Orthopedic Nuclear Medicine:
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| Main Author: | |
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| Format: | Book |
| Language: | English |
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Berlin
Springer
[2017]
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| Edition: | Second Edition |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | xvi, 431 Seiten Illustrationen, Diagramme |
| ISBN: | 9783319561653 |
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MARC
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| 650 | 4 | |a Orthopedics | |
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| adam_text | Contents 1 Basic Sciences of Bone and Joint Diseases..................................... 1 1.1 Introduction................................................................................. 2 1.2 Anatomy and Physiology of Bone............................................... 2 1.2.1 Bone Development.......................................................... 2 1.2.2 Bone Anatomy................................................................. 3 1.2.3 Bone Physiology............................................................ 7 1.3 Anatomy and Physiology of Bone Marrow.................................. 11 1.4 Anatomy and Physiology of Joints..............................................11 1.5 Spectrum of Bone and Joint Disease............................................13 1.6 Modalities for Imaging Bone and Joint Diseases....................... 14 1.7 Diagnosis of Bone and Joint Diseases by Nuclear Medicine Techniques.....................................................................15 1.8 Technical Considerations...............................................................18 1.8.1 Pre-imaging Considerations..............................................18 1.8.2 Imaging Considerations....................................................22 1.8.3 Post-Imaging Considerations........................................... 29 1.8.4 Sources of Diagnostic Errors............................................30 References..............................................................................................35 2 Diagnosis of Inflammatory Bone
Diseases......................................37 2.1 Introduction................................................................................... 38 2.2 Pathophysiology.............................................................................38 2.2.1 Inflammation.....................................................................38 2.2.2 Skeletal Infections............................................................ 41 2.3 Imaging Skeletal Infections.......................................................... 49 2.3.1 The Need for Diagnostic Imaging................................... 49 2.3.2 Imaging Modalities for Skeletal Infections.....................50 2.4 Diagnosis of Skeletal Infection by Imaging................................. 50 2.4.1 Diagnosis Using Morphologic Imaging Modalities.........................................................................50 2.4.2 Diagnosis by Scintigraphic Methods............................... 52 2.4.3 Imaging Using Combined Modalities............................. 63 2.5 Diagnosis of Specific Forms of Skeletal Infections.....................63 2.5.1 Diabetic Foot Osteomyelitis............................................63 2.5.2 Vertebral Osteomyelitis (Spondylodiscitis).....................70 2.5.3 Chronic Active Osteomyelitis......................................... 73 2.5.4 Periprosthetic Infection.................................................... 77 XI
x¡¡ Contents 2.5.5 2.5.6 Posttraumatic Osteomyelitis.......................................... 83 Osteomyelitis in Patients with Sickle Cell Disease.................................................................... 84 2.5.7 Neonatal Osteomyelitis.................................................. 84 2.5.8 Epiphyseal Osteomyelitis................................................ 84 2.6 Follow-Up of Response to Therapy............................................ 85 2.7 Differentiating Osteomyelitis from Infectious Arthritis...................................................................................... 85 2.8 Differentiating Infection from Tumors...................................... 85 2.9 Noninfectious Inflammatory Conditions.................................... 86 2.9.1 Chronic Nonbacterial Osteomyelitis.............................. 