Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches:
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| Format: | Thesis Book |
| Language: | English |
| Published: |
Erlangen ; Nürnberg
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 56 Seiten Illustrationen 21 cm |
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| 100 | 1 | |a Tschaikowsky, Tristan |e Verfasser |0 (DE-588)1193682517 |4 aut | |
| 245 | 1 | 0 | |a Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches |c vorgelegt von Tristan Alexander Tschaikowsky |
| 264 | 1 | |a Erlangen ; Nürnberg |b Friedrich-Alexander-Universität Erlangen-Nürnberg |c 2019 | |
| 300 | |a 56 Seiten |b Illustrationen |c 21 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Friedrich-Alexander-Universität Erlangen-Nürnberg |d 2019 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u http://d-nb.info/1192767187/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031561785&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031561785 | ||
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| _version_ | 1804180548867850240 |
|---|---|
| adam_text | TABLE
OF
CONTENT
SUMMARY
3
ZUSAMMENFASSUNG
4
1.
INTRODUCTION
5
1.1.
BIOCHEMICAL
BACKGROUND
AND
NOMENCLATURE
OF
THE
TCF4
PROTEIN
5
1.1.1.
CHARACTERIZATION
OF
TCF4
AS
A
MEMBER
OF
THE
BHLH
FAMILY
5
1.1.2.
STRUCTURE
OF
TCF4
6
1.1.3.
INTERACTION
PROPERTIES
OF
TCF4
7
1.2.
PUTATIVE
TARGET
GENES
OF
TCF4
9
1.3.
ROLE
OF
TCF4
IN
DISEASE
10
1.3.1.
PITT-HOPKINS-SYNDROME
(PTHS)
1.3.2.
SCHIZOPHRENIA
(SCZD)
1.3.3.
OTHER
DISEASES
ASSOCIATED
TO
TCF4
10
11
12
2.
AIM
OF
THE
STUDY
13
3.
MATERIAL
AND
METHODS
14
3.1
MATERIAL
14
3.1.1.
MOUSE
STRAINS
14
3.1.2.
ANTIBODIES
14
3.1.2.1.
PRIMARY
ANTIBODIES
3.1.2.2.
SECONDARY
ANTIBODIES
3.1.3.
CHEMICALS
14
15
15
3.1.4.
SOLUTIONS
16
3.1.5.
CONSUMABLES
AND
LABWARE
17
3.1.6.
EQUIPMENT
3.1.7.
SOFTWARE
AND
DATABASES
17
18
3.1.7.1.
SOFTWARE
18
3.1.7.2.
DATABASES
18
3.2.
METHODS
19
3.2.1.
ANIMAL
HUSBANDRY
3.2.2.
BRDU-TREATMENT
19
19
3.2.3.
DISSECTION
19
3.2.4. BRAIN
PREPARATION
3.2.5.
PRETREATMENT
FOR
STAINING
AGAINST
BRDU
19
19
1
3.2.6.
IMMUNOHISTOCHEMISTRY
3.2.7.
IMMUNOFLUORESCENCE
MICROSCOPY
19
20
4.
RESULTS
21
4.1.
FUNCTIONAL
DOMAIN
COMPOSITION
OF
TCF4
ISOFORMS
WITH
MAPPING
OF
IHC
AND
ISH
BINDING
EPITOPES
21
4.2.
REGIONAL
EXPRESSION
ANALYSIS
OF
TCF4
WITH
ISH
AND
IHC
REVEALS
WIDESPREAD
EXPRESSION
IN
ADULT
MURINE
BRAIN
23
4.2.1.
ADULT
ISOCORTEX
24
4.2.2.
HIPPOCAMPAL
FORMATION
AND
AMYGDALAR
COMPLEX
24
4.2.3.
OLFACTORY
BULB
AND
OLFACTORY
PROCESSING
REGIONS
26
4.2.4.
PONS,
MEDULLA
AND
CEREBELLUM
27
4.3.
CELL-TYPE
SPECIFIC
EXPRESSION
OF
TCF4
29
4.3.1.
TCF4
EXPRESSION
IN
MATURE
NEURONS
29
4.3.2.
TCF4
EXPRESSION
IN
ASTROCYTES
29
4.3.3.
TCF4
EXPRESSION
IN
OLIGODENDROCYTES
30
4.3.4.
TCF4
EXPRESSION
IN
MICROGLIA
30
4.4.
NEUROGENIC
NICHES
AND
THE
TCF4
EXPRESSION
THE
NEUROGENIC
LINEAGE
OF
OLFACTORY
BULB
NEUROGENESIS
31
4.4.1.
NEUROGENIC
NICHES
31
4.4.2.
ADULT
NEURAL
STEM
CELLS
(B-CELLS)
WITHIN
THE
SVZ
32
4.4.3.
TRANSIENT
AMPLIFYING
PROGENITORS
(C-CELLS)
WITHIN
THE
SVZ
33
4.4.4.
NEUROBLASTS
(A-CELLS)
WITHIN
THE
RMS
34
4.4.5.
OLFACTORY
BULB
(GRANULE)
INTERNEURONS
35
5.
DISCUSSION
36
6.
CONCLUSION
40
7.
LITERATURE
41
LIST
OF
ABBREVIATIONS
55
LIST
OF
FIGURES
56
LIST
OF
TABLES
56
ACKNOWLEDGEMENT
57
2
|
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| author_GND | (DE-588)1193682517 |
| author_facet | Tschaikowsky, Tristan |
| author_role | aut |
| author_sort | Tschaikowsky, Tristan |
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| id | DE-604.BV046182266 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:37:31Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031561785 |
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| physical | 56 Seiten Illustrationen 21 cm |
| publishDate | 2019 |
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| publishDateSort | 2019 |
| publisher | Friedrich-Alexander-Universität Erlangen-Nürnberg |
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| spelling | Tschaikowsky, Tristan Verfasser (DE-588)1193682517 aut Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches vorgelegt von Tristan Alexander Tschaikowsky Erlangen ; Nürnberg Friedrich-Alexander-Universität Erlangen-Nürnberg 2019 56 Seiten Illustrationen 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2019 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1192767187/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031561785&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tschaikowsky, Tristan Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches |
| subject_GND | (DE-588)4113937-9 |
| title | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches |
| title_auth | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches |
| title_exact_search | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches |
| title_full | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches vorgelegt von Tristan Alexander Tschaikowsky |
| title_fullStr | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches vorgelegt von Tristan Alexander Tschaikowsky |
| title_full_unstemmed | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches vorgelegt von Tristan Alexander Tschaikowsky |
| title_short | Expression analysis of the bHLH-factor TCF4 (ITF2; E2-2) in the adult murine brain and its neurogenic niches |
| title_sort | expression analysis of the bhlh factor tcf4 itf2 e2 2 in the adult murine brain and its neurogenic niches |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1192767187/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031561785&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT tschaikowskytristan expressionanalysisofthebhlhfactortcf4itf2e22intheadultmurinebrainanditsneurogenicniches |
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