Survival signals of human hematopoietic stem and progenitor cells:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Freiburg im Breisgau
2020
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Item Description: | Enthält Sonderabdrucke |
| Physical Description: | 134 Seiten Illustrationen, Diagramme 30 cm |
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| 100 | 1 | |a Bohler, Sheila |e Verfasser |0 (DE-588)1186180447 |4 aut | |
| 245 | 1 | 0 | |a Survival signals of human hematopoietic stem and progenitor cells |c vorgelegt von Sheila Bohler |
| 264 | 1 | |a Freiburg im Breisgau |c 2020 | |
| 300 | |a 134 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
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| 502 | |b Dissertation |c Albert-Ludwigs-Universität Freiburg im Breisgau |d 2020 | ||
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Record in the Search Index
| _version_ | 1804181750644998144 |
|---|---|
| adam_text | TABLE
OF
CONTENT
1
INTRODUCTION
................................................................................................................................
1
1.1
THE
HEMATOPOIETIC
SYSTEM
................................................................................................................
1
1.2
CELL
DEATH
...........................................................................................................................................
3
1.2.1
REGULATED
CELL
DEATH
...................................................................................................................
3
1.2.2
THE
EXTRINSIC
PATHWAY
.................................................................................................................4
1.2.3
THE
INTRINSIC
PATHWAY
..................................................................................................................4
1.3
THE
BCL-2
FAMILY
................................................................................................................................
5
1.3.1
THE
ROLE
OF
ANTI-APOPTOTIC
BCL-2
PROTEINS
FOR
FUNCTION
AND
MAINTENANCE
OF
THE
HEMATOPOIETIC
SYSTEM
.................................................................................................................
7
1.3.2
BH3-MIMETICS
...........................................................................................................................
10
1.4
PROTECTIVE
SUBSTANCES
....................................................................................................................
11
2
AIMS
OF
THE
THESIS
....................................................................................................................
13
3
RESULTS
....................................................................................................................................
14
3.1
INHIBITION
OF
THE
ANTI-APOPTOTIC
PROTEIN
MCL-1
SEVERELY
SUPPRESSES
HUMAN
HEMATOPOIESIS
.....
14
3.2
BCL-XL
EXPRESSION
IS
ESSENTIAL
FOR
HUMAN
ERYTHROPOIESIS
AND
ENGRAFTMENT
OF
HEMATOPOIETIC
STEM
CELLS
................................................................................................................42
3.3
IN
VITRO
AND
IN
VIVO
EVALUATION
OF
POSSIBLE
PRO-SURVIVAL
ACTIVITIES
OF
PGE
2
,
EGF,
TPO
AND
FLT3L
ON
HUMAN
HEMATOPOIESIS
..................................................................................................
71
3.4
TRANSIENT
APOPTOSIS
INHIBITION
IN
DONOR
STEM
CELLS
IMPROVES
HEMATOPOIETIC
STEM
CELL
TRANSPLANTATION
.................................................................................................................................
86
4
DISCUSSION
..............................................................................................................................
109
4.1
INHIBITING
APOPTOSIS
TO
IMPROVE
HSCT
..........................................................................................
109
4.2
PROTECTING
HSPC
VIA
ADMINISTRATION
OF
PROTECTIVE
SUBSTANCES
...................................................
ILL
4.3
DECIPHERING
THE
ROLES
OF
BCL-XL
AND
MCL-1
IN
THE
MAINTENANCE
OF
HUMAN
HEMATOPOIESIS
.113
4.4
SINGLE
AND
COMBINED
INHIBITION
OF
BCL-XL
AND
MCL-1
...............................................................
118
5
REFERENCES
.............................................................................................................................
120
6
ABBREVIATIONS
.........................................................................................................................
131
7
ACKNOWLEDGEMENTS
...............................................................................................................
133
|
| adam_txt |
TABLE
OF
CONTENT
1
INTRODUCTION
.
1
1.1
THE
HEMATOPOIETIC
SYSTEM
.
1
1.2
CELL
DEATH
.
3
1.2.1
REGULATED
CELL
DEATH
.
3
1.2.2
THE
EXTRINSIC
PATHWAY
.4
1.2.3
THE
INTRINSIC
PATHWAY
.4
1.3
THE
BCL-2
FAMILY
.
