Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors:
Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
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Vienna
Springer Vienna
1992
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| Schriftenreihe: | Journal of Neural Transmission. Supplementa
35 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model |
| Beschreibung: | 1 Online-Ressource (VII, 200 p) |
| ISBN: | 9783709192061 |
| DOI: | 10.1007/978-3-7091-9206-1 |
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| 520 | |a Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model | ||
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| spelling | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors edited by C. Marescaux, M. Vergnes, R. Bernasconi Vienna Springer Vienna 1992 1 Online-Ressource (VII, 200 p) txt rdacontent c rdamedia cr rdacarrier Journal of Neural Transmission. Supplementa 35 Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model Neurosciences Pharmacology/Toxicology Neurology Pathology Toxicology GABAB-Rezeptor (DE-588)4998568-1 gnd rswk-swf Epilepsie (DE-588)4015035-5 gnd rswk-swf Epilepsia nonconvulsiva (DE-588)4306760-8 gnd rswk-swf Aminobuttersäure gamma- (DE-588)4155919-8 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1990 Les Arcs gnd-content (DE-588)4143413-4 Aufsatzsammlung gnd-content Aminobuttersäure gamma- (DE-588)4155919-8 s Epilepsia nonconvulsiva (DE-588)4306760-8 s DE-604 Epilepsie (DE-588)4015035-5 s GABAB-Rezeptor (DE-588)4998568-1 s Marescaux, C. edt Vergnes, M. edt Bernasconi, R. edt Erscheint auch als Druck-Ausgabe 9783211823408 Erscheint auch als Druck-Ausgabe 9783709192078 https://doi.org/10.1007/978-3-7091-9206-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors Neurosciences Pharmacology/Toxicology Neurology Pathology Toxicology GABAB-Rezeptor (DE-588)4998568-1 gnd Epilepsie (DE-588)4015035-5 gnd Epilepsia nonconvulsiva (DE-588)4306760-8 gnd Aminobuttersäure gamma- (DE-588)4155919-8 gnd |
| subject_GND | (DE-588)4998568-1 (DE-588)4015035-5 (DE-588)4306760-8 (DE-588)4155919-8 (DE-588)1071861417 (DE-588)4143413-4 |
| title | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors |
| title_auth | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors |
| title_exact_search | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors |
| title_full | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors edited by C. Marescaux, M. Vergnes, R. Bernasconi |
| title_fullStr | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors edited by C. Marescaux, M. Vergnes, R. Bernasconi |
| title_full_unstemmed | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors edited by C. Marescaux, M. Vergnes, R. Bernasconi |
| title_short | Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors |
| title_sort | generalized non convulsive epilepsy focus on gaba b receptors |
| topic | Neurosciences Pharmacology/Toxicology Neurology Pathology Toxicology GABAB-Rezeptor (DE-588)4998568-1 gnd Epilepsie (DE-588)4015035-5 gnd Epilepsia nonconvulsiva (DE-588)4306760-8 gnd Aminobuttersäure gamma- (DE-588)4155919-8 gnd |
| topic_facet | Neurosciences Pharmacology/Toxicology Neurology Pathology Toxicology GABAB-Rezeptor Epilepsie Epilepsia nonconvulsiva Aminobuttersäure gamma- Konferenzschrift 1990 Les Arcs Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-7091-9206-1 |
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