Parkinson's and Alzheimer's today: about Neurodegeneration and its therapy
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English German |
| Published: |
Berlin, Germany
Springer
[2022]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xiii, 153 Seiten Illustrationen |
| ISBN: | 9783662663684 3662663686 |
Staff View
MARC
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| 100 | 1 | |a Klimaschewski, Lars Peter |d 1965- |e Verfasser |0 (DE-588)1107038499 |4 aut | |
| 245 | 1 | 0 | |a Parkinson's and Alzheimer's today |b about Neurodegeneration and its therapy |c Lars P. Klimaschewski |
| 264 | 1 | |a Berlin, Germany |b Springer |c [2022] | |
| 264 | 4 | |c © 2022 | |
| 300 | |a xiii, 153 Seiten |b Illustrationen | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Gehirn |0 (DE-588)4019752-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Neuroanatomie |0 (DE-588)4171577-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Parkinson-Krankheit |0 (DE-588)4044683-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nervenzelle |0 (DE-588)4041649-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nervendegeneration |0 (DE-588)4300182-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Alzheimerkrankheit |0 (DE-588)4112510-1 |2 gnd |9 rswk-swf |
| 653 | |a Alzheimer's dementia | ||
| 653 | |a Dementia | ||
| 653 | |a Brain | ||
| 653 | |a Neurodegeneration | ||
| 653 | |a Ageing | ||
| 653 | |a Neuroanatomy | ||
| 653 | |a Neuroscience | ||
| 653 | |a Neuro-Covid | ||
| 653 | |a Nerve cells | ||
| 653 | |a Stem cells | ||
| 653 | |a Covid-2 | ||
| 653 | |a Neuropathology | ||
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Record in the Search Index
| _version_ | 1817718740548059136 |
|---|---|
| adam_text |
1
INTRODUCTION
TO
BRAIN
DEVELOPMENT:
WHY
DO
WE
NEED
SO
MANY
NERVE
CELLS?
1
1.1
NEURONS
AND
GLIA
IN
THE
CENTRAL
NERVOUS
SYSTEM
3
1.2
WHAT
HAPPENS
DURING
BRAIN
DEVELOPMENT?
4
1.3
EVOLUTIONARILY
OLD
BRAIN
PARTS
ARE
SIMPLER
IN
STRUCTURE
THAN
THE
NEOCORTEX
6
1.4
WHAT
DISTINGUISHES
THE
LEFT
FROM
THE
RIGHT
BRAIN?
8
1.5
BRAIN
DEVELOPMENT
IN
CHILDHOOD
AND
ADOLESCENCE
9
1.6
THE
CHILD
'
S
BRAIN
IS
ENORMOUSLY
PLASTIC
AND
CAN
STILL
HEAL
10
1.7
IS
A
LARGE
BRAIN
"
SMARTER
"
THAN
A
SMALL
ONE?
11
1.8
ABSOLUTE
AND
RELATIVE
BRAIN
WEIGHT
14
1.9
WITH
THE
SECOND
EVOLUTIONARY
LEAP,
OUR
BRAIN
REACHES
ITS
MAXIMUM
SIZE
16
1.10
NEURAL
STEM
CELLS
REMAIN
CAPABLE
OF
DIVIDING
FOR
A
LONG
TIME
18
1.11
THE
FRONTAL
LOBE
IS
ESPECIALLY
IMPORTANT
FOR
HIGHER
BRAIN
FUNCTIONS
19
1.12
THE
PREFRONTAL
CORTEX
ENCODES
HUMAN
SPECIFIC
PROPERTIES
21
1.13
BRAIN
PERFORMANCE
IN
COMPARISON
23
FURTHER
READING
25
XI
XII
CONTENTS
2
AGING
AND
NEURODEGENERATIVE
DISEASES:
WHY
DO
NERVE
CELLS
DIE?
