Molecular biology: principles of genome function
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| Main Authors: | , , , , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford
Oxford University Press
[2021]
|
| Edition: | Third edition |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Seite 837-946 nur online verfügbar unter: www.oup.com/he/craig3e/ |
| Physical Description: | XXXIV, 983 Seiten Illustrationen, Diagramme |
| ISBN: | 9780198788652 |
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Abbreviations 1 m Genomes and the flow of biological information Introduction 1 1 1.1 The roots ol biology 1 1.2 The genome: a working blueprint for life 5 1.3 Bringing genes to life: gene expression 1.4 Regulating gene expression 9 12 1.5 Cellular infrastructure and gene expression 15 1.6 Expression of the genome 18 1.7 2 Evolution of the genome and the tree of life Biological molecules 21 30 Introduction 30 2.1 Atoms, molecules, and chemical bonds 31 2.2 Life in aqueous solution 35 2.3 Non-covalent interactions 37 2.4 Nucleotides and nucleic acids 40 2.5 The structure of DNA 45 2.6 Chemical properties of RNA 53 2.7 RNA folding and structure 56 2.8 The RNA world and its role in the evolution of modern-day life 58 2.9 Fundamentals of protein structure 61 Protein folding 65 2.10 2.11 Protein folds 70 2.12 Protein-DNA interactions 72 2.13 Sugars and carbohydrates 74 2.14 Lipids 76 2.15 Chemical modification in biologicalregulation 80 3 The chemical basis of life 86 Introduction 86 3.1 Thermodynamic rules in biological systems 86 3.2 Binding equilibria and kinetics 94 3.3 Binding processes in biology 3.4 Enzyme catalysis 104 3.5 Enzyme kinetics 111 4 Chromosome structure and function 98 117 Introduction 117 4.1 Organization of chromosomes 118 4.2 The cell cycle and chromosome dynamics 120
CONTENTS IN FULL 4.3 Packaging chromosomal DNA 123 4.4 Variation in chromatin structure 130 4.5 Covalent modifications of histones 131 4.6 Nucleosome remodeling complexes 137 4.7 DNA méthylation 139 4.8 Elements required for chromosome function 143 4.9 The centromere 144 The telomere 148 4.10 4.11 The separation of chromatin domains by boundaryelements 150 4.12 Chromosome architecture in the nucleus 153 5 The cell cycle 165 Introduction 165 5.1 Steps in the eukaryotic cell cycle 165 5.2 Cyclins and Cdks 169 5.3 Regulation of Cdk activity 174 5.4 Cell cycle regulation by Cdks 176 5.5 Regulation of proteolysis by Cdks 178 5.6 Checkpoints: intrinsic pathways that can haltthe cell cycle 183 5.7 Extrinsic regulators of cell cycle progression 186 5.8 The cell cycle and cancer 188 5.9 The bacterial cell cycle 190 6 DNA replication 200 Introduction 200 6.1 Overview of DNA replication 200 6.2 DNA polymerase: its mechanism of action 207 6.3 Initiation: origin binding and unwinding 209 6.4 Initiation: priming and strand elongation 215 6.5 Elongation: fidelity of DNA polymerases 220 6.6 Elongation: coordinating leading and lagging strandsynthesis at the fork 225 6.7 Termination of DNA replication 231 6.8 Regulation of the initiation of replication in E. coli 238 6.9 Regulation of the initiation of replication in eukaryotes 240 6.10 The end-replication problem and telomerase 244 6.11 Replicating through chromatin in eukaryotes 250 7 Chromosome segregation 257 Introduction 257 7.1 The stages of mitosis 257 7.2 Chromosome condensation and cohesion 259 7.3 The mitotic spindle 265 7.4
Prometaphase and metaphase 272 7.5 Anaphase: an irreversible step in chromosome segregation 278 7.6 The completion of mitosis and cytokinesis 285 7.7 Meiosis: generating haploid gametes from diploid cells 287 7.8 Chromosome segregation in bacteria 295
CONTENTS IN FULL 8 Transcription 305 Introduction 305 8.1 Overview of transcription 305 8.2 RNA polymerase core enzyme 308 8.3 Promoter recognition in bacteriaand eukaryotes 311 8.4 Initiation of transcription and transition to an elongating complex 324 8.5 Transcription elongation 330 8.6 Transcription termination 335 9 Regulation of transcription 9.1 341 Introduction 341 Principles of transcription regulation 341 9.2 DNA-binding domains in proteins that regulate transcription 346 9.3 Mechanisms for regulating transcriptioninitiation in bacteria 351 9.4 Competition between cl and Cro and control of the fate of bacteriophage lambda 356 9.5 Regulation of transcription termination in bacteria 362 9.6 Regulation of transcription initiation and elongation in eukaryotes 366 9.7 Combinatorial regulation of eukaryotic transcription 371 9.8 The role of signaling cascades in the regulation of transcription 374 9.9 Gene silencing 376 10 RNA processing 385 Introduction 385 10.1 Overview of RNA processing 385 10.2 tRNA and rRNA processing 388 10.3 tRNA and rRNA nucleotide modifications 393 10.4 mRNA capping and polyadenylation 395 10.5 RNA splicing 398 10.6 Eukaryotic mRNA splicing by the spliceosome 403 10.7 Exon definition and alternative splicing 410 10.8 RNA editing 416 10.9 Degradation of normal RNAs 10.10 Degradation of foreign and defective RNAs 10.11 11 RNA-binding domains in proteins Translation Introduction 11.1 Overview of translation 422 425 428 434 434 434 11.2 tRNA and the genetic code 436 11.3 Aminoacyl-tRNA synthetases 439 11.4 11.5 Structure of the ribosome The
