Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics
The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relati...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer US
2012
|
| Ausgabe: | 1st ed. 2012 |
| Schriftenreihe: | Cancer Drug Discovery and Development
|
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials |
| Beschreibung: | 1 Online-Ressource (XII, 284 Seiten) |
| ISBN: | 9781461405986 |
| DOI: | 10.1007/978-1-4614-0598-6 |
Internformat
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| edition | 1st ed. 2012 |
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| spelling | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics edited by Derek LeRoith 1st ed. 2012 New York, NY Springer US 2012 1 Online-Ressource (XII, 284 Seiten) txt rdacontent c rdamedia cr rdacarrier Cancer Drug Discovery and Development The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials Cancer Research Pharmacology/Toxicology Cancer research Pharmacology Insulin-like Growth Factor (DE-588)4258771-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Insulin-like Growth Factor (DE-588)4258771-2 s DE-604 LeRoith, Derek edt Erscheint auch als Druck-Ausgabe 9781461429623 Erscheint auch als Druck-Ausgabe 9781461405993 Erscheint auch als Druck-Ausgabe 9781461405979 https://doi.org/10.1007/978-1-4614-0598-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics Cancer Research Pharmacology/Toxicology Cancer research Pharmacology Insulin-like Growth Factor (DE-588)4258771-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| subject_GND | (DE-588)4258771-2 (DE-588)4073781-0 (DE-588)4143413-4 |
| title | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics |
| title_auth | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics |
| title_exact_search | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics |
| title_exact_search_txtP | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics |
| title_full | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics edited by Derek LeRoith |
| title_fullStr | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics edited by Derek LeRoith |
| title_full_unstemmed | Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics edited by Derek LeRoith |
| title_short | Insulin-like Growth Factors and Cancer |
| title_sort | insulin like growth factors and cancer from basic biology to therapeutics |
| title_sub | From Basic Biology to Therapeutics |
| topic | Cancer Research Pharmacology/Toxicology Cancer research Pharmacology Insulin-like Growth Factor (DE-588)4258771-2 gnd Krebs Medizin (DE-588)4073781-0 gnd |
| topic_facet | Cancer Research Pharmacology/Toxicology Cancer research Pharmacology Insulin-like Growth Factor Krebs Medizin Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-4614-0598-6 |
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