Human Cell Culture: Cancer Cell Lines Part 2
Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer Netherlands
2002
|
| Schriftenreihe: | Human Cell Culture
2 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading |
| Beschreibung: | 1 Online-Ressource (X, 377 p) |
| ISBN: | 9780306468612 |
| DOI: | 10.1007/0-306-46861-1 |
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| 520 | |a Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading | ||
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Datensatz im Suchindex
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| dewey-full | 614.5999 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 614 - Forensic medicine; incidence of disease |
| dewey-raw | 614.5999 |
| dewey-search | 614.5999 |
| dewey-sort | 3614.5999 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/0-306-46861-1 |
| format | Electronic eBook |
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| id | DE-604.BV046148503 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:34Z |
| institution | BVB |
| isbn | 9780306468612 |
| language | English |
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| physical | 1 Online-Ressource (X, 377 p) |
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| publisher | Springer Netherlands |
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| series2 | Human Cell Culture |
| spelling | Human Cell Culture Cancer Cell Lines Part 2 edited by John R. W. Masters, Bernhard Palsson Dordrecht Springer Netherlands 2002 1 Online-Ressource (X, 377 p) txt rdacontent c rdamedia cr rdacarrier Human Cell Culture 2 Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading Cancer Research Cell Biology Oncology Internal Medicine Cytology Oncology Internal medicine Masters, John R. W. edt Palsson, Bernhard edt Erscheint auch als Druck-Ausgabe 9789048152865 Erscheint auch als Druck-Ausgabe 9780792358787 Erscheint auch als Druck-Ausgabe 9789401741644 https://doi.org/10.1007/0-306-46861-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Human Cell Culture Cancer Cell Lines Part 2 Cancer Research Cell Biology Oncology Internal Medicine Cytology Oncology Internal medicine |
| title | Human Cell Culture Cancer Cell Lines Part 2 |
| title_auth | Human Cell Culture Cancer Cell Lines Part 2 |
| title_exact_search | Human Cell Culture Cancer Cell Lines Part 2 |
| title_full | Human Cell Culture Cancer Cell Lines Part 2 edited by John R. W. Masters, Bernhard Palsson |
| title_fullStr | Human Cell Culture Cancer Cell Lines Part 2 edited by John R. W. Masters, Bernhard Palsson |
| title_full_unstemmed | Human Cell Culture Cancer Cell Lines Part 2 edited by John R. W. Masters, Bernhard Palsson |
| title_short | Human Cell Culture |
| title_sort | human cell culture cancer cell lines part 2 |
| title_sub | Cancer Cell Lines Part 2 |
| topic | Cancer Research Cell Biology Oncology Internal Medicine Cytology Oncology Internal medicine |
| topic_facet | Cancer Research Cell Biology Oncology Internal Medicine Cytology Oncology Internal medicine |
| url | https://doi.org/10.1007/0-306-46861-1 |
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