Genetic analysis: genes, genomes, and networks in eukaryotes
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| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
[2020]
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| Ausgabe: | Third Edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xiv, 474 Seiten Illustrationen, Diagramme |
| ISBN: | 9780198809906 |
Internformat
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Datensatz im Suchindex
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| adam_text | DETAILED CONTENTS Preface to the third edition Acknowledgments Uniti Genes, Genomes, and Organisms 1 The basis for genetic analysis 3 Topic Summary 3 introduction 4 1.1 The logic of genetic analysis: An historica! we/vew 5 1.2 Genes are the units of inheritance, or ¡vs;:v.fc‘ / as right—up to a point 5 1.3 Genes are found on chromosomes, or ?vs r ;c ՝ : and the Fly Room were right—mostly 8 1.4 One gene, one polypeptide, or Garroti Иг ѕок, Ephrussi, and Tatum were right—for a while 10 1.5 Functional RNAs and the gene definition, or the centrai dogma may be neither a dogma nor cenital 15 1.6 Genetic analysis 23 2 Genomes, chromosomes, and epigei՛· 27 Topic Summary 27 Introduction 28 2.1 Genomes, chromosomes, and epigenetics: An overview 28 2.2 Gene organization and expression 33 2.3 Chromatin structure 38 2.4 Polycomb, Trithorax, and chromatin remodeling 45 2.5 Positive effect variegation and heterochromatin 51 2.6 Summary and limitations of genome annotation 55 Chapter Capsule 56 Case Study 2.1 Genomic imprinting 57 3 Model organisms and their genomes 65 Topic Summary Introduction 3.1 Model organisms: An overview 3.2 Saccharomyces cerevisiae, or the budding yeast 3.3 Caenorhabditis elegans, or the worm 3.4 Drosophila melanogaster, or the fly 3.5 Arabidopsis thaliana, sometimes known as the weed 65 66 68 73 80 88 95
Detailed contents I vii 3.6 Mus musculus, or the mouse 100 3.7 Model organisms: An overview 102 Chapter Capsule 106 Case Study 3.1 Regeneration in planaria 107 Unit li Mutants and Phenotypes 4 Identifying and classifying mutants 117 Topic Summary 117 Introduction 118 4.1 Finding mutations: An overview 118 4.2 Producing mutations 121 4.3 Finding mutations 128 4.4 Mapping genes 137 4.5 Complementation tests to assign mutants to genes 140 4.6 Classifying mutants 145 4.7 Summary: Find a mutant 155 Chapter Capsule 155 Case Study 4.1 Segmentation in Drosophila embryos 156 5 Connecting phenotypes with DNA sequences 171 Topic Summary 171 Introduction 172 5.1 Connecting mutants to DNA sequences: An overview 172 5.2 Identifying candidate genes: Map position 175 5.3 Identifying candidate genes: Expression pattern 178 5.4 Evaluating the candidate genes: Complementation and mutation 179 5.5 Direct searches for causative mutations: Exorne sequencing 183 5.6 Summary: Connecting a phenotype to a DNA sequence 193 Chapter Capsule 194 Case Study 5.1 Positional cloning of the cystic fibrosis gene in humans 6 Mutant phenotypes and gene activity 195 202 Topic Summary 202 Introduction 203 6.1 Overview of mutant phenotypes and gene activity 204 6.2 Interpreting mutant phenotypes 208 6.3 Conditional mutations and the time of gene activity 217 6.4 Gene activity, gene expression levels, and biological noise 225 6.5 Summary: Mutant phenotypes and gene activity 228 Chapter Capsule 228 Case Study 6.1 Temperature-sensitive periods and gene expression 229