86 2.9.2 Osteitis Condensans Ilii............................ 88 2.9.3 Osteitis Pubis.................................................................. 88 2.9.4 Infantile Cortical Hyperostosis (Caifey-Sillverman Disease).......................................... 88 2.9.5 Sternoclavicular Hyperostosis........................................ 88 2.9.6 Osteitis Condensans of the Clavicle.............................. 88 2.10 Scintigraphic Patterns of Skeletal Manifestations of Poliomyelitis.......................................................................... 90 References............................................................................................ 90 3 Diagnosis of Metabolic, Endocrine, and Congenital Bone
Disease.................................................................................. 101 3.1 Introduction............................................................................ 101 3.2 Paget’s Disease (Osteitis Deformans)...................................... 102 3.3 Osteoporosis...............................................................................109 3.4 Osteomalacia and Rickets........................................................ 114 3.5 Hyperparathyroidism.................................................................116 3.6 Renal Osteodystrophy...............................................................119 3.7 Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy)...........................................................122 3.8 Hypertrophic Osteoarthropathy................................................ 127 3.9 Fibrous Dysplasia...................................................................... 128 3.10 Other Metabolic and Endocrine Conditions............................ 131 3.10.1 Hypothyroidism............................................................ 131 3.10.2 Hyperthyroidism.......................................................... 131 3.10.3 Fluoride Toxicity...........................................................131 3.10.4 Aluminum Toxicity...................................................... 131 3.10.5 Hypervitaminosis A...................................................... 131 3.11 Osteopetrosis.............................................................................132 3.12 Medullary Diaphyseal Sclerosis
(Medullary Diaphyseal Stenosis or Hardcastle Syndrome)........................ 132 3.13 Gorlin’s Syndrome.................................................................... 132 3.14 Progressive Diaphyseal Dysplasia (Camurati-Engelmann Disease)................................................ 134 3.15 Infantile Cortical Hyperostosis (Caffey-Silverman Syndrome).................................................. 136 3.16 Madibular Condylar Hyperplasia.............................................. 136 References...........................................................................................138
Contents xiii 4 Diagnosis of Traumatic Disorders.................................................... 147 4.1 Introduction..................................................................................147 4.2 Pathophysiology........................................................................... 148 4.2.1 Acute Fractures...............................................................148 4.2.2 Stress Fractures...............................................................149 4.2.3 Spondylolysis................................................................... 150 4.2.4 Spondylolisthesis.............................................................150 4.2.5 Fracture Healing...............................................................150 4.2.6 Trauma to Bone-Adjacent Structures..............................153 4.3 Scintigraphic Diagnosis of Acute Fractures..............................153 4.3.1 Role of Scintigraphy in Acute Fracture......................... 153 4.3.2 Scintigraphic Appearance of Acute Fractures.............154 4.3.3 Scintigraphic Imaging of Specific Fractures.................155 4.4 Scintigraphic Diagnosis of Stress Fractures..............................168 4.4.1 Role of Scintigraphy in Stress Fractures....................... 168 4.4.2 Scintigraphic Appearance of Stress Fractures.............169 4.4.3 Scintigraphic Diagnosis of Specific Stress Fractures...............................................................172 4.5 Scintigraphic Evaluation of Fracture and Bone Graft
