Oxford textbook of psoriatic arthritis:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford, United Kingdom ; New York, NY, United States of America
Oxford University Press
2018
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| Edition: | First edition |
| Series: | Oxford textbooks in rheumatology
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Item Description: | Literaturangaben |
| Physical Description: | xviii, 318 Seiten Illustrationen, Diagramme |
| ISBN: | 9780198737582 |
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| 245 | 1 | 0 | |a Oxford textbook of psoriatic arthritis |c edited by Oliver FitzGerald, Dafna Gladman |
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Record in the Search Index
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| adam_text | Contents Listof contributors Is psoriatic arthritis an autoimmune disease or automflammatory disease? 21 xv Abbreviations xvii Aetiology of psoriatic arthritis 21 Immunogenetics Introduction 22 Environmental factors 22 Inflammatory process in psoriatic disease: the histopathology of psoriatic arthritis 25 1 Introduction з Dafna Gladman and Oliver FitzGerald Synovitis 25 Synovial fluid 25 Epidemiology Enthesitis 26 Osteitis and juxta-articular bone involvement 27 2 Epidemiology of psoriasis 7 Bone remodelling in PsA: specific tissue responses in PsA 28 Junko Takeshita and Joel M. Gelfand Prevalence 7 Cellular and molecular compartments involved in psoriatic arthritis 28 Incidence 7 Cellular compartment 28 Principal causes 7 Environmental and behavioural risk factors 7 Natural history and prognosis 7 Comorbid diseases in psoriasis 8 Cardiometabolic disease 8 9 Inflammatory bowel disease Psychiatric disorders Genetic epidemiology of psoriasis 35 Historical aspects of psoriasis genetics 35 12 Other emerging comorbidities 5 Genetics of psoriasis 35 Impact of psoriasis 35 9 12 Chronic kidney disease Conclusion 30 Philip E. Stuart, Lam C. Tsoi, Caely A. Hambro, and James T. Elder Malignancy 9 Gastrointestinal disease Molecular compartment 29 12 3 Epidemiology of psoriatic arthritis is Elaine Husnl and Madonna Michael HLA association studies 35 Linkage studies 36 Psoriasis genetics in the 21st century 36 DNA sequencing 36 Introduction 15 Epidemiology 15 Screening 16 Conclusion 16 Microarray-based genotyping 37 HLA associations in psoriasis—what do they mean? 45 Participation of
multiple HLA alleles 46 HLA-B amino acid 45 distinguishes PsA from PsC 46 Altered regulation of HLA-C*06 48 Pathogenesis 4 Overview of psoriatic arthritis pathogenesis 21 Kurt de Vlam Introduction 21 Presentation of other antigens by HLA-C*06 48 Future genetic studies of psoriasis: Challenges and opportunities 48 Summary 49
viii CONTENTS 6 Genetics of psoriatic arthritis 8 Mechanisms of bone destruction and proliferation in psoriatic arthritis si 57 Robert Winchester, Darren D. O Rielly, and Proton Rahman Introduction 57 Ri к Lories Genetic epidemiology of PsA 57 Introduction 81 Genetics of PsA 58 Basics of bone development, growth, and homeostasis si MHC genetics 58 Genetic heterogeneity within the overall psoriasis Structural damage in psoriatic arthritis 83 or psoriatic disease phenotype 58 The anatomic basis of bone destruction and remodelling in psoriatic arthritis 85 Genetic heterogeneity of psoriatic arthritis 58 Architecture and function ofHLA molecules encoded by susceptibility alleles 59 The molecular basis of tissue destruction and remodelling in psoriatic arthritis 86 Interval between the onset of psoriasis and the development of PsA 59 joint destruction 86 Relationship of PsA allelic heterogeneity to PsA phenotypic heterogeneity 59 New bone formation and ankylosis 86 Axial involvement in psoriatic arthritis is more strongly associated with HLA-B*08 rather than HLA-BL27 60 Clinical relevance of joint destruction and remodelling 87 Therapeutic strategies 87 Genotypic associations of other clinical features of the heterogeneous PsA phenotype 60 Conclusion 87 Genotypic contributions to phenotype assessed by propensity analysis 60 Clinical features Limitations and future directions 61 Implication of genetic and phenotypic heterogeneity on personalized medicine 61 9 Psoriasis: skin and nails Potential impact of genotypic and phenotypic heterogeneity on psoriatic arthritis
