Ribozymes: principles, methods, applications
Intro -- Table of Contents -- Title Page -- Title Page -- Copyright -- Preface -- Foreword -- References -- Volume 1 -- Part I: Nucleic Acid Catalysis: Principles, Strategies and Biological Function -- 1 The Chemical Principles of RNA Catalysis -- 1.1 RNA Catalysis -- 1.2 Rates of Chemical Reactions...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Weitere Verfasser: | , |
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Newark
Wiley-VCH
2021
|
| Schlagworte: | |
| Online-Zugang: | https://onlinelibrary.wiley.com/doi/book/10.1002/9783527814527 |
| Zusammenfassung: | Intro -- Table of Contents -- Title Page -- Title Page -- Copyright -- Preface -- Foreword -- References -- Volume 1 -- Part I: Nucleic Acid Catalysis: Principles, Strategies and Biological Function -- 1 The Chemical Principles of RNA Catalysis -- 1.1 RNA Catalysis -- 1.2 Rates of Chemical Reactions and Transition State Theory -- 1.3 Phosphoryl Transfer Reactions in the Ribozymes -- 1.4 Catalysis of Phosphoryl Transfer -- 1.5 General Acid-Base Catalysis in Nucleolytic Ribozymes -- 1.6 pKa Shifting of General Acids and Bases in Nucleolytic Ribozymes -- 1.7 Catalytic Roles of Metal Ions in Ribozymes -- 1.8 The Choice Between General Acid-Base Catalysis and the Use of Metal Ions -- 1.9 The Limitations to RNA Catalysis -- Acknowledgment -- References -- 2 Biological Roles of Self‐Cleaving Ribozymes -- 2.1 Introduction -- 2.2 Use of Self‐cleaving Ribozymes for Replication -- 2.3 Self‐cleaving Ribozymes as Part of Transposable Elements -- 2.4 Hammerhead Ribozymes with Suggested Roles in mRNA Biogenesis -- 2.5 The glmS Ribozyme Regulates Glucosamine‐6‐phosphate Levels in Bacteria -- 2.6 The Biological Roles of Many Ribozymes Are Unknown -- 2.7 Conclusion -- Acknowledgments -- References -- Part II: Naturally Occurring Ribozymes -- 3 Chemical Mechanisms of the Nucleolytic Ribozymes -- 3.1 The Nucleolytic Ribozymes -- 3.2 Some Nucleolytic Ribozymes Are Widespread -- 3.3 Secondary Structures of Nucleolytic Ribozymes - Junctions and Pseudoknots -- 3.4 Catalytic Players in the Nucleolytic Ribozymes -- 3.5 The Hairpin and VS Ribozymes: The G Plus A Mechanism -- 3.6 The Twister Ribozyme: A G Plus A Variant -- 3.7 The Hammerhead Ribozyme: A 2′‐Hydroxyl as a Catalytic Participant -- 3.8 The Hepatitis Delta Virus Ribozyme: A Direct Role for a Metal Ion -- 3.9 The Twister Sister (TS) Ribozyme: Another Metallo‐Ribozyme |
| Beschreibung: | 2 Volume Set |
| Beschreibung: | 1 Online-Ressource (xxii, 900 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783527814527 |
Internformat
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| 520 | 3 | |a Intro -- Table of Contents -- Title Page -- Title Page -- Copyright -- Preface -- Foreword -- References -- Volume 1 -- Part I: Nucleic Acid Catalysis: Principles, Strategies and Biological Function -- 1 The Chemical Principles of RNA Catalysis -- 1.1 RNA Catalysis -- 1.2 Rates of Chemical Reactions and Transition State Theory -- 1.3 Phosphoryl Transfer Reactions in the Ribozymes -- 1.4 Catalysis of Phosphoryl Transfer -- 1.5 General Acid-Base Catalysis in Nucleolytic Ribozymes -- 1.6 pKa Shifting of General Acids and Bases in Nucleolytic Ribozymes -- 1.7 Catalytic Roles of Metal Ions in Ribozymes -- 1.8 The Choice Between General Acid-Base Catalysis and the Use of Metal Ions -- 1.9 The Limitations to RNA Catalysis -- Acknowledgment -- References -- 2 Biological Roles of Self‐Cleaving Ribozymes -- 2.1 Introduction -- 2.2 Use of Self‐cleaving Ribozymes for Replication -- 2.3 Self‐cleaving Ribozymes as Part of Transposable Elements -- 2.4 Hammerhead Ribozymes with Suggested Roles in mRNA Biogenesis -- 2.5 The glmS Ribozyme Regulates Glucosamine‐6‐phosphate Levels in Bacteria -- 2.6 The Biological Roles of Many Ribozymes Are Unknown -- 2.7 Conclusion -- Acknowledgments -- References -- Part II: Naturally Occurring Ribozymes -- 3 Chemical Mechanisms of the Nucleolytic Ribozymes -- 3.1 The Nucleolytic Ribozymes -- 3.2 Some Nucleolytic Ribozymes Are Widespread -- 3.3 Secondary Structures of Nucleolytic Ribozymes - Junctions and Pseudoknots -- 3.4 Catalytic Players in the Nucleolytic Ribozymes -- 3.5 The Hairpin and VS Ribozymes: The G Plus A Mechanism -- 3.6 The Twister Ribozyme: A G Plus A Variant -- 3.7 The Hammerhead Ribozyme: A 2′‐Hydroxyl as a Catalytic Participant -- 3.8 The Hepatitis Delta Virus Ribozyme: A Direct Role for a Metal Ion -- 3.9 The Twister Sister (TS) Ribozyme: Another Metallo‐Ribozyme | |
