It was at the end of the 19th century that a Swiss biologist, Karl Nageli first proposed the existence of hereditary organelles that carried information from parent to offspring. Ensuing decades experienced vigorous studies that led to the development of discovery that chromosomes are indeed the car...

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Bibliographic Details

Other Authors:	Sobit, R. C. (Editor), Obe, G. (Editor), Athwal, R. S. (Editor)
Format:	Electronic eBook
Language:	English
Published:	Dordrecht Springer Netherlands 2002
Subjects:	Biochemistry, general Human Genetics Life Sciences, general Biochemistry Human genetics Life sciences
Online Access:	UBR01 Volltext
Summary:	It was at the end of the 19th century that a Swiss biologist, Karl Nageli first proposed the existence of hereditary organelles that carried information from parent to offspring. Ensuing decades experienced vigorous studies that led to the development of discovery that chromosomes are indeed the carriers of genetic information. Subsequent studies, especially by Morgan and Bridges, established unequivocally the chromosome theory of inheritance. Today, the structure of chromosome is well established. At the physical level, eukaryotic chromosomes are composed of a single, linear, double helix of DNA. The elementary helical structure involves nucleosomes, comprised of histones around which the DNA is wrapped. A hierarchy of higher order of chromosomal architecture may possibly be responsible for the regulation of gene helical structures expression. The localized condensations of DNA constitute chromomeres. Uncoiled structures sometimes extending from chromomeres, which form loops, is the result of discontinuities in the regular coiling of the DNA in the chromosome
Physical Description:	1 Online-Ressource (X, 238 p)
ISBN:	9789401003346
DOI:	10.1007/978-94-010-0334-6