Physiologically-based pharmacokinetic (PBPK) modeling and simulations: principles, methods, and applications in the pharmaceutical industry
Machine generated contents note:SECTION IPRINCIPLES AND METHODS --1.Modeling In The Pharmaceutical Industry --1.1.Introduction --1.2.Modeling Approaches --1.3.Steps Needed to Maximize Effective Integration of Models into R&D Workflow --1.4.Scope of the Book --Keywords --References --2.Physiologi...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J
Wiley
2022
|
| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | FUBA1 URL des Erstveröffentlichers |
| Zusammenfassung: | Machine generated contents note:SECTION IPRINCIPLES AND METHODS --1.Modeling In The Pharmaceutical Industry --1.1.Introduction --1.2.Modeling Approaches --1.3.Steps Needed to Maximize Effective Integration of Models into R&D Workflow --1.4.Scope of the Book --Keywords --References --2.Physiologically-Based Modeling --2.1.Introduction --2.2.Examples of Physiological Modeling --2.3.Need for Physiological Models in the Pharmaceutical Industry --2.4.Organs as Compartments --2.5.Bottom-Up vs. Top-Down Modeling in Pharmacokinetics --References --3.Review Of Pharmacokinetic Principles --3.1.Introduction --3.2.Routes of Administration --3.3.Drug Disposition --3.3.1.Absorption --3.3.2.Plasma Protein Binding, Blood-Plasma Ratio --3.3.3.Distribution, Elimination, Half-Life, and Clearance --3.3.4.Role of Transporters in ADME --3.4.Linear and Nonlinear Pharmacokinetics --3.5.Steady-State Pharmacokinetics --3.6.Dose Estimations --3.7.Successful PK Optimization in Drug Discovery --Keywords --References --4.Physiological Model For Absorption --4.1.Introduction --4.2.Drug Absorption and Gut Bioavailability --4.2.1.Solubility and Dissolution Rate --4.2.2.Permeability: Transcelluar, Paracellular, and Carrier-Mediated Pathways --4.2.3.Barriers to Membrane Transport -- Luminal Degradation, Efflux, and Gut Metabolism --4.3.Factors Affecting Drug Absorption and Gut Bioavailability --4.3.1.Physiological Factors Affecting Oral Drug Absorption and Species Differences in Physiology --4.3.2.Compound-Dependent Factors --4.3.3.Formulation-Dependent Factors --4.4.In Silico Predictions of Passive Permeability and Solubility --4.4.1.In Silico Models for Permeability --4.4.2.In Silico Models for Solubility --4.5.Measurement of Permeability, Solubility, Luminal Stability, Efflux, and Intestinal Metabolism --4.5.1.In Vitro, |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781118140291 111814029X 9781119497813 1119497817 |
| DOI: | 10.1002/9781119497813 |
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| 520 | 3 | |a Luminal Degradation, Efflux, and Gut Metabolism --4.3.Factors Affecting Drug Absorption and Gut Bioavailability --4.3.1.Physiological Factors Affecting Oral Drug Absorption and Species Differences in Physiology --4.3.2.Compound-Dependent Factors --4.3.3.Formulation-Dependent Factors --4.4.In Silico Predictions of Passive Permeability and Solubility --4.4.1.In Silico Models for Permeability --4.4.2.In Silico Models for Solubility --4.5.Measurement of Permeability, Solubility, Luminal Stability, Efflux, and Intestinal Metabolism --4.5.1.In Vitro, | |
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| discipline | Chemie / Pharmazie Medizin |
| discipline_str_mv | Chemie / Pharmazie Medizin |
| doi_str_mv | 10.1002/9781119497813 |
| edition | Second edition |
| format | Electronic eBook |
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| spelling | Peters, Sheila Annie Verfasser (DE-588)1248709373 aut Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry Sheila Annie Peters, Merck Healthcare, Translational Quantitative Pharmacology, Darmstadt Germany Physiologically based pharmacokinetic modeling and simulations PBPK modeling and simulations Second edition Hoboken, N.J Wiley 2022 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references and index Machine generated contents note:SECTION IPRINCIPLES AND METHODS --1.Modeling In The Pharmaceutical Industry --1.1.Introduction --1.2.Modeling