27
2.1
THE
NORMAL
AGING
PROCESS
28
2.1.1
MECHANISMS
OF
CELLULAR
AGING
30
2.1.2
NEURONAL
CELL
DEATH
41
2.1.3
BLOOD
SUPPLY
OF
THE
AGING
BRAIN
45
2.2
PARKINSONS
DISEASE
48
2.2.1
GENERAL
PATHOMECHANISMS
48
2.2.2
SPECIAL
MORPHOLOGY
OF
AFFECTED
NEURONS
56
2.2.3
SPECIFIC
CAUSES
OF
PARKINSONS
DISEASE
60
2.2.4
ALPHA-SYNUCLEIN:
A
KEY
PROTEIN
IN
PARKINSON
'
S
DISEASE
63
2.2.5
THE
PRION
THEORY
OF
PARKINSONS
DISEASE
67
2.3
DEMENTIA
AND
ALZHEIMER
'
S
DISEASE
71
2.3.1
HOW
DOES
ALZHEIMER
'
S
DISEASE
MANIFEST
ITSELF?
72
2.3.2
GENERAL
PATHOMECHANISMS
74
2.3.3
THE
DISTURBED
PROTEIN
HOMEOSTASIS
IN
ALZHEIMER
'
S
DISEASE
80
2.3.4
TAU
PATHOLOGY
82
2.3.5
THE
PRION
THEORY
IN ALZHEIMER
'
S
DISEASE
88
2.4
INFLAMMATORY
COMPONENTS
OF
ALZHEIMER
'
S
AND
PARKINSON
'
S
DISEASE
91
2.5
VIRAL
INFECTIONS
IN
NEURODEGENERATIVE
DISEASES
94
FURTHER
READING
97
3
SAVING
OR
REPLACING
NERVE
CELLS:
WHICH
STRATEGY
IS
MORE
SUCCESSFUL?
105
3.1
PARKINSON
'
S
DISEASE
108
3.1.1
PHARMACOLOGICAL
THERAPY
108
3.1.2
SURGICAL
AND
PHYSICAL
THERAPY
109
3.1.3
THERAPY
WITH
NEUROTROPHIC
FACTORS
111
3.1.4
THERAPY
WITH
ANTISENSE
OLIGONUCLEOTIDES
114
3.1.5
ALPHA-SYNUCLEIN
AGGREGATION
INHIBITORS
AND
SPECIFIC
IMMUNOTHERAPY
117
3.1.6
STEM
CELL
THERAPY
117
3.1.7
OTHER
CAUSAL
THERAPEUTIC
APPROACHES
119
3.2
DEMENTIA
AND
ALZHEIMER
'
S
DISEASE
120
3.2.1
CHOLINERGICA
120
3.2.2
THERAPY
WITH
SECRETASE
INHIBITORS
121
3.2.3
THERAPY
WITH
NEUROTROPHIC
FACTORS
122
CONTENTS
XIII
3.2.4
IMMUNOTHERAPY
3.2.5
STEM
CELL
THERAPY
3.2.6
OTHER
CAUSAL
THERAPEUTIC
APPROACHES
3.2.7
SYMPTOMATIC
THERAPY
3.2.8
WHICH
MEASURES
PROMISE
THE
MOST
SUCCESS?
3.3
DIAGNOSIS
AND
THERAPY
OF
NEURONAL
DEGENERATION
-
QUO
VADIS?
FURTHER
READING
GLOSSARY
123
125
125
127
129
130
134
137 |
| adam_txt |
1
INTRODUCTION
TO
BRAIN
DEVELOPMENT:
WHY
DO
WE
NEED
SO
MANY
NERVE
CELLS?
1
1.1
NEURONS
AND
GLIA
IN
THE
CENTRAL
NERVOUS
SYSTEM
3
1.2
WHAT
HAPPENS
DURING
BRAIN
DEVELOPMENT?
4
1.3
EVOLUTIONARILY
OLD
BRAIN
PARTS
ARE
SIMPLER
IN
STRUCTURE
THAN
THE
NEOCORTEX
6
1.4
WHAT
DISTINGUISHES
THE
LEFT
FROM
THE
RIGHT
BRAIN?
8
1.5
BRAIN
DEVELOPMENT
IN
CHILDHOOD
AND
ADOLESCENCE
9
1.6
THE
CHILD
'
S
BRAIN
IS
ENORMOUSLY
PLASTIC
AND
CAN
STILL
HEAL
10
1.7
IS
A
LARGE
BRAIN
"
SMARTER
"
THAN
A
SMALL
ONE?