classification, Cheryl F. Rosen and Brian Kirby Clinical features 93 diagnosis criteria, and therapeutic trials 61 Inverse psoriasis Non-МНС genetics 61 93 Sebopsoriasis 93 Barrier integrity 61 Palmoplantar psoriasis and Palmoplantar pustulosis 93 Innate immunity 62 Nail psoriasis 94 Antigen presentation 63 Ethnicity 94 Adaptive immunity 63 Gender 94 7 Immunology and cytokine pathways 69 Pathophysiology 94 Genetics of psoriasis Bruce Kirkham 94 Environmental factors Introduction 69 94 Human immunodeficiency virus infection 95 Cytokine networks 69 Medications 95 Cellular composition of PsA synovial pathology 69 Anti-TNF biologies 95 Enthesitis in spondyloarthritis 93 72 Serum markers of immune activity 73 New concepts of pathogenesis 73 The innate immune system 74 Psychological distress 95 Ultraviolet radiation/sunlight 95 Physical trauma 95 Cigarette smoking 95 Alcohol misuse 95 Obesity and metabolic syndrome 95 Innate and adaptive immune cells in psoriatic arthritis 74 уб T cells Cardiovascular disease 96 Measurement of psoriasis severity and outcome measures 96 74 10 Peripheral arthritis NK cells 74 99 Dendritic cells 75 Raffaele Scarpa, Francesco Caso, Luisa Costa, Rosario Peluso, Nicola Matteo Dario Dl Mlnno, and Antonio Del Puente CD4 cells 76 Introduction 99 Innate lymphoid cells 75 MAIT cells 75 CD8 cells 76 Conclusion 77 Symmetrical polyarthritis 99
CONTENTS Asymmetrical oligoarthritis 99 Ophthalmological manifestations 129 Uveitis: background, (differential) diagnosis and prevalence 129 Distal interphalangeal arthritis 99 Arthritis mutilans 100 Uveitis: clinical manifestations Psoriatic arthritis sine psoriasis 101 Laboratory tests and imaging for diagnosis 101 Gastrointestinal manifestations m Inflammatory bowel disease: clinical manifestations Differential diagnosis 102 Conclusion 134 107 15 Co-morbidities ¡37 Juan D. Cañete and Julio Ramirez Muhammad Haroon Definition, clinical evaluation and differential diagnosis 107 Introduction 137 Definition, clinical relevance and prevalence Cardiovascular diseases 137 107 Clinical evaluation, including outcome measures 107 Differentialdiagnosis 108 137 138 Obesity 139 Linking enthesitis and synovitis: the synovlal-entheseal complex 110 Immunogenetics of PsA enthesitis Depression 140 Autoimmune ophthalmic disease 140 110 Immunopathology of human enthesitis Animal models of enthesitis Conventional cardiovascular diseases Cardiovascular morbidity Pathogenesis 109 111 111 Malignancy 141 Inflammatory bowel disease 141 Imaging modalities 112 Burden of inflammation and co-morbidities 141 Ultrasound findings in patients with psoriasis only: the preclinical phase of PsA? 113 Screening and treating co-morbidities Ml The impact of comorbidities 141 Treatment из Conclusions 142 Research agenda 114 12 Dactylitis 132 Inflammatory bowel disease: treatment 133 Prognosis 103 11 Enthesitis 130 Uveitis: treatment 131 117 Ignazio Olivieri, Enrico Scarano, Salvatore D Angelo, Carlo Palazzi,
and Angela Padula Imaging 16 Plain radiography 147 Introduction 117 William Tillett and Neil McHugh Clinical aspects 117 Introduction 147 Imaging 118 Historical perspective and the role of plain radiography in defining psoriatic arthritis 147 Clinimetric assessment 120 Radiographic features of peripheral psoriatic arthritis 147 Therapy 120 13 Axial disease 123 Articular erosion 147 Ennio Lubrano Extra-articular erosions 148 Introduction 123 Osteolysis and psoriatic arthritis mutilans 148 Clinical manifestations of axial PsA 123 Imaging of axial PsA 124 Osteoproliferation (juxtaarticular/ periosteal) and ankylosis 148 Diagnosis of axial PsA (including differential diagnosis) 125 Radiographic features of psoriatic spondyloarthritis 150 Treatment of axial PsA 126 History of psoriatic spondyloarthritis Conclusion 126 Prevalence and associations of psoriatic spondyloarthritis 14 Extra-articular, extra-skin disease Filip Van den Bosch Introduction 129 129 150 Distribution and distinguishingfeatures of psoriatic spondyloarthritis and ankylosing spondylitis 151 Measurement of radiographic outcome in psoriatic arthritis 151 Measures of peripheral radiographic damage 151 151 ix