Approaches --1.3.Steps Needed to Maximize Effective Integration of Models into R&D Workflow --1.4.Scope of the Book --Keywords --References --2.Physiologically-Based Modeling --2.1.Introduction --2.2.Examples of Physiological Modeling --2.3.Need for Physiological Models in the Pharmaceutical Industry --2.4.Organs as Compartments --2.5.Bottom-Up vs. Top-Down Modeling in Pharmacokinetics --References --3.Review Of Pharmacokinetic Principles --3.1.Introduction --3.2.Routes of Administration --3.3.Drug Disposition --3.3.1.Absorption --3.3.2.Plasma Protein Binding, Blood-Plasma Ratio --3.3.3.Distribution, Elimination, Half-Life, and Clearance --3.3.4.Role of Transporters in ADME --3.4.Linear and Nonlinear Pharmacokinetics --3.5.Steady-State Pharmacokinetics --3.6.Dose Estimations --3.7.Successful PK Optimization in Drug Discovery --Keywords --References --4.Physiological Model For Absorption --4.1.Introduction --4.2.Drug Absorption and Gut Bioavailability --4.2.1.Solubility and Dissolution Rate --4.2.2.Permeability: Transcelluar, Paracellular, and Carrier-Mediated Pathways --4.2.3.Barriers to Membrane Transport -- Luminal Degradation, Efflux, and Gut Metabolism --4.3.Factors Affecting Drug Absorption and Gut Bioavailability --4.3.1.Physiological Factors Affecting Oral Drug Absorption and Species Differences in Physiology --4.3.2.Compound-Dependent Factors --4.3.3.Formulation-Dependent Factors --4.4.In Silico Predictions of Passive Permeability and Solubility --4.4.1.In Silico Models for Permeability --4.4.2.In Silico Models for Solubility --4.5.Measurement of Permeability, Solubility, Luminal Stability, Efflux, and Intestinal Metabolism --4.5.1.In Vitro, Mathematische Modellierung (DE-588)7651795-0 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Pharmacokinetics / Mathematical models Drugs / Design / Mathematical models Biological models Pharmacokinetics Drug Design Models, Biological Pharmacokinetics ; Mathematical models Pharmacocinétique Médicaments - Conception Modèles biologiques Electronic books Pharmakokinetik (DE-588)4115557-9 s Mathematische Modellierung (DE-588)7651795-0 s DE-604 Erscheint auch als Druck-Ausgabe 9781119497684 https://doi.org/10.1002/9781119497813 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Peters, Sheila Annie Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry Mathematische Modellierung (DE-588)7651795-0 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)7651795-0 (DE-588)4115557-9 |
| title | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry |
| title_alt | Physiologically based pharmacokinetic modeling and simulations PBPK modeling and simulations |
| title_auth | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry |
| title_exact_search | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry |
| title_exact_search_txtP | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry |
| title_full | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry Sheila Annie Peters, Merck Healthcare, Translational Quantitative Pharmacology, Darmstadt Germany |
| title_fullStr | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry Sheila Annie Peters, Merck Healthcare, Translational Quantitative Pharmacology, Darmstadt Germany |
| title_full_unstemmed | Physiologically-based pharmacokinetic (PBPK) modeling and simulations principles, methods, and applications in the pharmaceutical industry Sheila Annie Peters, Merck Healthcare, Translational Quantitative Pharmacology, Darmstadt Germany |
| title_short | Physiologically-based pharmacokinetic (PBPK) modeling and simulations |
| title_sort | physiologically based pharmacokinetic pbpk modeling and simulations principles methods and applications in the pharmaceutical industry |
| title_sub | principles, methods, and applications in the pharmaceutical industry |
| topic | Mathematische Modellierung (DE-588)7651795-0 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Mathematische Modellierung Pharmakokinetik |
| url | https://doi.org/10.1002/9781119497813 |
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