Healing................................................................................180 4.5.1 Evaluation of Fracture Healing......................................180 4.5.2 Evaluation of Bone Graft Viability............................... 180 4.5.3 Evaluation of Metallic Implants for Removal.............181 4.6 Scintigraphic Diagnosis of Injuries to Bone-Adjacent Structures......................................................................................182 4.6.1 Avulsion Injury...............................................................182 4.6.2 Skeletal Muscle Injury.................................................... 182 4.6.3 Post-Traumatic Soft Tissue Calcification....................... 183 4.6.4 Meniscal and Ligament Tears........................................183 4.6.5 Enthesopathies................................................................. 183 4.6.6 Impingement Syndromes................................................ 183 References.............................................................................................. 184 5 Diagnosis of Circulatory Disorders.................................................. 191 5.1 Introduction..................................................................................191 5.2 Pathophysiology........................................................................... 192 5.3 General Scintigraphic Features and Staging............................. 193 5.4 Distinctive Forms of Osteonecrosis............................................ 195 5.4.1 Post-traumatic
Osteonecrosis.......................................... 195 5.4.2 Osteonecrosis of the Femoral Head in Children (Legg-Calvé-Perthes Disease)........................................195 5.4.3 Osteonecrosis of the Femoral Head in Adults...............199 5.4.4 Spontaneous Osteonecrosis of the Knee.......................201 5.4.5 Multifocal Osteonecrosis................................................204 5.4.6 Sickle Cell Disease Osteonecrosis................................. 205 5.4.7 Dysbaric Osteonecrosis..................................................206 5.4.8 Osteochondroses Featuring Osteonecrosis...................206 References..............................................................................................209
xìv Contenti 6 Neoplastic Bone Diseases........................ .................................... 213 6.1 Introduction..............................................................................214 6.2 Pathophysiology........................................................................215 6.2.1 Primary Bone Tumors................................................ 215 6.2.2 Metastatic Bone Disease............................................ 225 6.3 Imaging of Primary Bone Tumors............................................232 6.3.1 Overall Role of Imaging..............................................232 6.3.2 Imaging of Major Specific Primary Tumors................236 6.4 Scintigraphy and Correlative Imaging of Metastatic Bone Disease............................................................................249 6.4.1 Scintigraphic Patterns of Bone Metastases on Bone Scans............................................................ 251 6.4.2 Scintigraphic Evaluation of Metastases of Certain Tumors........................................................257 6.5 Follow-Up of Malignant Bone Disease....................................269 References......................................................................................... 272 7 Diagnosis of Joint Disorders..........................................................281 7.1 Introduction..............................................................................282 7.2 Classification............................................................................282 7.3 Rheumatoid
Arthritis................................................................283 7.4 Crystal Deposition Arthropathies............................................286 7.4.1 Gouty Arthritis..............................................................286 7.4.2 Calcium Pyrophosphate Dihydrate Deposition Disease........................................................287 7.5 Infectious Arthritis....................................................................288 7.6 Osteoarthritis............................................................................288 7.7 Sacroiliitis................................................................................293 7.8 Neuroarthropathy......................................................................296 