chemie Chemistry Genomforschung u. Proteomik Genomics & Proteomics Kapillarelektrophorese Life Sciences Mass Spectrometry Massenspektrometrie Metabolomics Proteomics CH16: Massenspektrometrie CH1D: Bioanalytische Chemie LS33: Genomforschung u. Proteomik (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteomanalyse (DE-588)4596545-6 s Metabolomik (DE-588)1138059420 s Kapillarelektrophorese (DE-588)4290002-5 s Massenspektrometrie (DE-588)4037882-2 s DE-604 Ramautar, Rawi (DE-588)116333376X edt Chen, David D.Y. edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-527-83308-5 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-83310-8 Erscheint auch als Online-Ausgabe 978-3-527-83309-2 X:MVB http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34921-0/ B:DE-101 application/pdf https://d-nb.info/1258092069/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034081796&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p dnb 20230203 DE-101 https://d-nb.info/provenance/plan#dnb 2\p dnb 20230203 DE-101 https://d-nb.info/provenance/plan#dnb 3\p dnb 20230203 DE-101 https://d-nb.info/provenance/plan#dnb
spellingShingle	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications Kapillarelektrophorese (DE-588)4290002-5 gnd Metabolomik (DE-588)1138059420 gnd Massenspektrometrie (DE-588)4037882-2 gnd Proteomanalyse (DE-588)4596545-6 gnd
subject_GND	(DE-588)4290002-5 (DE-588)1138059420 (DE-588)4037882-2 (DE-588)4596545-6 (DE-588)4143413-4
title	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications
title_auth	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications
title_exact_search	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications
title_exact_search_txtP	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications
title_full	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications edited by Rawi Ramautar and David D.Y. Chen
title_fullStr	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications edited by Rawi Ramautar and David D.Y. Chen
title_full_unstemmed	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics principles and applications edited by Rawi Ramautar and David D.Y. Chen
title_short	Capillary electrophoresis-mass spectrometry for proteomics and metabolomics
title_sort	capillary electrophoresis mass spectrometry for proteomics and metabolomics principles and applications
title_sub	principles and applications
topic	Kapillarelektrophorese (DE-588)4290002-5 gnd Metabolomik (DE-588)1138059420 gnd Massenspektrometrie (DE-588)4037882-2 gnd Proteomanalyse (DE-588)4596545-6 gnd
topic_facet	Kapillarelektrophorese Metabolomik Massenspektrometrie Proteomanalyse Aufsatzsammlung
url	http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34921-0/ https://d-nb.info/1258092069/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034081796&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT ramautarrawi capillaryelectrophoresismassspectrometryforproteomicsandmetabolomicsprinciplesandapplications AT chendaviddy capillaryelectrophoresismassspectrometryforproteomicsandmetabolomicsprinciplesandapplications AT wileyvch capillaryelectrophoresismassspectrometryforproteomicsandmetabolomicsprinciplesandapplications

Verfügbarkeit

Es ist kein Print-Exemplar vorhanden.

Fernleihe Bestellen Achtung: Nicht im THWS-Bestand! Inhaltsverzeichnis
Inhaltsverzeichnis

MARC

Datensatz im Suchindex

Es ist kein Print-Exemplar vorhanden.

Ähnliche Einträge