Mitochondria and longevity:
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London ; San Diego, CA ; Cambridge, MA ; Oxford
Academic Press
2018
|
| Edition: | First edition |
| Series: | International review of cell and molecular biology
volume 340 |
| Subjects: | |
| Physical Description: | xii, 344 Seiten Illustrationen, Diagramme 24 cm |
| ISBN: | 9780128157367 0128157364 |
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| 245 | 1 | 0 | |a Mitochondria and longevity |c edited by Carlos López-Otín (Department of Biochemistry and Molecular Biology, Universidad de Oviedo, Asturias, Spain), Lorenzo Galluzzi (Weill Cornell Medical College, New York, NY, United States) |
| 250 | |a First edition | ||
| 264 | 1 | |a London ; San Diego, CA ; Cambridge, MA ; Oxford |b Academic Press |c 2018 | |
| 300 | |a xii, 344 Seiten |b Illustrationen, Diagramme |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a International review of cell and molecular biology |v volume 340 | |
| 505 | 8 | |a Front Cover; International Review of Cell and Molecular Biology; INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY; INTERNATIONAL REVIEW OFCELL AND MOLECULAR BIOLOGY: Mitochondria and Longevity; Contents; CONTRIBUTORS; One -- Mitochondrial Metabolism and Aging in Yeast; 1. INTRODUCTION; 2. THE TRICARBOXYLIC ACID CYCLE; 3. TRICARBOXYLIC ACID CYCLE DYSFUNCTIONS AND AGING; 4. IMPAIRED MITOCHONDRIAL PYRUVATE/ACETYL-COA METABOLISM AND AGING; 5. MITOCHONDRIAL METABOLISM OF BRANCHED-CHAIN AMINO ACIDS AND AGING; 6. THE OXIDATIVE PHOSPHORYLATION. | |
| 505 | 8 | |a 7. RESPIRATION, ROS PRODUCTION AND AGING: A COMPLEX INTERPLAY7.1 Complex I; 7.2 Complex II; 7.3 Complex III; 7.4 Complex IV; 7.5 F1FO ATPase; 8. ROLE OF NAD+ METABOLISM IN MITOCHONDRIAL FUNCTIONALITY; 9. NAD+ METABOLISM AND AGING; 10. NAD+ IS A KEY MODULATOR OF PATHWAYS INVOLVED IN THE AGING PROCESS; 11. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Two -- Mitohormesis, an Antiaging Paradigm; 1. INTRODUCTION; 2. MITONUCLEAR COMMUNICATION; 3. MITOHORMESIS SIGNALING; 3.1 Reactive Oxygen Species; 3.2 Mitochondrial Ions and Metabolites; 3.3 Proteotoxic Signals | |
| 505 | 8 | |a 3.4 Mitochondria-Cytosol Stress Responses3.4.1 Translational Stress Response; 3.4.2 Post-translational Stress Responses; 3.5 Mitokines; 4. MITOHORMESIS AND LIFESPAN; 5. MITOHORMESIS AND HEALTHSPAN; 6. CONCLUDING REMARKS AND FUTURE OUTLOOK; REFERENCES; Three -- Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases; 1. INTRODUCTION; 1.1 Organization and Activity of the Mitochondrial Proteolytic Network; 1.1.1 Processing Peptidases Facilitate Establishment of the Mitochondrial Proteome | |
| 505 | 8 | |a 1.1.2 Mitochondrial Quality Control Proteases Regulate the Integrity and Function of the Mitochondrial Proteome1.1.3 Oligopeptidases Degrade Polypeptides Within Mitochondria; 1.2 Mitochondrial Proteases Are Key Regulators of Organellar Quality Control; 1.2.1 Mitochondrial Morphology Is Regulated by the Activity of Mitochondrial Proteases; 1.2.2 Proteolytic Control of Mitophagy; 1.3 Mitochondrial Proteases Link Mitochondrial Proteostasis to Apoptotic Signaling; 1.4 Stress-Responsive Regulation of the Mitochondrial Proteolytic Network | |
| 505 | 8 | |a 1.4.1 Mitochondrial Unfolded Protein Response-Dependent Regulation of Mitochondrial Proteostasis1.4.2 The Integrated Stress Response Coordinates Mitochondrial Proteostasis in Response to Diverse Insults; 1.4.3 LON Is Also Transcriptionally Regulated by Other Stress-Responsive Signaling Pathways; 1.4.4 Posttranslational Regulation of Mitochondrial Proteolytic Activity; 1.5 Altered Mitochondrial Protease Activity in Aging and Disease; 1.5.1 Mutations in Mitochondrial Proteases Are Genetically Linked to Diverse Neurodegenerative Disorders | |
