Verfügbarkeit: Medical physics

Medical physics: models and technologies in cancer research

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Bibliographische Detailangaben
Weitere Verfasser:	Bajek, Anna (HerausgeberIn), Tylkowski, Bartosz (HerausgeberIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Berlin ; Boston De Gruyter [2021]
Schriftenreihe:	De Gruyter STEM
Schlagworte:	Krebsbekämpfung Medizinische Physik Krebsforschung 1675: Hardcover, Softcover / Biologie/Biochemie, Biophysik Allgemein MF: Pre-clinical medicine: basic sciences MQW: Biomedical engineering PHVD: Medical physics PHVN: Biophysics PSF: Cellular biology (cytology) Paperback / softback Strahlentherapie TGM: Materials science Aufsatzsammlung
Online-Zugang:	http://www.degruyter.com/search?f_0=isbnissn&q_0=9783110662290&searchTitles=true Inhaltsverzeichnis
Beschreibung:	XV, 248 Seiten Illustrationen 24 cm x 17 cm
ISBN:	3110662299 9783110662290

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Datensatz im Suchindex

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adam_text	CONTENTS PEFACE ---- V LIST OF CONTRIBUTING AUTHORS ---- XIII MAGDALENA WISNIEWSKA, MICHAL WISNIEWSKI AND MARZENA A. LEWANDOWSKA 1 PERSONALIZED AND TARGETED THERAPIES - 1 1.1 INTRODUCTION ---- 1 1.1.1 PREDICTIVE BIOMARKERS ------ 1 1.1.2 DIAGNOSTIC BIOMARKER ---- 2 1.1.3 MONITORING BIOMARKER ------ 3 1.1.4 RISK (SCREENING) BIOMARKERS ---- 3 1.1.5 PHARMACODYNAMIC (RESPONSE) BIOMARKERS ---- 3 1.1.6 SAFETY BIOMARKER - 3 1.2 EGFR MUTATIONS ---- 4 1.3 ALK GENE REARRANGEMENTS ---- 5 1.4 ROS1 REARRANGEMENTS ------ 6 1.5 RET REARRANGEMENTS ---- 6 1.6 NTRK GENE FUSIONS ---- 7 1.7 MET EXL4 SKIPPING MUTATIONS ----- 8 1.8 BRAF-TARGETED THERAPIES - 8 1.9 KRAS, NRAS AND BRAF WILD TYPE IN COLORECTAL CANCER - 10 1.10 OVEREXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR P (PDGFRB) IN DERMATOFIBROSARCOMA PROTUBERANS (DFSP) AND GIANT CELL FIBROBLASTOMA (GCF) - 11 1.11 KIT AND PDGFRA MUTATIONS IN GASTROINTESTINAL STROMAL TUMORS ---- 12 1.12 ESTROGEN RECEPTOR ---- 13 1.13 PIK3CA MUTATIONS ---- 13 1.14 BRCA MUTATIONS ---- 14 1.15 HER-2 OVEREXPRESSION ----- 14 1.16 PD-L1 (PROGRAMMED CELL DEATH RECEPTOR LIGAND 1) ---- 17 1.17 DMMR/MSI STATUS ---- 18 REFERENCES ---- 19 KRZYSZTOF KOPER, SLAWOMIR WILENSKI AND AGNIESZKA KOPER 2 ADVANCEMENTS IN CANCER CHEMOTHERAPY ---- 27 2.1 INTRODUCTION ---- 27 2.2 THE ROLE OF CHEMOTHERAPY IN CANCER TREATMENT ---- 28 2.3 THE BIOLOGICAL BASIS OF CHEMOTHERAPY ---- 28 2.4 CLASSIFICATION OF CYTOSTATIC DRUGS ----- 28 2.4.1 ALKYLATING DRUGS ---- 29 VIII - CONTENTS 2.4.2 2.4.3 2.4.4 2.5 ANTIMETHABOLITES - 31 PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS ---- 33 PLATINUM DERIVATIVES ---- 36 CELL