The effect of CTLA-4 lg on B cells:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Freiburg im Breisgau
2019
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | VIII, 74 Blätter Illustrationen, Diagramme |
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MARC
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| 245 | 1 | 0 | |a The effect of CTLA-4 lg on B cells |c vorgelegt 2019 von Lea Isabella Walter |
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Record in the Search Index
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|---|---|
| adam_text | TABLE
OF
CONTENTS
1
ABBREVIATIONS
VII
2
INTRODUCTION
1
2.1
RHEUMATOID
ARTHRITIS
1
2.2
THE
ROLE
OF
AGFA
IN
RA
6
2.3
B
CELL
DEVELOPMENT
7
2.4
GERMINAL
CENTER
FORMATION
8
2.5
REGULATION
OF
COSTIMULATORY
SIGNAL
IN
T-B-COOPERATION
10
2.6
ABATACEPT
IN
RA
13
2.7
OBJECTIVES
14
3
MATERIAL
AND
METHODS
15
3.1
MEDIA
AND
BUFFERS
15
3.1.1
MEDIA
15
3.1.2
BUFFERS
15
3.2
HUMAN
MATERIAL
16
3.3
PBMC
ISOLATION
FROM
WHOLE
BLOOD
18
3.4
FREEZING
AND
THAWING
OF
CELLS
18
3.5
DETERMINATION
OF
LIVE
CELL
NUMBERS
19
3.6
B
CELL
SEPARATION
19
3.7
FLOW
CYTOMETRY
20
3.8
POLYCLONAL
STIMULATION
OF
B
CELLS
23
3.9
ENZYME-LINKED
IMMUNOSORBENT
ASSAY
23
3.10
STUDY
DESIGN
23
4
RESULTS
25
4.1
TREATMENT
WITH
ABATACEPT
REDUCES
DAS28-CRP,
CRP
AND
RF
AND
RESULTS
IN
DECREASED
MINIMAL
CORTICOSTEROID
DOSE
REQUIREMENT
25
4.2
PATIENTS
TREATED
WITH
ABATACEPT
PRESENT
A
REDUCTION
IN
TOTAL
LEUKOCYTES
AND
CD19+
CELL
NUMBER
30
4.3
DISTRIBUTION
OF
B
CELL
SUBPOPULATIONS
IS
STABLE
UNDER
ABATACEPT
TREATMENT
IN
RA
PATIENTS
33
4.4
ISOTYPE
SPECIFIC
DISTRIBUTION
OF
MEMORY
CELLS
IS
MAINTAINED
THROUGHOUT
ABATACEPT
TREATMENT
36
4.5
CD80
AND
CD86
EXPRESSION
CONSTANT
UNDER
ABATACEPT
THERAPY,
HLA-DR
SLIGHTLY
IN
CREASED
37
4.6
TACI
EXPRESSION
IS
STABLE,
BAFFR
EXPRESSION
TENDS
TO
INCREASE
UNDER
ABATACEPT
THERAPY
40
4.7
CD71+
B
CELL
FRACTION
CONSTANT
UNDER
ABATACEPT
THERAPY
41
IV
4.8
TREND
TO
REDUCTION
OF
CD21
LOW
CELLS
UNDER
ABATACEPT
THERAPY
........................................
42
4.9
PLASMABLAST
PROPORTION
MAINTAINED,
TRANSITIONAL
CELLS
SLIGHTLY
INCREASING
THROUGHOUT
ABATACEPT
TREATMENT
.................................................................................................................
43
4.10
REDUCTION
OF
ACPA-SPECIFIC
MEMORY
CELL
FREQUENCY
UNDER
ABATACEPT
TREATMENT
...........
44
4.11
DIVERSIFICATION
OF
ACPA
EPITOPE
SPECIFICITIES
UPON
ABATACEPT
TREATMENT
.........................
45
5
DISCUSSION
.......................................................................................................47
5.1
CLINICAL
RESPONSE
TO
ABATACEPT
TREATMENT
IN
RA
PATIENTS
..................................................
47
5.2
IMMUNOLOGICAL
PHENOTYPE
RESPONSE
TO
CTLA-4
IG
THERAPY
...............................................
48
5.3
ABATACEPT
INITIATES
A
DECREASE
OF
ACPA-SPECIFIC
MEMORY
B
CELLS
...................................
51
5.4
CHANGES
IN
ACPA
EPITOPE
SPECIFICITY
.................................................................................
52
5.5
OUTLOOK
...............................................................................................................................
54
6
SUMMARY
..........................................................................................................
56
7
ZUSAMMENFASSUNG
..........................................................................................
57
8
APPENDIX
.........................................................................................................
58
8.1
REFERENCES
.........................................................................................................................
58
8.2
LIST
OF
FIGURES
......................................................................................................................
68
8.3
LIST
OF
TABLES
.......................................................................................................................
69
8.4
PUBLICATIONS
........................................................................................................................
70
8.5
EIDESSTATTLICHE
VERSICHERUNG
..............................................................................................
72
8.6
ERKLARUNG
ZUM
EIGENANTEIL
.................................................................................................
73
8.7
ACKNOWLEDGEMENTS
............................................................................................................
74
V
|
| any_adam_object | 1 |
| author | Walter, Lea Isabella |
| author_GND | (DE-588)1199399892 |
| author_facet | Walter, Lea Isabella |
| author_role | aut |
| author_sort | Walter, Lea Isabella |
| author_variant | l i w li liw |
| building | Verbundindex |
| bvnumber | BV046287030 |
| ctrlnum | (OCoLC)1130285679 (DE-599)KXP1681690470 |
| discipline | Medizin |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV046287030 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:40:38Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031664590 |
| oclc_num | 1130285679 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | VIII, 74 Blätter Illustrationen, Diagramme |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| record_format | marc |
| spelling | Walter, Lea Isabella Verfasser (DE-588)1199399892 aut The effect of CTLA-4 lg on B cells vorgelegt 2019 von Lea Isabella Walter Freiburg im Breisgau 2019 VIII, 74 Blätter Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Albert-Ludwigs-Universität Freiburg im Breisgau 2019 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1200558626/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031664590&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Walter, Lea Isabella The effect of CTLA-4 lg on B cells |
| subject_GND | (DE-588)4113937-9 |
| title | The effect of CTLA-4 lg on B cells |
| title_auth | The effect of CTLA-4 lg on B cells |
| title_exact_search | The effect of CTLA-4 lg on B cells |
| title_full | The effect of CTLA-4 lg on B cells vorgelegt 2019 von Lea Isabella Walter |
| title_fullStr | The effect of CTLA-4 lg on B cells vorgelegt 2019 von Lea Isabella Walter |
| title_full_unstemmed | The effect of CTLA-4 lg on B cells vorgelegt 2019 von Lea Isabella Walter |
| title_short | The effect of CTLA-4 lg on B cells |
| title_sort | the effect of ctla 4 lg on b cells |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1200558626/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031664590&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT walterleaisabella theeffectofctla4lgonbcells |
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