| 653 | 0 | |a Aging / Molecular aspects | |
| 653 | 0 | |a Mitochondria | |
| 700 | 1 | |a López Otín, Carlos |0 (DE-588)1056396555 |4 edt | |
| 700 | 1 | |a Galluzzi, Lorenzo |d 1980- |0 (DE-588)112867842X |4 edt | |
| 830 | 0 | |a International review of cell and molecular biology |v volume 340 |w (DE-604)BV023310100 |9 340 | |
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| author2 | López Otín, Carlos Galluzzi, Lorenzo 1980- |
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| author_GND | (DE-588)1056396555 (DE-588)112867842X |
| author_facet | López Otín, Carlos Galluzzi, Lorenzo 1980- |
| building | Verbundindex |
| bvnumber | BV045510545 |
| contents | Front Cover; International Review of Cell and Molecular Biology; INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY; INTERNATIONAL REVIEW OFCELL AND MOLECULAR BIOLOGY: Mitochondria and Longevity; Contents; CONTRIBUTORS; One -- Mitochondrial Metabolism and Aging in Yeast; 1. INTRODUCTION; 2. THE TRICARBOXYLIC ACID CYCLE; 3. TRICARBOXYLIC ACID CYCLE DYSFUNCTIONS AND AGING; 4. IMPAIRED MITOCHONDRIAL PYRUVATE/ACETYL-COA METABOLISM AND AGING; 5. MITOCHONDRIAL METABOLISM OF BRANCHED-CHAIN AMINO ACIDS AND AGING; 6. THE OXIDATIVE PHOSPHORYLATION. 7. RESPIRATION, ROS PRODUCTION AND AGING: A COMPLEX INTERPLAY7.1 Complex I; 7.2 Complex II; 7.3 Complex III; 7.4 Complex IV; 7.5 F1FO ATPase; 8. ROLE OF NAD+ METABOLISM IN MITOCHONDRIAL FUNCTIONALITY; 9. NAD+ METABOLISM AND AGING; 10. NAD+ IS A KEY MODULATOR OF PATHWAYS INVOLVED IN THE AGING PROCESS; 11. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Two -- Mitohormesis, an Antiaging Paradigm; 1. INTRODUCTION; 2. MITONUCLEAR COMMUNICATION; 3. MITOHORMESIS SIGNALING; 3.1 Reactive Oxygen Species; 3.2 Mitochondrial Ions and Metabolites; 3.3 Proteotoxic Signals 3.4 Mitochondria-Cytosol Stress Responses3.4.1 Translational Stress Response; 3.4.2 Post-translational Stress Responses; 3.5 Mitokines; 4. MITOHORMESIS AND LIFESPAN; 5. MITOHORMESIS AND HEALTHSPAN; 6. CONCLUDING REMARKS AND FUTURE OUTLOOK; REFERENCES; Three -- Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases; 1. INTRODUCTION; 1.1 Organization and Activity of the Mitochondrial Proteolytic Network; 1.1.1 Processing Peptidases Facilitate Establishment of the Mitochondrial Proteome 1.1.2 Mitochondrial Quality Control Proteases Regulate the Integrity and Function of the Mitochondrial Proteome1.1.3 Oligopeptidases Degrade Polypeptides Within Mitochondria; 1.2 Mitochondrial Proteases Are Key Regulators of Organellar Quality Control; 1.2.1 Mitochondrial Morphology Is Regulated by the Activity of Mitochondrial Proteases; 1.2.2 Proteolytic Control of Mitophagy; 1.3 Mitochondrial Proteases Link Mitochondrial Proteostasis to Apoptotic Signaling; 1.4 Stress-Responsive Regulation of the Mitochondrial Proteolytic Network 1.4.1 Mitochondrial Unfolded Protein Response-Dependent Regulation of Mitochondrial Proteostasis1.4.2 The Integrated Stress Response Coordinates Mitochondrial Proteostasis in Response to Diverse Insults; 1.4.3 LON Is Also Transcriptionally Regulated by Other Stress-Responsive Signaling Pathways; 1.4.4 Posttranslational Regulation of Mitochondrial Proteolytic Activity; 1.5 Altered Mitochondrial Protease Activity in Aging and Disease; 1.5.1 Mutations in Mitochondrial Proteases Are Genetically Linked to Diverse Neurodegenerative Disorders |
| ctrlnum | (OCoLC)1073868483 (DE-599)BVBBV045510545 |
| edition | First edition |
| format | Book |
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| id | DE-604.BV045510545 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T08:20:07Z |
| institution | BVB |
| isbn | 9780128157367 0128157364 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030895058 |