7.9 Spondyloarthropathies..............................................................296 7.9.1 Ankylosing Spondylitis................................................297 7.9.2 Psoriatic Arthritis..........................................................297 7.9.3 Reactive Arthritis (Reiter’s Disease)............................298 7.9.4 Enteropathie Spondylitis..............................................299 7.10 Other Arthropathies and Related Conditions............................299 7.10.1 Behçet’s Syndrome......................................................299 7.10.2 Costochondritis (Tietze’s Syndrome)............................299 7.10.3 SAPHO Syndrome........................................................299 7.10.4 Synovitis......................................................................300 7.11 Periarticular Soft
Tissue Syndromes........................................301 7.11.1 Diffuse Idiopathic Skeletal Hyperostosis (DISH)....................................................301 7.11.2 Septic Bursitis..............................................................302 7.11.3 Septic Tenosynovitis....................................................302 7.11.4 Plantar Fasciitis............................................................302 References..........................................................................................303
Contents XV 8 Bone Marrow Imaging....................................................................... 307 8.1 Introduction................................................................................. 307 8.2 Development and Structure of Bone Marrow........................... 307 8.3 Conversion and Reconversion.................................................... 310 8.4 Alterations to Bone Marrow...................................................... 311 8.5 Imaging of Bone Marrow.............................................................311 8.6 Bone Marrow Scintigraphy........................................................ 312 8.7 Clinical Uses of Bone Marrow Scintigraphy............................. 314 8.7.1 Diagnosis of Skeletal Infections................................... 314 8.7.2 Assessment and Follow-Up of Gaucher’s Disease............................................................................. 317 8.7.3 Treatment Planning in Cancer Patients......................... 318 8.7.4 Paget’s Disease.................................................................319 8.7.5 Bone Marrow Tumors and Bone Marrow Extension......................................................................... 320 8.7.6 Other Uses....................................................................... 320 References............................................................................................ 320 9 Diagnosis of Soft Tissue Calcification............................................ 323 9.1
Introduction..................................................................................324 9.2 Dystrophic Calcification.............................................................324 9.3 Metastatic Calcification...............................................................325 9.4 Heterotopic Bone Formation...................................................... 331 9.4.1 Pathophysiology...............................................................331 9.4.2 Scintigraphic Evaluation................................................334 9.4.3 Correlative Imaging........................................................ 339 9.4.4 Special Forms of Heterotopic Bone Formation.........................................................................339 9.5 Calcinosis Cutis........................................................................... 344 9.5.1 Calcinosis Cutis Universalis..........................................344 9.5.2 Calcinosis Cutis Circumscripta..................................... 345 9.6 Rhabdomyolysis........................................................................... 345 References............................................................................................ 345 10 Hybrid Imaging in the Diagnosis of Bone Diseases.....................349 10.1 Introduction................................................................................. 349 10.2 SPECT/CT....................................................................................349 10.2.1 Uses of SPECT/CT in Neoplastic Diseases.................350 10.2.2 Uses of SPECT/CT in
