Hemophilia Care in the New Millennium:
There should be, and in the best of cases there is, a synergy between basic research and patient care. However, this synergy is hard to develop because the techniques required to be a successful researcher are so different from the skills required to be an outstanding physician. Harold R. Roberts, M...
Gespeichert in:
| Weitere Verfasser: | , , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2001
|
| Schriftenreihe: | Advances in Experimental Medicine and Biology
489 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | There should be, and in the best of cases there is, a synergy between basic research and patient care. However, this synergy is hard to develop because the techniques required to be a successful researcher are so different from the skills required to be an outstanding physician. Harold R. Roberts, M.D., of the University of North Carolina at Chapel Hill, is an example of a physician-researcher who has benefited from having his feet in both the world of patient care and the world of the laboratory: he has let clinical problems direct his basic research effort and conversely has adopted research advances in his care of patients. Dr. Roberts's long and continuing career has included many research and clinical advances. He was part of the first group to determine the amino acid sequence of the important thrombin inhibitor hirudin and part of the group that prepared the first cryoprecipitates which were the first alternative to plasma as therapy in hemophilia A. Dr. Roberts has made significant advances in understanding the protein chemistry behind hemophilia B; he was among the first researchers to identify some patients as not being completely deficient but instead as having measurable levels of protein and subsequently demonstrated that this protein was dysfunctional. This important advance led him to a classification scheme for patients into Cross Reacting Material (CRM) positive, negative, and reduced. Dr |
| Beschreibung: | 1 Online-Ressource (XIV, 182 p) |
| ISBN: | 9781461512776 |
| DOI: | 10.1007/978-1-4615-1277-6 |
Internformat
MARC
| LEADER | 00000nmm a2200000zcb4500 | ||
|---|---|---|---|
| 001 | BV046148616 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 190906s2001 |||| o||u| ||||||eng d | ||
| 020 | |a 9781461512776 |9 978-1-4615-1277-6 | ||
| 024 | 7 | |a 10.1007/978-1-4615-1277-6 |2 doi | |
| 035 | |a (ZDB-2-SBL)978-1-4615-1277-6 | ||
| 035 | |a (OCoLC)1119040152 | ||
| 035 | |a (DE-599)BVBBV046148616 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 082 | 0 | |a 616 |2 23 | |
| 245 | 1 | 0 | |a Hemophilia Care in the New Millennium |c edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White |
| 264 | 1 | |a Boston, MA |b Springer US |c 2001 | |
| 300 | |a 1 Online-Ressource (XIV, 182 p) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Advances in Experimental Medicine and Biology |v 489 | |
| 520 | |a There should be, and in the best of cases there is, a synergy between basic research and patient care. However, this synergy is hard to develop because the techniques required to be a successful researcher are so different from the skills required to be an outstanding physician. Harold R. Roberts, M.D., of the University of North Carolina at Chapel Hill, is an example of a physician-researcher who has benefited from having his feet in both the world of patient care and the world of the laboratory: he has let clinical problems direct his basic research effort and conversely has adopted research advances in his care of patients. Dr. Roberts's long and continuing career has included many research and clinical advances. He was part of the first group to determine the amino acid sequence of the important thrombin inhibitor hirudin and part of the group that prepared the first cryoprecipitates which were the first alternative to plasma as therapy in hemophilia A. Dr. Roberts has made significant advances in understanding the protein chemistry behind hemophilia B; he was among the first researchers to identify some patients as not being completely deficient but instead as having measurable levels of protein and subsequently demonstrated that this protein was dysfunctional. This important advance led him to a classification scheme for patients into Cross Reacting Material (CRM) positive, negative, and reduced. Dr | ||
| 650 | 4 | |a Internal Medicine | |
| 650 | 4 | |a Hematology | |
| 650 | 4 | |a Internal medicine | |
| 650 | 4 | |a Hematology | |
| 650 | 0 | 7 | |a Hämophilie |0 (DE-588)4072214-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 1999 |z Chapel Hill NC |2 gnd-content | |
| 689 | 0 | 0 | |a Hämophilie |0 (DE-588)4072214-4 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Monroe, Dougald M. |4 edt | |
| 700 | 1 | |a Hedner, Ulla |4 edt | |
| 700 | 1 | |a Hoffman, Maureane R. |4 edt | |
