Recent Advances in Cell Biology of Acute Leukemia: Impact on Clinical Diagnosis and Therapy
The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1993
|
| Schriftenreihe: | Recent Results in Cancer Research
131 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias |
| Beschreibung: | 1 Online-Ressource (XV, 407 p. 3 illus. in color) |
| ISBN: | 9783642848957 |
| DOI: | 10.1007/978-3-642-84895-7 |
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| 520 | |a The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias | ||
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Datensatz im Suchindex
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| author2 | Ludwig, Wolf-Dieter Thiel, Eckhard |
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| author2_variant | w d l wdl e t et |
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| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
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| discipline | Medizin |
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| id | DE-604.BV046146548 |
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| indexdate | 2024-07-10T08:36:30Z |
| institution | BVB |
| isbn | 9783642848957 |
| language | English |
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| spelling | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy edited by Wolf-Dieter Ludwig, Eckhard Thiel Berlin, Heidelberg Springer Berlin Heidelberg 1993 1 Online-Ressource (XV, 407 p. 3 illus. in color) txt rdacontent c rdamedia cr rdacarrier Recent Results in Cancer Research 131 The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias Oncology Hematology Allergology Immunology Oncology Allergy Akute Leukämie (DE-588)4112478-9 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf Cytopathologie (DE-588)4122103-5 gnd rswk-swf Berlin (DE-588)4005728-8 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1993 Berlin gnd-content Akute Leukämie (DE-588)4112478-9 s Cytologie (DE-588)4070177-3 s Berlin (DE-588)4005728-8 g DE-604 Cytopathologie (DE-588)4122103-5 s Ludwig, Wolf-Dieter edt Thiel, Eckhard edt Erscheint auch als Druck-Ausgabe 9783642848971 Erscheint auch als Druck-Ausgabe 9783540564171 Erscheint auch als Druck-Ausgabe 9783642848964 https://doi.org/10.1007/978-3-642-84895-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy Oncology Hematology Allergology Immunology Oncology Allergy Akute Leukämie (DE-588)4112478-9 gnd Cytologie (DE-588)4070177-3 gnd Cytopathologie (DE-588)4122103-5 gnd |
| subject_GND | (DE-588)4112478-9 (DE-588)4070177-3 (DE-588)4122103-5 (DE-588)4005728-8 (DE-588)1071861417 |
| title | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy |
| title_auth | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy |
| title_exact_search | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy |
| title_full | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy edited by Wolf-Dieter Ludwig, Eckhard Thiel |
| title_fullStr | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy edited by Wolf-Dieter Ludwig, Eckhard Thiel |
| title_full_unstemmed | Recent Advances in Cell Biology of Acute Leukemia Impact on Clinical Diagnosis and Therapy edited by Wolf-Dieter Ludwig, Eckhard Thiel |
| title_short | Recent Advances in Cell Biology of Acute Leukemia |
| title_sort | recent advances in cell biology of acute leukemia impact on clinical diagnosis and therapy |
| title_sub | Impact on Clinical Diagnosis and Therapy |
| topic | Oncology Hematology Allergology Immunology Oncology Allergy Akute Leukämie (DE-588)4112478-9 gnd Cytologie (DE-588)4070177-3 gnd Cytopathologie (DE-588)4122103-5 gnd |
| topic_facet | Oncology Hematology Allergology Immunology Oncology Allergy Akute Leukämie Cytologie Cytopathologie Berlin Konferenzschrift 1993 Berlin |
| url | https://doi.org/10.1007/978-3-642-84895-7 |
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