Nonneoplastic Diseases.......... 353 10.3 PET/CT......................................................................................372 10.3.1 F-18FDG PET/CT........................................................ 372 10.3.2 F-18 Sodium Fluoride PET/CT................................... 374 10.3.3 Combined F-18 NaF and F-18FDG PET/CT............376 10.3.4 Ga-68-Citrate PET/CT.................................................. 378 10.3.5 Ga-68 PSMA PET/CT.................................................. 378 10.4 PET/MR......................................................................................378 References............................................................................................ 382
Contents XVI 11 Therapeutic Use of Radionuclides in Bone and Joint Disease.............................................................................. 387 11.1 Introduction.............................................................................. 388 11.2 Treatment of Cancer-Related Bone Pain..................................388 11.2.1 Rationale.................................................................... 388 11.2.2 Radiopharmaceuticals................................................389 11.2.3 Mechanism of Action..................................................392 11.2.4 Choice of Radiopharmaceutical.................................393 11.2.5 Clinical Use................................................................ 394 11.3 Radionuclide Synovectomy...................................................... 397 11.3.1 Rationale.................................................................... 397 11.3.2 Radiopharmaceuticals................................................397 11.3.3 Choice of Radiopharmaceutical..................................400 11.3.4 Clinical Uses..............................................................401 11.4 Other Radionuclide Therapies..................................................407 11.4.1 Treatment of Primary Osteogenic Sarcoma............... 407 11.4.2 Metastatic Prostate Carcinoma..................................408 11.4.3 Multiple Myeloma......................................................408 11.4.4 Treatment of Neuroblastoma......................................409 11.4.5 Bone Marrow
Ablation..............................................410 References..........................................................................................410 Glossary.................................................................................................... 417 Index.......................................................................................................... 421
This book, now in a revised and updated second edition, offers a comprehensive over view of the state of the art in orthopedic nuclear medicine, including the impressive recent advances in the field and the diagno sis of under-recognized conditions ori the basis of their imaging patterns. The opening chapters acquaint the reader briefly with anatomic, physiologic, pathologic, and tech nical concepts crucial to a sound under standing of orthopedic nuclear medicine and its utilization in clinical practice. The imaging diagnosis of skeletal infections, trauma, vascular disorders, metabolic and neoplastic bone diseases, soft tissue calcifica tions, and joint disorders is then explained in detail. Two entirely new chapters, on bone marrow imaging and hybrid imaging of bone diseases, have been added to this edition. A separate chapter is devoted to the use of radionuclides for the treatment of bone and joint disorders. The book is richly illustrated and amply documents the effec tiveness of nuclear medicine in diagnosing bone disease. It will prove invaluable to all with an interest in diagnostic and therapeu tic orthopedics, including orthopedists, radiologists, rheumatologists, pediatricians, podiatrists, other clinicians, and all nuclear and molecular imaging professionals. Elgazzar Orthopedic Nuclear Medicine Second Edition
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Contents 1 Basic Sciences of Bone and Joint Diseases. 1 1.1 Introduction. 2 1.2 Anatomy and Physiology of Bone. 2 1.2.1 Bone Development. 2 1.2.2 Bone Anatomy. 3 1.2.3 Bone Physiology. 7 1.3 Anatomy and Physiology of Bone Marrow. 11 1.4 Anatomy and Physiology of Joints.11 1.5 Spectrum of Bone and Joint Disease.13 1.6 Modalities for Imaging Bone and Joint Diseases. 14 1.7 Diagnosis of Bone and Joint Diseases by Nuclear Medicine Techniques.15 1.8 Technical Considerations.18 1.8.1 Pre-imaging Considerations.18 1.8.2 Imaging Considerations.22 1.8.3 Post-Imaging Considerations. 29 1.8.4 Sources of Diagnostic Errors.30 References.35 2 Diagnosis of Inflammatory Bone