CYCLE-NONSPECIFIC AND CELL CYCLE-SPECIFIC ANTICANCER DRUGS ---- 36 2.6 ROUTE OF ADMINISTRATION OF CHEMOTHERAPY AND FORMS OF ANTICANCER DRUGS ---- 37 2.6.1 IMPORTANCE OF LIPOSOMES IN CLINICAL PRACTICE ON THE EXAMPLE OF DOXORUBICIN - 41 2.6.2 2.6.3 2.6.4 2.6.5 2.6.6 2.6.7 2.6.8 2.7 SUBCUTANEOUS ADMINISTRATION - 42 INTRAPERITONEAL CHEMOTHERAPY - 43 INTRATHECAL CHEMOTHERAPY - 45 TRANSARTERIAL CHEMOEMBOLISATION - 45 ELECTROCHEMOTHERAPY - 46 IMPLANTS ---- 46 GENE THERAPY - 46 CONCLUSION ---- 47 REFERENCES ---- 47 JANUSZ WINIECKI 3 3.7.1 3.7.2 PRINCIPLES OF RADIATION THERAPY - 51 IONIZING RADIATION INTERACTION WITH A LIVING MATTER - 51 TREATMENT PLANNING AND REALIZATION OF RADIOTHERAPY - 61 REFERENCES - 79 KAROLINA BALIK, KAROLINA MATULEWICZ, PAULINA MODRAKOWSKA, JOLANTA KOWALSKA, XAVIER MONTANE, BARTOSZ TYLKOWSKI AND ANNA BAJEK 4 ADVANCED CELL CULTURE TECHNIQUES FOR CANCER RESEARCH - 81 4.1 4.1.1 4.1.2 4.2 4.3 4.3.1 4.3.2 4.4 4.4.1 4.4.2 4.5 4.6 4.7 4.7.1 CELL-TO-CELL INTERACTIONS - 81 IMMUNOTHERAPY AND CANCER RESEARCH - 81 CANCER MICROENVIRONMENT - 82 STANDARD METHODS OF CELL-TO-CELL INTERACTIONS STUDIES ---- 83 MICROFLUIDIC DEVICES ---- 84 MICROFLUIDIC 2D MODELS ---- 84 MICROFLUIDS 3D MODELS ---- 85 ARTIFICIAL ORGANS - WHY DO WE NEED THEM? -----87 CELL CULTURE ANALOG (CCA) SYSTEM - 88 ORGANOIDS SYSTEM - 90 OMIC TECHNIQUES IN BIOLOGICAL RESEARCH -----92 METABOLOMICS ---- 93 TECHNIQUES FOR METABOLOMICS IN 2D CELL CULTURE ---- 95 EXPERIMENTAL DESIGN AT THE LEVEL OF 2D CELL CULTURE ---- 95 CONTENTS - - IX 4.7.2 4.8 EXPERIMENTAL DESIGN AT THE LEVEL OF 3D CELL CULTURE - 97 THE DIRECTION OF IN VITRO CANCER RESEARCH ---- 98 REFERENCES - 98 ADRIANNA SOBOLEWSKA, ALEKSANDRA DUNISLAWSKA AND KATARZYNA STADNICKA 5 NATURAL SUBSTANCES IN CANCER - DO THEY WORK? - 103 6.1 6.2 6.2.1 6.3 6.3.1 6.3.2 6.3.3 6.4 INTRODUCTION ---- 103 MICROBIOME AND CANCER ---- 103 PROBIOTICS AND SYNBIOTICS IN IMMUNOTHERAPY ---- 105 FOOD INGREDIENTS AND CANCER - 116 RESVERATROL - 119 CURCUMIN ---- 122 QUERCETIN - 125 SUMMARY ---- 127 REFERENCES - 128 ANNA HELMIN-BASA, LIDIA GACKOWSKA, SARA BALCEROWSKA, MARCELINA ORNAWKA, NATALIA NARUSZEWICZ AND MALGORZATA WIESE-SZADKOWSKA 6 THE APPLICATION OF THE NATURAL KILLER CELLS, MACROPHAGES AND DENDRITIC CELLS IN TREATING VARIOUS TYPES OF CANCER - 137 6.1 INTRODUCTION ---- 137 6.2 INNATE IMMUNE CELLS AND THE TUMOR MICROENVIRONMENT - 141 6.3 NK CELL-BASED IMMUNOTHERAPY IN TREATING CANCERS - 144 6.3.1 NOVEL STRATEGIES FOR RESTORING NK CELL ANTI-TUMORAL ACTIVITY - 144 6.3.2 ANTI-CHECKPOINT RECEPTOR MONOCLONAL ANTIBODIES - 144 6.3.3 OTHER ANTIBODIES - 148 6.3.4 AGONIST ANTIBODIES ---- 149 6.3.5 MODIFIED ANTIBODY MOLECULES ------- 149 6.3.6 FUSION PROTEINS ---- 150 6.3.7 