5
1.3.1
THE
ROLE
OF
ANTI-APOPTOTIC
BCL-2
PROTEINS
FOR
FUNCTION
AND
MAINTENANCE
OF
THE
HEMATOPOIETIC
SYSTEM
.
7
1.3.2
BH3-MIMETICS
.
10
1.4
PROTECTIVE
SUBSTANCES
.
11
2
AIMS
OF
THE
THESIS
.
13
3
RESULTS
.
14
3.1
INHIBITION
OF
THE
ANTI-APOPTOTIC
PROTEIN
MCL-1
SEVERELY
SUPPRESSES
HUMAN
HEMATOPOIESIS
.
14
3.2
BCL-XL
EXPRESSION
IS
ESSENTIAL
FOR
HUMAN
ERYTHROPOIESIS
AND
ENGRAFTMENT
OF
HEMATOPOIETIC
STEM
CELLS
.42
3.3
IN
VITRO
AND
IN
VIVO
EVALUATION
OF
POSSIBLE
PRO-SURVIVAL
ACTIVITIES
OF
PGE
2
,
EGF,
TPO
AND
FLT3L
ON
HUMAN
HEMATOPOIESIS
.
71
3.4
TRANSIENT
APOPTOSIS
INHIBITION
IN
DONOR
STEM
CELLS
IMPROVES
HEMATOPOIETIC
STEM
CELL
TRANSPLANTATION
.
86
4
DISCUSSION
.
109
4.1
INHIBITING
APOPTOSIS
TO
IMPROVE
HSCT
.
109
4.2
PROTECTING
HSPC
VIA
ADMINISTRATION
OF
PROTECTIVE
SUBSTANCES
.
ILL
4.3
DECIPHERING
THE
ROLES
OF
BCL-XL
AND
MCL-1
IN
THE
MAINTENANCE
OF
HUMAN
HEMATOPOIESIS
.113
4.4
SINGLE
AND
COMBINED
INHIBITION
OF
BCL-XL
AND
MCL-1
.
118
5
REFERENCES
.
120
6
ABBREVIATIONS
.
131
7
ACKNOWLEDGEMENTS
.
133 |
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| author_GND | (DE-588)1186180447 |
| author_facet | Bohler, Sheila |
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| building | Verbundindex |
| bvnumber | BV046887717 |
| ctrlnum | (OCoLC)1194966148 (DE-599)DNB1213554616 |
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| discipline_str_mv | Biologie Medizin |
| format | Thesis Book |
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| illustrated | Illustrated |
| index_date | 2024-07-03T15:19:59Z |
| indexdate | 2024-07-10T08:56:37Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032297608 |
| oclc_num | 1194966148 |
| open_access_boolean | |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | 134 Seiten Illustrationen, Diagramme 30 cm |
| publishDate | 2020 |
| publishDateSearch | 2020 |
| publishDateSort | 2020 |
| record_format | marc |
| spelling | Bohler, Sheila Verfasser (DE-588)1186180447 aut Survival signals of human hematopoietic stem and progenitor cells vorgelegt von Sheila Bohler Freiburg im Breisgau 2020 134 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Enthält Sonderabdrucke Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2020 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1213554616/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032297608&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bohler, Sheila Survival signals of human hematopoietic stem and progenitor cells |
| subject_GND | (DE-588)4113937-9 |
| title | Survival signals of human hematopoietic stem and progenitor cells |
| title_auth | Survival signals of human hematopoietic stem and progenitor cells |
| title_exact_search | Survival signals of human hematopoietic stem and progenitor cells |
| title_exact_search_txtP | Survival signals of human hematopoietic stem and progenitor cells |
| title_full | Survival signals of human hematopoietic stem and progenitor cells vorgelegt von Sheila Bohler |
| title_fullStr | Survival signals of human hematopoietic stem and progenitor cells vorgelegt von Sheila Bohler |
| title_full_unstemmed | Survival signals of human hematopoietic stem and progenitor cells vorgelegt von Sheila Bohler |
| title_short | Survival signals of human hematopoietic stem and progenitor cells |
| title_sort | survival signals of human hematopoietic stem and progenitor cells |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1213554616/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032297608&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bohlersheila survivalsignalsofhumanhematopoieticstemandprogenitorcells |
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