Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic ther...

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Bibliographic Details

Other Authors:	Bashey, Asad (Editor), Ball, Edward D. (Editor)
Format:	Electronic eBook
Language:	English
Published:	Boston, MA Springer US 2002
Series:	Cancer Treatment and Research 110
Subjects:	Oncology Transplant Surgery Oncology   Transplantation of organs, tissu Aufsatzsammlung
Online Access:	UBR01 Volltext
Summary:	Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use
Physical Description:	1 Online-Ressource (X, 216 p)
ISBN:	9781461509196
DOI:	10.1007/978-1-4615-0919-6