IMMUNOMODULATORY DRUGS ----- 150 6.3.8 CYTOKINES ---- 151 6.3.9 ADOPTIVE TRANSFER OF NK CELLS ---- 151 6.3.10 NK CELLS AND COMBINATION IMMUNOTHERAPY ---- 152 6.3.11 ONCOLYTIC VIRUS-BASED THERAPY - 153 6.4 MACROPHAGES IN CANCER TREATMENT - 153 6.4.1 DEPLETING TAMS ---- 154 6.4.2 REPROGRAMING TAMS - 155 6.5 DCS IN CANCER TREATMENT ---- 156 6.5.1 EX VIVO GENERATED DC VACCINES ---- 156 6.5.2 TARGETING ANTIGEN TO DCS IN VIVO ---- 158 6.6 CONCLUSIONS ---- 159 REFERENCES - 159 X - CONTENTS TUKASZ KIRAGA, PAULINA KUCHARZEWSKA, DAMIAN STRZEMECKI, TOMASZ P. RYGIEL AND MAGDALENA KROL 7 NON-RADIOACTIVE IMAGING STRATEGIES FOR IN VIVO IMMUNE CELL TRACKING - 173 7.1 7.2 7.2.1 7.2.2 7.3 7.3.1 7.3.2 7.3.3 7.3.4 7.3.5 7.3.6 7.4 7.4.1 7.4.2 7.5 INTRODUCTION ---- 173 X-RAY COMPUTED TOMOGRAPHY (CT) ---- 174 CT CONTRAST AGENTS - 174 CT-BASED IMMUNE CELL TRACKING ---- 176 MAGNETIC RESONANCE IMAGING (MRI) ---- 178 PARAMAGNETIC CONTRAST AGENTS (T1 - SHORTENING) ---- 178 SUPERPARAMAGNETIC CONTRAST AGENTS (T2 - SHORTENING) - 179 HOT-SPOT MRI ---- 180 HIGHLY-SHIFTED PROTON (HSP) MRI ---- 181 CESTMRI---- 182 PARACESTMRI ---- 182 OPTICAL IMAGING - 183 BIOLUMINESCENCE IMAGING (BLI) ---- 183 FLUORESCENCE IMAGING (FLI) ---- 184 SUMMARY ---- 186 REFERENCES - 188 XAVIER MONTANE, KAROLINA MATULEWICZ, KAROLINA BALIK, PAULINA MODRAKOWSKA, MARCIN TUCZAK, YARIDE PEREZ PACHECO, BELEN REIG VANO, JOSEP M. MONTORNES, ANNA BAJEK AND BARTOSZ TYLKOWSKI 8 PRESENT TRENDS IN THE ENCAPSULATION OF ANTICANCER DRUGS - 193 8.1 8.2 8.2.1 8.2.2 8.2.3 8.2.4 8.2.5 8.2.6 8.2.7 8.2.8 8.3 8.4 8.4 INTRODUCTION - 193 ENCAPSULATED ANTICANCER DRUG DELIVERY SYSTEMS - 194 INORGANIC NPS ---- 196 DENDRIMERS ---- 196 BIOPOLYMERIC NPS ---- 198 POLYMERIC MICELLES ---- 199 LIPOSOMES ---- 200 POLYMERSOMES ---- 200 CNTS ---- 201 QDS ---- 202 HYBRID ENCAPSULATION SYSTEMS ---- 203 OVERVIEW ---- 204 CONCLUSIONS ---- 204 REFERENCES ---- 207 CONTENTS - - XI TUKASZ KAZMIERSKI AND MALGORZATA MAJ 9 3D TUMOR MODEL - A PLATFORM FOR ANTICANCER DRUG DEVELOPMENT---- 213 9.1 NEED FOR 3D TUMOR MODEL (PERSONALIZED MEDICINE AND DRUG DEVELOPMENT) ---- 213 9.1.1 3D PRINTED TUMOR MODELS ---- 214 9.1.2 NEED FOR NEW IN VITRO MODELS ---- 214 9.2 GENERAL UNDERSTANDING OF 3D PRINTING TECHNOLOGY ---- 214 9.2.1 FDM 3D PRINTING ---- 215 9.2.2 SLA AND MSLA 3D PRINTING ---- 220 9.2.3 SLM AND DMLS 3D PRINTING --- 221 9.3 3D IN VITRO MODEL ----- 221 9.3.1 CLASSICAL 2D CELL CULTURE ---- 222 9.3.2 SPHEROID CULTURE ----- 222 9.3.3 CLASSICAL 2D VERSUS 3D CELL CULTURE APPROACH ---- 223 9.3.4 SPHEROID FORMATION METHODS 224 9.4 BIOPRINTING ---- 228 9.4.1 BIOPRINTER TYPES ----- 228 9.4.2 BIOPRINTER MEDIA (BIOINKS) ---- 231 9.4.3 WORKFLOW AND SOFTWARE ---- 232 9.4.4 TYPICAL CONCERNS IN BIO-PRINTING ---- 234 REFERENCES ---- 238 INDEX ---- 241
