The Somatotrophic Axis and the Reproductive Process in Health and Disease:
For many years now, our understanding of the somatotrophic and reproduc tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under standing. Along the way, however, it became apparent that in some circumstances the r...
Gespeichert in:
| Weitere Verfasser: | , |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
1995
|
| Schriftenreihe: | Serono Symposia USA
|
| Schlagworte: | |
| Online-Zugang: | DE-355 URL des Erstveröffentlichers |
| Zusammenfassung: | For many years now, our understanding of the somatotrophic and reproduc tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation |
| Beschreibung: | 1 Online-Ressource (XVIII, 332 p) |
| ISBN: | 9781461225188 |
| DOI: | 10.1007/978-1-4612-2518-8 |
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| 520 | |a For many years now, our understanding of the somatotrophic and reproduc tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation | ||
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Datensatz im Suchindex
| _version_ | 1823215009496301568 |
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| adam_text | |
| any_adam_object | |
| author2 | Adashi, Eli Y. Thorner, Michael O. |
| author2_role | edt edt |
| author2_variant | e y a ey eya m o t mo mot |
| author_facet | Adashi, Eli Y. Thorner, Michael O. |
| building | Verbundindex |
| bvnumber | BV046143510 |
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| collection | ZDB-2-SME |
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| dewey-full | 616.4 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.4 |
| dewey-search | 616.4 |
| dewey-sort | 3616.4 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-1-4612-2518-8 |
| format | Electronic eBook |
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| id | DE-604.BV046143510 |
| illustrated | Not Illustrated |
| indexdate | 2025-02-05T11:02:07Z |
| institution | BVB |
| isbn | 9781461225188 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031523694 |
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| spelling | The Somatotrophic Axis and the Reproductive Process in Health and Disease edited by Eli Y. Adashi, Michael O. Thorner New York, NY Springer New York 1995 1 Online-Ressource (XVIII, 332 p) txt rdacontent c rdamedia cr rdacarrier Serono Symposia USA For many years now, our understanding of the somatotrophic and reproduc tive axes has evolved essentially independently, both fields of study reaching a highly advanced, although far from complete, level of under standing. Along the way, however, it became apparent that in some circumstances the reproductive and somatotrophic axes may be inter dependent. Inklings to this effect were at times feeble and at other times more convincing. Among those inklings are the clinical recognition by pediatric endocrinologists of the apparent association between isolated GH deficiency and delayed puberty, as well as of the apparent permissive, pUberty-promoting property of GH. Equally important is a body of experi mental studies establishing the ovary of multiple species as a site of GH reception and action. Arguing against an essential role for GH in the reproductive process is the observation that individuals who have GH resistance of the Laron variety are fertile arid that isolated GH deficiency does not constitute an absolute barrier to the attainment of sexual maturation and fertility. The intraovarian insulin-like growth factor (IGF) hypothesis proposes that IGFs may serve as amplifiers of gonadotropin action. Although the dependence of intraovarian IGFs on systemic GH action has never been unequivocally demonstrated, that leap of faith has often been made. The intraovarian IGF hypothesis serves as the rationale for the adjunctive use of GH in the induction of ovulation Endocrinology Gynecology Human Physiology Cell Biology Human physiology Cytology Fortpflanzung (DE-588)4017982-5 gnd rswk-swf Frauenkrankheit (DE-588)4113621-4 gnd rswk-swf Menstruationszyklus (DE-588)4074728-1 gnd rswk-swf Reproduktionsmedizin (DE-588)4197011-1 gnd rswk-swf Ovulation (DE-588)4173004-5 gnd rswk-swf Hormontherapie (DE-588)4025870-1 gnd rswk-swf Somatotropin (DE-588)4137446-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1993 Baltimore Md. gnd-content Frauenkrankheit (DE-588)4113621-4 s Somatotropin (DE-588)4137446-0 s DE-604 Ovulation (DE-588)4173004-5 s Hormontherapie (DE-588)4025870-1 s Reproduktionsmedizin (DE-588)4197011-1 s Fortpflanzung (DE-588)4017982-5 s Menstruationszyklus (DE-588)4074728-1 s Adashi, Eli Y. edt Thorner, Michael O. edt Erscheint auch als Druck-Ausgabe 9781461275671 Erscheint auch als Druck-Ausgabe 9780387944197 Erscheint auch als Druck-Ausgabe 9781461225195 https://doi.org/10.1007/978-1-4612-2518-8 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | The Somatotrophic Axis and the Reproductive Process in Health and Disease Endocrinology Gynecology Human Physiology Cell Biology Human physiology Cytology Fortpflanzung (DE-588)4017982-5 gnd Frauenkrankheit (DE-588)4113621-4 gnd Menstruationszyklus (DE-588)4074728-1 gnd Reproduktionsmedizin (DE-588)4197011-1 gnd Ovulation (DE-588)4173004-5 gnd Hormontherapie (DE-588)4025870-1 gnd Somatotropin (DE-588)4137446-0 gnd |
| subject_GND | (DE-588)4017982-5 (DE-588)4113621-4 (DE-588)4074728-1 (DE-588)4197011-1 (DE-588)4173004-5 (DE-588)4025870-1 (DE-588)4137446-0 (DE-588)1071861417 |
| title | The Somatotrophic Axis and the Reproductive Process in Health and Disease |
| title_auth | The Somatotrophic Axis and the Reproductive Process in Health and Disease |
| title_exact_search | The Somatotrophic Axis and the Reproductive Process in Health and Disease |
| title_full | The Somatotrophic Axis and the Reproductive Process in Health and Disease edited by Eli Y. Adashi, Michael O. Thorner |
| title_fullStr | The Somatotrophic Axis and the Reproductive Process in Health and Disease edited by Eli Y. Adashi, Michael O. Thorner |
| title_full_unstemmed | The Somatotrophic Axis and the Reproductive Process in Health and Disease edited by Eli Y. Adashi, Michael O. Thorner |
| title_short | The Somatotrophic Axis and the Reproductive Process in Health and Disease |
| title_sort | the somatotrophic axis and the reproductive process in health and disease |
| topic | Endocrinology Gynecology Human Physiology Cell Biology Human physiology Cytology Fortpflanzung (DE-588)4017982-5 gnd Frauenkrankheit (DE-588)4113621-4 gnd Menstruationszyklus (DE-588)4074728-1 gnd Reproduktionsmedizin (DE-588)4197011-1 gnd Ovulation (DE-588)4173004-5 gnd Hormontherapie (DE-588)4025870-1 gnd Somatotropin (DE-588)4137446-0 gnd |
| topic_facet | Endocrinology Gynecology Human Physiology Cell Biology Human physiology Cytology Fortpflanzung Frauenkrankheit Menstruationszyklus Reproduktionsmedizin Ovulation Hormontherapie Somatotropin Konferenzschrift 1993 Baltimore Md. |
| url | https://doi.org/10.1007/978-1-4612-2518-8 |
| work_keys_str_mv | AT adashieliy thesomatotrophicaxisandthereproductiveprocessinhealthanddisease AT thornermichaelo thesomatotrophicaxisandthereproductiveprocessinhealthanddisease |