CONTENTS Outcome measurement in psoriatic spondyloarthritis 152 Natural history/prognosis 152 17 Use of ultrasound in psoriatic arthritis 155 Gurjit S. Kaeley Introduction 155 Enthesitis 155 Clues to the diagnosis of psoriatic arthritis in a clinical setting 185 Symptoms and signs 185 Predictors of PsA within psoriasis patients 187 Investigations—blood tests and imaging 188 Historical development of classification criteria for psoriatic arthritis 188 Sonographic indices 155 Moll and Wright 188 Nail disease 158 Later modifications 189 Synovitis 159 Dactylitis 160 Conclusion 161 18 MRI 165 Dennis McGonagle and Iris Eshed Introduction 165 History of MRI and psoriatic arthritis 165 MRI interpretation considerations 165 Evaluation of different joints in psoriatic arthritis I66 Knee joint and other large joints 166 Imaging of hand metacarpophalangeal and proximal interphalangeal joints 167 Imaging of hand distal interphalangeal joint disease 168 DIP joint disease in psoriatic arthritis and osteoarthritis 169 The nail 169 Dactylitis 170 The development of the CASPAR criteria 189 Accuracy of the CASPAR criteria in established and early disease 189 Accuracy in development 189 Testing in prospective studies of established disease 189 Retrospective application in registries 190 Use in early disease study 190 Proposed modifications to the CASPAR criteria 191 Psoriatic arthritis and axial/peripheral spondyloarthritis 191 Psoriatic arthritis within the umbrella of spondyloarthritides 191 Axial and peripheral spondyloarthritides classification criteria 191 Direct comparison of peripheral
spondyloarthritides criteria and CASPAR criteria in psoriatic arthritis 192 Subtypes of psoriatic arthritis 192 Classical subtypes proposed by Moll and Wright 192 The SAPHO syndrome 170 Proposed modifications to subtypes 192 Spine and sacroiliac joints 171 Evolution in subtypes over time 192 The sacroiliac joint 173 The foot 173 Other manifestations 173 Future evolution of PsA classification criteria 193 GRAPPA project to define the inflammatory musculoskeletal stem of CASPAR 193 Measuring MRI changes 173 Other MRI techniques 174 Summary 175 19 Assessment of joint and bone structure in PsA patients: Using high-resolution computed tomography 179 Camille Figueiredo and Georg Schett Outcome and biomarkers 21 The clinical course and outcome of psoriatic arthritis 199 Lihi Eder Introduction 199 Introduction 179 Disease onset and pattern of presentation and progression 199 Local bone erosions in PsA 179 Mild non-erosive PsA 199 Enthesiophyte formation in PsA 179 Progressive destructive PsA 200 Systemic bone loss in PsA 180 Spondylitis 200 Summary ısı Dactylitis and enthesitis 200 Outcomes of PsA 201 Diagnosis and classification 20 Diagnosis and classification criteria m Laura C. Coates and William J. Taylor The difference between diagnosis and classification 185 Remission and minimal disease activity state 201 Peripheral joint damage 202 HLA alleles and disease outcome 202 Physical functioning and work disability 202 Economic considerations 203 Mortality 203 Summary 20Յ
CONTENTS 22 Biomarkers of psoriatic arthritis outcomes 207 Katerina Oikonomopoulou and Vinod Chandran Domains of health reported in recently published studies of PsA 228 Domains of health important for PsA Introduction 207 patients—qualitative aspects 228 Definition and biomarker categorization 207 Biomarkers of psoriatic arthritis 207 Serum/plasma protein soluble biomarkers 208 Tissue protein biomarkers 209 Specific PROs for PsA 229 The PsAQoL questionnaire 230 The PsAID questionnaire 230 Widely-used PROs in PsA 231 Biomarkers from synovial fluid 210 Single questions used in PsA 231 Genomic markers 210 Assessment offunctional capacity 231 Transcriptomic markers 211 Generic quality of life measured by the Medical Outcomes Study Short Form-36 (SF36) 232 Cellular biomarkers 211 Imaging biomarkers 211 Fatigue 232 Challenges in bringing biological markers to clinical practice 212 Conclusions and future directions 212 Conclusions 233 25 Composite scores in psoriatic arthritis 237 Philip S. Helliwell Introduction 237 Domains, instruments, and composite scores 23 Domains and instruments 217 Alberto Cauli Introduction 217 Musculoskeletal domains 217 What are composite scores? 237 History of composite scores in psoriatic arthritis clinical trials 237 Utility of composite scores 237 The GRAPPA composite index study 237 Response measures 238 American College of Rheumatology response criteria 238 Psoriatic arthritis response criteria, PsARC 239 Skin and nail domains 218 Psoriatic arthritis Joint Activity Index, PsAJAl 239 Patient reported outcome and imaging domains 218 Minimal disease
