Function and dysfunction of the cochlea: from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine
"Complex molecular machinery within the cells of the inner ear allow it to sense sounds of different frequencies and relay information to the brain. This volume examines the nature of this machinery, the cells involved, and how defects in these components lead to deafness"--
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cold Spring Harbor, New York
Cold Spring Harbor Laboratory Press
[2019]
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| Series: | Cold Spring Harbor perspectives in medicine
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Summary: | "Complex molecular machinery within the cells of the inner ear allow it to sense sounds of different frequencies and relay information to the brain. This volume examines the nature of this machinery, the cells involved, and how defects in these components lead to deafness"-- |
| Physical Description: | viii, 347 Seiten Illustrationen, Diagramme |
| ISBN: | 9781621822790 |
Staff View
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Record in the Search Index
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| adam_text | Contents Preface, vii A Functional Perspective on the Evolution of the Cochlea, 1 Christine Koppi and Geoffrey A. Manley Cochlear Frequency Tuning and Otoacoustic Emissions, 15 Christopher A. Shera and Karolina K. Charaziak Active Biomechanics of Sensory Hair Bundles, 27 Dolores Bozovic Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity, 41 Mireille Montcouquiol and Matthew W. Kelley Hair-Bundle Links: Genetics as the Gateway to Function, 59 Guy P. Richardson and Christine Petit Function and Dysfunction of TMC Channels in Inner Ear Hair Cells, 79 David P. Corey, Nurunisa Akyuz, and Jeffrey R. Holt Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex, 93 Christopher L. Cunningham and Ulrich Müller Molecular Composition of Vestibular Hair Bundles, 113 Jocelyn E Krey and Peter G. Barr-Gillespie The Tectorial Membrane: Mechanical Properties and Functions, 129 Jonathan B. Sellon, Roozbeh Ghaffari, and Dennis M. Freeman Hair Cell Afferent Synapses: Function and Dysfunction, 141 Stuart L. Johnson, Saaid Safieddine, Mirna Mustapha, and Walter Marcotti Outer Hair Cells and Electromotility, 165 Jonathan Ashmore Efferent Inhibition of the Cochlea, 175 Paul Albert Fuchs and Amanda M. Lauer
Contents Inner Ear Connexin Channels: Roles in Development and Maintenance of Cochlear Function, 191 Fabio Mammano The Epidemiology of Deafness, 21 7 Abraham M. Sheffield, and Richard ).H. Smith Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms, 233 David Kohrman, Guoqiang Wan, Luis Cassinoliі, and Gabriel Corlas Aminoglycoside- and Cisplatin-lnduced Ototoxicity: Mechanisms and Otoprotective Strategies, 253 Corné ]. Kros and Peter S. Steyger Age-Related Hearing Loss, 271 Michael R. Bowl and Sally J. Dawson Interactions between Macrophages and the Sensory Cells of the Inner Ear, 285 MarkE. Warchol Stem Cells and the Bird Cochlea—Where Is Everybody?, 299 Amanda S. Janesick and Stefan Heller Cochlear Gene Therapies, 309 Lawrence Lustig and Omar Akil Toward the Optical Cochlear Implant, 325 Tobias Dombrowski, Vladan Rankovic, and Tobias Moser Index, 341 VI
Function and Dysfunction of the Cochlea From Mechanisms to Potential Therapies The cochlea, the mammalian auditory organ, is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with a remarkable tem poral precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular mechanisms that are responsible for cochlear function and were, for the most part, revealed by the discovery of genes responsible for hearing impairment. It describes major advances in our understanding of the pathogenic processes underlying various forms of hearing loss and the emergence of treatments for deafness. The contributors focus on the highly specialized cells which mediate auditory transduction—the hair cells—and their unique architectural, mechanical, and molecular charac teristics. They also consider the properties of other cochlear components, including the tectorial membrane, the synaptic connections with auditory neurons, and the resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed. In addition, the authors examine the epidemiology of hearing loss and emerging, innovative, therapeutic strategies (e.g., gene therapy, optical cochlear
implants). This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physician-scientists seeking new approaches to alleviate hearing im pairments.
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| isbn | 9781621822790 |
| language | English |
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| physical | viii, 347 Seiten Illustrationen, Diagramme |
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| spelling | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine edited by Guy P. Richardson, Sussex Neuroscience, University of Sussex, Christine Petit, Collège de France, Institut Pasteur Cold Spring Harbor, New York Cold Spring Harbor Laboratory Press [2019] © 2019 viii, 347 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Cold Spring Harbor perspectives in medicine "Complex molecular machinery within the cells of the inner ear allow it to sense sounds of different frequencies and relay information to the brain. This volume examines the nature of this machinery, the cells involved, and how defects in these components lead to deafness"-- Cochlea (DE-588)4143413-4 Aufsatzsammlung gnd-content Richardson, Guy P. edt wpr aut Petit, Christine 1982- (DE-588)1083284479 edt wpr aut Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031549341&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031549341&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Richardson, Guy P. Petit, Christine 1982- Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine Cochlea |
| subject_GND | (DE-588)4143413-4 |
| title | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_auth | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_exact_search | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine |
| title_full | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine edited by Guy P. Richardson, Sussex Neuroscience, University of Sussex, Christine Petit, Collège de France, Institut Pasteur |
| title_fullStr | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine edited by Guy P. Richardson, Sussex Neuroscience, University of Sussex, Christine Petit, Collège de France, Institut Pasteur |
| title_full_unstemmed | Function and dysfunction of the cochlea from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine edited by Guy P. Richardson, Sussex Neuroscience, University of Sussex, Christine Petit, Collège de France, Institut Pasteur |
| title_short | Function and dysfunction of the cochlea |
| title_sort | function and dysfunction of the cochlea from mechanisms to potential therapies a subject collection from cold spring harbor perspectives in medicine |
| title_sub | from mechanisms to potential therapies : a subject collection from Cold Spring Harbor perspectives in medicine |
| topic | Cochlea |
| topic_facet | Cochlea Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031549341&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031549341&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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