A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Köln
[2020]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 156 Seiten Illustrationen, Diagramme 21 cm |
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| 245 | 1 | 0 | |a A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |c vorgelegt von Jaswinder Singh |
| 264 | 1 | |a Köln |c [2020] | |
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Record in the Search Index
| _version_ | 1804183427614769152 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
1
INTRODUCTION
..................................................................................................
10
1.1
ALLERGY
-
DEFINITION
.............................................................................
11
1.2
ATOPY
..................................................................................................
12
1.2.1
TYPES
OF
ALLERGIC
REACTIONS
-
HYPERSENSITIVITY
.............................
12
1.2.2
TYPE-I
REACTIONS
.........................................................................
14
1.2.2.1
TYPE-I
ALLERGY
SYMPTOMS
...................................................
16
1.2.2.2
THE
PROGRESS
OF
TYPE
I
HYPERSENSITIVITY
REACTIONS
...........
16
1.3
DIAGNOSIS
OF
ALLERGIC
DISEASES
...........................................................
17
1.3.1
HISTORY
OF
ALLERGOLOGY,
SKIN
ALLERGY
TEST
AND
BACKGROUND
..........
18
1.3.1.1
SKIN
PRICK
TEST
..................................................................
18
1.3.1.2
DIFFERENCES
IN
THE
VARIOUS
SKIN
TESTS
.................................
19
1.4
ALLERGENS
............................................................................................
20
1.4.1
COMPOSITION
OF
ALLERGEN
EXTRACTS
...............................................
20
1.4.2
STRUCTURE
OF
ALLERGENS
AND
CLASSIFICATION
....................................
21
1.4.3
TIMOTHY
GRASS
POLLEN
..................................................................
22
1.5
POTENCY
OF
ALLERGEN
EXTRACTS
AND
STANDARDIZATION
...............................
22
2
RATIONALE
AND
AIMS
....................................................................................
25
3
MATERIAL
AND
METHODS
................................................................................
26
3.1
DESIGN
OF
STUDY
.................................................................................
26
3.1.1
PLANNING
OF
STUDY
......................................................................
26
3.1.2
TYPE
OF
STUDY
............................................................................
27
3.1.3
SITES
OF
STUDY
............................................................................
27
3.1.4
CONTROLS
.....................................................................................
28
3.1.5
PATIENT
SELECTION
........................................................................
28
3.2
CONDUCT
OF
THE
STUDY
........................................................................
29
3.2.1
TRAINING
OF
STUDY
STAFF
...............................................................
29
3.2.2
CONCENTRATION
OF
ALLERGEN
EXTRACTS
FOR
SKIN
PRICK
TESTS
..............
30
3.2.3
BLINDING
/
UNBLINDING
.................................................................
31
3.2.4
SKIN
PRICK
TEST
.........................................................................
32
3.3
COMPUTER-AIDED
ANALYSIS
OF
SPT
......................................................
34
3.3.1
COMPUTER-BASED
SURFACE
AREA
CALCULATION
WITH
IMAGED
...........
34
3.3.2
TEST
CALCULATIONS
FOR
DUMMY
IMAGES
........................................
36
3.4
CASE
REPORT
FORMS
.............................................................................
39
3.4.1
READING
AND
DATA
TRANSFER
OF
SPT
............................................
39
3.4.2
DIGITIZATION
OF
SKIN
PRICK
TESTS
*
RESULTS
.......................................
40
3.4.3
EDITING
OF
SCANNED
IMAGES
......................................................
42
3.4.4
COMPUTER-ASSISTED
MEASUREMENT
OF
THE
SKIN
REACTIONS
(SURFACE
AREA
OF
WHEALS)
WITH
IMAGED
......................................................................
45
3.4.5
DATA
ENTRY
IN
SPSS
DATABASE
..................................................
47
3.5
STATISTICAL
ANALYSIS
OF
THE
SKIN
TEST
RESULTS
.........................................
