The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Münster
[2021]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | IV, 76 Seiten Illustrationen, Diagramme 29 cm |
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MARC
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| 245 | 1 | 0 | |a The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |c vorgelegt von: Zhenhan Li |
| 264 | 1 | |a Münster |c [2021] | |
| 300 | |a IV, 76 Seiten |b Illustrationen, Diagramme |c 29 cm | ||
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|---|---|
| adam_text | TABLE
OF
CONTENTS
ABBREVIATIONS
......................................................................................................................................
HI
1.
INTRODUCTION
......................................................................................................................................
1
1.1
THE
DEFINITION,
DIAGNOSIS,
AND
STAGES
OF
ACUTE
KIDNEY
INJURY
........................................
1
1.2
ETIOLOGY
OF
AKI
.......................................................................................................................
3
1.2.1
MECHANISM
OF
SEPSIS-INDUCED
AKI
...............................................................................
3
1.2.2
MECHANISM
OF
ISCHEMIA/REPERFUSION-INDUCED
AKI
......................................................
4
1.2.3
THE
PROCESS
OF
LEUKOCYTE
MIGRATION
.............................................................................
5
1.2.4
THE
ROLE
OF
POLYMORPHONUCLEAR
NEUTROPHIL
LEUKOCYTES
(PMNS)
IN
AKI
.......................
6
1.3
VASCULAR
ENDOTHELIAL
(VE)
-
CADHERIN
..................................................................................
6
1.3.1
ENDOTHELIAL
CELL-CELL
ADHESIVE
STRUCTURE
......................................................................
6
1.3.2
VE-CADHERIN
STRUCTURE
AND
FUNCTION
.............................................................................
6
1.3.3
VE-CADHERIN
RESIDUE
TYROSINE
731
(TYR731)
................................................................
7
1.4
ANIMAL
MODEL
DESCRIPTION
....................................................................................................
8
1.4.1
SEPSIS-INDUCED
AKI
ANIMAL
MODEL
..............................................................................
8
1.4.2
ISCHEMIA/REPERFUSION
INJURY-INDUCED
AKI
ANIMAL
MODEL
.............................................
8
1.5
RESEARCH
PURPOSE
................................................................................................................
9
2.
MATERIALS
AND
METHODS
.................................................................................................................
10
2.1
ANIMAL
....................................................................................................................................
10
2.2
MATERIALS
...............................................................................................................................
10
2.3
EXPERIMENTAL
METHODS
.......................................................................................................
14
2.3.1
GROUPING
INFORMATION
AND
EXPERIMENTAL
OVERVIEW
....................................................
14
2.3.2
CLP
(SEPSIS)-INDUCED
AKI
ANIMAL
MODEL
..................................................................
14
2.3.3
IRI-INDUCED
AKI
ANIMAL
MODEL
...................................................................................
16
2.3.4
MICE
PERFUSION
AND
TISSUE
DISSECTION
.........................................................................
18
2.3.5
PERIPHERAL
GRANULOCYTES
(KIMURA
STAINING)
................................................................
18
2.3.6
PMNS
INFILTRATED
INTO
THE
KIDNEY
.................................................................................
19
2.3.7
SERUM
AND
URINE
CREATININE
.......................................................................................
21
2.3.8
BLOOD
UREA
NITROGEN
....................................................................................................
22
I
2.3.9
RENAL
HISTOCHEMISTRY
AND
IMMUNOHISTOCHEMISTRY
.....................................................
23
2.3.10
RENAL
TUBULAR
INJURY
BIOMARKERS
...............................................................................
28
2.4
STATISTICAL
ANALYSIS
...........................................................................................................
34
3.
RESULTS
............................................................................................................................................
35
3.1
PERIPHERAL
GRANULOCYTES
BEFORE
INTERVENTION
.................................................................
35
3.2
NEUTROPHIL
RECRUITMENT
INTO
THE
KIDNEY
............................................................................
35
3.3
EVALUATION
OF
RENAL
FUNCTION
.............................................................................................
38
3.3.1
BLOOD
UREA
NITROGEN
....................................................................................................
38
3.3.2
SERUM
CREATININE
........................................................................................................
39
3.3.3
URINE
CREATININE
..........................................................................................................
41
3.3.4
URINE
OUTPUT
................................................................................................................43
3.3.5
CREATININE
CLEARANCE
.................................................................................................
45
3.4
RENAL
TUBULAR
INJURY
BIOMARKERS
.......................................................................................47
3.4.1
URINARY
NGAL
.............................................................................................................47
3.4.2
URINARY
KIM-1
.............................................................................................................
48
3.4.3
URINARY
TIMP-2*IGFBP7
............................................................................................
50
3.5
HISTOLOGICAL
EXAMINATION
...................................................................................................
50
3.5.1
HE
STAINING
.................................................................................................................
51
3.5.2
PAS
STAINING
...............................................................................................................
53
3.6
APOPTOSIS
EXAMINATION
BY
TUNEL
ASSAY
.......................................................................
55
3.7
ROS
EXAMINATION
................................................................................................................
58
4.
DISCUSSION
....................................................................................................................................
62
5.
REFERENCES
....................................................................................................................................
66
|
| adam_txt |
TABLE
OF
CONTENTS
ABBREVIATIONS
.
HI
1.
INTRODUCTION
.
1
1.1
THE
DEFINITION,
DIAGNOSIS,
AND
STAGES
OF
ACUTE
KIDNEY
INJURY
.
