The Vascular Pole of the Renal Glomerulus of Rat:
Knowledge of the architecture of the renal glomerulus is a prerequisite for understanding both glomerular function and pathology. Glomerular filtration depends on comparably high intracapillary hydrostatic pressures. These high pressures must be balanced by commensurate counterforces to maintain str...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1998
|
| Schriftenreihe: | Advances in Anatomy, Embryology and Cell Biology
139 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | Knowledge of the architecture of the renal glomerulus is a prerequisite for understanding both glomerular function and pathology. Glomerular filtration depends on comparably high intracapillary hydrostatic pressures. These high pressures must be balanced by commensurate counterforces to maintain structural integrity. Elevated pressures can damage the glomerulus. The "window" for pressures high enough for effective filtration and yet tolerable to the glomerulus is narrow. Precise regulation is therefore necessary to keep intraglomerular pressure within an appropriate range. This study provides a comprehensive description of the glomerular arterioles, which are the vessels primarily responsible for the regulation of intraglomerular pressures. It thereby describes the structures which may be presumed to generate counterforces needed to assure structural stability. The arterioles are closely associated with the supporting system comprised of the intra- and extraglomerular mesangium. The extraglomerular mesangium forms a spider-like clamp providing a mechanical interconnection of all components of the vascular pole. At the same time, it may act as a tension receptor, i.e. as a sensor of intraglomerular pressures. Due to its intimate relationship to the macula densa, the extraglomerular mesangium receives information on the distal solute delivery and therefore may act as the integrative center within the juxtaglomerular apparatus. The close spatial association between the afferent and efferent arterioles at the vascular pole suggests a direct regulatory interaction between both arterioles. In addition, the specific wall structure of the efferent arteriole exhibiting the features of a shear stress receptor suggests new pathways for feedback regulation of glomerular hemodynamics |
| Beschreibung: | 1 Online-Ressource (IX, 98 p. 32 illus) |
| ISBN: | 9783642804496 |
| DOI: | 10.1007/978-3-642-80449-6 |
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| 520 | |a Knowledge of the architecture of the renal glomerulus is a prerequisite for understanding both glomerular function and pathology. Glomerular filtration depends on comparably high intracapillary hydrostatic pressures. These high pressures must be balanced by commensurate counterforces to maintain structural integrity. Elevated pressures can damage the glomerulus. The "window" for pressures high enough for effective filtration and yet tolerable to the glomerulus is narrow. Precise regulation is therefore necessary to keep intraglomerular pressure within an appropriate range. This study provides a comprehensive description of the glomerular arterioles, which are the vessels primarily responsible for the regulation of intraglomerular pressures. It thereby describes the structures which may be presumed to generate counterforces needed to assure structural stability. The arterioles are closely associated with the supporting system comprised of the intra- and extraglomerular mesangium. The extraglomerular mesangium forms a spider-like clamp providing a mechanical interconnection of all components of the vascular pole. At the same time, it may act as a tension receptor, i.e. as a sensor of intraglomerular pressures. Due to its intimate relationship to the macula densa, the extraglomerular mesangium receives information on the distal solute delivery and therefore may act as the integrative center within the juxtaglomerular apparatus. The close spatial association between the afferent and efferent arterioles at the vascular pole suggests a direct regulatory interaction between both arterioles. In addition, the specific wall structure of the efferent arteriole exhibiting the features of a shear stress receptor suggests new pathways for feedback regulation of glomerular hemodynamics | ||
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Datensatz im Suchindex
| _version_ | 1804180479122866176 |
|---|---|
| any_adam_object | |
| author | Elger, Marlies Sakai, Tatsuo Kriz, Wilhelm |
| author_facet | Elger, Marlies Sakai, Tatsuo Kriz, Wilhelm |
| author_role | aut aut aut |
| author_sort | Elger, Marlies |
| author_variant | m e me t s ts w k wk |
| building | Verbundindex |
| bvnumber | BV046144130 |
| classification_rvk | WW 7000 |
| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-3-642-80449-6 (OCoLC)1119094181 (DE-599)BVBBV046144130 |
| dewey-full | 612 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612 |
| dewey-search | 612 |
| dewey-sort | 3612 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-642-80449-6 |
