Personalized drug screening for functional tumor profiling:
Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements obse...
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| Main Authors: | , , , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cambridge
Cambridge University Press
2022
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| Series: | Elements in Molecular Oncology
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| Subjects: | |
| Online Access: | DE-12 DE-473 Volltext |
| Summary: | Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology |
| Item Description: | Title from publisher's bibliographic system (viewed on 10 Jun 2022) |
| Physical Description: | 1 Online-Ressource (22 Seiten) |
| ISBN: | 9781009037877 |
| DOI: | 10.1017/9781009037877 |
Staff View
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| 520 | |a Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology | ||
| 650 | 4 | |a Cancer / Chemotherapy | |
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Record in the Search Index
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| author | El-Khoury, Victoria 1977- Michel, Tatiana 1975- Kim, Hichul 1976- Kwon, Yong-Jun 1976- |
| author_GND | (DE-588)1264159633 (DE-588)1264160062 (DE-588)1264160437 (DE-588)1264160739 |
| author_facet | El-Khoury, Victoria 1977- Michel, Tatiana 1975- Kim, Hichul 1976- Kwon, Yong-Jun 1976- |
| author_role | aut aut aut aut |
| author_sort | El-Khoury, Victoria 1977- |
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| bvnumber | BV048388165 |
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| dewey-full | 616.994061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994061 |
| dewey-search | 616.994061 |
| dewey-sort | 3616.994061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1017/9781009037877 |
| format | Electronic eBook |
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| id | DE-604.BV048388165 |
| illustrated | Not Illustrated |
| index_date | 2024-07-03T20:20:19Z |
| indexdate | 2024-07-20T04:02:58Z |
| institution | BVB |
| isbn | 9781009037877 |
| language | English |
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| physical | 1 Online-Ressource (22 Seiten) |
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| publishDate | 2022 |
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| publisher | Cambridge University Press |
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| series2 | Elements in Molecular Oncology |
| spelling | El-Khoury, Victoria 1977- (DE-588)1264159633 aut Personalized drug screening for functional tumor profiling Victoria El-Khoury, Tatiana Michel, Hichul Kim, Yong-Jun Kwon Cambridge Cambridge University Press 2022 1 Online-Ressource (22 Seiten) txt rdacontent c rdamedia cr rdacarrier Elements in Molecular Oncology Title from publisher's bibliographic system (viewed on 10 Jun 2022) Despite considerable advances in our understanding of the biology that underlies tumor development and progression of cancer and the rapidly evolving field of personalized medicine, cancer is still one of the deadliest diseases. Many cancer patients have benefited from the survival improvements observed with targeted therapies but only a small subset of patients receiving targeted drugs experience an objective response. Because cancer is a complex and heterogeneous disease, the search for effective cancer treatments will need to address not only patient-specific molecular defects but also aspects of the tumor microenvironment. The functional tumor profiling directly measures the cellular phenotype, in particular tumor growth, in response to drugs using patient-derived tumor models and might be the next step toward precision oncology. In this Element, the authors discuss the personalized drug screening as a novel patient stratification strategy for the determination of individualized treatment choices in oncology Cancer / Chemotherapy Personalized medicine Antineoplastic agents Michel, Tatiana 1975- (DE-588)1264160062 aut Kim, Hichul 1976- (DE-588)1264160437 aut Kwon, Yong-Jun 1976- (DE-588)1264160739 aut Erscheint auch als Druck-Ausgabe 978-1-00-901693-3 https://doi.org/10.1017/9781009037877 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | El-Khoury, Victoria 1977- Michel, Tatiana 1975- Kim, Hichul 1976- Kwon, Yong-Jun 1976- Personalized drug screening for functional tumor profiling Cancer / Chemotherapy Personalized medicine Antineoplastic agents |
| title | Personalized drug screening for functional tumor profiling |
| title_auth | Personalized drug screening for functional tumor profiling |
| title_exact_search | Personalized drug screening for functional tumor profiling |
| title_exact_search_txtP | Personalized drug screening for functional tumor profiling |
| title_full | Personalized drug screening for functional tumor profiling Victoria El-Khoury, Tatiana Michel, Hichul Kim, Yong-Jun Kwon |
| title_fullStr | Personalized drug screening for functional tumor profiling Victoria El-Khoury, Tatiana Michel, Hichul Kim, Yong-Jun Kwon |
| title_full_unstemmed | Personalized drug screening for functional tumor profiling Victoria El-Khoury, Tatiana Michel, Hichul Kim, Yong-Jun Kwon |
| title_short | Personalized drug screening for functional tumor profiling |
| title_sort | personalized drug screening for functional tumor profiling |
| topic | Cancer / Chemotherapy Personalized medicine Antineoplastic agents |
| topic_facet | Cancer / Chemotherapy Personalized medicine Antineoplastic agents |
| url | https://doi.org/10.1017/9781009037877 |
| work_keys_str_mv | AT elkhouryvictoria personalizeddrugscreeningforfunctionaltumorprofiling AT micheltatiana personalizeddrugscreeningforfunctionaltumorprofiling AT kimhichul personalizeddrugscreeningforfunctionaltumorprofiling AT kwonyongjun personalizeddrugscreeningforfunctionaltumorprofiling |