Structural biology in drug discovery: methods, techniques, and practices
"This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in...
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| Other Authors: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, NJ
Wiley
2020
|
| Subjects: | |
| Online Access: | DE-188 DE-29 Volltext |
| Summary: | "This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural, thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Altogether, this book is an up-to-date resource about structure-based drug discovery that provides academic and industry insights, novel concepts, and advances in a fast-growing field"--Provided by publisher |
| Physical Description: | 1 Online-Ressource (xxviii, 660 Seiten, 9 ungezählte Seiten) Illustrationen, Diagramme |
| ISBN: | 9781118681121 9781118900505 9781118900406 |
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| 520 | 3 | |a "This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural, thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Altogether, this book is an up-to-date resource about structure-based drug discovery that provides academic and industry insights, novel concepts, and advances in a fast-growing field"--Provided by publisher | |
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| id | DE-604.BV047180671 |
| illustrated | Illustrated |
| index_date | 2024-07-03T16:45:51Z |
| indexdate | 2025-02-10T13:14:41Z |
| institution | BVB |
| isbn | 9781118681121 9781118900505 9781118900406 |
| language | English |
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| physical | 1 Online-Ressource (xxviii, 660 Seiten, 9 ungezählte Seiten) Illustrationen, Diagramme |
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| spelling | Structural biology in drug discovery methods, techniques, and practices edited by Jean-Paul Renaud (President & CSO at Urania Therapeutics, Ostwald, France, Cofounder at NovAliX, Illkirch, France, CNRS Research Director at IGBMC, Illkirch, France) Hoboken, NJ Wiley 2020 1 Online-Ressource (xxviii, 660 Seiten, 9 ungezählte Seiten) Illustrationen, Diagramme txt rdacontent c rdamedia cr rdacarrier "This book acts as a comprehensive guide about the principles, methods, and applications of structure-based drug discovery. It includes successful examples as well as recent developments in the field. Part 1 of the book covers necessary information and concepts of applying structural biology in the drug discovery process. It provides experimental and computational approaches to drug characterization and evaluation, an overview of fragment-based drug design, and a description of how to combine structural, thermodynamic and kinetic information for hit-to-lead drug development. Part 2 covers novel tools and techniques related to drug discovery, like automated platforms for protein characterization, various types of crystallizations, and high-throughput crystallography. Part 3 features case studies of structure-based discovery on important, established but still challenging therapeutic target families, as well as on monoclonal antibodies as an example of biotherapeutics. The final section illustrates new frontiers and challenges in the field, like intrinsically disordered proteins, neglected diseases, or viral resistance, and promising techniques for the future (XFELs and cryo-EM). Altogether, this book is an up-to-date resource about structure-based drug discovery that provides academic and industry insights, novel concepts, and advances in a fast-growing field"--Provided by publisher Strukturbiologie (DE-588)1081522143 gnd rswk-swf Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf Drug Discovery / methods Molecular Biology / methods Genetic Techniques Drug Design Arzneimittelforschung (DE-588)4003120-2 s Strukturbiologie (DE-588)1081522143 s DE-604 Renaud, Jean-Paul 1960- (DE-588)1207794678 edt Erscheint auch als Druck-Ausgabe, Hardcover 978-1-118-68112-1 https://onlinelibrary.wiley.com/doi/book/10.1002/9781118681121 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Structural biology in drug discovery methods, techniques, and practices Strukturbiologie (DE-588)1081522143 gnd Arzneimittelforschung (DE-588)4003120-2 gnd |
| subject_GND | (DE-588)1081522143 (DE-588)4003120-2 |
| title | Structural biology in drug discovery methods, techniques, and practices |
| title_auth | Structural biology in drug discovery methods, techniques, and practices |
| title_exact_search | Structural biology in drug discovery methods, techniques, and practices |
| title_exact_search_txtP | Structural biology in drug discovery methods, techniques, and practices |
| title_full | Structural biology in drug discovery methods, techniques, and practices edited by Jean-Paul Renaud (President & CSO at Urania Therapeutics, Ostwald, France, Cofounder at NovAliX, Illkirch, France, CNRS Research Director at IGBMC, Illkirch, France) |
| title_fullStr | Structural biology in drug discovery methods, techniques, and practices edited by Jean-Paul Renaud (President & CSO at Urania Therapeutics, Ostwald, France, Cofounder at NovAliX, Illkirch, France, CNRS Research Director at IGBMC, Illkirch, France) |
| title_full_unstemmed | Structural biology in drug discovery methods, techniques, and practices edited by Jean-Paul Renaud (President & CSO at Urania Therapeutics, Ostwald, France, Cofounder at NovAliX, Illkirch, France, CNRS Research Director at IGBMC, Illkirch, France) |
| title_short | Structural biology in drug discovery |
| title_sort | structural biology in drug discovery methods techniques and practices |
| title_sub | methods, techniques, and practices |
| topic | Strukturbiologie (DE-588)1081522143 gnd Arzneimittelforschung (DE-588)4003120-2 gnd |
| topic_facet | Strukturbiologie Arzneimittelforschung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781118681121 |
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