Genetic factors in coronary heart disease:
Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyf...
Saved in:
| Other Authors: | , , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Dordrecht
Springer Netherlands
1994
|
| Series: | Developments in Cardiovascular Medicine
156 |
| Subjects: | |
| Online Access: | UBR01 Volltext |
| Summary: | Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health |
| Physical Description: | 1 Online-Ressource (XIV, 463 p) |
| ISBN: | 9789401111300 |
| DOI: | 10.1007/978-94-011-1130-0 |
Staff View
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| 520 | |a Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health | ||
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| spelling | Genetic factors in coronary heart disease edited by Uri Goldbourt, Ulf de Faire, Kåre Berg Dordrecht Springer Netherlands 1994 1 Online-Ressource (XIV, 463 p) txt rdacontent c rdamedia cr rdacarrier Developments in Cardiovascular Medicine 156 Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health Cardiology Epidemiology Koronare Herzkrankheit (DE-588)4073731-7 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Koronare Herzkrankheit (DE-588)4073731-7 s Genetik (DE-588)4071711-2 s DE-604 Goldbourt, Uri edt Faire, Ulf de edt Berg, Kåre edt Erscheint auch als Druck-Ausgabe 9780792327523 Erscheint auch als Druck-Ausgabe 9789401044943 Erscheint auch als Druck-Ausgabe 9789401111317 https://doi.org/10.1007/978-94-011-1130-0 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Genetic factors in coronary heart disease Cardiology Epidemiology Koronare Herzkrankheit (DE-588)4073731-7 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4073731-7 (DE-588)4071711-2 (DE-588)4143413-4 |
| title | Genetic factors in coronary heart disease |
| title_auth | Genetic factors in coronary heart disease |
| title_exact_search | Genetic factors in coronary heart disease |
| title_full | Genetic factors in coronary heart disease edited by Uri Goldbourt, Ulf de Faire, Kåre Berg |
| title_fullStr | Genetic factors in coronary heart disease edited by Uri Goldbourt, Ulf de Faire, Kåre Berg |
| title_full_unstemmed | Genetic factors in coronary heart disease edited by Uri Goldbourt, Ulf de Faire, Kåre Berg |
| title_short | Genetic factors in coronary heart disease |
| title_sort | genetic factors in coronary heart disease |
| topic | Cardiology Epidemiology Koronare Herzkrankheit (DE-588)4073731-7 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | Cardiology Epidemiology Koronare Herzkrankheit Genetik Aufsatzsammlung |
| url | https://doi.org/10.1007/978-94-011-1130-0 |
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