adam_txt	CONTENTS PEFACE ---- V LIST OF CONTRIBUTING AUTHORS ---- XIII MAGDALENA WISNIEWSKA, MICHAL WISNIEWSKI AND MARZENA A. LEWANDOWSKA 1 PERSONALIZED AND TARGETED THERAPIES - 1 1.1 INTRODUCTION ---- 1 1.1.1 PREDICTIVE BIOMARKERS ------ 1 1.1.2 DIAGNOSTIC BIOMARKER ---- 2 1.1.3 MONITORING BIOMARKER ------ 3 1.1.4 RISK (SCREENING) BIOMARKERS ---- 3 1.1.5 PHARMACODYNAMIC (RESPONSE) BIOMARKERS ---- 3 1.1.6 SAFETY BIOMARKER - 3 1.2 EGFR MUTATIONS ---- 4 1.3 ALK GENE REARRANGEMENTS ---- 5 1.4 ROS1 REARRANGEMENTS ------ 6 1.5 RET REARRANGEMENTS ---- 6 1.6 NTRK GENE FUSIONS ---- 7 1.7 MET EXL4 SKIPPING MUTATIONS ----- 8 1.8 BRAF-TARGETED THERAPIES - 8 1.9 KRAS, NRAS AND BRAF WILD TYPE IN COLORECTAL CANCER - 10 1.10 OVEREXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR P (PDGFRB) IN DERMATOFIBROSARCOMA PROTUBERANS (DFSP) AND GIANT CELL FIBROBLASTOMA (GCF) - 11 1.11 KIT AND PDGFRA MUTATIONS IN GASTROINTESTINAL STROMAL TUMORS ---- 12 1.12 ESTROGEN RECEPTOR ---- 13 1.13 PIK3CA MUTATIONS ---- 13 1.14 BRCA MUTATIONS ---- 14 1.15 HER-2 OVEREXPRESSION ----- 14 1.16 PD-L1 (PROGRAMMED CELL DEATH RECEPTOR LIGAND 1) ---- 17 1.17 DMMR/MSI STATUS ---- 18 REFERENCES ---- 19 KRZYSZTOF KOPER, SLAWOMIR WILENSKI AND AGNIESZKA KOPER 2 ADVANCEMENTS IN CANCER CHEMOTHERAPY ---- 27 2.1 INTRODUCTION ---- 27 2.2 THE ROLE OF CHEMOTHERAPY IN CANCER TREATMENT ---- 28 2.3 THE BIOLOGICAL BASIS OF CHEMOTHERAPY ---- 28 2.4 CLASSIFICATION OF CYTOSTATIC DRUGS ----- 28 2.4.1 ALKYLATING DRUGS ---- 29 VIII - CONTENTS 2.4.2 2.4.3 2.4.4 2.5 ANTIMETHABOLITES - 31 PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS ---- 33 PLATINUM DERIVATIVES ---- 36 CELL CYCLE-NONSPECIFIC AND CELL CYCLE-SPECIFIC ANTICANCER DRUGS ---- 36 2.6 ROUTE OF ADMINISTRATION OF CHEMOTHERAPY AND FORMS OF ANTICANCER DRUGS ---- 37 2.6.1 IMPORTANCE OF LIPOSOMES IN CLINICAL PRACTICE ON THE EXAMPLE OF DOXORUBICIN - 41 2.6.2 2.6.3 2.6.4 2.6.5 2.6.6 2.6.7 2.6.8 2.7 SUBCUTANEOUS ADMINISTRATION - 42 INTRAPERITONEAL CHEMOTHERAPY - 43 INTRATHECAL CHEMOTHERAPY - 45 TRANSARTERIAL CHEMOEMBOLISATION - 45 ELECTROCHEMOTHERAPY - 46 IMPLANTS ---- 46 GENE THERAPY - 46 CONCLUSION ---- 47 REFERENCES ---- 47 JANUSZ WINIECKI 3 3.7.1 3.7.2 PRINCIPLES OF RADIATION THERAPY - 51 IONIZING RADIATION INTERACTION WITH A LIVING MATTER - 51 TREATMENT PLANNING AND REALIZATION OF RADIOTHERAPY - 61 REFERENCES - 79 KAROLINA BALIK, KAROLINA MATULEWICZ, PAULINA MODRAKOWSKA, JOLANTA KOWALSKA, XAVIER MONTANE, BARTOSZ TYLKOWSKI AND ANNA BAJEK 4 ADVANCED CELL CULTURE TECHNIQUES FOR CANCER RESEARCH - 81 4.1 4.1.1 4.1.2 4.2 4.3 4.3.1 4.3.2 4.4 4.4.1 4.4.2 4.5 4.6 4.7 4.7.1 CELL-TO-CELL INTERACTIONS - 81 IMMUNOTHERAPY