2-Hydroxyisobutyryl-CoA mutase: kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Elektronisch Software E-Book |
| Sprache: | English |
| Veröffentlicht: |
Leipzig
2018
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 1 CD-ROM (vi, 123 Seiten) Illustrationen 12 cm |
Internformat
MARC
| LEADER | 00000nmm a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV046142192 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 006 | a m||| 00||| | ||
| 007 | co|uuu---uuuuu | ||
| 008 | 190905s2018 gw |||| q||u| ||||||eng d | ||
| 015 | |a 18,H12 |2 dnb | ||
| 016 | 7 | |a 1170068596 |2 DE-101 | |
| 035 | |a (OCoLC)1118992752 | ||
| 035 | |a (DE-599)DNB1170068596 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE | ||
| 049 | |a DE-355 | ||
| 084 | |a 660 |2 sdnb | ||
| 100 | 1 | |a Kurteva, Nadya Atanasova |d 1982- |e Verfasser |0 (DE-588)1168038790 |4 aut | |
| 245 | 1 | 0 | |a 2-Hydroxyisobutyryl-CoA mutase |b kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |c vorgelegt von Diplom-Biochemikerin Nadya Atanasova Kurteva |
| 264 | 1 | |a Leipzig |c 2018 | |
| 300 | |a 1 CD-ROM (vi, 123 Seiten) |b Illustrationen |c 12 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cd |2 rdacarrier | ||
| 502 | |b Dissertation |c Universität Leipzig |d 2018 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 655 | 7 | |0 (DE-588)4139307-7 |a CD-ROM |2 gnd-carrier | |
| 856 | 4 | 2 | |m B:DE-101 |q application/pdf |u http://d-nb.info/1170068596/04 |3 Inhaltsverzeichnis |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031522408&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-031522408 | ||
| 347 | |a Textdatei |b PDF | ||
Datensatz im Suchindex
| _version_ | 1804180475478016000 |
|---|---|
| adam_text | TABLE OF CONTENTS
ZUSAMMENFASSUNG...................................................................................................................1
SUMMARY..................................................................................................................................6
INTRODUCTION...........................................................................................................................11
1. COENZYME BI
2
-DEPENDENT ACYL-COA
MUTASES......................................................................11
1.1. SUB-FAMILIES AND METABOLIC
ROLES.....................................................................................
11
1.2. REACTION MECHANISM AND STRUCTURAL DOMAIN/SUBUNIT ORGANIZATION
....................................
12
1.3. ACTIVE SITE ARCHITECTURE AND DETERMINANTS OF SUBSTRATE SPECIFICITY
....................................
15
2. NOVEL ACYL-COA MUTASE INVOLVED IN DEGRADATION OF 2-HYDROXYISOBUTYRIC
ACID..................16
2.1. FUEL OXYGENATE
ETHERS.......................................................................................................
17
2.2. BIODEGRADATION OF CHEMICALS WITH TERT-BUTYL
MOIETY........................................................18
2.3. B
12
-DEPENDENT 2-HYDROXYISOBUTYRYL-COA MUTASE
...........................................................
21
2.4. BIOTECHNOLOGICAL PRODUCTION OF
2-HIBA..........................................................................
22
3. AIMS OF THIS
STUDY...............................................................................................................23
CHAPTER 1: SUBSTRATE SPECIFICITY OF 2-HYDROXYISOBUTYRYL-COA MUTASE HCM
FROM
AQUINCOLA TERTIARICARBONIS
L108..................................................................................
25
CHAPTER 2: CRYSTAL STRUCTURE OF 2-HYDROXYISOBUTYRYL-COA MUTASE HCM
FROM
AQUINCOLA TERTIARICARBONIS
L108.................................................................................
43
CHAPTER 3: CHARACTERIZATION OF 2-HYDROXYISOBUTYRYL-COA MUTASE RCM
FROM
KYRPIDIA TUSCIAE DSM
2912..........................................................................................55
CHAPTER 4: SYNTHESIS OF 2-HYDROXYISOBUTYRIC ACID FROM FRUCTOSE AND
BUTYRATE
BY TWO ENGINEERED CUPRIAVIDUS NECATOR STRAINS
..................................................................
77
DISCUSSION..............................................................................................................................
89
1. DETERMINANTS OF SUBSTRATE SPECIFICITY OF ACYL-COA
MUTASES................................................89
2. ORIGIN OF 2-HYDROXYISOBUTYRYL-COA
MUTASES.....................................................................
