The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Aachen
[2019]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | V, 67 Seiten Illustrationen 21 cm |
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| 245 | 1 | 0 | |a The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model |c vorgelegt von Weikang Wang |
| 264 | 1 | |a Aachen |c [2019] | |
| 300 | |a V, 67 Seiten |b Illustrationen |c 21 cm | ||
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| 502 | |b Dissertation |c Rheinisch-Westfälische Technische Hochschule Aachen |d 2019 | ||
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|---|---|
| adam_text | TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
................................................................................................
I
LIST
OF
ABBREVIATIONS
......................................................................................
ILL
1.
INTRODUCTION
.......................................................................................................
1
1.1
TRAUMA AND
HEMORRHAGIC
SHOCK
...........................................................................
1
1.2
SEPSIS
.....................................................................................................................
3
1.3
THE
VULNERABILITY
OF
LIVER
TO
HEMORRHAGIC
SHOCK
AND
SEPSIS
................................
4
1.4
POST-TRAUMATIC
IMMUNOLOGICAL
REACTIONS
WITHIN
THE
LIVER
...................................
5
1.4.1
MACROPHAGES
AND
KUPFFER
CELLS
..................................................................
5
1.4.2
PRO-INFLAMMATORY
FACTORS
...........................................................................
6
1.4.3
CHEMOKINES
.................................................................................................
8
1.4.4
ANTI-INFLAMMATORY
FACTOR
...........................................................................
9
1.5
MACROPHAGE-ACTIVATING
LIPOPEPTIDE-2
..............................................................
10
1.6
EXPERIMENTAL
*
TWO-HIT
*
MODEL
............................................................................
13
2.
RESEARCH
OBJECTIVE
.....................................................................................
17
3.
MATERIALS
AND
METHODS
............................................................................
18
3.1
MATERIALS
...............................................................................................................
18
3.1.1
EXPERIMENTAL
REAGENTS
...............................................................................
18
3.1.2
ASSAY
KITS
..................................................................................................
19
3.1.3
GENERAL
LABORATORY
EQUIPMENT
..................................................................
19
3.2
METHODS
...............................................................................................................
20
3.2.1
ANIMALS
.....................................................................................................
20
3.2.2
GROUP
DISTRIBUTION
.....................................................................................
20
3.2.3
THE
PROCEDURE
OF
THE
*
TWO-HIT
*
MODEL
.....................................................
21
3.3
SAMPLE
COLLECTION
AND
MEASUREMENTS
.................................................................
23
3.3.1
THE
END-POINT
OF
EXPERIMENT
....................................................................
23
3.3.2
ISOLATION
AND
CULTIVATION
OF
KUPFFER
CELLS
................................................
23
3.3.3
VERIFICATION
OF
KUPFFER
CELLS
.....................................................................
24
3.3.4
HISTOLOGY
OF
THE
LIVER
...............................................................................
25
I
TABLE
OF
CONTENTS
3.3.5
MPO
ACTIVITY
IN
THE
LIVER
..........................................................................
25
3.3.6
MEASUREMENT
OF
CYTOKINES
IN
SUPERNATANTS
OF
KUPFFER
CELL
CULTURES
....
25
3.3.7
STATISTICAL
METHODOLOGY
............................................................................
25
4.
RESULTS
..................................................................................................................
27
4.1
IMMUNOFLUORESCENCE
STAINING
OF
KUPFFER
CELLS
..................................................
27
4.2
HISTOLOGY
OF
THE
LIVER
..........................................................................................
27
4.3
MPO
ACTIVITY
OF
THE
LIVER
....................................................................................
29
4.4
CYTOKINES
IN
SUPERNATANTS
OF
KUPFFER
CELL
CULTURES
............................................
30
5.
DISCUSSION
...........................................................................................................
36
5.1
MPO
ACTIVITY
AND
HISTOLOGY
OF
THE
LIVER
.............................................................
36
5.2
THE
INFLUENCE
OF
MALP-2
ON
CYTOKINE
SECRETION
OF
KUPFFER
CELLS
...................
39
5.2.1
PRO-INFLAMMATORY
FACTORS
........................................................................
40
5.2.2
CHEMOKINES
..............................................................................................
41
5.2.3
ANTI-INFLAMMATORY
FACTOR
........................................................................
42
LIMITATIONS
.................................................................................................................
43
OUTLOOK
......................................................................................................................
43
6.
SUMMARY
...............................................................................................................
44
7.
REFERENCES
........................................................................................................
45
8.
APPENDIX
................................................................................................................
61
PUBLICATIONS
...............................................................................................................
61
ACKNOWLEDGEMENTS
...................................................................................................
62
ERKLARUNG
§
5
ADS.
1
ZUR
DATENAUFBEWAHRUNG
.........................................................
64
EIDESSTATTLICHE
ERKLARUNG
GEMAB
§
5
ABS.
(1)
UND
§
11
ABS.
(3)
12.
DER
PROMOTIONSORDNUNG
...................................................................................................
65
CURRICULUM
VITAE
.......................................................................................................
66
|
| any_adam_object | 1 |
| author | Wang, Weikang 1991- |
| author_GND | (DE-588)1191716031 |
| author_facet | Wang, Weikang 1991- |
| author_role | aut |
| author_sort | Wang, Weikang 1991- |
| author_variant | w w ww |
| building | Verbundindex |
| bvnumber | BV046236800 |
| ctrlnum | (OCoLC)1127301039 (DE-599)DNB1196712549 |
| discipline | Medizin |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV046236800 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:39:10Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031615198 |
| oclc_num | 1127301039 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | V, 67 Seiten Illustrationen 21 cm |
| publishDate | 2019 |
| publishDateSearch | 2019 |
| publishDateSort | 2019 |
| record_format | marc |
| spelling | Wang, Weikang 1991- Verfasser (DE-588)1191716031 aut The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model vorgelegt von Weikang Wang Aachen [2019] V, 67 Seiten Illustrationen 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Rheinisch-Westfälische Technische Hochschule Aachen 2019 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1196712549/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031615198&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wang, Weikang 1991- The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model |
| subject_GND | (DE-588)4113937-9 |
| title | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model |
| title_auth | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model |
| title_exact_search | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model |
| title_full | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model vorgelegt von Weikang Wang |
| title_fullStr | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model vorgelegt von Weikang Wang |
| title_full_unstemmed | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model vorgelegt von Weikang Wang |
| title_short | The influence of macrophage-activating lipopeptide-2 in regard to liver-specific changes within a two-hit murine model |
| title_sort | the influence of macrophage activating lipopeptide 2 in regard to liver specific changes within a two hit murine model |
| topic_facet | Hochschulschrift |
| url | https://d-nb.info/1196712549/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031615198&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wangweikang theinfluenceofmacrophageactivatinglipopeptide2inregardtoliverspecificchangeswithinatwohitmurinemodel |
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