activity, MDA 239 Present and future directions 219 Instruments 219 Peripheral joints 220 Spine 221 Sacroiliac joint assessment 221 Back movements 221 Composite disease activity measures 240 Disease activity score for 28 joints (DAS28) 240 Disease activity for psoriatic arthritis, DAPSA 240 Composite psoriatic disease activity index, CPDAI 240 GRAPPA composite score, GRACE 240 Psoriatic arthritis Disease Activity Score, PASDAS 241 Comparative studies and overall assessment 242 Finger to floor distance 221 Schober test 221 Conclusions and future considerations 242 Spine lateral flexion 221 Cervical flexion-extension and rotation 221 Other measurements related to spondylitis 222 Enthesitis 222 Dactylitis 222 Skin 223 Nails 223 24 Patient-reported outcome measures in psoriatic arthritis 227 Laure Gossec, Tania Gudu, and Maarten de Wit Treatment 26 Psoriasis treatment Introduction 249 Topical therapy 249 Phototherapy and photochemotherapy 250 Systemic therapy 250 Methotrexate 250 Acitretin 250 Introduction 227 Cyclosporine 250 Importance of PROs in rheumatology and their Apremilast 250 advantages as outcome measures 227 Biological therapy 251 PRO assessment historically in rheumatology 227 TNF inhibitors 251 PROs as valid outcomes 227 Ustekinumab 251 Domains of health assessed by PROs in PsA 228 The PsA OMERACT core set 228 249 Ami Saraiya, Deep Joshipura, and Alice Gottlieb. Combination therapy 252 xi
xii CONTENTS New biological therapies 252 Rationale for the use of TNF inhibitors in PsA IL-17 inhibitors 252 Clinical trial data IL-23 inhibitors 253 Conclusion 271 272 Evidence for the efficacy of TNF inhibitors in PsA 253 272 Etanercept (Enbrel՞) 272 Infliximab (Remicade՞) 273 27 Approach to management and symptomatic (including non-pharmacologic) management of psoriatic arthritis 257 Adalimumab (Humira՞) 274 Colimumab (Simponi՞) 275 Certolizumab pegoI (Cimzia՞) 275 Laura Acosta Felquer and Enrique R. Soriano Safety and tolerability General approach to the management of psoriatic arthritis 257 Symptoms in psoriatic arthritis 257 GRAPPA recommendations 276 Nonsteroidal anti-inflammatory drugs 258 EULAR recommendations 276 Intra-articular and soft tissue injections of steroids Rehabilitation and physical therapy 275 Current recommendations and clinical practice guidelines 275 258 General consensus: when to use TNF inhibitors in PsA 276 Novel treatment concepts involving the use of TNF inhibitors 276 258 Surgical management 260 Early intervention in PsA 276 Summary 260 Targeted therapy in PsA 276 28 Synthetic DMARDs Benefits of tight control in PsA 277 263 Frank Behrens, Michaela Koehm, and Michael J. Parnham TNF.inhibitor switching 277 Tapering therapy in controlled disease 277 Introduction 263 Combination therapy 277 sDMARDs as a treatment option for peripheral arthritis 263 Alternative treatment options for treatmentfailures 277 Conclusion 278 Methotrexate 263 30 Biologic treatments for psoriatic arthritis apart from TNF inhibition 28i Leflunomide 263 Sulfasalazine 265
Cyclosporin 265 Philip Mease Apremilast 265 Introduction Responses to treatment of additional musculoskeletal manifestations 265 281 Targeting the ТҺ17 cell axis in PsA 281 IL-12/23 inhibition 282 Enthesitis 265 Ustekinumab 282 Dactylitis 265 IL-17 inhibition sDMARDs in axial PsA 266 282 Secukinumab 282 Effects of sDMARDs on skin psoriasis in PsA patients 266 Ixekizumab 283 Brodalumab 283 Plaque psoriasis in PsA patients 266 Dual TNF and IL-17 inhibitor 283 Nail psoriasis 267 IL-23 inhibitors 283 Effects on extra-musculoskeletal manifestations and comorbidities in PsA patients 268 Guselkumab 283 Combination therapy with other sDMARDs or with biologicals 268 Risankizumab 284 Co-stimulatory blockade modulating T lymphocyte function 284 sDMARD treatment in patients planning to have children 269 29 Biologic DMARDs (TNF inhibitors) Abatacept 284 IL-6 inhibition 271 В lymphocyte inhibition 271 Traditional DMARDs and PsA: unmet needs 284 Clazakizumab 284 Tristan Boyd and Arthur Kavanaugh Introduction Tildrakizumab 284 Conclusion 271 284 284
