Brain Ischemia:
Ischemia is localized tissue anemia due to obstruction of the inflow of arterial blood, thus brain ischemia is the condition where insufficient blood is delivered to the brain. Many physiological processes occurring in the brain critically depend on the state of its energy metabolism. The state of b...
Gespeichert in:
| Hauptverfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boston, MA
Springer US
2003
|
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | Ischemia is localized tissue anemia due to obstruction of the inflow of arterial blood, thus brain ischemia is the condition where insufficient blood is delivered to the brain. Many physiological processes occurring in the brain critically depend on the state of its energy metabolism. The state of brain energy metabolism in turn depends on the delivery of oxygen and glucose to the brain via the bloodstream. Although it comprises only 2% of the total body weight, the human brain consumes 20-25% of the oxygen and up to 70% of the free glucose taken in by the body. The brain respires more intensively than any other organ of the body. The intensity of oxygen consumption by cortical brain tissue much exceeds the demands of other tissues (5.43 mmol 02/g per h versus 3.06 and 4.02 mmol for heart at rest and intensively working, respectively, 2.4 mmol for kidneys, and 1.8 mmol for liver). Oxidative phosphorylation in mitochondria generates 95% of the adenosine triphosphate (ATP) that is formed in the brain. Thus, it is clear why insufficiency of oxygen delivery to brain cells adversely affects brain function. Glucose is the main energy-providing substrate in the brain. The basic pathway of its metabolism in neural tissue is aerobic glycolysis |
| Beschreibung: | 1 Online-Ressource (XIV, 382 p) |
| ISBN: | 9781441992482 |
| DOI: | 10.1007/978-1-4419-9248-2 |
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| 520 | |a Ischemia is localized tissue anemia due to obstruction of the inflow of arterial blood, thus brain ischemia is the condition where insufficient blood is delivered to the brain. Many physiological processes occurring in the brain critically depend on the state of its energy metabolism. The state of brain energy metabolism in turn depends on the delivery of oxygen and glucose to the brain via the bloodstream. Although it comprises only 2% of the total body weight, the human brain consumes 20-25% of the oxygen and up to 70% of the free glucose taken in by the body. The brain respires more intensively than any other organ of the body. The intensity of oxygen consumption by cortical brain tissue much exceeds the demands of other tissues (5.43 mmol 02/g per h versus 3.06 and 4.02 mmol for heart at rest and intensively working, respectively, 2.4 mmol for kidneys, and 1.8 mmol for liver). Oxidative phosphorylation in mitochondria generates 95% of the adenosine triphosphate (ATP) that is formed in the brain. Thus, it is clear why insufficiency of oxygen delivery to brain cells adversely affects brain function. Glucose is the main energy-providing substrate in the brain. The basic pathway of its metabolism in neural tissue is aerobic glycolysis | ||
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Datensatz im Suchindex
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| author | Gusev, Eugene Skvortsova, Veronica I. |
| author_facet | Gusev, Eugene Skvortsova, Veronica I. |
| author_role | aut aut |
| author_sort | Gusev, Eugene |
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| collection | ZDB-2-SME |
| ctrlnum | (ZDB-2-SME)978-1-4419-9248-2 (OCoLC)1119019657 (DE-599)BVBBV046143707 |
| dewey-full | 616.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.8 |
| dewey-search | 616.8 |
| dewey-sort | 3616.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-1-4419-9248-2 |
| format | Electronic eBook |
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| id | DE-604.BV046143707 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:24Z |
| institution | BVB |
| isbn | 9781441992482 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031523891 |
| oclc_num | 1119019657 |
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| physical | 1 Online-Ressource (XIV, 382 p) |
| psigel | ZDB-2-SME ZDB-2-SME_1990/2004 ZDB-2-SME ZDB-2-SME_1990/2004 |
| publishDate | 2003 |
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| publisher | Springer US |
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| spelling | Gusev, Eugene Verfasser aut Brain Ischemia by Eugene Gusev, Veronica I. Skvortsova Boston, MA Springer US 2003 1 Online-Ressource (XIV, 382 p) txt rdacontent c rdamedia cr rdacarrier Ischemia is localized tissue anemia due to obstruction of the inflow of arterial blood, thus brain ischemia is the condition where insufficient blood is delivered to the brain. Many physiological processes occurring in the brain critically depend on the state of its energy metabolism. The state of brain energy metabolism in turn depends on the delivery of oxygen and glucose to the brain via the bloodstream. Although it comprises only 2% of the total body weight, the human brain consumes 20-25% of the oxygen and up to 70% of the free glucose taken in by the body. The brain respires more intensively than any other organ of the body. The intensity of oxygen consumption by cortical brain tissue much exceeds the demands of other tissues (5.43 mmol 02/g per h versus 3.06 and 4.02 mmol for heart at rest and intensively working, respectively, 2.4 mmol for kidneys, and 1.8 mmol for liver). Oxidative phosphorylation in mitochondria generates 95% of the adenosine triphosphate (ATP) that is formed in the brain. Thus, it is clear why insufficiency of oxygen delivery to brain cells adversely affects brain function. Glucose is the main energy-providing substrate in the brain. The basic pathway of its metabolism in neural tissue is aerobic glycolysis Neurology Cardiology Neurosciences Neurosurgery Cardiac Surgery Heart / Surgery Skvortsova, Veronica I. aut Erscheint auch als Druck-Ausgabe 9780306476945 Erscheint auch als Druck-Ausgabe 9781461348573 Erscheint auch als Druck-Ausgabe 9781441992499 https://doi.org/10.1007/978-1-4419-9248-2 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Gusev, Eugene Skvortsova, Veronica I. Brain Ischemia Neurology Cardiology Neurosciences Neurosurgery Cardiac Surgery Heart / Surgery |
| title | Brain Ischemia |
| title_auth | Brain Ischemia |
| title_exact_search | Brain Ischemia |
| title_full | Brain Ischemia by Eugene Gusev, Veronica I. Skvortsova |
| title_fullStr | Brain Ischemia by Eugene Gusev, Veronica I. Skvortsova |
| title_full_unstemmed | Brain Ischemia by Eugene Gusev, Veronica I. Skvortsova |
| title_short | Brain Ischemia |
| title_sort | brain ischemia |
| topic | Neurology Cardiology Neurosciences Neurosurgery Cardiac Surgery Heart / Surgery |
| topic_facet | Neurology Cardiology Neurosciences Neurosurgery Cardiac Surgery Heart / Surgery |
| url | https://doi.org/10.1007/978-1-4419-9248-2 |
| work_keys_str_mv | AT guseveugene brainischemia AT skvortsovaveronicai brainischemia |