translation cycle: the ribosome in action 444 448 11.6 Protein factors critical to the translation cycle 452 11.7 Translation initiation: shared featuresin bacteria and eukaryotes 457 11.8 Bacterial translation initiation 458 11.9 Eukaryotic translation initiation 460 XXI
11.10 Translation elongation: decoding, peptide bond formation, and translocation 465 11.11 Translation termination, recycling, and reinitiation 470 11.12 Ribosome rescue in bacteria and eukaryotes 475 11.13 Recoding: programmed stop codon read-through and frameshifting 484 11.14 Antibiotics that target the ribosome 490 12 Regulation of translation 498 Introduction 498 12.1 Global regulation of translation initiation in bacteria and eukaryotes 498 12.2 Regulation of translation initiation by c/s-acting sequences in the 5' untranslated region in bacteria and eukaryotes 501 12.3 Regulation of translation initiation through c/s-acting sequences in the 3' UTR in eukaryotes 506 12.4 Regulation of translation elongation in bacteria and eukaryotes 512 12.5 Viral corruption of the translational machinery 514 13 Regulatory RNAs 520 Introduction 520 13.1 Overview of regulatory RNAs 523 13.2 Bacterial base-pairing sRNAs 525 13.3 Eukaryotic sRNAs: miRNAs, siRNAs, and piRNAs 528 13.4 Processing of eukaryotic sRNAs 529 13.5 Loading of Argonaute family proteins with eukaryotic sRNAs 539 13.6 Gene silencing by small eukaryotic RNAs 542 13.7 Viral defense by the CRISPR systems in bacteria and archaea 549 13.8 RNA-mediated regulation in cis 557 13.9 Protein-binding regulatory RNAs 560 13.10 Long intergenic non-coding RNAs 562 14 Protein modification and targeting 573 Introduction 573 14.1 Chaperone-assisted protein folding 573 14.2 Targeting of proteins throughout the cell 578 14.3 Post-translational cleavage of the polypeptide chain 582 14.4 Covalent rearrangements yield a fluorescent
protein 584 14.5 Lipid modification of proteins 586 14.6 Glycosylation of proteins 592 14.7 Protein phosphorylation, acetylation, and méthylation 595 14.8 Protein modification by nucleotides 603 14.9 Direct chemical modification of proteins 606 14.10 Ubiquitination and sumoylation of proteins 608 14.11 Protein degradation 615 15 Cellular responses to DNA damage 622 Introduction 622 15.1 Types of DNA damage 623 15.2 Post-replication mismatch repair 627 15.3 Repair of DNA damage by direct reversal 630
CONTENTS IN FULL Repair of DNA damage by base excision repair 15.4 631 15.5 Nucleotide excision repair of bulky lesions 632 15.6 Translesion DNA synthesis 635 15.7 The DNA damage response 637 15.8 The DNA damage response in bacteria 641 15.9 The DNA damage response in eukaryotes 644 DNA damage and cell death in mammalian cells 655 15.10 16 Repair of DNA double-strand breaks and homologous recombination Introduction 16.1 664 664 An overview of DNA double-strand break repair and homologous recombination 665 16.2 Double-strand break repair by NHEJ 667 16.3 Homology-directed repair of double-strand breaks 669 16.4 Generation of single-stranded DNA by helicases and nucleases 672 16.5 The mechanism of DNA strand pairing and exchange 676 16.6 Gene conversion through homology-directed repair 679 16.7 Homologous recombination 685 16.8 Repair of damaged replication forks by homology-directed repair 699 16.9 Chromosome rearrangements during aberrant recombination and repair 702 17 Mobile DNA 711 Introduction 711 17.1 Transposable elements: overview 711 17.2 An overview of DNA-only transposons 718 17.3 The mechanism of DNA-only cut-and-paste transposition 719 17.4 DNA cut-and-paste transposition in adaptive immunity 724 17.5 Retrotransposons 736 17.6 LTR retrotransposons 737 17.7 Non-LTR retrotransposons: LINES, SINEs, and Group II mobile introns 740 17.8 Transposable elements in the human genome 744 17.9 17.10 Control of transposition 748 CSSR: overview 756 17.11 CSSR systems that control gene expression 760 17.12 CSSR conversion of DNA dimers to monomers 763 17.13 18 Bacteriophage