CONTENTS Treatment algorithms 297 31 Small molecules in the treatment of psoriatic arthritis 287 Step up vs Step down approaches 297 Does early treatment improve outcome? 297 George E. Fragoulis and lain B. Mclnnes Treat to target 298 Introduction 287 EULAR review of treating to target in SpA 298 Current treatment landscape 287 Deciding on a target for treatment in PsA 299 Molecules approved or in phase III trials in PsA 287 Apremilast 287 Potential targets in PsA 299 The Tight Control of PsA study (TICOPA) 300 JAK/STAT inhibitors 290 What about comorbidities and other Fumarie acid esters 291 related conditions? Molecular pathways under exploration 291 Ponesimod 291 Voclosporin 292 Molecules postulated to have promise, that were tested but failed 292 Future directions Apilimod 292 33 Recent progress in psoriatic arthritis and areas for further research зо7 A3 adenosise receptors agonists 292 Protein kinase C inhibitors 293 Oliver FitzGerald and Dafna Gladman Possible future targets 293 Research agenda 308 RORyt inhibitors 293 Conclusion 293 Index 32 Treatment algorithm and treat to target зоі How should these treatment algorithms be adopted in clinical practice? зоі 309 297 Laura C. Coates, Arthur Kavanaugh, and Christopher T. Ritchlin ifi xiii
This new textbook on psoriatic arthritis, or PsA, is a fitting and important addition to the Oxford Textbooks in Rheumatology series, written to reflect the significant advances in the field in recent years. With increased understanding of pathogenesis and the development of novel therapies, the Oxford Textbook of Psoriatic Arthritis provides a comprehensive overview of the disease. Each chapter is written by leading clinicians and scientists in the field of psoriatic arthritis to provide a contemporary view of PsA and a look into future directions of research. Covering everything from epidemiology and diagnosis to genetics and pathology, detailed sections on treatment and outcomes provide an invaluable resource for the clinician. The book is also highly illustrated with both clinical images such as x-rays and histological photographs to aid clinical knowledge, and diagrams of the immunology and genetics that underlie the disease. Practical and all-inclusive, with summary boxes to distil the most important information, the Oxford Textbook of Psoriatic Arthritis will prove an indispensable resource for rheumatologists, dermatologists, trainees, and all members of the multidisciplinary team who are interested in recent advances in PsA.
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| series2 | Oxford textbooks in rheumatology |
| spelling | Oxford textbook of psoriatic arthritis edited by Oliver FitzGerald, Dafna Gladman Psoriatic arthritis First edition Oxford, United Kingdom ; New York, NY, United States of America Oxford University Press 2018 xviii, 318 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Oxford textbooks in rheumatology Literaturangaben Arthritis psoriatica (DE-588)4233798-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Arthritis psoriatica (DE-588)4233798-7 s DE-604 FitzGerald, Oliver (DE-588)1175925411 edt win aut Gladman, Dafna (DE-588)1175925616 edt win aut Erscheint auch als Online-Ausgabe 978-0-19-180107-5 Erscheint auch als Online-Ausgabe, PDF 978-0-19-105756-4 Erscheint auch als Online-Ausgabe, EPUB 978-0-19-251528-5 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030694199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030694199&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | FitzGerald, Oliver Gladman, Dafna Oxford textbook of psoriatic arthritis Arthritis psoriatica (DE-588)4233798-7 gnd |
| subject_GND | (DE-588)4233798-7 (DE-588)4123623-3 |
| title | Oxford textbook of psoriatic arthritis |
| title_alt | Psoriatic arthritis |
| title_auth | Oxford textbook of psoriatic arthritis |
| title_exact_search | Oxford textbook of psoriatic arthritis |
| title_full | Oxford textbook of psoriatic arthritis edited by Oliver FitzGerald, Dafna Gladman |
| title_fullStr | Oxford textbook of psoriatic arthritis edited by Oliver FitzGerald, Dafna Gladman |
| title_full_unstemmed | Oxford textbook of psoriatic arthritis edited by Oliver FitzGerald, Dafna Gladman |
| title_short | Oxford textbook of psoriatic arthritis |
| title_sort | oxford textbook of psoriatic arthritis |
| topic | Arthritis psoriatica (DE-588)4233798-7 gnd |
| topic_facet | Arthritis psoriatica Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030694199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030694199&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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