Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
Jena
[2019]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 100 Blätter Illustrationen 30 cm |
Staff View
MARC
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| 264 | 1 | |a Jena |c [2019] | |
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| 650 | 0 | 7 | |8 3\p |a Somatostatin |0 (DE-588)4055484-3 |2 gnd |
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Record in the Search Index
| _version_ | 1804180713878061056 |
|---|---|
| adam_text | INHALTSVERZEICHNIS
1.
ZUSAMMENFASSUNG
..........................................................................................................................
7
2.
EINLEITUNG
.....................................................................................................................................
10
2.1.
ASTROZYTOME
...........................................................................................................................
10
2.1.1.
DEFINITION
........................................................................................................................
10
2.1.2.
EINORDNUNG
......................................................................................................................
10
2.1.3.
EPIDEMIOLOGIE
................................................................................................................
10
2.1.4.
AETIOLOGIE
.........................................................................................................................
11
2.1.5.
PATHOGENESE
....................................................................................................................
12
2.1.6.
MAKROSKOPISCHE
MORPHOLOGIE
.....................................................................................
17
2.1.7.
HISTOLOGIE
........................................................................................................................
18
2.1.8.
KLINIK
..............................................................................................................................
19
2.1.9.
DIAGNOSTIK
......................................................................................................................
19
2.1.10.
THERAPIE
.......................................................................................................................
22
2.1.11.
PROGNOSE
.......................................................................................................................
25
2.2.
SOMATOSTATINE
........................................................................................................................
25
2.2.1.
AUFBAU
UND
VORKOMMEN
.............................................................................................
25
2.2.2.
FUNKTIONEN
.....................................................................................................................
25
2.3.
SOMATOSTATIN-REZEPTOREN
.....................................................................................................
26
2.3.1.
AUFBAU
UND
VORKOMMEN
..............................................................................................26
2.3.2.
SIGNALTRANSDUKTION
........................................................................................................
27
2.3.3.
SOMATOSTATIN-REZEPTOREN
UND
KANZEROGENESE
........................................................... 28
2.3.4.
SOMATOSTATIN-REZEPTOREN
ALS
ZIELSTRUKTUREN
FUER
DIE
DIAGNOSTIK
UND
THERAPIE
......
29
2.4.
CHEMOKINE
............................................................................................................................
30
2.4.1.
AUFBAU
............................................................................................................................
30
2.4.2.
FUNKTION
.........................................................................................................................
31
2.4.3.
DAS
CHEMOKIN
CXCL12
...............................................................................................
31
2.5.
CHEMOKIN-REZEPTOREN
.........................................................................................................
32
2.5.1.
ALLGEMEINER
AUFBAU
......................................................................................................
32
2.5.2.
CXCR4-REZEPTOR
..........................................................................................................
33
2.5.2.1.
VORKOMMEN
UND
FUNKTIONEN
................................................................................
33
2.5.2.2.
SIGNALTRANSDUKTION
DES
CXCR4
............................................................................34
2.5.2.3.
CXCR4-REZEPTOR
UND
KANZEROGENESE
.................................................................
35
2.5.2.4.
DER
CXCR4
ALS
DIAGNOSTISCHE
ZIELSTRUKTUR
.........................................................
36
2.5.2.5.
DER
CXCR4
ALS
THERAPEUTISCHE
ZIELSTRUKTUR
........................................................
38
4
2.6.
ENDOTHELINE
............................................................................................................................
39
2.6.1.
AUFBAU
UND
VORKOMMEN
..............................................................................................39
2.7.
ENDOTHELIN-REZEPTOREN
........................................................................................................
39
2.7.1.
AUFBAU,
VORKOMMEN
UND
FUNKTIONEN
........................................................................
39
2.7.2.
SIGNALTRANSDUKTION
........................................................................................................
40
2.7.3.
ENDOTHELIN-REZEPTOREN
UND
KANZEROGENESE
...............................................................42
2.7.4.
NUTZUNG
ALS
THERAPEUTISCHE
ZIELSTRUKTUREN
..................................................................
42
3.
ZIELE
DER
ARBEIT
...........................................................................................................................
44
4.
MATERIALIEN
UND
METHODEN
.........................................................................................................
45
4.1.
MATERIALIEN
UND
SUBSTANZEN
.................................................................................................
45
4.1.1.
PRAEPARATE
........................................................................................................................
45
4.1.2.
PUFFER
UND
LOESUNGEN
.....................................................................................................
45
4.1.3.
SUBSTANZEN
FUER
DIE
IMMUNHISTOCHEMIE
.......................................................................
46
4.1.4.
GERAETE
UND
SONSTIGE
MATERIALIEN
..................................................................................47
4.1.5.
ANTIKOERPER
......................................................................................................................
48
4.2.
METHODEN
...............................................................................................................................50
4.2.1.
IMMUNHISTOCHEMIE
........................................................................................................
50
4.2.1.1.
ENTPARAFFINIEREN
DER
SCHNITTE
UND
DEMASKIERUNG
DER
ANTIGENSTRUKTUREN
....... 50
4.2.1.2.
ANTIKOERPERBINDUNG
UND
FAERBUNG
..........................................................................
51
4.2.1.3.
HAEMATOXYLIN-GEGENFARBUNG
UND
EINDECKEN
DER
PRAEPARATE
................................
52
4.2.2.
HAEMATOXYLIN-EOSIN-UEBERSICHTSFARBUNG
......................................................................
52
4.2.3.