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| discipline_str_mv | Chemie / Pharmazie Biologie |
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| illustrated | Not Illustrated |
| index_date | 2024-07-03T18:08:25Z |
| indexdate | 2024-08-01T00:14:36Z |
| institution | BVB |
| isbn | 9783527814527 |
| language | English |
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| spelling | Müller, Sabine 1966- Verfasser (DE-588)134258827 aut Ribozymes principles, methods, applications edited by Sabine Müller, Benoît Masquida, Wade Winkler Newark Wiley-VCH 2021 1 Online-Ressource (xxii, 900 Seiten) Illustrationen, Diagramme txt rdacontent c rdamedia cr rdacarrier 2 Volume Set Intro -- Table of Contents -- Title Page -- Title Page -- Copyright -- Preface -- Foreword -- References -- Volume 1 -- Part I: Nucleic Acid Catalysis: Principles, Strategies and Biological Function -- 1 The Chemical Principles of RNA Catalysis -- 1.1 RNA Catalysis -- 1.2 Rates of Chemical Reactions and Transition State Theory -- 1.3 Phosphoryl Transfer Reactions in the Ribozymes -- 1.4 Catalysis of Phosphoryl Transfer -- 1.5 General Acid-Base Catalysis in Nucleolytic Ribozymes -- 1.6 pKa Shifting of General Acids and Bases in Nucleolytic Ribozymes -- 1.7 Catalytic Roles of Metal Ions in Ribozymes -- 1.8 The Choice Between General Acid-Base Catalysis and the Use of Metal Ions -- 1.9 The Limitations to RNA Catalysis -- Acknowledgment -- References -- 2 Biological Roles of Self‐Cleaving Ribozymes -- 2.1 Introduction -- 2.2 Use of Self‐cleaving Ribozymes for Replication -- 2.3 Self‐cleaving Ribozymes as Part of Transposable Elements -- 2.4 Hammerhead Ribozymes with Suggested Roles in mRNA Biogenesis -- 2.5 The glmS Ribozyme Regulates Glucosamine‐6‐phosphate Levels in Bacteria -- 2.6 The Biological Roles of Many Ribozymes Are Unknown -- 2.7 Conclusion -- Acknowledgments -- References -- Part II: Naturally Occurring Ribozymes -- 3 Chemical Mechanisms of the Nucleolytic Ribozymes -- 3.1 The Nucleolytic Ribozymes -- 3.2 Some Nucleolytic Ribozymes Are Widespread -- 3.3 Secondary Structures of Nucleolytic Ribozymes - Junctions and Pseudoknots -- 3.4 Catalytic Players in the Nucleolytic Ribozymes -- 3.5 The Hairpin and VS Ribozymes: The G Plus A Mechanism -- 3.6 The Twister Ribozyme: A G Plus A Variant -- 3.7 The Hammerhead Ribozyme: A 2′‐Hydroxyl as a Catalytic Participant -- 3.8 The Hepatitis Delta Virus Ribozyme: A Direct Role for a Metal Ion -- 3.9 The Twister Sister (TS) Ribozyme: Another Metallo‐Ribozyme Ribozym (DE-588)4356469-0 gnd rswk-swf Electronic books Ribozym (DE-588)4356469-0 s DE-604 Masquida, Benoît 1970- (DE-588)1239704887 ctb Winkler, Wade (DE-588)1239705107 ctb Erscheint auch als Druck-Ausgabe, Hardcover 978-3-527-34454-3 https://onlinelibrary.wiley.com/doi/book/10.1002/9783527814527 Verlag |
| spellingShingle | Müller, Sabine 1966- Ribozymes principles, methods, applications Ribozym (DE-588)4356469-0 gnd |
| subject_GND | (DE-588)4356469-0 |
| title | Ribozymes principles, methods, applications |
| title_auth | Ribozymes principles, methods, applications |
| title_exact_search | Ribozymes principles, methods, applications |
| title_exact_search_txtP | Ribozymes principles, methods, applications |
| title_full | Ribozymes principles, methods, applications edited by Sabine Müller, Benoît Masquida, Wade Winkler |
| title_fullStr | Ribozymes principles, methods, applications edited by Sabine Müller, Benoît Masquida, Wade Winkler |
| title_full_unstemmed | Ribozymes principles, methods, applications edited by Sabine Müller, Benoît Masquida, Wade Winkler |
| title_short | Ribozymes |
| title_sort | ribozymes principles methods applications |
| title_sub | principles, methods, applications |
| topic | Ribozym (DE-588)4356469-0 gnd |
| topic_facet | Ribozym |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9783527814527 |
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