lambda integration and excision Genomics and genetic variation 18.1 766 777 Introduction 777 Genome sequences and sequencing projects 778 18.2 Finding functions in a genome 781 18.3 Functional genomics 785 18.4 High-throughput genome-wide-omics projects 796 18.5 The evolving genome: evolutionary forces 798 18.6 The evolving genome: mechanisms of variation 800 18.7 Gene duplication and divergence of gene function 807 18.8 Reorganization of chromosomes 810 XXIII
XXIV CONTENTS IN FULL 18.9 Epigenetics and imprinting 18.10 Human genome variation 811 812 18.11 Human genetic diseases: finding disease loci 815 18.12 Human genetics: impacts and implications 825 19 Tools and techniques in molecular biology 835 Introduction 835 19.1 Model organisms 836 19.2 Cultured cells and viruses 845 19.3 Amplification of DNA and RNA sequences 849 19.4 DNA cloning 854 19.5 Undirected genome manipulation 861 19.6 Directed genome manipulation 864 19.7 Detection of biological molecules 19.8 Separation and isolation of biological molecules 19.9 873 878 Identifying the composition of biological molecules 887 19.10 Obtaining and analyzing sequences ona genomic scale 894 19.11 Detection of specific DNA sequences 901 19.12 Detection of specific RNA molecules 907 19.13 Detection of specific proteins 913 19.14 Detection of interactions between molecules 916 19.15 Genome-wide detection of interactions between molecules 923 19.16 Imaging cells and molecules 927 19.17 Molecular structure determination 936 Glossary 947 Index 969 |
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| spelling | Craig, Nancy Lynn 1952- Verfasser (DE-588)142435937 aut Molecular biology principles of genome function Nancy L Craig, Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, Orna Cohen-Fix ; with end of chapter questions by Deborah Zies and Claire burns Third edition Oxford Oxford University Press [2021] XXXIV, 983 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Seite 837-946 nur online verfügbar unter: www.oup.com/he/craig3e/ Genome Genomes Molecular Biology Molecular biology Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Molekulargenetik (DE-588)4039987-4 s DE-604 Molekularbiologie (DE-588)4039983-7 s Green, Rachel Verfasser aut Greider, Carol W. 1961- Verfasser (DE-588)139389415 aut Storz, Gisela Verfasser (DE-588)1171011059 aut Wolberger, Cynthia 1957- Verfasser (DE-588)1259096149 aut Cohen-Fix, Orna Verfasser aut Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031828773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Craig, Nancy Lynn 1952- Green, Rachel Greider, Carol W. 1961- Storz, Gisela Wolberger, Cynthia 1957- Cohen-Fix, Orna Molecular biology principles of genome function Genome Genomes Molecular Biology Molecular biology Molekulargenetik (DE-588)4039987-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4039987-4 (DE-588)4039983-7 (DE-588)4123623-3 |
| title | Molecular biology principles of genome function |
| title_auth | Molecular biology principles of genome function |
| title_exact_search | Molecular biology principles of genome function |
| title_full | Molecular biology principles of genome function Nancy L Craig, Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, Orna Cohen-Fix ; with end of chapter questions by Deborah Zies and Claire burns |
| title_fullStr | Molecular biology principles of genome function Nancy L Craig, Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, Orna Cohen-Fix ; with end of chapter questions by Deborah Zies and Claire burns |
| title_full_unstemmed | Molecular biology principles of genome function Nancy L Craig, Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, Orna Cohen-Fix ; with end of chapter questions by Deborah Zies and Claire burns |
| title_short | Molecular biology |
| title_sort | molecular biology principles of genome function |
| title_sub | principles of genome function |
| topic | Genome Genomes Molecular Biology Molecular biology Molekulargenetik (DE-588)4039987-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Genome Genomes Molecular Biology Molecular biology Molekulargenetik Molekularbiologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031828773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT craignancylynn molecularbiologyprinciplesofgenomefunction AT greenrachel molecularbiologyprinciplesofgenomefunction AT greidercarolw molecularbiologyprinciplesofgenomefunction AT storzgisela molecularbiologyprinciplesofgenomefunction AT wolbergercynthia molecularbiologyprinciplesofgenomefunction AT cohenfixorna molecularbiologyprinciplesofgenomefunction |