¥111 Detailed contents 7 Reverse genetics: Editing genes in yeast and mice 237 Topic Summary 237 Introduction 238 7.1 An overview of reverse genetics 240 7.2 Genome editing in yeast 244 7.3 Targeted gene disruptions and replacements in the mouse 246 7.4 Summary: Reverse genetics and genome editing allow specific types of mutations to be made and analysed 259 Chapter Capsule 260 Case Study 7.1 Patched knockout mutations in mice 261 8 Genome editing 265 Topic Summary 265 Introduction 266 8.1 Genome editing: An overview 269 8.2 Double-stranded break response and repair 272 8.3 Before the revolution: Genome editing prior to CRISPR 277 8.4 CRISPR 281 8.5 Summary: Genome editing and the many mechanisms to make mutants 291 Chapter Capsule 292 Case Study 8.1 Genome editing in the human germline 293 9 Genome-wide mutant screens 299 Topic Summary 299 Introduction 300 9.1 Genome-wide mutant screens: An overview 301 9.2 Identifying the genes to be mutated 304 9.3 Disrupting and perturbing genes 305 9.4 RNAi and large-scale mutant analysis 310 9.5 CRISPR in genome-wide mutant screens 321 9.6 Screening for mutant phenotypes 323 9.7 Confirming the effects 325 9.8 Lessons from genome-wide screens 325 9.9 Summary: Genome-wide mutant screens attempt to identify phenotypes for every gene in the genome 327 Chapter Capsule 328 Unit III Interactions, Pathways, and Networks 10 Gene interactions: Suppressors and synthetic enhancers ззз Topic Summary 333 Introduction 334
Detailed contents Į їж 10.1 Gene interactions affecting a biological process: Overview 335 10.2 Genetic interactions: Suppressors 336 10.3 Genetic interactions: Synthetic enhancers 350 10.4 Genetic interactions: Summary 358 10.5 Molecular interactions between proteins 359 10.6 Summary: Genetic interactions, both genes and proteins 365 Chapter Capsule 366 Case Study 10.1 Genetic analysis of spindle morphogenesis in budding yeast 367 11 Epistasis and genetic pathways 381 Topic Summary 381 Introduction 382 11.1 Epistasis and genetic pathways: An overview 382 11.2 Combining mutants and molecular expression assays 384 11.3 Epistasis and genetic pathways 387 11.4 The ptc pathway 400 11.5 The pathways unveiled 404 Chapter Capsule 405 Case Study 11.1 Dauer larva formation in C. elegans 406 12 Pathways, networks, and phenotypes 415 Topic Summary 415 Introduction 416 12.1 Pathways, networks, and phenotypes: An overview 417 12.2 Networks and graphs 419 12.3 The interactions between transcription factors and DNA sequences 421 12.4 microRNA and mRNA interactions 428 12.5 The interactions between proteins 431 12.6 Genetic interaction networks 436 12.7 Gene expression, biological noise, and phenotypes 443 12.8 Pathways, networks, and phenotypes: A summary 449 Glossary Index Chapter Capsule 451 Case Study 12.1 A Systems analysis ofTGF-ß signaling in C. elegans 452 459 467
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| spelling | Meneely, Philip Verfasser (DE-588)1134887620 aut Genetic analysis genes, genomes, and networks in eukaryotes Philip Meneely, Haverford College Third Edition Oxford Oxford University Press [2020] xiv, 474 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Eukaryoten (DE-588)4070991-7 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Eukaryoten (DE-588)4070991-7 s Genanalyse (DE-588)4200230-8 s DE-604 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031415523&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Meneely, Philip Genetic analysis genes, genomes, and networks in eukaryotes Eukaryoten (DE-588)4070991-7 gnd Genanalyse (DE-588)4200230-8 gnd |
| subject_GND | (DE-588)4070991-7 (DE-588)4200230-8 |
| title | Genetic analysis genes, genomes, and networks in eukaryotes |
| title_auth | Genetic analysis genes, genomes, and networks in eukaryotes |
| title_exact_search | Genetic analysis genes, genomes, and networks in eukaryotes |
| title_full | Genetic analysis genes, genomes, and networks in eukaryotes Philip Meneely, Haverford College |
| title_fullStr | Genetic analysis genes, genomes, and networks in eukaryotes Philip Meneely, Haverford College |
| title_full_unstemmed | Genetic analysis genes, genomes, and networks in eukaryotes Philip Meneely, Haverford College |
| title_short | Genetic analysis |
| title_sort | genetic analysis genes genomes and networks in eukaryotes |
| title_sub | genes, genomes, and networks in eukaryotes |
| topic | Eukaryoten (DE-588)4070991-7 gnd Genanalyse (DE-588)4200230-8 gnd |
| topic_facet | Eukaryoten Genanalyse |
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