Leucocyte Trafficking: The Role of Fucosyltransferases and Selectins
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in heal...
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| Weitere Verfasser: | , , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
2004
|
| Schriftenreihe: | Ernst Schering Foundation Symposium Proceedings
44 |
| Schlagworte: | |
| Online-Zugang: | UBR01 Volltext |
| Zusammenfassung: | An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases |
| Beschreibung: | 1 Online-Ressource (XIV, 242 p) |
| ISBN: | 9783662053973 |
| DOI: | 10.1007/978-3-662-05397-3 |
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| 520 | |a An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases | ||
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Datensatz im Suchindex
| _version_ | 1804180477675831296 |
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| any_adam_object | |
| author2 | Hamann, Alf Asadullah, Khusru Schottelius, Arndt |
| author2_role | edt edt edt |
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| author_facet | Hamann, Alf Asadullah, Khusru Schottelius, Arndt |
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| collection | ZDB-2-SME |
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| dewey-full | 612 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612 |
| dewey-search | 612 |
| dewey-sort | 3612 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-662-05397-3 |
| format | Electronic eBook |
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| id | DE-604.BV046143519 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:23Z |
| institution | BVB |
| isbn | 9783662053973 |
| language | English |
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| publishDate | 2004 |
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| spelling | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins edited by Alf Hamann, Khusru Asadullah, Arndt Schottelius Berlin, Heidelberg Springer Berlin Heidelberg 2004 1 Online-Ressource (XIV, 242 p) txt rdacontent c rdamedia cr rdacarrier Ernst Schering Foundation Symposium Proceedings 44 An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases Human Physiology Immunology Molecular Medicine Dermatology Human physiology Medicine Fucosylierung (DE-588)4755516-6 gnd rswk-swf Leukozyt (DE-588)4074195-3 gnd rswk-swf Glucosyltransferasen (DE-588)4467214-7 gnd rswk-swf Selectine (DE-588)4472944-3 gnd rswk-swf Glycosyltransferasen (DE-588)4157751-6 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2002 Berlin gnd-content Leukozyt (DE-588)4074195-3 s Fucosylierung (DE-588)4755516-6 s Glucosyltransferasen (DE-588)4467214-7 s DE-604 Glycosyltransferasen (DE-588)4157751-6 s Selectine (DE-588)4472944-3 s Hamann, Alf edt Asadullah, Khusru edt Schottelius, Arndt edt Erscheint auch als Druck-Ausgabe 9783662053997 Erscheint auch als Druck-Ausgabe 9783540401124 Erscheint auch als Druck-Ausgabe 9783662053980 https://doi.org/10.1007/978-3-662-05397-3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins Human Physiology Immunology Molecular Medicine Dermatology Human physiology Medicine Fucosylierung (DE-588)4755516-6 gnd Leukozyt (DE-588)4074195-3 gnd Glucosyltransferasen (DE-588)4467214-7 gnd Selectine (DE-588)4472944-3 gnd Glycosyltransferasen (DE-588)4157751-6 gnd |
| subject_GND | (DE-588)4755516-6 (DE-588)4074195-3 (DE-588)4467214-7 (DE-588)4472944-3 (DE-588)4157751-6 (DE-588)1071861417 |
| title | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins |
| title_auth | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins |
| title_exact_search | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins |
| title_full | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins edited by Alf Hamann, Khusru Asadullah, Arndt Schottelius |
| title_fullStr | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins edited by Alf Hamann, Khusru Asadullah, Arndt Schottelius |
| title_full_unstemmed | Leucocyte Trafficking The Role of Fucosyltransferases and Selectins edited by Alf Hamann, Khusru Asadullah, Arndt Schottelius |
| title_short | Leucocyte Trafficking |
| title_sort | leucocyte trafficking the role of fucosyltransferases and selectins |
| title_sub | The Role of Fucosyltransferases and Selectins |
| topic | Human Physiology Immunology Molecular Medicine Dermatology Human physiology Medicine Fucosylierung (DE-588)4755516-6 gnd Leukozyt (DE-588)4074195-3 gnd Glucosyltransferasen (DE-588)4467214-7 gnd Selectine (DE-588)4472944-3 gnd Glycosyltransferasen (DE-588)4157751-6 gnd |
| topic_facet | Human Physiology Immunology Molecular Medicine Dermatology Human physiology Medicine Fucosylierung Leukozyt Glucosyltransferasen Selectine Glycosyltransferasen Konferenzschrift 2002 Berlin |
| url | https://doi.org/10.1007/978-3-662-05397-3 |
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