Development of sustained release formulations for phytopharmaceuticals:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg
[2018]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | iv, 165 Seiten Illustrationen, Diagramme 30 cm |
Internformat
MARC
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| 100 | 1 | |a Disch, Lucia |e Verfasser |0 (DE-588)1156286778 |4 aut | |
| 245 | 1 | 0 | |a Development of sustained release formulations for phytopharmaceuticals |c presented by Lucia Disch ; referees: Prof. Dr. Gert Fricker ; Prof. Dr. Jürgen Drewe |
| 264 | 1 | |a Heidelberg |c [2018] | |
| 300 | |a iv, 165 Seiten |b Illustrationen, Diagramme |c 30 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |b Dissertation |c Ruperto-Carola University of Heidelberg |d 2018 | ||
| 546 | |a Text englisch, Zusammenfassungen in deutscher und englischer Sprache | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 710 | 2 | |a Universität Heidelberg |0 (DE-588)2024349-2 |4 dgg | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-030665820 | |
Datensatz im Suchindex
| _version_ | 1822127855838953472 |
|---|---|
| adam_text |
CONTENT
1 A IM
.
1
2
INTRODUCTION.
1
2.1
PHYTOEPHARMACEUTICALS.
2
2.1.1
DEFINITION.2
2.1.2 CLASSIFICATION OF HERBAL
EXTRACTS.
2
2.1.3
HYPERICUM PEFORATUM
L.
3
2.1.4 PETASITES HYBRIDUS
L.
6
2.1.5 CIMICIFUGA RACEMOSA (L.) NUTT. (ACTAEA RACEMOSA
L.).9
2.2 PHARMACEUTICAL DEVELOPMENT: FROM IDEA TO
PRODUCTION.12
2.3 SUSTAINED RELEASE DELIVERY SYSTEMS
.
13
2.3.1 DIFFUSION-CONTROLLED
SYSTEMS.13
2.3.2 DISSOLUTION-CONTROLLED
SYSTEMS.
14
2.3.3 ION-EXCHANGE
SYSTEMS.15
2.3.4 OSMOTIC PUMP
SYSTEMS.15
2.3.5 HYDRODYNAMICALLY
SYSTEMS.16
2.4
PHARMACOKINETICS.16
2.4.1
LIBERATION.
16
2.4.2
ABSORPTION.
16
2.4.3
DISTRIBUTION.
19
2.4.4 M ETABOLISM
.19
2.4.5
EXCRETION.
20
2.4.6
BIOAVAILABILITY.
20
2.5 BIOPHARMACEUTICS CLASSIFICATION SYSTEM (BCS)
.
21
2.6 IN VITRO DISSOLUTION
TESTING.
22
2.6.1
SOLUBILITY.
23
2.6.2
SOLUBILIZATION.
23
2.6.3 RELEASE
KINETICS.25
2.7 MODEL SYSTEMS TO INVESTIGATE INTESTINAL
ABSORPTION.
27
2.7.1 IN VIVO AND IN SITU MODEL
SYSTEMS.
28
2.7.2 EX VIVO MODEL
SYSTEMS.
28
2.7.3 IN VITRO MODEL
SYSTEMS.
28
3 M
ATERIALS.30
3.1 CHEMICALS AND
EXCIPIENTS.30
3.2 EQUIPMENT.
.
.
. 34
3.3 HERBAL
EXTRACTS.37
4 M ETHODS. 37
4.1
SOLUBILITY.37
4.1.1 DETERMINATION OF PH-DEPENDENT THERMODYNAMIC
SOLUBILITY.37
4.1.2 DETERMINATION OF SOLUBILITY ISOTHERMS WITH POLYSORBATE 2 0
.38
4.2
PERMEABILITY.38
4.2.1 CACO-2 CELL CULTURE SYSTEM
.
38
4.2.2 IN SITU STUDIES IN RA
T.41
4.3 DEVELOPMENT OF PHARMACEUTICAL
FORMULATIONS.
42
4.3.1 QUALITY BY DESIGN (Q BD
).42
4.3.2 DESIGN OF EXPERIMENT (D
OE).43
4.4 PREPARATION OF DOSAGE
FORMS.44
4.4.1 ZE 339 DRY
EXTRACT.44
4.4.2 SOFT GELATINE
CAPSULES.