92
3. BIOSYNTHESIS OF 2-HIBA AND
METHACRYLATES........................................................................
95
4.
OUTLOOK...............................................................................................................................
97
REFERENCES..............................................................................................................................99
ACKNOWLEDGEMENT,
APPENDIX...............................................................................................................................109
PUBLICATION
LIST........................................................................................................................109
CURRICULUM
VITAE....................................................................................................................112
DECLARATION OF
AUTHORSHIP......................................................................................................114
DOCUMENTATION OF CONTINGENTS OF
COAUTHORS.........................................................................
115
|
| any_adam_object | 1 |
| author | Kurteva, Nadya Atanasova 1982- |
| author_GND | (DE-588)1168038790 |
| author_facet | Kurteva, Nadya Atanasova 1982- |
| author_role | aut |
| author_sort | Kurteva, Nadya Atanasova 1982- |
| author_variant | n a k na nak |
| building | Verbundindex |
| bvnumber | BV046142192 |
| ctrlnum | (OCoLC)1118992752 (DE-599)DNB1170068596 |
| discipline | Chemie / Pharmazie |
| format | Thesis Electronic Software eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01556nmm a2200373 c 4500</leader><controlfield tag="001">BV046142192</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="006">a m||| 00||| </controlfield><controlfield tag="007">co|uuu---uuuuu</controlfield><controlfield tag="008">190905s2018 gw |||| q||u| ||||||eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">18,H12</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">1170068596</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1118992752</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB1170068596</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">660</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kurteva, Nadya Atanasova</subfield><subfield code="d">1982-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1168038790</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">2-Hydroxyisobutyryl-CoA mutase</subfield><subfield code="b">kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates</subfield><subfield code="c">vorgelegt von Diplom-Biochemikerin Nadya Atanasova Kurteva</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Leipzig</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 CD-ROM (vi, 123 Seiten)</subfield><subfield code="b">Illustrationen</subfield><subfield code="c">12 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cd</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="b">Dissertation</subfield><subfield code="c">Universität Leipzig</subfield><subfield code="d">2018</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4139307-7</subfield><subfield code="a">CD-ROM</subfield><subfield code="2">gnd-carrier</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">B:DE-101</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://d-nb.info/1170068596/04</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031522408&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-031522408</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">Textdatei</subfield><subfield code="b">PDF</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content (DE-588)4139307-7 CD-ROM gnd-carrier |
| genre_facet | Hochschulschrift CD-ROM |
| id | DE-604.BV046142192 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:21Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031522408 |
| oclc_num | 1118992752 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 1 CD-ROM (vi, 123 Seiten) Illustrationen 12 cm |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| record_format | marc |
| spelling | Kurteva, Nadya Atanasova 1982- Verfasser (DE-588)1168038790 aut 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates vorgelegt von Diplom-Biochemikerin Nadya Atanasova Kurteva Leipzig 2018 1 CD-ROM (vi, 123 Seiten) Illustrationen 12 cm txt rdacontent c rdamedia cd rdacarrier Dissertation Universität Leipzig 2018 (DE-588)4113937-9 Hochschulschrift gnd-content (DE-588)4139307-7 CD-ROM gnd-carrier B:DE-101 application/pdf http://d-nb.info/1170068596/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031522408&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Textdatei PDF |
| spellingShingle | Kurteva, Nadya Atanasova 1982- 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |
| subject_GND | (DE-588)4113937-9 (DE-588)4139307-7 |
| title | 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |
| title_auth | 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |
| title_exact_search | 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |
| title_full | 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates vorgelegt von Diplom-Biochemikerin Nadya Atanasova Kurteva |
| title_fullStr | 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates vorgelegt von Diplom-Biochemikerin Nadya Atanasova Kurteva |
| title_full_unstemmed | 2-Hydroxyisobutyryl-CoA mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates vorgelegt von Diplom-Biochemikerin Nadya Atanasova Kurteva |
| title_short | 2-Hydroxyisobutyryl-CoA mutase |
| title_sort | 2 hydroxyisobutyryl coa mutase kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |
| title_sub | kinetic and structural characterization of an enzyme for the biotechnological production of methacrylates |
| topic_facet | Hochschulschrift CD-ROM |
| url | http://d-nb.info/1170068596/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031522408&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kurtevanadyaatanasova 2hydroxyisobutyrylcoamutasekineticandstructuralcharacterizationofanenzymeforthebiotechnologicalproductionofmethacrylates |
Es ist kein Print-Exemplar vorhanden.
Inhaltsverzeichnis