| oclc_num | 1073868483 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | xii, 344 Seiten Illustrationen, Diagramme 24 cm |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Academic Press |
| record_format | marc |
| series | International review of cell and molecular biology |
| series2 | International review of cell and molecular biology |
| spelling | Mitochondria and longevity edited by Carlos López-Otín (Department of Biochemistry and Molecular Biology, Universidad de Oviedo, Asturias, Spain), Lorenzo Galluzzi (Weill Cornell Medical College, New York, NY, United States) First edition London ; San Diego, CA ; Cambridge, MA ; Oxford Academic Press 2018 xii, 344 Seiten Illustrationen, Diagramme 24 cm txt rdacontent n rdamedia nc rdacarrier International review of cell and molecular biology volume 340 Front Cover; International Review of Cell and Molecular Biology; INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY; INTERNATIONAL REVIEW OFCELL AND MOLECULAR BIOLOGY: Mitochondria and Longevity; Contents; CONTRIBUTORS; One -- Mitochondrial Metabolism and Aging in Yeast; 1. INTRODUCTION; 2. THE TRICARBOXYLIC ACID CYCLE; 3. TRICARBOXYLIC ACID CYCLE DYSFUNCTIONS AND AGING; 4. IMPAIRED MITOCHONDRIAL PYRUVATE/ACETYL-COA METABOLISM AND AGING; 5. MITOCHONDRIAL METABOLISM OF BRANCHED-CHAIN AMINO ACIDS AND AGING; 6. THE OXIDATIVE PHOSPHORYLATION. 7. RESPIRATION, ROS PRODUCTION AND AGING: A COMPLEX INTERPLAY7.1 Complex I; 7.2 Complex II; 7.3 Complex III; 7.4 Complex IV; 7.5 F1FO ATPase; 8. ROLE OF NAD+ METABOLISM IN MITOCHONDRIAL FUNCTIONALITY; 9. NAD+ METABOLISM AND AGING; 10. NAD+ IS A KEY MODULATOR OF PATHWAYS INVOLVED IN THE AGING PROCESS; 11. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Two -- Mitohormesis, an Antiaging Paradigm; 1. INTRODUCTION; 2. MITONUCLEAR COMMUNICATION; 3. MITOHORMESIS SIGNALING; 3.1 Reactive Oxygen Species; 3.2 Mitochondrial Ions and Metabolites; 3.3 Proteotoxic Signals 3.4 Mitochondria-Cytosol Stress Responses3.4.1 Translational Stress Response; 3.4.2 Post-translational Stress Responses; 3.5 Mitokines; 4. MITOHORMESIS AND LIFESPAN; 5. MITOHORMESIS AND HEALTHSPAN; 6. CONCLUDING REMARKS AND FUTURE OUTLOOK; REFERENCES; Three -- Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases; 1. INTRODUCTION; 1.1 Organization and Activity of the Mitochondrial Proteolytic Network; 1.1.1 Processing Peptidases Facilitate Establishment of the Mitochondrial Proteome 1.1.2 Mitochondrial Quality Control Proteases Regulate the Integrity and Function of the Mitochondrial Proteome1.1.3 Oligopeptidases Degrade Polypeptides Within Mitochondria; 1.2 Mitochondrial Proteases Are Key Regulators of Organellar Quality Control; 1.2.1 Mitochondrial Morphology Is Regulated by the Activity of Mitochondrial Proteases; 1.2.2 Proteolytic Control of Mitophagy; 1.3 Mitochondrial Proteases Link Mitochondrial Proteostasis to Apoptotic Signaling; 1.4 Stress-Responsive Regulation of the Mitochondrial Proteolytic Network 1.4.1 Mitochondrial Unfolded Protein Response-Dependent Regulation of Mitochondrial Proteostasis1.4.2 The Integrated Stress Response Coordinates Mitochondrial Proteostasis in Response to Diverse Insults; 1.4.3 LON Is Also Transcriptionally Regulated by Other Stress-Responsive Signaling Pathways; 1.4.4 Posttranslational Regulation of Mitochondrial Proteolytic Activity; 1.5 Altered Mitochondrial Protease Activity in Aging and Disease; 1.5.1 Mutations in Mitochondrial Proteases Are Genetically Linked to Diverse Neurodegenerative Disorders Aging / Molecular aspects Mitochondria López Otín, Carlos (DE-588)1056396555 edt Galluzzi, Lorenzo 1980- (DE-588)112867842X edt International review of cell and molecular biology volume 340 (DE-604)BV023310100 340 |
