Genetic Engineering: Principles and Methods: Principles and Methods
Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose inde...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2001
|
| Schriftenreihe: | Genetic Engineering: Principles and Methods
23 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4) |
| Beschreibung: | 1 Online-Ressource (XVIII, 232 p) |
| ISBN: | 9780306475726 |
| DOI: | 10.1007/b113582 |
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| 520 | |a Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4) | ||
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Datensatz im Suchindex
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| dewey-full | 660.65 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 660 - Chemical engineering |
| dewey-raw | 660.65 |
| dewey-search | 660.65 |
| dewey-sort | 3660.65 |
| dewey-tens | 660 - Chemical engineering |
| discipline | Chemie / Pharmazie |
| doi_str_mv | 10.1007/b113582 |
| format | Electronic eBook |
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| id | DE-604.BV046148299 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:33Z |
| institution | BVB |
| isbn | 9780306475726 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031528476 |
| oclc_num | 1119024795 |
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| physical | 1 Online-Ressource (XVIII, 232 p) |
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| series2 | Genetic Engineering: Principles and Methods |
| spelling | Genetic Engineering: Principles and Methods Principles and Methods edited by Jane K. Setlow Boston, MA Springer US 2001 1 Online-Ressource (XVIII, 232 p) txt rdacontent c rdamedia cr rdacarrier Genetic Engineering: Principles and Methods 23 Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4) Genetic Engineering Human Genetics Biochemistry, general Plant Sciences Genetic engineering Human genetics Biochemistry Botany Setlow, Jane K. edt Erscheint auch als Druck-Ausgabe 9781475787986 Erscheint auch als Druck-Ausgabe 9780306466458 Erscheint auch als Druck-Ausgabe 9781475787979 https://doi.org/10.1007/b113582 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Genetic Engineering: Principles and Methods Principles and Methods Genetic Engineering Human Genetics Biochemistry, general Plant Sciences Genetic engineering Human genetics Biochemistry Botany |
| title | Genetic Engineering: Principles and Methods Principles and Methods |
| title_auth | Genetic Engineering: Principles and Methods Principles and Methods |
| title_exact_search | Genetic Engineering: Principles and Methods Principles and Methods |
| title_full | Genetic Engineering: Principles and Methods Principles and Methods edited by Jane K. Setlow |
| title_fullStr | Genetic Engineering: Principles and Methods Principles and Methods edited by Jane K. Setlow |
| title_full_unstemmed | Genetic Engineering: Principles and Methods Principles and Methods edited by Jane K. Setlow |
| title_short | Genetic Engineering: Principles and Methods |
| title_sort | genetic engineering principles and methods principles and methods |
| title_sub | Principles and Methods |
| topic | Genetic Engineering Human Genetics Biochemistry, general Plant Sciences Genetic engineering Human genetics Biochemistry Botany |
| topic_facet | Genetic Engineering Human Genetics Biochemistry, general Plant Sciences Genetic engineering Human genetics Biochemistry Botany |
| url | https://doi.org/10.1007/b113582 |
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