11
1.8
ABSOLUTE
AND
RELATIVE
BRAIN
WEIGHT
14
1.9
WITH
THE
SECOND
EVOLUTIONARY
LEAP,
OUR
BRAIN
REACHES
ITS
MAXIMUM
SIZE
16
1.10
NEURAL
STEM
CELLS
REMAIN
CAPABLE
OF
DIVIDING
FOR
A
LONG
TIME
18
1.11
THE
FRONTAL
LOBE
IS
ESPECIALLY
IMPORTANT
FOR
HIGHER
BRAIN
FUNCTIONS
19
1.12
THE
PREFRONTAL
CORTEX
ENCODES
HUMAN
SPECIFIC
PROPERTIES
21
1.13
BRAIN
PERFORMANCE
IN
COMPARISON
23
FURTHER
READING
25
XI
XII
CONTENTS
2
AGING
AND
NEURODEGENERATIVE
DISEASES:
WHY
DO
NERVE
CELLS
DIE?
27
2.1
THE
NORMAL
AGING
PROCESS
28
2.1.1
MECHANISMS
OF
CELLULAR
AGING
30
2.1.2
NEURONAL
CELL
DEATH
41
2.1.3
BLOOD
SUPPLY
OF
THE
AGING
BRAIN
45
2.2
PARKINSONS
DISEASE
48
2.2.1
GENERAL
PATHOMECHANISMS
48
2.2.2
SPECIAL
MORPHOLOGY
OF
AFFECTED
NEURONS
56
2.2.3
SPECIFIC
CAUSES
OF
PARKINSONS
DISEASE
60
2.2.4
ALPHA-SYNUCLEIN:
A
KEY
PROTEIN
IN
PARKINSON
'
S
DISEASE
63
2.2.5
THE
PRION
THEORY
OF
PARKINSONS
DISEASE
67
2.3
DEMENTIA
AND
ALZHEIMER
'
S
DISEASE
71
2.3.1
HOW
DOES
ALZHEIMER
'
S
DISEASE
MANIFEST
ITSELF?
72
2.3.2
GENERAL
PATHOMECHANISMS
74
2.3.3
THE
DISTURBED
PROTEIN
HOMEOSTASIS
IN
ALZHEIMER
'
S
DISEASE
80
2.3.4
TAU
PATHOLOGY
82
2.3.5
THE
PRION
THEORY
IN ALZHEIMER
'
S
DISEASE
88
2.4
INFLAMMATORY
COMPONENTS
OF
ALZHEIMER
'
S
AND
PARKINSON
'
S
DISEASE
91
2.5
VIRAL
INFECTIONS
IN
NEURODEGENERATIVE
DISEASES
94
FURTHER
READING
97
3
SAVING
OR
REPLACING
NERVE
CELLS:
WHICH
STRATEGY
IS
MORE
SUCCESSFUL?
105
3.1
PARKINSON
'
S
DISEASE
108
3.1.1
PHARMACOLOGICAL
THERAPY
108
3.1.2
SURGICAL
AND
PHYSICAL
THERAPY
109
3.1.3
THERAPY
WITH
NEUROTROPHIC
FACTORS
111
3.1.4
THERAPY
WITH
ANTISENSE
OLIGONUCLEOTIDES
114
3.1.5
ALPHA-SYNUCLEIN
AGGREGATION
INHIBITORS
AND
SPECIFIC
IMMUNOTHERAPY
117
3.1.6
STEM
CELL
THERAPY
117
3.1.7
OTHER
CAUSAL
THERAPEUTIC
APPROACHES
119
3.2
DEMENTIA
AND
ALZHEIMER
'
S
DISEASE
120
3.2.1
CHOLINERGICA
120
3.2.2
THERAPY
WITH
SECRETASE
INHIBITORS
121
3.2.3
THERAPY
WITH
NEUROTROPHIC
FACTORS
122
CONTENTS
XIII
3.2.4
IMMUNOTHERAPY
3.2.5
STEM
CELL
THERAPY
3.2.6
OTHER
CAUSAL
THERAPEUTIC
APPROACHES
3.2.7
SYMPTOMATIC
THERAPY
3.2.8
WHICH
MEASURES
PROMISE
THE
MOST
SUCCESS?