45
4.4.3
TABLETS.
45
4.4.4 DROPLET TE S
T.
45
4.4.5 FUNCTIONAL
PELLETS.
45
4.5 GALENICAL CHARACTERIZATION OF DRY EXTRACTS AND DOSAGE FORMS
.
46
4.5.1 POURED AND TAPPED DENSITY, HAUSNER RATIO AND CARR
INDEX.46
4.5.2
FLOWABILITY.
47
4.5.3 PARTICLE
SIZE.
48
4.5.4 WEIGHT AND CONTENT UNIFORMITY OF DOSAGE
UNITS.49
4.5.5
HARDNESS.49
4.5.6
FRIABILITY.
50
4.5.7
DISSOLUTION.
50
4.5.8 DRUG RELEASE KINETICS M
ODEL.51
4.6 ANALYTICAL
METHODS.
51
4.6.1 LIQUID CHROMATOGRAPHY (HPLC AND
UPLC).
51
4.6.2 MASS SPECTROMETRY (M S
).52
4.6.3 LC-MS AND
LC-MS/MS.
52
5 METHOD DEVELOPM
ENT.53
5.1 SELECTION OF ANALYTICAL MARKER
SUBSTANCES.
53
5.2 ANALYTICAL METHOD DEVELOPMENT AND
VALIDATION.56
5.3 DISSOLUTION METHOD
DEVELOPMENT.62
5.3.1 SELECTION OF DISSOLUTION M
EDIA.
62
5.3.2 SELECTION OF DISSOLUTION APPARATUS AND APPARATUS
SETTINGS.64
5.3.4 SELECTION OF ANALYTICAL MARKERS FOR DISSOLUTION
TESTING.
65
5.3.5 DISSOLUTION METHOD
SET-UP.
66
6 RESULTS AND
DISCUSSION.67
6.1 BCS CLASSIFICATION OF ANALYTICAL MARKER SUBSTANCES
.
67
6.1.1 PH-DEPENDENT
SOLUBILITY.67
6.1.2 DISSOLUTION
PERFORMANCE.
72
6.1.3 CACO-2 PERMEABILITY
ASSAY.
73
6.1.4 OVERVIEW AND
DISCUSSION.
83
6.2 LOCAL INTESTINAL ABSORPTION CAPACITY OF ANALYTICAL MARKERS
.
86
6.2.1 DOSE FINDING
STUDY.87
6.2.2 IN SITU INTESTINAL ABSORPTION STUDY IN R A T
.
88
6.2.3
DISCUSSION.
94
6.3 PHARMACEUTICAL CHARACTERIZATION OF
EXTRACTS.
95
6.3.1 GALENICAL
CHARACTERIZATION.
95
6.3.2 ANALYTICAL
CHARACTERIZATION.96
6.3.3
DISCUSSION.
97
6.4 PHARMACEUTICAL FORMULATION DEVELOPMENT: ZE 339 SR SOFT CAPSULE
.
98
6.4.1 TARGET PRODUCT PROFILE OF ZE 339 SR SOFT CAPSULE
.
99
6.4.2 DRUG SUBSTANCE OF ZE 339 SR SOFT
CAPSULE.99
6.4.3 EXCIPIENTS OF ZE 339 SR SOFT
CAPSULE.
99
6.4.4 DRUG PRODUCT FORMULATION DEVELOPMENT OF ZE 339 SR SOFT
CAPSULE.101
6.4.5 RELEASE KINETICS OF ZE 339 SR SOFT
CAPSULE.
105
6.4.6 PHARMACEUTICAL MANUFACTURING PROCESS OF ZE 339 SR SOFT
CAPSULE. 106
6.4.7
DISCUSSION.109
6.5 PHARMACEUTICAL FORMULATION DEVELOPMENT: ZE 339 SR TABLET
.
110
6.5.1 TARGET PRODUCT PROFILE OF ZE 339 SR T
ABLET.
110
6.5.2 DRUG SUBSTANCE OF ZE 339 SR
TABLET.
M
6.5.3 EXCIPIENTS OF ZE 339 SR
TABLET.
