Pharmacology of drug stereoisomers:
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Singapore
Springer
[2022]
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| Series: | Progress in drug research
volume 76 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | xi, 207 Seiten Illustrationen 24 cm |
| ISBN: | 9789811923197 |
Staff View
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Record in the Search Index
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| adam_text | Contents 1 1.1 Types of Isomers ................................................................................. 3 1.2 Stereoisomers with Different Chirality Types ................................... 15 1.3 Conformational Isomerism ............................................................... 19 References ........................................................................................................ 21 1 General Principles of Molecular Chirality ............................................... 2 Separation, Asymmetric Synthesis and Analysis of Stereoisomers 3 23 29 31 General Issues of Chirality in Pharmacology........................................... 35 36 56 61 63 67 3.1 Chirality and Pharmacokinetics......................................................... 3.2 Chirality and Pharmacodynamics ..................................................... 3.3 Chirality and Toxicology ................................................................... 3.4 Classification of Drugs from Stereochemical Point of View........... References .. . ................................................................................................. 4 23 2.1 Separation of Stereoisomers ............................................................ 2.2 Quantitative Methods of Analysing Chiral Drugs........................... References ..................................................................................................... The Significance of Chirality in Pharmacological and Toxicological Properties of Drugs ....................................................... 4.1 4.2 4.3
4.4 4.5 4.6 4.7 4.8 Drugs Regulating the Function of Peripheral Nervous System .... Drugs Affecting the Central Nervous System Function.................. Drugs Regulating the Functions of Major Organs and Systems ............................................................................ 126 Drugs Affecting theImmunity Processes........................................... Drugs Used in Endocrine Disorders .................................................. Antibacterial Drugs............................................................................. Antitumor Drugs ................................................................................. Pros and Cons of Administering Drugs in the Form of Racemic Mixtures or Single Stereoisomers in Clinical Practice ............................................................................................. 75 75 100 144 149 153 163 164 vii
viii 5 Contents 4.9 Rules of Developing and Administering Chiral Drugs................... 4.10 Conclusion ......................................................................................... References ..................................................................................................... 166 169 170 In Silice Search for Chiral Drug Compounds ....................................... 5.1 Ways of Describing Chirality of Compounds for in Silico Analysis .................................................................................. 193 5.2 2D in Silico Analysis of Chiral Compounds .................................... 5.3 3D in Silico Analysis of Chiral Compounds .................................... 5.4 Molecular Dockingof Chiral Compounds......................................... 5.5 Prediction of Pharmacological Activity of Chiral Compounds Using IT Microcosm......................................... 200 5.6 Conclusion .......................................................................................... References ..................... 193 194 196 198 204 205
Progress in Drug Research 76 Series Editor: K. D. Rainsford Alexander A. Špásov ■ Igor N. lezhitsa · Pavel M. Vassiliev · Alexander A. Ozerov · Renu Agarwal Pharmacology of Drug Stereoisomers The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
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| adam_txt |
Contents 1 1.1 Types of Isomers . 3 1.2 Stereoisomers with Different Chirality Types . 15 1.3 Conformational Isomerism . 19 References . 21 1 General Principles of Molecular Chirality . 2 Separation, Asymmetric Synthesis and Analysis of Stereoisomers 3 23 29 31 General Issues of Chirality in Pharmacology. 35 36 56 61 63 67 3.1 Chirality and Pharmacokinetics. 3.2 Chirality and Pharmacodynamics . 3.3 Chirality and Toxicology . 3.4 Classification of Drugs from Stereochemical Point of View. References . . . 4 23 2.1 Separation of Stereoisomers . 2.2 Quantitative Methods of Analysing Chiral Drugs. References . The Significance of Chirality in Pharmacological and Toxicological Properties of Drugs . 4.1 4.2 4.3
4.4 4.5 4.6 4.7 4.8 Drugs Regulating the Function of Peripheral Nervous System . Drugs Affecting the Central Nervous System Function. Drugs Regulating the Functions of Major Organs and Systems . 126 Drugs Affecting theImmunity Processes. Drugs Used in Endocrine Disorders . Antibacterial Drugs. Antitumor Drugs . Pros and Cons of Administering Drugs in the Form of Racemic Mixtures or Single Stereoisomers in Clinical Practice . 75 75 100 144 149 153 163 164 vii
viii 5 Contents 4.9 Rules of Developing and Administering Chiral Drugs. 4.10 Conclusion . References . 166 169 170 In Silice Search for Chiral Drug Compounds . 5.1 Ways of Describing Chirality of Compounds for in Silico Analysis . 193 5.2 2D in Silico Analysis of Chiral Compounds . 5.3 3D in Silico Analysis of Chiral Compounds . 5.4 Molecular Dockingof Chiral Compounds. 5.5 Prediction of Pharmacological Activity of Chiral Compounds Using IT Microcosm. 200 5.6 Conclusion . References . 193 194 196 198 204 205
Progress in Drug Research 76 Series Editor: K. D. Rainsford Alexander A. Špásov ■ Igor N. lezhitsa · Pavel M. Vassiliev · Alexander A. Ozerov · Renu Agarwal Pharmacology of Drug Stereoisomers The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials. |
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| index_date | 2024-07-03T20:40:45Z |
| indexdate | 2024-07-10T09:39:28Z |
| institution | BVB |
| isbn | 9789811923197 |
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| spelling | Spasov, Alexander A. Verfasser aut Pharmacology of drug stereoisomers Alexander A. Spasov, Igor N. Iezhitsa, Pavel M. Vassiliev, Alexander A. Ozerov, Renu Agarwal Singapore Springer [2022] xi, 207 Seiten Illustrationen 24 cm txt rdacontent sti rdacontent n rdamedia nc rdacarrier Progress in drug research volume 76 Pharmacology Stereoisomers / Therapeutic use Stereoisomers / Physiological effect Iezhitsa, Igor N. Verfasser aut Vassiliev, Pavel M. Verfasser aut Ozerov, Alexander A. Verfasser aut Agarwal, Renu Verfasser aut Erscheint auch als Online-Ausgabe 978-981-19-2320-3 Progress in drug research volume 76 (DE-604)BV002528909 76 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033865099&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033865099&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Spasov, Alexander A. Iezhitsa, Igor N. Vassiliev, Pavel M. Ozerov, Alexander A. Agarwal, Renu Pharmacology of drug stereoisomers Progress in drug research |
| title | Pharmacology of drug stereoisomers |
| title_auth | Pharmacology of drug stereoisomers |
| title_exact_search | Pharmacology of drug stereoisomers |
| title_exact_search_txtP | Pharmacology of drug stereoisomers |
| title_full | Pharmacology of drug stereoisomers Alexander A. Spasov, Igor N. Iezhitsa, Pavel M. Vassiliev, Alexander A. Ozerov, Renu Agarwal |
| title_fullStr | Pharmacology of drug stereoisomers Alexander A. Spasov, Igor N. Iezhitsa, Pavel M. Vassiliev, Alexander A. Ozerov, Renu Agarwal |
| title_full_unstemmed | Pharmacology of drug stereoisomers Alexander A. Spasov, Igor N. Iezhitsa, Pavel M. Vassiliev, Alexander A. Ozerov, Renu Agarwal |
| title_short | Pharmacology of drug stereoisomers |
| title_sort | pharmacology of drug stereoisomers |
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