| 700 | 1 | |a Negrier, Claude |4 edt | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781461354741 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9780306465215 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781461512783 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-1-4615-1277-6 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-2-SBL | ||
| 940 | 1 | |q ZDB-2-SBL_2000/2004 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031528793 | ||
| 966 | e | |u https://doi.org/10.1007/978-1-4615-1277-6 |l UBR01 |p ZDB-2-SBL |q ZDB-2-SBL_2000/2004 |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804180489102163968 |
|---|---|
| any_adam_object | |
| author2 | Monroe, Dougald M. Hedner, Ulla Hoffman, Maureane R. Negrier, Claude |
| author2_role | edt edt edt edt |
| author2_variant | d m m dm dmm u h uh m r h mr mrh c n cn |
| author_facet | Monroe, Dougald M. Hedner, Ulla Hoffman, Maureane R. Negrier, Claude |
| building | Verbundindex |
| bvnumber | BV046148616 |
| collection | ZDB-2-SBL |
| ctrlnum | (ZDB-2-SBL)978-1-4615-1277-6 (OCoLC)1119040152 (DE-599)BVBBV046148616 |
| dewey-full | 616 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616 |
| dewey-search | 616 |
| dewey-sort | 3616 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-1-4615-1277-6 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03392nmm a2200529zcb4500</leader><controlfield tag="001">BV046148616</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">190906s2001 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781461512776</subfield><subfield code="9">978-1-4615-1277-6</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/978-1-4615-1277-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-2-SBL)978-1-4615-1277-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1119040152</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV046148616</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">616</subfield><subfield code="2">23</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hemophilia Care in the New Millennium</subfield><subfield code="c">edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boston, MA</subfield><subfield code="b">Springer US</subfield><subfield code="c">2001</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (XIV, 182 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Advances in Experimental Medicine and Biology</subfield><subfield code="v">489</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">There should be, and in the best of cases there is, a synergy between basic research and patient care. However, this synergy is hard to develop because the techniques required to be a successful researcher are so different from the skills required to be an outstanding physician. Harold R. Roberts, M.D., of the University of North Carolina at Chapel Hill, is an example of a physician-researcher who has benefited from having his feet in both the world of patient care and the world of the laboratory: he has let clinical problems direct his basic research effort and conversely has adopted research advances in his care of patients. Dr. Roberts's long and continuing career has included many research and clinical advances. He was part of the first group to determine the amino acid sequence of the important thrombin inhibitor hirudin and part of the group that prepared the first cryoprecipitates which were the first alternative to plasma as therapy in hemophilia A. Dr. Roberts has made significant advances in understanding the protein chemistry behind hemophilia B; he was among the first researchers to identify some patients as not being completely deficient but instead as having measurable levels of protein and subsequently demonstrated that this protein was dysfunctional. This important advance led him to a classification scheme for patients into Cross Reacting Material (CRM) positive, negative, and reduced. Dr</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Internal Medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hematology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Internal medicine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hematology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Hämophilie</subfield><subfield code="0">(DE-588)4072214-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)1071861417</subfield><subfield code="a">Konferenzschrift</subfield><subfield code="y">1999</subfield><subfield code="z">Chapel Hill NC</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Hämophilie</subfield><subfield code="0">(DE-588)4072214-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Monroe, Dougald M.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hedner, Ulla</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hoffman, Maureane R.