Airways Smooth Muscle: Structure, Innervation and Neurotransmission
Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in air...
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Basel
Birkhäuser Basel
1994
|
| Schriftenreihe: | Respiratory Pharmacology and Pharmacotherapy
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| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter |
| Beschreibung: | 1 Online-Ressource (VIII, 332 p. 64 illus) |
| ISBN: | 9783034875585 |
| DOI: | 10.1007/978-3-0348-7558-5 |
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| 520 | |a Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter | ||
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| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-0348-7558-5 |
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| indexdate | 2024-07-10T08:36:26Z |
| institution | BVB |
| isbn | 9783034875585 |
| language | English |
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| spelling | Airways Smooth Muscle Structure, Innervation and Neurotransmission edited by David Raeburn, Mark A. Giembycz Basel Birkhäuser Basel 1994 1 Online-Ressource (VIII, 332 p. 64 illus) txt rdacontent c rdamedia cr rdacarrier Respiratory Pharmacology and Pharmacotherapy Many factors may influence the release of neurotransmitters from airway nerves [1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are marked differences be tween species in airway innervation and in neuromodulatory effects and, wherever possible, studies in human airways have been emphasised, although information on neuromodulation in human airways is some what limited at present. Release of neurotransmitters from nerve terminals occurs via a Ca2+ dependent secretion evoked by a nerve action potential, but may also be evoked experimentally by a high extracellular K + concentration which directly depolarises the nerve terminal membrane. Modulation refers to the alteration of neurotransmitter release, which may either be increased (facilitation) or reduced (inhibition) by the action of a particular agent, thus changing the magnitude of the neurally-mediated response. Such agents would normally act on receptors on the nerve terminal which are referred to as pre-junctional (or presynaptic) receptors, in contrast to post-junctional (or post-synaptic) receptors located on the target cells which are influenced by that particular transmitter Human Physiology Pneumology/Respiratory System Pharmacology/Toxicology Anatomy Human physiology Pneumology Toxicology Human anatomy Atemwege (DE-588)4068903-7 gnd rswk-swf Glatte Muskulatur (DE-588)4157472-2 gnd rswk-swf Atemwege (DE-588)4068903-7 s Glatte Muskulatur (DE-588)4157472-2 s 1\p DE-604 Raeburn, David edt Giembycz, Mark A. edt Erscheint auch als Druck-Ausgabe 9783034875608 Erscheint auch als Druck-Ausgabe 9783764350109 Erscheint auch als Druck-Ausgabe 9783034875592 https://doi.org/10.1007/978-3-0348-7558-5 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Airways Smooth Muscle Structure, Innervation and Neurotransmission Human Physiology Pneumology/Respiratory System Pharmacology/Toxicology Anatomy Human physiology Pneumology Toxicology Human anatomy Atemwege (DE-588)4068903-7 gnd Glatte Muskulatur (DE-588)4157472-2 gnd |
| subject_GND | (DE-588)4068903-7 (DE-588)4157472-2 |
| title | Airways Smooth Muscle Structure, Innervation and Neurotransmission |
| title_auth | Airways Smooth Muscle Structure, Innervation and Neurotransmission |
| title_exact_search | Airways Smooth Muscle Structure, Innervation and Neurotransmission |
| title_full | Airways Smooth Muscle Structure, Innervation and Neurotransmission edited by David Raeburn, Mark A. Giembycz |
| title_fullStr | Airways Smooth Muscle Structure, Innervation and Neurotransmission edited by David Raeburn, Mark A. Giembycz |
| title_full_unstemmed | Airways Smooth Muscle Structure, Innervation and Neurotransmission edited by David Raeburn, Mark A. Giembycz |
| title_short | Airways Smooth Muscle |
| title_sort | airways smooth muscle structure innervation and neurotransmission |
| title_sub | Structure, Innervation and Neurotransmission |
| topic | Human Physiology Pneumology/Respiratory System Pharmacology/Toxicology Anatomy Human physiology Pneumology Toxicology Human anatomy Atemwege (DE-588)4068903-7 gnd Glatte Muskulatur (DE-588)4157472-2 gnd |
| topic_facet | Human Physiology Pneumology/Respiratory System Pharmacology/Toxicology Anatomy Human physiology Pneumology Toxicology Human anatomy Atemwege Glatte Muskulatur |
| url | https://doi.org/10.1007/978-3-0348-7558-5 |
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