AND CANCER RESEARCH - 81 CANCER MICROENVIRONMENT - 82 STANDARD METHODS OF CELL-TO-CELL INTERACTIONS STUDIES ---- 83 MICROFLUIDIC DEVICES ---- 84 MICROFLUIDIC 2D MODELS ---- 84 MICROFLUIDS 3D MODELS ---- 85 ARTIFICIAL ORGANS - WHY DO WE NEED THEM? -----87 CELL CULTURE ANALOG (CCA) SYSTEM - 88 ORGANOIDS SYSTEM - 90 " OMIC " TECHNIQUES IN BIOLOGICAL RESEARCH -----92 METABOLOMICS ---- 93 TECHNIQUES FOR METABOLOMICS IN 2D CELL CULTURE ---- 95 EXPERIMENTAL DESIGN AT THE LEVEL OF 2D CELL CULTURE ---- 95 CONTENTS - - IX 4.7.2 4.8 EXPERIMENTAL DESIGN AT THE LEVEL OF 3D CELL CULTURE - 97 THE DIRECTION OF IN VITRO CANCER RESEARCH ---- 98 REFERENCES - 98 ADRIANNA SOBOLEWSKA, ALEKSANDRA DUNISLAWSKA AND KATARZYNA STADNICKA 5 NATURAL SUBSTANCES IN CANCER - DO THEY WORK? - 103 6.1 6.2 6.2.1 6.3 6.3.1 6.3.2 6.3.3 6.4 INTRODUCTION ---- 103 MICROBIOME AND CANCER ---- 103 PROBIOTICS AND SYNBIOTICS IN IMMUNOTHERAPY ---- 105 FOOD INGREDIENTS AND CANCER - 116 RESVERATROL - 119 CURCUMIN ---- 122 QUERCETIN - 125 SUMMARY ---- 127 REFERENCES - 128 ANNA HELMIN-BASA, LIDIA GACKOWSKA, SARA BALCEROWSKA, MARCELINA ORNAWKA, NATALIA NARUSZEWICZ AND MALGORZATA WIESE-SZADKOWSKA 6 THE APPLICATION OF THE NATURAL KILLER CELLS, MACROPHAGES AND DENDRITIC CELLS IN TREATING VARIOUS TYPES OF CANCER - 137 6.1 INTRODUCTION ---- 137 6.2 INNATE IMMUNE CELLS AND THE TUMOR MICROENVIRONMENT - 141 6.3 NK CELL-BASED IMMUNOTHERAPY IN TREATING CANCERS - 144 6.3.1 NOVEL STRATEGIES FOR RESTORING NK CELL ANTI-TUMORAL ACTIVITY - 144 6.3.2 ANTI-CHECKPOINT RECEPTOR MONOCLONAL ANTIBODIES - 144 6.3.3 OTHER ANTIBODIES - 148 6.3.4 AGONIST ANTIBODIES ---- 149 6.3.5 MODIFIED ANTIBODY MOLECULES ------- 149 6.3.6 FUSION PROTEINS ---- 150 6.3.7 IMMUNOMODULATORY DRUGS ----- 150 6.3.8 CYTOKINES ---- 151 6.3.9 ADOPTIVE TRANSFER OF NK CELLS ---- 151 6.3.10 NK CELLS AND COMBINATION IMMUNOTHERAPY ---- 152 6.3.11 ONCOLYTIC VIRUS-BASED THERAPY - 153 6.4 MACROPHAGES IN CANCER TREATMENT - 153 6.4.1 DEPLETING TAMS ---- 154 6.4.2 REPROGRAMING TAMS - 155 6.5 DCS IN CANCER TREATMENT ---- 156 6.5.1 EX VIVO GENERATED DC VACCINES ---- 156 6.5.2 TARGETING ANTIGEN TO DCS IN VIVO ---- 158 6.6 CONCLUSIONS ---- 159 REFERENCES - 159 X - CONTENTS TUKASZ KIRAGA, PAULINA KUCHARZEWSKA, DAMIAN STRZEMECKI, TOMASZ P. RYGIEL AND MAGDALENA KROL 7 NON-RADIOACTIVE IMAGING STRATEGIES FOR IN VIVO IMMUNE CELL TRACKING - 173 7.1 7.2 7.2.1 7.2.2 7.3 7.3.1 7.3.2 7.3.3 7.3.4 7.3.5 7.3.6 7.4 7.4.1 7.4.2 7.5 INTRODUCTION ---- 173 X-RAY COMPUTED TOMOGRAPHY (CT) ---- 174 CT CONTRAST AGENTS - 174 CT-BASED IMMUNE CELL TRACKING ---- 176 MAGNETIC RESONANCE IMAGING (MRI) ---- 178 PARAMAGNETIC CONTRAST AGENTS (T1 - SHORTENING) ---- 178 SUPERPARAMAGNETIC CONTRAST AGENTS (T2 - SHORTENING) - 