3.3
DIAGNOSIS
AND
THERAPY
OF
NEURONAL
DEGENERATION
-
QUO
VADIS?
FURTHER
READING
GLOSSARY
123
125
125
127
129
130
134
137 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Klimaschewski, Lars Peter 1965- |
| author_GND | (DE-588)1107038499 |
| author_facet | Klimaschewski, Lars Peter 1965- |
| author_role | aut |
| author_sort | Klimaschewski, Lars Peter 1965- |
| author_variant | l p k lp lpk |
| building | Verbundindex |
| bvnumber | BV048640059 |
| ctrlnum | (OCoLC)1370251489 (DE-599)DNB1269128191 |
| format | Book |
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| id | DE-604.BV048640059 |
| illustrated | Illustrated |
| index_date | 2024-07-03T21:17:23Z |
| indexdate | 2024-12-06T19:01:16Z |
| institution | BVB |
| institution_GND | (DE-588)1065168780 |
| isbn | 9783662663684 3662663686 |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-034015007 |
| oclc_num | 1370251489 |
| open_access_boolean | |
| owner | DE-29 |
| owner_facet | DE-29 |
| physical | xiii, 153 Seiten Illustrationen |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | Springer |
| record_format | marc |
| spelling | Klimaschewski, Lars Peter 1965- Verfasser (DE-588)1107038499 aut Parkinson's and Alzheimer's today about Neurodegeneration and its therapy Lars P. Klimaschewski Berlin, Germany Springer [2022] © 2022 xiii, 153 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Gehirn (DE-588)4019752-9 gnd rswk-swf Neuroanatomie (DE-588)4171577-9 gnd rswk-swf Parkinson-Krankheit (DE-588)4044683-9 gnd rswk-swf Nervenzelle (DE-588)4041649-5 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Alzheimer's dementia Dementia Brain Neurodegeneration Ageing Neuroanatomy Neuroscience Neuro-Covid Nerve cells Stem cells Covid-2 Neuropathology Neuroanatomie (DE-588)4171577-9 s Gehirn (DE-588)4019752-9 s Nervenzelle (DE-588)4041649-5 s Nervendegeneration (DE-588)4300182-8 s DE-604 Alzheimerkrankheit (DE-588)4112510-1 s Parkinson-Krankheit (DE-588)4044683-9 s Springer-Verlag GmbH (DE-588)1065168780 pbl Erscheint auch als Online-Ausgabe 978-3-662-66369-1 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034015007&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Klimaschewski, Lars Peter 1965- Parkinson's and Alzheimer's today about Neurodegeneration and its therapy Gehirn (DE-588)4019752-9 gnd Neuroanatomie (DE-588)4171577-9 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd Nervenzelle (DE-588)4041649-5 gnd Nervendegeneration (DE-588)4300182-8 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd |
| subject_GND | (DE-588)4019752-9 (DE-588)4171577-9 (DE-588)4044683-9 (DE-588)4041649-5 (DE-588)4300182-8 (DE-588)4112510-1 |
| title | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy |
| title_auth | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy |
| title_exact_search | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy |
| title_exact_search_txtP | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy |
| title_full | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy Lars P. Klimaschewski |
| title_fullStr | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy Lars P. Klimaschewski |
| title_full_unstemmed | Parkinson's and Alzheimer's today about Neurodegeneration and its therapy Lars P. Klimaschewski |
| title_short | Parkinson's and Alzheimer's today |
| title_sort | parkinson s and alzheimer s today about neurodegeneration and its therapy |
| title_sub | about Neurodegeneration and its therapy |
| topic | Gehirn (DE-588)4019752-9 gnd Neuroanatomie (DE-588)4171577-9 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd Nervenzelle (DE-588)4041649-5 gnd Nervendegeneration (DE-588)4300182-8 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd |
| topic_facet | Gehirn Neuroanatomie Parkinson-Krankheit Nervenzelle Nervendegeneration Alzheimerkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034015007&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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