Mitochondria-targeted drug delivery:
Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell dea...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Basel
MDPI - Multidisciplinary Digital Publishing Institute
[2022]
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| Subjects: | |
| Online Access: | Volltext Volltext |
| Summary: | Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers. |
| Physical Description: | 1 Online-Ressource (ix, 278 Seiten) |
| ISBN: | 9783036540405 |
| DOI: | 10.3390/books978-3-0365-4040-5 |
Staff View
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| 520 | 3 | |a Mitochondria, organelles surrounded by a double membrane and with their own small genome, are the cells’ energy centers. Besides the production of ATP through cellular respiration, mitochondria play a pivotal role in other aspects of the life and death of a cell: heat production, programmed cell death, the regulation of metabolic activity, immunity, and calcium homeostasis. A number of diseases are associated with mitochondrial dysfunction, including cardiovascular, neurological, inflammatory, and metabolic disorders as well as cancer. Mitochondria therefore represent an important therapy target, and it is not surprising that a number of different treatment strategies have emerged. Approaches targeting mitochondria can be split into two opposite categories: drugs that restore mitochondrial function and drugs that trigger mitochondria-mediated cell death. Targeted drug delivery to achieve the selective accumulation of drug molecules in mitochondria is complex and involves methods such as direct drug modification or encapsulation into nanocarriers. | |
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Record in the Search Index
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| id | DE-604.BV048449658 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T20:30:18Z |
| indexdate | 2025-02-20T07:15:41Z |
| institution | BVB |
| isbn | 9783036540405 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033827830 |
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| physical | 1 Online-Ressource (ix, 278 Seiten) |
| psigel | ZDB-94-OAB |
| publishDate | 2022 |
| publishDateSearch | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | marc |
| spellingShingle | Mitochondria-targeted drug delivery Mitochondrium (DE-588)4124939-2 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| subject_GND | (DE-588)4124939-2 (DE-588)4190018-2 (DE-588)4143413-4 |
| title | Mitochondria-targeted drug delivery |
| title_auth | Mitochondria-targeted drug delivery |
| title_exact_search | Mitochondria-targeted drug delivery |
| title_exact_search_txtP | Mitochondria-targeted drug delivery |
| title_full | Mitochondria-targeted drug delivery editor Joanna Kopecka |
| title_fullStr | Mitochondria-targeted drug delivery editor Joanna Kopecka |
| title_full_unstemmed | Mitochondria-targeted drug delivery editor Joanna Kopecka |
| title_short | Mitochondria-targeted drug delivery |
| title_sort | mitochondria targeted drug delivery |
| topic | Mitochondrium (DE-588)4124939-2 gnd Wirkstofffreisetzung (DE-588)4190018-2 gnd |
| topic_facet | Mitochondrium Wirkstofffreisetzung Aufsatzsammlung |
| url | https://directory.doabooks.org/handle/20.500.12854/84478 https://doi.org/10.3390/books978-3-0365-4040-5 |
| work_keys_str_mv | AT kopeckajoanna mitochondriatargeteddrugdelivery |