KI-67-PROTEIN
.................................................................................................................
52
4.2.4.
IMMUNREAKTIVER
SCORE
NACH
REMMELE
UND
STEGNER
...................................................
53
4.2.5.
STATISTISCHE
AUSWERTUNG
................................................................................................54
5.
ERGEBNISSE
....................................................................................................................................
56
5.1.
PATIENTENDATEN
.......................................................................................................................
56
5.2.
KLINISCHE
DATEN
....................................................................................................................
58
5.2.1.
HISTOPATHOLOGISCHE
UND
IMMUNHISTOCHEMISCHE
MARKER
............................................
58
5.2.2.
UEBERLEBEN
.......................................................................................................................
59
5.3.
IMMUNHISTOCHEMIE
...............................................................................................................
61
5.3.1.
AUSWERTUNG
DER
SOMATOSTATIN-REZEPTOR-FAERBUNG
......................................................
61
5.3.2.
AUSWERTUNG
DER
CXCR4-FAERBUNG
...............................................................................67
5.3.3.
AUSWERTUNG
DER
ETA-FAERBUNG
....................................................................................
68
5.3.4.
EXPRESSIONSMUSTER
........................................................................................................
70
5.4.
KORRELATIONEN
........................................................................................................................
72
5
5.4.1.
REZEPTOREXPRESSION
UND
KLINISCHE
DATEN
....................................................................
72
6.
DISKUSSION
....................................................................................................................................
80
6.1.
IMMUNHISTOCHEMISCHE
UNTERSUCHUNG
DER
TUMORPRAEPARATE
..............................................
80
6.1.1.
HAEUFIGKEITEN
DER
EXPRESSION
DER
SOMATOSTATIN-REZEPTORSUBTYPEN
...........................80
6.1.2.
HAEUFIGKEIT
DER
EXPRESSION
DES
CXCR4
......................................................................
82
6.1.3.
HAEUFIGKEIT
DER
EXPRESSION
DES
ETA
.............................................................................
83
6.1.4.
EXPRESSIONSMUSTER
........................................................................................................
83
6.1.5.
REZEPTOREXPRESSION
AUF
TUMORGEFAESSEN
......................................................................
84
6.2.
KORRELATION
DER
EXPRESSIONSSTAERKE
DER
REZEPTORSUBTYPEN
UNTEREINANDER
.......................
85
6.3.
KORRELATION
DER
EXPRESSIONSSTAERKE
DER
REZEPTORSUBTYPEN
MIT
WEITEREN
KLINISCHEN
PARAMETERN
....................................................................................................................................
85
6.4.
UEBERLEBEN
...............................................................................................................................
86
7.
SCHLUSSFOLGERUNGEN
.....................................................................................................................
89
8.
LITERATURVERZEICHNIS
.....................................................................................................................
91
9.
ANHANG
.........................................................................................................................................
98
9.1.
LEBENSLAUF
............................................................................................................................
98
9.2.
EHRENWOERTLICHE
ERKLAERUNG
....................................................................................................99
9.3.
DANKSAGUNG
.........................................................................................................................
100
6
|
| any_adam_object | 1 |
| author | Lange, Franziska 1994- |
| author_GND | (DE-588)1196808724 |
| author_facet | Lange, Franziska 1994- |
| author_role | aut |
| author_sort | Lange, Franziska 1994- |
| author_variant | f l fl |
| building | Verbundindex |
| bvnumber | BV046270695 |
| ctrlnum | (OCoLC)1129395502 (DE-599)DNB1196556822 |
| discipline | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV046270695 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:40:08Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031648523 |
| oclc_num | 1129395502 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 100 Blätter Illustrationen 30 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| record_format | marc |
| spelling | Lange, Franziska 1994- Verfasser (DE-588)1196808724 aut Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen von Franziska Lange Jena [2019] 100 Blätter Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Schiller-Universität Jena 2019 1\p Rezeptor (DE-588)4049722-7 gnd 2\p Astrozytom (DE-588)4143258-7 gnd 3\p Somatostatin (DE-588)4055484-3 gnd (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1196556822/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031648523&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p maschinell gebildet 0,20620 20191015 DE-101 2\p maschinell gebildet 0,07332 20191015 DE-101 3\p maschinell gebildet 0,03086 20191015 DE-101 |
| spellingShingle | Lange, Franziska 1994- Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen 1\p Rezeptor (DE-588)4049722-7 gnd 2\p Astrozytom (DE-588)4143258-7 gnd 3\p Somatostatin (DE-588)4055484-3 gnd |
| subject_GND | (DE-588)4049722-7 (DE-588)4143258-7 (DE-588)4055484-3 (DE-588)4113937-9 |
| title | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen |
| title_auth | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen |
| title_exact_search | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen |
| title_full | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen von Franziska Lange |
| title_fullStr | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen von Franziska Lange |
| title_full_unstemmed | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen von Franziska Lange |
| title_short | Expression verschiedener Neuropeptid-Rezeptoren in Astrozytomen |
| title_sort | expression verschiedener neuropeptid rezeptoren in astrozytomen |
| topic | 1\p Rezeptor (DE-588)4049722-7 gnd 2\p Astrozytom (DE-588)4143258-7 gnd 3\p Somatostatin (DE-588)4055484-3 gnd |
| topic_facet | Rezeptor Astrozytom Somatostatin Hochschulschrift |
| url | https://d-nb.info/1196556822/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031648523&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT langefranziska expressionverschiedenerneuropeptidrezeptoreninastrozytomen |
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