Estimands, estimators and sensitivity analysis in clinical trials:
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| Main Authors: | , , , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Boca Raton
CRC Press
[2020]
|
| Series: | Chapman & Hall/CRC biostatistics series
|
| Subjects: | |
| Online Access: | TUM01 |
| Item Description: | Includes bibliographical references and index Why estimands are important -- Estimands and how to define them -- Strategies for dealing with intercurrent events -- Real world examples in choosing and specifying estimands -- Causal inference and estimands -- Putting the principles into practice -- Overview of estimators -- Modeling considerations -- Overview of analyses for composite intercurrent event strategies -- Overview of analyses for hypothetical intercurrent event strategies -- Overview of analyses for principal stratification intercurrent event strategies -- Overview of analyses for while-on-treatment intercurrent event strategies -- Overview of analyses for treatment policy intercurrent event strategies -- Missing data -- Sensitivity analyses -- Example data -- Direct maximum likelihood -- Multiple imputation -- Inverse probability weighted generalized estimated equations -- Doubly robust methods -- Reference-based imputation -- Delta adjustment -- Overview of principal stratification methods -- Analytic case study of depression clinical trials -- Analytic case study #2 -- Analytic case study #3 |
| Physical Description: | 1 Online-Ressource illustrations (black and white) |
| ISBN: | 9780429950056 0429950055 |
Staff View
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| 245 | 1 | 0 | |a Estimands, estimators and sensitivity analysis in clinical trials |c by Craig Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch |
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| 650 | 4 | |a Clinical trials |x Statistical methods | |
| 650 | 4 | |a Estimation theory | |
| 650 | 4 | |a Sensitivity theory (Mathematics) | |
| 700 | 1 | |a Molenberghs, Geert |4 aut | |
| 700 | 1 | |a Lipkovich, Ilya |4 aut | |
| 700 | 1 | |a Ratitch, Bohdana |4 aut | |
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| dewey-ones | 610 - Medicine and health |
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| dewey-sort | 3610.72 14 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV047050743 |
| illustrated | Illustrated |
| index_date | 2024-07-03T16:07:55Z |
| indexdate | 2024-07-10T09:01:11Z |
| institution | BVB |
| isbn | 9780429950056 0429950055 |
| language | English |
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| publisher | CRC Press |
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| series2 | Chapman & Hall/CRC biostatistics series |
| spelling | Mallinckrodt, Craig H. 1958- aut Estimands, estimators and sensitivity analysis in clinical trials by Craig Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch Boca Raton CRC Press [2020] 1 Online-Ressource illustrations (black and white) txt rdacontent c rdamedia cr rdacarrier Chapman & Hall/CRC biostatistics series Includes bibliographical references and index Why estimands are important -- Estimands and how to define them -- Strategies for dealing with intercurrent events -- Real world examples in choosing and specifying estimands -- Causal inference and estimands -- Putting the principles into practice -- Overview of estimators -- Modeling considerations -- Overview of analyses for composite intercurrent event strategies -- Overview of analyses for hypothetical intercurrent event strategies -- Overview of analyses for principal stratification intercurrent event strategies -- Overview of analyses for while-on-treatment intercurrent event strategies -- Overview of analyses for treatment policy intercurrent event strategies -- Missing data -- Sensitivity analyses -- Example data -- Direct maximum likelihood -- Multiple imputation -- Inverse probability weighted generalized estimated equations -- Doubly robust methods -- Reference-based imputation -- Delta adjustment -- Overview of principal stratification methods -- Analytic case study of depression clinical trials -- Analytic case study #2 -- Analytic case study #3 Clinical trials Statistical methods Estimation theory Sensitivity theory (Mathematics) Molenberghs, Geert aut Lipkovich, Ilya aut Ratitch, Bohdana aut Erscheint auch als Druck-Ausgabe 9781138592506 Erscheint auch als Druck-Ausgabe 1138592501 Erscheint auch als Druck-Ausgabe 9780429950056 |
| spellingShingle | Mallinckrodt, Craig H. 1958- Molenberghs, Geert Lipkovich, Ilya Ratitch, Bohdana Estimands, estimators and sensitivity analysis in clinical trials Clinical trials Statistical methods Estimation theory Sensitivity theory (Mathematics) |
| title | Estimands, estimators and sensitivity analysis in clinical trials |
| title_auth | Estimands, estimators and sensitivity analysis in clinical trials |
| title_exact_search | Estimands, estimators and sensitivity analysis in clinical trials |
| title_exact_search_txtP | Estimands, estimators and sensitivity analysis in clinical trials |
| title_full | Estimands, estimators and sensitivity analysis in clinical trials by Craig Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch |
| title_fullStr | Estimands, estimators and sensitivity analysis in clinical trials by Craig Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch |
| title_full_unstemmed | Estimands, estimators and sensitivity analysis in clinical trials by Craig Mallinckrodt, Geert Molenberghs, Ilya Lipkovich, Bohdana Ratitch |
| title_short | Estimands, estimators and sensitivity analysis in clinical trials |
| title_sort | estimands estimators and sensitivity analysis in clinical trials |
| topic | Clinical trials Statistical methods Estimation theory Sensitivity theory (Mathematics) |
| topic_facet | Clinical trials Statistical methods Estimation theory Sensitivity theory (Mathematics) |
| work_keys_str_mv | AT mallinckrodtcraigh estimandsestimatorsandsensitivityanalysisinclinicaltrials AT molenberghsgeert estimandsestimatorsandsensitivityanalysisinclinicaltrials AT lipkovichilya estimandsestimatorsandsensitivityanalysisinclinicaltrials AT ratitchbohdana estimandsestimatorsandsensitivityanalysisinclinicaltrials |