49
4
RESULTS
.......................................................................................................
51
4.1
DEMOGRAPHIC
DATA
OF
STUDY
PATIENTS
.................................................
51
4.2
CALCULATION
OF
THE
SURFACE
AREA
OF
WHEALS
.........................................
51
4.3
CALCULATION
OF
THE
CONCENTRATION
........................................................
57
4.4
CALCULATIONS
OF
THE
P-VALUES
(WILCOXON
TEST)
.....................................
67
5
DISCUSSION
..................................................................................................
70
5.1
ADVANTAGES
OF
THE
USED
METHODS
AND
SOFTWARE
................................
70
5.2
A
REVIEW
OF
EFFORTS
AND
CHALLENGES
OF
DIGITIZATION
OF
THE
DATA
...........
71
5.3
CLINICAL
REVIEW
OF
SKIN
ALLERGY
TESTS
...................................................
72
5.4
DISCUSSION
OF
THE
RESULTS
...................................................................
72
5.5
COMPARISON
WITH
OTHER
STUDIES
..........................................................
75
6
SUMMARY
AND
FUTURE
PROSPECTS
.................................................................
77
6
7
ZUSAMMENFASSUNG
.....................................................................................
79
8
REFERENCES
.................................................................................................
81
9
PRELIMINARY
PUBLICATIONS
.............................................................................
99
10
APPENDIX
...............................................................................................
100
10.1
LIST
OF
TABLES
...................................................................................
100
10.2
LIST
OF
FIGURES
..................................................................................
100
10.3
TABLES:
.......................................................................................
102
11
LEBENSLAUF
............................................................................................
156
7
|
| adam_txt |
TABLE
OF
CONTENTS
1
INTRODUCTION
.
10
1.1
ALLERGY
-
DEFINITION
.
11
1.2
ATOPY
.
12
1.2.1
TYPES
OF
ALLERGIC
REACTIONS
-
HYPERSENSITIVITY
.
12
1.2.2
TYPE-I
REACTIONS
.
14
1.2.2.1
TYPE-I
ALLERGY
SYMPTOMS
.
16
1.2.2.2
THE
PROGRESS
OF
TYPE
I
HYPERSENSITIVITY
REACTIONS
.
16
1.3
DIAGNOSIS
OF
ALLERGIC
DISEASES
.
17
1.3.1
HISTORY
OF
ALLERGOLOGY,
SKIN
ALLERGY
TEST
AND
BACKGROUND
.
18
1.3.1.1
SKIN
PRICK
TEST
.
18
1.3.1.2
DIFFERENCES
IN
THE
VARIOUS
SKIN
TESTS
.
19
1.4
ALLERGENS
.
20
1.4.1
COMPOSITION
OF
ALLERGEN
EXTRACTS
.
20
1.4.2
STRUCTURE
OF
ALLERGENS
AND
CLASSIFICATION
.
21
1.4.3
TIMOTHY
GRASS
POLLEN
.
22
1.5
POTENCY
OF
ALLERGEN
EXTRACTS
AND
STANDARDIZATION
.
22
2
RATIONALE
AND
AIMS
.
25
3
MATERIAL
AND
METHODS
.
26
3.1
DESIGN
OF
STUDY
.
26
3.1.1
PLANNING
OF
STUDY
.
26
3.1.2
TYPE
OF
STUDY
.
27
3.1.3
SITES
OF
STUDY
.
27
3.1.4
CONTROLS
.
28
3.1.5
PATIENT
SELECTION
.
28
3.2
CONDUCT
OF
THE
STUDY
.
29
3.2.1
TRAINING
OF
STUDY
STAFF
.
29
3.2.2
CONCENTRATION
OF
ALLERGEN
EXTRACTS
FOR
SKIN
PRICK
TESTS
.
30
3.2.3
BLINDING
/
UNBLINDING
.
31
3.2.4
SKIN
PRICK
TEST
.
32
3.3
COMPUTER-AIDED
ANALYSIS
OF
SPT
.