Diseases.37 2.1 Introduction. 38 2.2 Pathophysiology.38 2.2.1 Inflammation.38 2.2.2 Skeletal Infections. 41 2.3 Imaging Skeletal Infections. 49 2.3.1 The Need for Diagnostic Imaging. 49 2.3.2 Imaging Modalities for Skeletal Infections.50 2.4 Diagnosis of Skeletal Infection by Imaging. 50 2.4.1 Diagnosis Using Morphologic Imaging Modalities.50 2.4.2 Diagnosis by Scintigraphic Methods. 52 2.4.3 Imaging Using Combined Modalities. 63 2.5 Diagnosis of Specific Forms of Skeletal Infections.63 2.5.1 Diabetic Foot Osteomyelitis.63 2.5.2 Vertebral Osteomyelitis (Spondylodiscitis).70 2.5.3 Chronic Active Osteomyelitis. 73 2.5.4 Periprosthetic Infection. 77 XI
x¡¡ Contents 2.5.5 2.5.6 Posttraumatic Osteomyelitis. 83 Osteomyelitis in Patients with Sickle Cell Disease. 84 2.5.7 Neonatal Osteomyelitis. 84 2.5.8 Epiphyseal Osteomyelitis. 84 2.6 Follow-Up of Response to Therapy. 85 2.7 Differentiating Osteomyelitis from Infectious Arthritis. 85 2.8 Differentiating Infection from Tumors. 85 2.9 Noninfectious Inflammatory Conditions. 86 2.9.1 Chronic Nonbacterial Osteomyelitis. 86 2.9.2 Osteitis Condensans Ilii. 88 2.9.3 Osteitis Pubis. 88 2.9.4 Infantile Cortical Hyperostosis (Caifey-Sillverman Disease). 88 2.9.5 Sternoclavicular Hyperostosis. 88 2.9.6 Osteitis Condensans of the Clavicle. 88 2.10 Scintigraphic Patterns of Skeletal Manifestations of Poliomyelitis. 90 References. 90 3 Diagnosis of Metabolic, Endocrine, and Congenital Bone
Disease. 101 3.1 Introduction. 101 3.2 Paget’s Disease (Osteitis Deformans). 102 3.3 Osteoporosis.109 3.4 Osteomalacia and Rickets. 114 3.5 Hyperparathyroidism.116 3.6 Renal Osteodystrophy.119 3.7 Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy).122 3.8 Hypertrophic Osteoarthropathy. 127 3.9 Fibrous Dysplasia. 128 3.10 Other Metabolic and Endocrine Conditions. 131 3.10.1 Hypothyroidism. 131 3.10.2 Hyperthyroidism. 131 3.10.3 Fluoride Toxicity.131 3.10.4 Aluminum Toxicity. 131 3.10.5 Hypervitaminosis A. 131 3.11 Osteopetrosis.132 3.12 Medullary Diaphyseal Sclerosis
(Medullary Diaphyseal Stenosis or Hardcastle Syndrome). 132 3.13 Gorlin’s Syndrome. 132 3.14 Progressive Diaphyseal Dysplasia (Camurati-Engelmann Disease). 134 3.15 Infantile Cortical Hyperostosis (Caffey-Silverman Syndrome). 136 3.16 Madibular Condylar Hyperplasia. 136 References.138
Contents xiii 4 Diagnosis of Traumatic Disorders. 147 4.1 Introduction.147 4.2 Pathophysiology. 148 4.2.1 Acute Fractures.148 4.2.2 Stress Fractures.149 4.2.3 Spondylolysis. 150 4.2.4 Spondylolisthesis.150 4.2.5 Fracture Healing.150 4.2.6 Trauma to Bone-Adjacent Structures.153 4.3 Scintigraphic Diagnosis of Acute Fractures.153 4.3.1 Role of Scintigraphy in Acute Fracture. 153 4.3.2 Scintigraphic Appearance of Acute Fractures.154 4.3.3 Scintigraphic Imaging of Specific Fractures.155 4.4 Scintigraphic Diagnosis of Stress Fractures.168 4.4.1 Role of Scintigraphy in Stress Fractures. 168 4.4.2 Scintigraphic Appearance of Stress Fractures.169 4.4.3 Scintigraphic Diagnosis of Specific Stress Fractures.172 4.5 Scintigraphic Evaluation of Fracture and Bone Graft
Healing.180 4.5.1 Evaluation of Fracture Healing.180 4.5.2 Evaluation of Bone Graft Viability. 180 4.5.3 Evaluation of Metallic Implants for Removal.181 4.6 Scintigraphic Diagnosis of Injuries to Bone-Adjacent Structures.182 4.6.1 Avulsion Injury.182 4.6.2 Skeletal Muscle Injury. 182 4.6.3 Post-Traumatic Soft Tissue Calcification. 183 4.6.4 Meniscal and Ligament Tears.183 4.6.5 Enthesopathies. 183 4.6.6 Impingement Syndromes. 183 References. 184 5 Diagnosis of Circulatory Disorders. 191 5.1 Introduction.191 5.2 Pathophysiology. 192 5.3 General Scintigraphic Features and Staging. 193 5.4 Distinctive Forms of Osteonecrosis. 195 5.4.1 Post-traumatic
Osteonecrosis. 195 5.4.2 Osteonecrosis of the Femoral Head in Children (Legg-Calvé-Perthes Disease).195 5.4.3 Osteonecrosis of the Femoral Head in Adults.199 5.4.4 Spontaneous Osteonecrosis of the Knee.201 5.4.5 Multifocal Osteonecrosis.204 5.4.6 Sickle Cell Disease Osteonecrosis. 205 5.4.7 Dysbaric Osteonecrosis.206 5.4.8 Osteochondroses Featuring Osteonecrosis.206 References.209