179 " HOT-SPOT " MRI ---- 180 HIGHLY-SHIFTED PROTON (HSP) MRI ---- 181 CESTMRI---- 182 PARACESTMRI ---- 182 OPTICAL IMAGING - 183 BIOLUMINESCENCE IMAGING (BLI) ---- 183 FLUORESCENCE IMAGING (FLI) ---- 184 SUMMARY ---- 186 REFERENCES - 188 XAVIER MONTANE, KAROLINA MATULEWICZ, KAROLINA BALIK, PAULINA MODRAKOWSKA, MARCIN TUCZAK, YARIDE PEREZ PACHECO, BELEN REIG VANO, JOSEP M. MONTORNES, ANNA BAJEK AND BARTOSZ TYLKOWSKI 8 PRESENT TRENDS IN THE ENCAPSULATION OF ANTICANCER DRUGS - 193 8.1 8.2 8.2.1 8.2.2 8.2.3 8.2.4 8.2.5 8.2.6 8.2.7 8.2.8 8.3 8.4 8.4 INTRODUCTION - 193 ENCAPSULATED ANTICANCER DRUG DELIVERY SYSTEMS - 194 INORGANIC NPS ---- 196 DENDRIMERS ---- 196 BIOPOLYMERIC NPS ---- 198 POLYMERIC MICELLES ---- 199 LIPOSOMES ---- 200 POLYMERSOMES ---- 200 CNTS ---- 201 QDS ---- 202 HYBRID ENCAPSULATION SYSTEMS ---- 203 OVERVIEW ---- 204 CONCLUSIONS ---- 204 REFERENCES ---- 207 CONTENTS - - XI TUKASZ KAZMIERSKI AND MALGORZATA MAJ 9 3D TUMOR MODEL - A PLATFORM FOR ANTICANCER DRUG DEVELOPMENT---- 213 9.1 NEED FOR 3D TUMOR MODEL (PERSONALIZED MEDICINE AND DRUG DEVELOPMENT) ---- 213 9.1.1 3D PRINTED TUMOR MODELS ---- 214 9.1.2 NEED FOR NEW IN VITRO MODELS ---- 214 9.2 GENERAL UNDERSTANDING OF 3D PRINTING TECHNOLOGY ---- 214 9.2.1 FDM 3D PRINTING ---- 215 9.2.2 SLA AND MSLA 3D PRINTING ---- 220 9.2.3 SLM AND DMLS 3D PRINTING --- 221 9.3 3D IN VITRO MODEL ----- 221 9.3.1 CLASSICAL 2D CELL CULTURE ---- 222 9.3.2 SPHEROID CULTURE ----- 222 9.3.3 CLASSICAL 2D VERSUS 3D CELL CULTURE APPROACH ---- 223 9.3.4 SPHEROID FORMATION METHODS 224 9.4 BIOPRINTING ---- 228 9.4.1 BIOPRINTER TYPES ----- 228 9.4.2 BIOPRINTER MEDIA (BIOINKS) ---- 231 9.4.3 WORKFLOW AND SOFTWARE ---- 232 9.4.4 TYPICAL CONCERNS IN BIO-PRINTING ---- 234 REFERENCES ---- 238 INDEX ---- 241
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genre_facet	Aufsatzsammlung
id	DE-604.BV047399969
illustrated	Illustrated
index_date	2024-07-03T17:52:11Z
indexdate	2024-07-10T09:11:04Z
institution	BVB
institution_GND	(DE-588)10095502-2
isbn	3110662299 9783110662290
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-032801107
oclc_num	1104470460
open_access_boolean
owner	DE-29T DE-19 DE-BY-UBM
owner_facet	DE-29T DE-19 DE-BY-UBM
physical	XV, 248 Seiten Illustrationen 24 cm x 17 cm
publishDate	2021
publishDateSearch	2021
publishDateSort	2021
publisher	De Gruyter
record_format	marc
series2	De Gruyter STEM
