This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workfl...

Ausführliche Beschreibung

Bibliographische Detailangaben

Weitere Verfasser:	Lai, Xin 1983- (HerausgeberIn), Gupta, Shailendra ca. 20./21. Jh (HerausgeberIn), Vera-González, Julio ca. 20./21. Jh (HerausgeberIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	New York, NY Springer New York 2019
Ausgabe:	1st ed. 2019
Schriftenreihe:	Methods in Molecular Biology 1912
Schlagworte:	Bioinformatics Human genetics
Online-Zugang:	UBR01 TUM01 Volltext
Zusammenfassung:	This volume details a collection of state-of-art methods including identification of novel ncRNAs and their targets, functional annotation and disease association in different biological contexts. Chapters guide readers through an overview of disease-specific ncRNAs, computational methods and workflows for ncRNA discovery, annotation based on high-throughput sequencing data, bioinformatics tools and databases for ncRNA analyses, network-based methods, and kinetic modelling of ncRNA-mediated gene regulation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Biology of Non-Coding RNA: Methods and Protocols aims to provide a state-of-the-art collection of computational methods and approaches that will be of value to researchers interested in ncRNA field
Beschreibung:	ncRNAs in Inflammatory and Infectious Diseases -- p73-Governed miRNA Networks: Translating Bioinformatics Approaches to Therapeutic Solutions for Cancer Metastasis -- Methods for Annotation and Validation of Circular RNAs from RNAseq Data -- Methods to Study Long Non-coding RNA Expression and Dynamics in Zebrafish using RNA Sequencing -- Workflow Development for the Functional Characterization of ncRNAs -- ncRNA Editing: Functional Characterization and Computational Resources -- Computational Prediction of Functional microRNA - mRNA Interactions -- Tools for Understanding miRNA-mRNA Interactions for Reproducible RNA Analysis -- Computational Resources for Prediction and Analysis of Functional miRNA and their Targetome -- Non-coding RNAs Databases: Current Status and Trends -- Controllability Methods for Identifying Associations between Critical Control ncRNAs and Human Diseases -- Network-based Methods and Other Approaches for Predicting lncRNA Functions and Disease Associations -- Integration of miRNA and mRNA Expression Data for Understanding Etiology of Gynecologic Cancers -- Quantitative Characteristic of ncRNA Regulation in Gene Regulatory Networks -- Kinetic Modeling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs -- Modeling ncRNA-mediated Circuits in Cell Fate Decision -- Modeling Long ncRNA-mediated Regulation in the Mammalian Cell Cycle
Beschreibung:	1 Online-Ressource (XII, 451 Seiten) Illustrationen
ISBN:	9781493989829
DOI:	10.1007/978-1-4939-8982-9