| spellingShingle | Mitochondria and longevity International review of cell and molecular biology Front Cover; International Review of Cell and Molecular Biology; INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY; INTERNATIONAL REVIEW OFCELL AND MOLECULAR BIOLOGY: Mitochondria and Longevity; Contents; CONTRIBUTORS; One -- Mitochondrial Metabolism and Aging in Yeast; 1. INTRODUCTION; 2. THE TRICARBOXYLIC ACID CYCLE; 3. TRICARBOXYLIC ACID CYCLE DYSFUNCTIONS AND AGING; 4. IMPAIRED MITOCHONDRIAL PYRUVATE/ACETYL-COA METABOLISM AND AGING; 5. MITOCHONDRIAL METABOLISM OF BRANCHED-CHAIN AMINO ACIDS AND AGING; 6. THE OXIDATIVE PHOSPHORYLATION. 7. RESPIRATION, ROS PRODUCTION AND AGING: A COMPLEX INTERPLAY7.1 Complex I; 7.2 Complex II; 7.3 Complex III; 7.4 Complex IV; 7.5 F1FO ATPase; 8. ROLE OF NAD+ METABOLISM IN MITOCHONDRIAL FUNCTIONALITY; 9. NAD+ METABOLISM AND AGING; 10. NAD+ IS A KEY MODULATOR OF PATHWAYS INVOLVED IN THE AGING PROCESS; 11. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Two -- Mitohormesis, an Antiaging Paradigm; 1. INTRODUCTION; 2. MITONUCLEAR COMMUNICATION; 3. MITOHORMESIS SIGNALING; 3.1 Reactive Oxygen Species; 3.2 Mitochondrial Ions and Metabolites; 3.3 Proteotoxic Signals 3.4 Mitochondria-Cytosol Stress Responses3.4.1 Translational Stress Response; 3.4.2 Post-translational Stress Responses; 3.5 Mitokines; 4. MITOHORMESIS AND LIFESPAN; 5. MITOHORMESIS AND HEALTHSPAN; 6. CONCLUDING REMARKS AND FUTURE OUTLOOK; REFERENCES; Three -- Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases; 1. INTRODUCTION; 1.1 Organization and Activity of the Mitochondrial Proteolytic Network; 1.1.1 Processing Peptidases Facilitate Establishment of the Mitochondrial Proteome 1.1.2 Mitochondrial Quality Control Proteases Regulate the Integrity and Function of the Mitochondrial Proteome1.1.3 Oligopeptidases Degrade Polypeptides Within Mitochondria; 1.2 Mitochondrial Proteases Are Key Regulators of Organellar Quality Control; 1.2.1 Mitochondrial Morphology Is Regulated by the Activity of Mitochondrial Proteases; 1.2.2 Proteolytic Control of Mitophagy; 1.3 Mitochondrial Proteases Link Mitochondrial Proteostasis to Apoptotic Signaling; 1.4 Stress-Responsive Regulation of the Mitochondrial Proteolytic Network 1.4.1 Mitochondrial Unfolded Protein Response-Dependent Regulation of Mitochondrial Proteostasis1.4.2 The Integrated Stress Response Coordinates Mitochondrial Proteostasis in Response to Diverse Insults; 1.4.3 LON Is Also Transcriptionally Regulated by Other Stress-Responsive Signaling Pathways; 1.4.4 Posttranslational Regulation of Mitochondrial Proteolytic Activity; 1.5 Altered Mitochondrial Protease Activity in Aging and Disease; 1.5.1 Mutations in Mitochondrial Proteases Are Genetically Linked to Diverse Neurodegenerative Disorders |
| title | Mitochondria and longevity |
| title_auth | Mitochondria and longevity |
| title_exact_search | Mitochondria and longevity |
| title_full | Mitochondria and longevity edited by Carlos López-Otín (Department of Biochemistry and Molecular Biology, Universidad de Oviedo, Asturias, Spain), Lorenzo Galluzzi (Weill Cornell Medical College, New York, NY, United States) |
| title_fullStr | Mitochondria and longevity edited by Carlos López-Otín (Department of Biochemistry and Molecular Biology, Universidad de Oviedo, Asturias, Spain), Lorenzo Galluzzi (Weill Cornell Medical College, New York, NY, United States) |
| title_full_unstemmed | Mitochondria and longevity edited by Carlos López-Otín (Department of Biochemistry and Molecular Biology, Universidad de Oviedo, Asturias, Spain), Lorenzo Galluzzi (Weill Cornell Medical College, New York, NY, United States) |
| title_short | Mitochondria and longevity |
| title_sort | mitochondria and longevity |
| volume_link | (DE-604)BV023310100 |
| work_keys_str_mv | AT lopezotincarlos mitochondriaandlongevity AT galluzzilorenzo mitochondriaandlongevity |