xìv Contenti 6 Neoplastic Bone Diseases. . 213 6.1 Introduction.214 6.2 Pathophysiology.215 6.2.1 Primary Bone Tumors. 215 6.2.2 Metastatic Bone Disease. 225 6.3 Imaging of Primary Bone Tumors.232 6.3.1 Overall Role of Imaging.232 6.3.2 Imaging of Major Specific Primary Tumors.236 6.4 Scintigraphy and Correlative Imaging of Metastatic Bone Disease.249 6.4.1 Scintigraphic Patterns of Bone Metastases on Bone Scans. 251 6.4.2 Scintigraphic Evaluation of Metastases of Certain Tumors.257 6.5 Follow-Up of Malignant Bone Disease.269 References. 272 7 Diagnosis of Joint Disorders.281 7.1 Introduction.282 7.2 Classification.282 7.3 Rheumatoid
Arthritis.283 7.4 Crystal Deposition Arthropathies.286 7.4.1 Gouty Arthritis.286 7.4.2 Calcium Pyrophosphate Dihydrate Deposition Disease.287 7.5 Infectious Arthritis.288 7.6 Osteoarthritis.288 7.7 Sacroiliitis.293 7.8 Neuroarthropathy.296 7.9 Spondyloarthropathies.296 7.9.1 Ankylosing Spondylitis.297 7.9.2 Psoriatic Arthritis.297 7.9.3 Reactive Arthritis (Reiter’s Disease).298 7.9.4 Enteropathie Spondylitis.299 7.10 Other Arthropathies and Related Conditions.299 7.10.1 Behçet’s Syndrome.299 7.10.2 Costochondritis (Tietze’s Syndrome).299 7.10.3 SAPHO Syndrome.299 7.10.4 Synovitis.300 7.11 Periarticular Soft
Tissue Syndromes.301 7.11.1 Diffuse Idiopathic Skeletal Hyperostosis (DISH).301 7.11.2 Septic Bursitis.302 7.11.3 Septic Tenosynovitis.302 7.11.4 Plantar Fasciitis.302 References.303
Contents XV 8 Bone Marrow Imaging. 307 8.1 Introduction. 307 8.2 Development and Structure of Bone Marrow. 307 8.3 Conversion and Reconversion. 310 8.4 Alterations to Bone Marrow. 311 8.5 Imaging of Bone Marrow.311 8.6 Bone Marrow Scintigraphy. 312 8.7 Clinical Uses of Bone Marrow Scintigraphy. 314 8.7.1 Diagnosis of Skeletal Infections. 314 8.7.2 Assessment and Follow-Up of Gaucher’s Disease. 317 8.7.3 Treatment Planning in Cancer Patients. 318 8.7.4 Paget’s Disease.319 8.7.5 Bone Marrow Tumors and Bone Marrow Extension. 320 8.7.6 Other Uses. 320 References. 320 9 Diagnosis of Soft Tissue Calcification. 323 9.1
Introduction.324 9.2 Dystrophic Calcification.324 9.3 Metastatic Calcification.325 9.4 Heterotopic Bone Formation. 331 9.4.1 Pathophysiology.331 9.4.2 Scintigraphic Evaluation.334 9.4.3 Correlative Imaging. 339 9.4.4 Special Forms of Heterotopic Bone Formation.339 9.5 Calcinosis Cutis. 344 9.5.1 Calcinosis Cutis Universalis.344 9.5.2 Calcinosis Cutis Circumscripta. 345 9.6 Rhabdomyolysis. 345 References. 345 10 Hybrid Imaging in the Diagnosis of Bone Diseases.349 10.1 Introduction. 349 10.2 SPECT/CT.349 10.2.1 Uses of SPECT/CT in Neoplastic Diseases.350 10.2.2 Uses of SPECT/CT in
Nonneoplastic Diseases. 353 10.3 PET/CT.372 10.3.1 F-18FDG PET/CT. 372 10.3.2 F-18 Sodium Fluoride PET/CT. 374 10.3.3 Combined F-18 NaF and F-18FDG PET/CT.376 10.3.4 Ga-68-Citrate PET/CT. 378 10.3.5 Ga-68 PSMA PET/CT. 378 10.4 PET/MR.378 References. 382
Contents XVI 11 Therapeutic Use of Radionuclides in Bone and Joint Disease. 387 11.1 Introduction. 388 11.2 Treatment of Cancer-Related Bone Pain.388 11.2.1 Rationale. 388 11.2.2 Radiopharmaceuticals.389 11.2.3 Mechanism of Action.392 11.2.4 Choice of Radiopharmaceutical.393 11.2.5 Clinical Use. 394 11.3 Radionuclide Synovectomy. 397 11.3.1 Rationale. 397 11.3.2 Radiopharmaceuticals.397 11.3.3 Choice of Radiopharmaceutical.400 11.3.4 Clinical Uses.401 11.4 Other Radionuclide Therapies.407 11.4.1 Treatment of Primary Osteogenic Sarcoma. 407 11.4.2 Metastatic Prostate Carcinoma.408 11.4.3 Multiple Myeloma.408 11.4.4 Treatment of Neuroblastoma.409 11.4.5 Bone Marrow
Ablation.410 References.410 Glossary. 417 Index. 421
This book, now in a revised and updated second edition, offers a comprehensive over view of the state of the art in orthopedic nuclear medicine, including the impressive recent advances in the field and the diagno sis of under-recognized conditions ori the basis of their imaging patterns. The opening chapters acquaint the reader briefly with anatomic, physiologic, pathologic, and tech nical concepts crucial to a sound under standing of orthopedic nuclear medicine and its utilization in clinical practice. The imaging diagnosis of skeletal infections, trauma, vascular disorders, metabolic and neoplastic bone diseases, soft tissue calcifica tions, and joint disorders is then explained in detail. Two entirely new chapters, on bone marrow imaging and hybrid imaging of bone diseases, have been added to this edition. A separate chapter is devoted to the use of radionuclides for the treatment of bone and joint disorders. The book is richly illustrated and amply documents the effec tiveness of nuclear medicine in diagnosing bone disease. It will prove invaluable to all with an interest in diagnostic and therapeu tic orthopedics, including orthopedists, radiologists, rheumatologists, pediatricians, podiatrists, other clinicians, and all nuclear and molecular imaging professionals. Elgazzar Orthopedic Nuclear Medicine Second Edition |
