A primer of molecular population genetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford
Oxford University Press
2019
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| Ausgabe: | First edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | xvii, 247 Seiten Illustrationen, Diagramme |
| ISBN: | 9780198838951 9780198838944 |
Internformat
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Datensatz im Suchindex
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| adam_text | Contents 1 Introduction: What is molecular population genetics? 1.1 On the origins of molecular population genetics 1.2 What is the use of molecular population genetics? Further reading 2 The origins of molecular diversity 2.1 Kinds of mutations 2.1.1 2.1.2 2.1.3 2.1.4 2.1.5 Single nucleotide mutation Simple insertions and deietions Tandem repeat mutations Transposable elements Duplications and large-scale mutations 2.2 Fitness effects of new mutations 2.2.1 2.2.2 2.2.3 2.2.4 Deleterious mutations Neutral and nearly neutral mutations Advantageous mutations Magnitude and distribution of effects 2.3 Models of mutation 2.3.1 2.3.2 2.3.3 2.3.4 2.3.5 2.3.6 2.3.7 Recurrent mutation model Infinite alleles model Infinite sites model Finite sites models Stepwise mutation model Birth-death model of gene duplication Biological complexities in mutation Further reading 3 Quantifying genetic variation at the molecular level 3.1 Heterozygosity 3.2 Allozyme variation 3.3 DNA sequence variation 3.3.1 Nucleotide polymorphism and diversity: 6w and θπ 3.3.2 The site frequency spectmm 3.4 Simple sequence repeat variation 3.5 Other measures of molecular diversity 3.6 Genetic variation among multiple populations 3.6.1 Quantifying population genetic structure with Fst 3.6.2 Migration models and effects on population subdivision Further reading l 1 8 10 lí 11 11 18 18 20 21 22 22 25 26 26 27 28 29 29 29 30 30 31 32 34 36 42 43 44 50 52 52 54 54 59 65
xvi CONTENTS 4 Neutral theories of molecular evolution 67 4.1 The standard neutral model 4.1.1 Neutral divergence and the molecular clock 4.1.2 Neutral predictions for polymorphism 67 69 74 4.2 Nearly Neutral Theory 4.3 More complex models of selective neutrality 78 81 4.4 Misconceptions about Neutral Theory 82 Further reading 83 5 Genealogy in evolution 85 5.1 Gene trees forward-in-time within species 5.2 Gene trees in reverse-time coalescence within species 5.3 Gene trees, species trees, and phylogeny among species 5.3.1 Substitution rates in divergence 5.3.2 Multiple hits in sequence divergence 5.3.3 Phylogeny: topology, discordance, and molecular clocks 5.4 Effects of recombination and hybridization on genealogies Further reading 6 Recombination and linkage disequilibrium in evolutionary signatures 6.1 6.2 6.3 6.4 Linkage disequilibrium: what is it? The causes of linkage disequilibrium Measuring linkage disequilibrium Gene conversion: non-crossover recombination Further reading 7 Natural selection and demography as causes of molecular non-randomness 7.1 Natural selection 7.1.1 Positive selection 7.1.2 Balancing selection 7.1.3 Purifying selection 7.1.4 Connecting notions of selection at phenotypic and molecular levels 7.2 Population size changes 7.2.1 Population expansions 7.2.2 Population contractions and bottlenecks 7.3 Population structure and migration 7.3.1 Population structure and genealogies 7.3.2 Local adaptation in subpopulations 7.4 Genomic compartments of chromosomal linkage Further reading 85 88 94 98 104 107 110 112 из 115 116 119 126 128 129 129 130 136
138 142 143 144 145 146 148 153 153 158
CONTENTS 8 Molecular deviants: Sequence signatures of selection and demography 8.1 Skewed patterns of polymorphism 159 159 8.1.1 Too little or too much polymorphism 8.1.2 Skewed site frequency spectra 161 164 8.2 Sequence divergence and differentiation 170 8.2.1 Кд/Ks ratios 8.2.2 Population differentiation and Fsr outliers 8.2.3 Characterizing population structure and admixture 8.3 Polymorphism and divergence 8.3.1 The НКЛ test 8.3.2 The MK test 8.3.3 Extensions to the MK framework 171 175 180 181 182 184 189 8.4 Connecting quantitative genetics and molecular population genetics Further reading 191 192 9 Case studies in molecular population genetics: Genotype to phenotype to selection 195 9.1 9.2 9.3 9.4 9.5 9.6 Coat color adaptation in mice Flight ability in butterflies Insecticide resistance in Drosophila Body armor in stickleback fish Alcohol tolerance in Drosophila Advanced issues in molecular evolutionary signatures Further reading Glossary of units, metrics, acronyms, and abbreviations Glossary of tenns and jargon Index 195 200 202 205 209 212 214 217 223 243 xvii
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| isbn | 9780198838951 9780198838944 |
| language | English |
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| spelling | Cutter, Asher D. Verfasser aut A primer of molecular population genetics Asher D. Cutter First edition Oxford Oxford University Press 2019 xvii, 247 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Populationsgenetik (DE-588)4046804-5 gnd rswk-swf Molekularbiologe (DE-588)1023071983 gnd rswk-swf Populationsgenetik (DE-588)4046804-5 s Molekularbiologe (DE-588)1023071983 s DE-604 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030914261&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cutter, Asher D. A primer of molecular population genetics Populationsgenetik (DE-588)4046804-5 gnd Molekularbiologe (DE-588)1023071983 gnd |
| subject_GND | (DE-588)4046804-5 (DE-588)1023071983 |
| title | A primer of molecular population genetics |
| title_auth | A primer of molecular population genetics |
| title_exact_search | A primer of molecular population genetics |
| title_full | A primer of molecular population genetics Asher D. Cutter |
| title_fullStr | A primer of molecular population genetics Asher D. Cutter |
| title_full_unstemmed | A primer of molecular population genetics Asher D. Cutter |
| title_short | A primer of molecular population genetics |
| title_sort | a primer of molecular population genetics |
| topic | Populationsgenetik (DE-588)4046804-5 gnd Molekularbiologe (DE-588)1023071983 gnd |
| topic_facet | Populationsgenetik Molekularbiologe |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030914261&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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