| format | Electronic eBook |
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| id | DE-604.BV046144130 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:25Z |
| institution | BVB |
| isbn | 9783642804496 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031524315 |
| oclc_num | 1119094181 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 Online-Ressource (IX, 98 p. 32 illus) |
| psigel | ZDB-2-SME ZDB-2-SME_1990/2004 ZDB-2-SME ZDB-2-SME_1990/2004 |
| publishDate | 1998 |
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| publisher | Springer Berlin Heidelberg |
| record_format | marc |
| series2 | Advances in Anatomy, Embryology and Cell Biology |
| spelling | Elger, Marlies Verfasser aut The Vascular Pole of the Renal Glomerulus of Rat by Marlies Elger, Tatsuo Sakai, Wilhelm Kriz Berlin, Heidelberg Springer Berlin Heidelberg 1998 1 Online-Ressource (IX, 98 p. 32 illus) txt rdacontent c rdamedia cr rdacarrier Advances in Anatomy, Embryology and Cell Biology 139 Knowledge of the architecture of the renal glomerulus is a prerequisite for understanding both glomerular function and pathology. Glomerular filtration depends on comparably high intracapillary hydrostatic pressures. These high pressures must be balanced by commensurate counterforces to maintain structural integrity. Elevated pressures can damage the glomerulus. The "window" for pressures high enough for effective filtration and yet tolerable to the glomerulus is narrow. Precise regulation is therefore necessary to keep intraglomerular pressure within an appropriate range. This study provides a comprehensive description of the glomerular arterioles, which are the vessels primarily responsible for the regulation of intraglomerular pressures. It thereby describes the structures which may be presumed to generate counterforces needed to assure structural stability. The arterioles are closely associated with the supporting system comprised of the intra- and extraglomerular mesangium. The extraglomerular mesangium forms a spider-like clamp providing a mechanical interconnection of all components of the vascular pole. At the same time, it may act as a tension receptor, i.e. as a sensor of intraglomerular pressures. Due to its intimate relationship to the macula densa, the extraglomerular mesangium receives information on the distal solute delivery and therefore may act as the integrative center within the juxtaglomerular apparatus. The close spatial association between the afferent and efferent arterioles at the vascular pole suggests a direct regulatory interaction between both arterioles. In addition, the specific wall structure of the efferent arteriole exhibiting the features of a shear stress receptor suggests new pathways for feedback regulation of glomerular hemodynamics Human Physiology Human physiology Niere (DE-588)4042270-7 gnd rswk-swf Glomerulus (DE-588)4157648-2 gnd rswk-swf Blutgefäßsystem (DE-588)4133061-4 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Arteriole (DE-588)4276342-3 gnd rswk-swf Ratte (DE-588)4177011-0 gnd rswk-swf Ratte (DE-588)4177011-0 s Niere (DE-588)4042270-7 s Glomerulus (DE-588)4157648-2 s Blutgefäßsystem (DE-588)4133061-4 s DE-604 Arteriole (DE-588)4276342-3 s Tiermodell (DE-588)4140660-6 s Sakai, Tatsuo aut Kriz, Wilhelm aut Erscheint auch als Druck-Ausgabe 9783540632412 Erscheint auch als Druck-Ausgabe 9783642804502 https://doi.org/10.1007/978-3-642-80449-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Elger, Marlies Sakai, Tatsuo Kriz, Wilhelm The Vascular Pole of the Renal Glomerulus of Rat Human Physiology Human physiology Niere (DE-588)4042270-7 gnd Glomerulus (DE-588)4157648-2 gnd Blutgefäßsystem (DE-588)4133061-4 gnd Tiermodell (DE-588)4140660-6 gnd Arteriole (DE-588)4276342-3 gnd Ratte (DE-588)4177011-0 gnd |
| subject_GND | (DE-588)4042270-7 (DE-588)4157648-2 (DE-588)4133061-4 (DE-588)4140660-6 (DE-588)4276342-3 (DE-588)4177011-0 |
| title | The Vascular Pole of the Renal Glomerulus of Rat |
| title_auth | The Vascular Pole of the Renal Glomerulus of Rat |
| title_exact_search | The Vascular Pole of the Renal Glomerulus of Rat |
| title_full | The Vascular Pole of the Renal Glomerulus of Rat by Marlies Elger, Tatsuo Sakai, Wilhelm Kriz |
| title_fullStr | The Vascular Pole of the Renal Glomerulus of Rat by Marlies Elger, Tatsuo Sakai, Wilhelm Kriz |
| title_full_unstemmed | The Vascular Pole of the Renal Glomerulus of Rat by Marlies Elger, Tatsuo Sakai, Wilhelm Kriz |
| title_short | The Vascular Pole of the Renal Glomerulus of Rat |
| title_sort | the vascular pole of the renal glomerulus of rat |
| topic | Human Physiology Human physiology Niere (DE-588)4042270-7 gnd Glomerulus (DE-588)4157648-2 gnd Blutgefäßsystem (DE-588)4133061-4 gnd Tiermodell (DE-588)4140660-6 gnd Arteriole (DE-588)4276342-3 gnd Ratte (DE-588)4177011-0 gnd |
| topic_facet | Human Physiology Human physiology Niere Glomerulus Blutgefäßsystem Tiermodell Arteriole Ratte |
| url | https://doi.org/10.1007/978-3-642-80449-6 |
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