Mechanical blood trauma in circulatory-assist devices:
Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components � the material, fluid flow paths, and flow related stresses �...
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| Main Authors: | , , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, New York
American Society Of Mechanical Engineers
[2015]
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| Subjects: | |
| Online Access: | Volltext |
| Summary: | Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components � the material, fluid flow paths, and flow related stresses � as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often suboptimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions � device removal, replacement, or additional medical therapies including surgery or plasmapheresis � that take into account the risk/benefit of intervention must be quickly evaluated. The various pre-clinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points |
| Item Description: | Includes bibliographical references Introduction -- Hemolysis -- Testing blood trauma in circulatory assist devices -- Sublethal blood trauma -- Damage to leukocytes -- In vitro testing devices for blood biocompatibility -- Clinical issues and experience -- Medical therapy for elevated plasma free hemoglobin -- Concluding remarks. - System requirements: Adobe Acrobat Reader. - Mode of access: World Wide Web |
| Physical Description: | 1 Online-Ressource (62 Seiten) Illustrationen |
| ISBN: | 9781606507841 |
Staff View
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| 500 | |a Introduction -- Hemolysis -- Testing blood trauma in circulatory assist devices -- Sublethal blood trauma -- Damage to leukocytes -- In vitro testing devices for blood biocompatibility -- Clinical issues and experience -- Medical therapy for elevated plasma free hemoglobin -- Concluding remarks. - System requirements: Adobe Acrobat Reader. - Mode of access: World Wide Web | ||
| 520 | |a Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components � the material, fluid flow paths, and flow related stresses � as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often suboptimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions � device removal, replacement, or additional medical therapies including surgery or plasmapheresis � that take into account the risk/benefit of intervention must be quickly evaluated. The various pre-clinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points | ||
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| author | Maul, Timothy M. Kameneva, Marina V. Wearden, Peter D. |
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| spelling | Maul, Timothy M. Verfasser aut Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva and Peter D. Wearden New York, New York American Society Of Mechanical Engineers [2015] © 2015 1 Online-Ressource (62 Seiten) Illustrationen txt rdacontent c rdamedia cr rdacarrier Includes bibliographical references Introduction -- Hemolysis -- Testing blood trauma in circulatory assist devices -- Sublethal blood trauma -- Damage to leukocytes -- In vitro testing devices for blood biocompatibility -- Clinical issues and experience -- Medical therapy for elevated plasma free hemoglobin -- Concluding remarks. - System requirements: Adobe Acrobat Reader. - Mode of access: World Wide Web Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components � the material, fluid flow paths, and flow related stresses � as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often suboptimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions � device removal, replacement, or additional medical therapies including surgery or plasmapheresis � that take into account the risk/benefit of intervention must be quickly evaluated. The various pre-clinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points Blutpumpe (DE-588)4146083-2 gnd rswk-swf Blut (DE-588)4007259-9 gnd rswk-swf Trauma (DE-588)4060748-3 gnd rswk-swf Blutpumpe (DE-588)4146083-2 s Blut (DE-588)4007259-9 s Trauma (DE-588)4060748-3 s DE-604 Kameneva, Marina V. Verfasser aut Wearden, Peter D. Verfasser aut American Society of Mechanical Engineers Boiler and Pressure Vessel Committee Sonstige (DE-588)5512934-1 oth American Society of Mechanical Engineers Sonstige (DE-588)861-8 oth Erscheint auch als Druck-Ausgabe 978-0-7918-6039-7 https://asmedigitalcollection.asme.org/ebooks/book/3/Mechanical-Blood-Trauma-in-Circulatory-Assist Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Maul, Timothy M. Kameneva, Marina V. Wearden, Peter D. Mechanical blood trauma in circulatory-assist devices Blutpumpe (DE-588)4146083-2 gnd Blut (DE-588)4007259-9 gnd Trauma (DE-588)4060748-3 gnd |
| subject_GND | (DE-588)4146083-2 (DE-588)4007259-9 (DE-588)4060748-3 |
| title | Mechanical blood trauma in circulatory-assist devices |
| title_auth | Mechanical blood trauma in circulatory-assist devices |
| title_exact_search | Mechanical blood trauma in circulatory-assist devices |
| title_exact_search_txtP | Mechanical blood trauma in circulatory-assist devices |
| title_full | Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva and Peter D. Wearden |
| title_fullStr | Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva and Peter D. Wearden |
| title_full_unstemmed | Mechanical blood trauma in circulatory-assist devices Timothy M. Maul, Marina V. Kameneva and Peter D. Wearden |
| title_short | Mechanical blood trauma in circulatory-assist devices |
| title_sort | mechanical blood trauma in circulatory assist devices |
| topic | Blutpumpe (DE-588)4146083-2 gnd Blut (DE-588)4007259-9 gnd Trauma (DE-588)4060748-3 gnd |
| topic_facet | Blutpumpe Blut Trauma |
| url | https://asmedigitalcollection.asme.org/ebooks/book/3/Mechanical-Blood-Trauma-in-Circulatory-Assist |
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