spelling	Medical physics models and technologies in cancer research edited by Anna Bajek and Bartosz Tylkowski Berlin ; Boston De Gruyter [2021] XV, 248 Seiten Illustrationen 24 cm x 17 cm txt rdacontent n rdamedia nc rdacarrier De Gruyter STEM Krebsbekämpfung (DE-588)4165563-1 gnd rswk-swf Medizinische Physik (DE-588)4130758-6 gnd rswk-swf Krebsforschung (DE-588)4165564-3 gnd rswk-swf 1675: Hardcover, Softcover / Biologie/Biochemie, Biophysik Allgemein Krebsforschung MF: Pre-clinical medicine: basic sciences MQW: Biomedical engineering Medizinische Physik PHVD: Medical physics PHVN: Biophysics PSF: Cellular biology (cytology) Paperback / softback Strahlentherapie TGM: Materials science (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebsbekämpfung (DE-588)4165563-1 s DE-604 Krebsforschung (DE-588)4165564-3 s Medizinische Physik (DE-588)4130758-6 s Bajek, Anna edt Tylkowski, Bartosz (DE-588)1097289567 edt Walter de Gruyter GmbH & Co. KG (DE-588)10095502-2 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-11-066230-6 Erscheint auch als Online-Ausgabe, EPUB 978-3-11-066234-4 X:MVB http://www.degruyter.com/search?f_0=isbnissn&q_0=9783110662290&searchTitles=true DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032801107&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Medical physics models and technologies in cancer research Krebsbekämpfung (DE-588)4165563-1 gnd Medizinische Physik (DE-588)4130758-6 gnd Krebsforschung (DE-588)4165564-3 gnd
subject_GND	(DE-588)4165563-1 (DE-588)4130758-6 (DE-588)4165564-3 (DE-588)4143413-4
title	Medical physics models and technologies in cancer research
title_auth	Medical physics models and technologies in cancer research
title_exact_search	Medical physics models and technologies in cancer research
title_exact_search_txtP	Medical physics models and technologies in cancer research
title_full	Medical physics models and technologies in cancer research edited by Anna Bajek and Bartosz Tylkowski
title_fullStr	Medical physics models and technologies in cancer research edited by Anna Bajek and Bartosz Tylkowski
title_full_unstemmed	Medical physics models and technologies in cancer research edited by Anna Bajek and Bartosz Tylkowski
title_short	Medical physics
title_sort	medical physics models and technologies in cancer research
title_sub	models and technologies in cancer research
topic	Krebsbekämpfung (DE-588)4165563-1 gnd Medizinische Physik (DE-588)4130758-6 gnd Krebsforschung (DE-588)4165564-3 gnd
topic_facet	Krebsbekämpfung Medizinische Physik Krebsforschung Aufsatzsammlung
url	http://www.degruyter.com/search?f_0=isbnissn&q_0=9783110662290&searchTitles=true http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032801107&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT bajekanna medicalphysicsmodelsandtechnologiesincancerresearch AT tylkowskibartosz medicalphysicsmodelsandtechnologiesincancerresearch AT walterdegruytergmbhcokg medicalphysicsmodelsandtechnologiesincancerresearch

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