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| author | Elgazzar, Abdelhamid H. 1949- |
| author_GND | (DE-588)122224531 |
| author_facet | Elgazzar, Abdelhamid H. 1949- |
| author_role | aut |
| author_sort | Elgazzar, Abdelhamid H. 1949- |
| author_variant | a h e ah ahe |
| building | Verbundindex |
| bvnumber | BV046622068 |
| classification_rvk | YR 7300 YR 7301 |
| ctrlnum | (OCoLC)1159263826 (DE-599)BVBBV046622068 |
| dewey-full | 616.07548 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07548 |
| dewey-search | 616.07548 |
| dewey-sort | 3616.07548 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| edition | Second Edition |
| format | Book |
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| id | DE-604.BV046622068 |
| illustrated | Illustrated |
| index_date | 2024-07-03T14:08:26Z |
| indexdate | 2024-07-10T08:49:30Z |
| institution | BVB |
| isbn | 9783319561653 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-032033764 |
| oclc_num | 1159263826 |
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| owner | DE-384 |
| owner_facet | DE-384 |
| physical | xvi, 431 Seiten Illustrationen, Diagramme |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Springer |
| record_format | marc |
| spelling | Elgazzar, Abdelhamid H. 1949- Verfasser (DE-588)122224531 aut Orthopedic Nuclear Medicine Abdelhamid H. Elgazzar Second Edition Berlin Springer [2017] xvi, 431 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Medicine Nuclear medicine Internal medicine Orthopedics Medicine & Public Health Nuclear Medicine Internal Medicine Medizin Skelettszintigraphie (DE-588)4116512-3 gnd rswk-swf Knochenkrankheit (DE-588)4120576-5 gnd rswk-swf Gelenkkrankheit (DE-588)4121336-1 gnd rswk-swf Bewegungsapparat (DE-588)4006318-5 gnd rswk-swf Nuklearmedizin (DE-588)4042770-5 gnd rswk-swf Knochenkrebs (DE-588)4031331-1 gnd rswk-swf Knochenkrebs (DE-588)4031331-1 s Skelettszintigraphie (DE-588)4116512-3 s DE-604 Gelenkkrankheit (DE-588)4121336-1 s Bewegungsapparat (DE-588)4006318-5 s Nuklearmedizin (DE-588)4042770-5 s Knochenkrankheit (DE-588)4120576-5 s 1\p DE-604 Erscheint auch als Online-Ausgabe 978-3-319-56167-7 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032033764&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032033764&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Elgazzar, Abdelhamid H. 1949- Orthopedic Nuclear Medicine Medicine Nuclear medicine Internal medicine Orthopedics Medicine & Public Health Nuclear Medicine Internal Medicine Medizin Skelettszintigraphie (DE-588)4116512-3 gnd Knochenkrankheit (DE-588)4120576-5 gnd Gelenkkrankheit (DE-588)4121336-1 gnd Bewegungsapparat (DE-588)4006318-5 gnd Nuklearmedizin (DE-588)4042770-5 gnd Knochenkrebs (DE-588)4031331-1 gnd |
| subject_GND | (DE-588)4116512-3 (DE-588)4120576-5 (DE-588)4121336-1 (DE-588)4006318-5 (DE-588)4042770-5 (DE-588)4031331-1 |
| title | Orthopedic Nuclear Medicine |
| title_auth | Orthopedic Nuclear Medicine |
| title_exact_search | Orthopedic Nuclear Medicine |
| title_exact_search_txtP | Orthopedic Nuclear Medicine |
| title_full | Orthopedic Nuclear Medicine Abdelhamid H. Elgazzar |
| title_fullStr | Orthopedic Nuclear Medicine Abdelhamid H. Elgazzar |
| title_full_unstemmed | Orthopedic Nuclear Medicine Abdelhamid H. Elgazzar |
| title_short | Orthopedic Nuclear Medicine |
| title_sort | orthopedic nuclear medicine |
| topic | Medicine Nuclear medicine Internal medicine Orthopedics Medicine & Public Health Nuclear Medicine Internal Medicine Medizin Skelettszintigraphie (DE-588)4116512-3 gnd Knochenkrankheit (DE-588)4120576-5 gnd Gelenkkrankheit (DE-588)4121336-1 gnd Bewegungsapparat (DE-588)4006318-5 gnd Nuklearmedizin (DE-588)4042770-5 gnd Knochenkrebs (DE-588)4031331-1 gnd |
| topic_facet | Medicine Nuclear medicine Internal medicine Orthopedics Medicine & Public Health Nuclear Medicine Internal Medicine Medizin Skelettszintigraphie Knochenkrankheit Gelenkkrankheit Bewegungsapparat Nuklearmedizin Knochenkrebs |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032033764&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=032033764&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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