34
3.3.1
COMPUTER-BASED
SURFACE
AREA
CALCULATION
WITH
IMAGED
.
34
3.3.2
TEST
CALCULATIONS
FOR
DUMMY
IMAGES
.
36
3.4
CASE
REPORT
FORMS
.
39
3.4.1
READING
AND
DATA
TRANSFER
OF
SPT
.
39
3.4.2
DIGITIZATION
OF
SKIN
PRICK
TESTS
*
RESULTS
.
40
3.4.3
EDITING
OF
SCANNED
IMAGES
.
42
3.4.4
COMPUTER-ASSISTED
MEASUREMENT
OF
THE
SKIN
REACTIONS
(SURFACE
AREA
OF
WHEALS)
WITH
IMAGED
.
45
3.4.5
DATA
ENTRY
IN
SPSS
DATABASE
.
47
3.5
STATISTICAL
ANALYSIS
OF
THE
SKIN
TEST
RESULTS
.
49
4
RESULTS
.
51
4.1
DEMOGRAPHIC
DATA
OF
STUDY
PATIENTS
.
51
4.2
CALCULATION
OF
THE
SURFACE
AREA
OF
WHEALS
.
51
4.3
CALCULATION
OF
THE
CONCENTRATION
.
57
4.4
CALCULATIONS
OF
THE
P-VALUES
(WILCOXON
TEST)
.
67
5
DISCUSSION
.
70
5.1
ADVANTAGES
OF
THE
USED
METHODS
AND
SOFTWARE
.
70
5.2
A
REVIEW
OF
EFFORTS
AND
CHALLENGES
OF
DIGITIZATION
OF
THE
DATA
.
71
5.3
CLINICAL
REVIEW
OF
SKIN
ALLERGY
TESTS
.
72
5.4
DISCUSSION
OF
THE
RESULTS
.
72
5.5
COMPARISON
WITH
OTHER
STUDIES
.
75
6
SUMMARY
AND
FUTURE
PROSPECTS
.
77
6
7
ZUSAMMENFASSUNG
.
79
8
REFERENCES
.
81
9
PRELIMINARY
PUBLICATIONS
.
99
10
APPENDIX
.
100
10.1
LIST
OF
TABLES
.
100
10.2
LIST
OF
FIGURES
.
100
10.3
TABLES:
.
102
11
LEBENSLAUF
.
156
7 |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV047858127 |
| illustrated | Illustrated |
| index_date | 2024-07-03T19:16:58Z |
| indexdate | 2024-07-10T09:23:16Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-033240809 |
| oclc_num | 1245386974 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 156 Seiten Illustrationen, Diagramme 21 cm |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| record_format | marc |
| spelling | Singh, Jaswinder 1972- Verfasser (DE-588)1223187950 aut A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts vorgelegt von Jaswinder Singh Köln [2020] 156 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität zu Köln 2020 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1225946514/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033240809&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p aepgnd 0,21696 20210329 DE-101 https://d-nb.info/provenance/plan#aepgnd 2\p aepgnd 0,18724 20210329 DE-101 https://d-nb.info/provenance/plan#aepgnd |
| spellingShingle | Singh, Jaswinder 1972- A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |
| subject_GND | (DE-588)4113937-9 |
| title | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |
| title_auth | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |
| title_exact_search | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |
| title_exact_search_txtP | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |
| title_full | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts vorgelegt von Jaswinder Singh |
| title_fullStr | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts vorgelegt von Jaswinder Singh |
| title_full_unstemmed | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts vorgelegt von Jaswinder Singh |
| title_short | A method for computer-aided analysis to determine the relative potency in skin testing of allergen extracts |
| title_sort | a method for computer aided analysis to determine the relative potency in skin testing of allergen extracts |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1225946514/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=033240809&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT singhjaswinder amethodforcomputeraidedanalysistodeterminetherelativepotencyinskintestingofallergenextracts |
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