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Negrier, Claude</subfield><subfield code="4">edt</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9781461354741</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9780306465215</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9781461512783</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1007/978-1-4615-1277-6</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-2-SBL</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">ZDB-2-SBL_2000/2004</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031528793</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1007/978-1-4615-1277-6</subfield><subfield code="l">UBR01</subfield><subfield code="p">ZDB-2-SBL</subfield><subfield code="q">ZDB-2-SBL_2000/2004</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| genre | (DE-588)1071861417 Konferenzschrift 1999 Chapel Hill NC gnd-content |
| genre_facet | Konferenzschrift 1999 Chapel Hill NC |
| id | DE-604.BV046148616 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:34Z |
| institution | BVB |
| isbn | 9781461512776 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031528793 |
| oclc_num | 1119040152 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (XIV, 182 p) |
| psigel | ZDB-2-SBL ZDB-2-SBL_2000/2004 ZDB-2-SBL ZDB-2-SBL_2000/2004 |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Springer US |
| record_format | marc |
| series2 | Advances in Experimental Medicine and Biology |
| spelling | Hemophilia Care in the New Millennium edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White Boston, MA Springer US 2001 1 Online-Ressource (XIV, 182 p) txt rdacontent c rdamedia cr rdacarrier Advances in Experimental Medicine and Biology 489 There should be, and in the best of cases there is, a synergy between basic research and patient care. However, this synergy is hard to develop because the techniques required to be a successful researcher are so different from the skills required to be an outstanding physician. Harold R. Roberts, M.D., of the University of North Carolina at Chapel Hill, is an example of a physician-researcher who has benefited from having his feet in both the world of patient care and the world of the laboratory: he has let clinical problems direct his basic research effort and conversely has adopted research advances in his care of patients. Dr. Roberts's long and continuing career has included many research and clinical advances. He was part of the first group to determine the amino acid sequence of the important thrombin inhibitor hirudin and part of the group that prepared the first cryoprecipitates which were the first alternative to plasma as therapy in hemophilia A. Dr. Roberts has made significant advances in understanding the protein chemistry behind hemophilia B; he was among the first researchers to identify some patients as not being completely deficient but instead as having measurable levels of protein and subsequently demonstrated that this protein was dysfunctional. This important advance led him to a classification scheme for patients into Cross Reacting Material (CRM) positive, negative, and reduced. Dr Internal Medicine Hematology Internal medicine Hämophilie (DE-588)4072214-4 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1999 Chapel Hill NC gnd-content Hämophilie (DE-588)4072214-4 s DE-604 Monroe, Dougald M. edt Hedner, Ulla edt Hoffman, Maureane R. edt Negrier, Claude edt Erscheint auch als Druck-Ausgabe 9781461354741 Erscheint auch als Druck-Ausgabe 9780306465215 Erscheint auch als Druck-Ausgabe 9781461512783 https://doi.org/10.1007/978-1-4615-1277-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Hemophilia Care in the New Millennium Internal Medicine Hematology Internal medicine Hämophilie (DE-588)4072214-4 gnd |
| subject_GND | (DE-588)4072214-4 (DE-588)1071861417 |
| title | Hemophilia Care in the New Millennium |
| title_auth | Hemophilia Care in the New Millennium |
| title_exact_search | Hemophilia Care in the New Millennium |
| title_full | Hemophilia Care in the New Millennium edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White |
| title_fullStr | Hemophilia Care in the New Millennium edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White |
| title_full_unstemmed | Hemophilia Care in the New Millennium edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White |
| title_short | Hemophilia Care in the New Millennium |
| title_sort | hemophilia care in the new millennium |
| topic | Internal Medicine Hematology Internal medicine Hämophilie (DE-588)4072214-4 gnd |
| topic_facet | Internal Medicine Hematology Internal medicine Hämophilie Konferenzschrift 1999 Chapel Hill NC |
| url | https://doi.org/10.1007/978-1-4615-1277-6 |
| work_keys_str_mv | AT monroedougaldm hemophiliacareinthenewmillennium AT hednerulla hemophiliacareinthenewmillennium AT hoffmanmaureaner hemophiliacareinthenewmillennium AT negrierclaude hemophiliacareinthenewmillennium |