Cytokines in Severe Sepsis and Septic Shock:
t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host&...
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| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Birkhäuser Basel
1999
|
| Schriftenreihe: | Progress in Inflammation Research
|
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome |
| Beschreibung: | 1 Online-Ressource (XX, 372 p) |
| ISBN: | 9783034887557 |
| DOI: | 10.1007/978-3-0348-8755-7 |
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| 520 | |a t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome | ||
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| indexdate | 2024-07-10T08:36:26Z |
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| isbn | 9783034887557 |
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| spelling | Cytokines in Severe Sepsis and Septic Shock edited by Heinz Redl, Günther Schlag Basel Birkhäuser Basel 1999 1 Online-Ressource (XX, 372 p) txt rdacontent c rdamedia cr rdacarrier Progress in Inflammation Research t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome Medicine/Public Health, general Medicine Sepsis (DE-588)4181014-4 gnd rswk-swf Cytokine (DE-588)4205701-2 gnd rswk-swf Septischer Schock (DE-588)4193151-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Sepsis (DE-588)4181014-4 s Cytokine (DE-588)4205701-2 s DE-604 Septischer Schock (DE-588)4193151-8 s Redl, Heinz edt Schlag, Günther edt Erscheint auch als Druck-Ausgabe 9783034897594 Erscheint auch als Druck-Ausgabe 9783764358778 Erscheint auch als Druck-Ausgabe 9783034887564 https://doi.org/10.1007/978-3-0348-8755-7 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Cytokines in Severe Sepsis and Septic Shock Medicine/Public Health, general Medicine Sepsis (DE-588)4181014-4 gnd Cytokine (DE-588)4205701-2 gnd Septischer Schock (DE-588)4193151-8 gnd |
| subject_GND | (DE-588)4181014-4 (DE-588)4205701-2 (DE-588)4193151-8 (DE-588)4143413-4 |
| title | Cytokines in Severe Sepsis and Septic Shock |
| title_auth | Cytokines in Severe Sepsis and Septic Shock |
| title_exact_search | Cytokines in Severe Sepsis and Septic Shock |
| title_full | Cytokines in Severe Sepsis and Septic Shock edited by Heinz Redl, Günther Schlag |
| title_fullStr | Cytokines in Severe Sepsis and Septic Shock edited by Heinz Redl, Günther Schlag |
| title_full_unstemmed | Cytokines in Severe Sepsis and Septic Shock edited by Heinz Redl, Günther Schlag |
| title_short | Cytokines in Severe Sepsis and Septic Shock |
| title_sort | cytokines in severe sepsis and septic shock |
| topic | Medicine/Public Health, general Medicine Sepsis (DE-588)4181014-4 gnd Cytokine (DE-588)4205701-2 gnd Septischer Schock (DE-588)4193151-8 gnd |
| topic_facet | Medicine/Public Health, general Medicine Sepsis Cytokine Septischer Schock Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-0348-8755-7 |
| work_keys_str_mv | AT redlheinz cytokinesinseveresepsisandsepticshock AT schlaggunther cytokinesinseveresepsisandsepticshock |