1
1.2
ETIOLOGY
OF
AKI
.
3
1.2.1
MECHANISM
OF
SEPSIS-INDUCED
AKI
.
3
1.2.2
MECHANISM
OF
ISCHEMIA/REPERFUSION-INDUCED
AKI
.
4
1.2.3
THE
PROCESS
OF
LEUKOCYTE
MIGRATION
.
5
1.2.4
THE
ROLE
OF
POLYMORPHONUCLEAR
NEUTROPHIL
LEUKOCYTES
(PMNS)
IN
AKI
.
6
1.3
VASCULAR
ENDOTHELIAL
(VE)
-
CADHERIN
.
6
1.3.1
ENDOTHELIAL
CELL-CELL
ADHESIVE
STRUCTURE
.
6
1.3.2
VE-CADHERIN
STRUCTURE
AND
FUNCTION
.
6
1.3.3
VE-CADHERIN
RESIDUE
TYROSINE
731
(TYR731)
.
7
1.4
ANIMAL
MODEL
DESCRIPTION
.
8
1.4.1
SEPSIS-INDUCED
AKI
ANIMAL
MODEL
.
8
1.4.2
ISCHEMIA/REPERFUSION
INJURY-INDUCED
AKI
ANIMAL
MODEL
.
8
1.5
RESEARCH
PURPOSE
.
9
2.
MATERIALS
AND
METHODS
.
10
2.1
ANIMAL
.
10
2.2
MATERIALS
.
10
2.3
EXPERIMENTAL
METHODS
.
14
2.3.1
GROUPING
INFORMATION
AND
EXPERIMENTAL
OVERVIEW
.
14
2.3.2
CLP
(SEPSIS)-INDUCED
AKI
ANIMAL
MODEL
.
14
2.3.3
IRI-INDUCED
AKI
ANIMAL
MODEL
.
16
2.3.4
MICE
PERFUSION
AND
TISSUE
DISSECTION
.
18
2.3.5
PERIPHERAL
GRANULOCYTES
(KIMURA
STAINING)
.
18
2.3.6
PMNS
INFILTRATED
INTO
THE
KIDNEY
.
19
2.3.7
SERUM
AND
URINE
CREATININE
.
21
2.3.8
BLOOD
UREA
NITROGEN
.
22
I
2.3.9
RENAL
HISTOCHEMISTRY
AND
IMMUNOHISTOCHEMISTRY
.
23
2.3.10
RENAL
TUBULAR
INJURY
BIOMARKERS
.
28
2.4
STATISTICAL
ANALYSIS
.
34
3.
RESULTS
.
35
3.1
PERIPHERAL
GRANULOCYTES
BEFORE
INTERVENTION
.
35
3.2
NEUTROPHIL
RECRUITMENT
INTO
THE
KIDNEY
.
35
3.3
EVALUATION
OF
RENAL
FUNCTION
.
38
3.3.1
BLOOD
UREA
NITROGEN
.
38
3.3.2
SERUM
CREATININE
.
39
3.3.3
URINE
CREATININE
.
41
3.3.4
URINE
OUTPUT
.43
3.3.5
CREATININE
CLEARANCE
.
45
3.4
RENAL
TUBULAR
INJURY
BIOMARKERS
.47
3.4.1
URINARY
NGAL
.47
3.4.2
URINARY
KIM-1
.
48
3.4.3
URINARY
TIMP-2*IGFBP7
.
50
3.5
HISTOLOGICAL
EXAMINATION
.
50
3.5.1
HE
STAINING
.
51
3.5.2
PAS
STAINING
.
53
3.6
APOPTOSIS
EXAMINATION
BY
TUNEL
ASSAY
.
55
3.7
ROS
EXAMINATION
.
58
4.
DISCUSSION
.
62
5.
REFERENCES
.
66 |
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| index_date | 2024-07-03T19:57:40Z |
| indexdate | 2024-07-10T09:33:13Z |
| institution | BVB |
| language | English |
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| open_access_boolean | |
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| physical | IV, 76 Seiten Illustrationen, Diagramme 29 cm |
| publishDate | 2021 |
| publishDateSearch | 2021 |
| publishDateSort | 2021 |
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| spelling | Li, Zhenhan 1990- Verfasser (DE-588)1247638812 aut The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury vorgelegt von: Zhenhan Li Münster [2021] IV, 76 Seiten Illustrationen, Diagramme 29 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Westfälische Wilhelms-Universität Münster 2021 Beschränkt für den Austausch (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1249102502/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033634006&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,26772 20220429 DE-101 https://d-nb.info/provenance/plan#emakn 2\p dnb 20220502 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Li, Zhenhan 1990- The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |
| subject_GND | (DE-588)4113937-9 |
| title | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |
| title_auth | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |
| title_exact_search | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |
| title_exact_search_txtP | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |
| title_full | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury vorgelegt von: Zhenhan Li |
| title_fullStr | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury vorgelegt von: Zhenhan Li |
| title_full_unstemmed | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury vorgelegt von: Zhenhan Li |
| title_short | The role of neutrophils in ischemia/reperfusion- and sepsis-induced acute kidney injury |
| title_sort | the role of neutrophils in ischemia reperfusion and sepsis induced acute kidney injury |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1249102502/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033634006&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lizhenhan theroleofneutrophilsinischemiareperfusionandsepsisinducedacutekidneyinjury |
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