113
6.5.4 DRUG PRODUCT FORMULATION DEVELOPMENT OF ZE 339 SR
TABLET.113
6.5.5 RELEASE KINETICS OF ZE 339 SR
TABLET.117
6.5.6 PHARMACEUTICAL MANUFACTURING PROCESS OF ZE 339 SR MATRIX TABLET
.
117
6.5.7
DISCUSSION.120
6.6 PHARMACEUTICAL FORMULATION DEVELOPMENT: ZE 450 SR TABLET
.
121
6.6.1 TARGET PRODUCT PROFILE OF ZE 450 SR T
ABLET.
121
6.6.2 DRUG SUBSTANCE ZE 450 SR
TABLET.
122
6.6.3 EXCIPIENTS OF ZE 450 SR
TABLET.122
6.6.4 DRUG PRODUCT FORMULATION DEVELOPMENT OF ZE 450 SR
TABLET.122
6.6.5 RELEASE KINETICS OF ZE 450 SR
TABLET.
124
6
.
6.6
PHARMACEUTICAL MANUFACTURING PROCESS OF ZE 450 SR
TABLET.124
6.6.7
DISCUSSION.126
6.7 PHARMACEUTICAL FORMULATION DEVELOPMENT: ZE 450 SR PELLET
SYSTEM.126
6.7.1 TARGET PRODUCT PROFILE OF ZE 450 SR PELLET
SYSTEM.127
6.7.2 DRUG SUBSTANCE OF ZE 450 SR PELLET
SYSTEM.
127
6.7.3 EXCIPIENTS OF ZE 450 SR PELLET SYSTEM
.
.127
6.7.4 DRUG PRODUCT FORMULATION DEVELOPMENT OF ZE 450 SR PELLET SYSTEM
.
130
6.7.5 PHARMACEUTICAL MANUFACTURING PROCESS OF ZE 450 PELLET
SYSTEM.134
6.7.6
DISCUSSION.
135
7
CONCLUSION.
136
LIST OF
REFERENCES.138
PUBLICATIONS.148
APPENDIX.149
EXAMPLE FOR
CHROMMATOGRAMS.
149
FIGURE
LEGENDS.
158
TABLE
LEGENDS.163 |
| any_adam_object | 1 |
| author | Disch, Lucia |
| author_GND | (DE-588)1156286778 |
| author_facet | Disch, Lucia |
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| author_sort | Disch, Lucia |
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| discipline | Chemie / Pharmazie Biologie Medizin |
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| indexdate | 2025-01-24T11:02:16Z |
| institution | BVB |
| institution_GND | (DE-588)2024349-2 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030665820 |
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| physical | iv, 165 Seiten Illustrationen, Diagramme 30 cm |
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| spelling | Disch, Lucia Verfasser (DE-588)1156286778 aut Development of sustained release formulations for phytopharmaceuticals presented by Lucia Disch ; referees: Prof. Dr. Gert Fricker ; Prof. Dr. Jürgen Drewe Heidelberg [2018] iv, 165 Seiten Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Ruperto-Carola University of Heidelberg 2018 Text englisch, Zusammenfassungen in deutscher und englischer Sprache (DE-588)4113937-9 Hochschulschrift gnd-content Universität Heidelberg (DE-588)2024349-2 dgg B:DE-101 application/pdf http://d-nb.info/1167544803/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030665820&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Disch, Lucia Development of sustained release formulations for phytopharmaceuticals |
| subject_GND | (DE-588)4113937-9 |
| title | Development of sustained release formulations for phytopharmaceuticals |
| title_auth | Development of sustained release formulations for phytopharmaceuticals |
| title_exact_search | Development of sustained release formulations for phytopharmaceuticals |
| title_full | Development of sustained release formulations for phytopharmaceuticals presented by Lucia Disch ; referees: Prof. Dr. Gert Fricker ; Prof. Dr. Jürgen Drewe |
| title_fullStr | Development of sustained release formulations for phytopharmaceuticals presented by Lucia Disch ; referees: Prof. Dr. Gert Fricker ; Prof. Dr. Jürgen Drewe |
| title_full_unstemmed | Development of sustained release formulations for phytopharmaceuticals presented by Lucia Disch ; referees: Prof. Dr. Gert Fricker ; Prof. Dr. Jürgen Drewe |
| title_short | Development of sustained release formulations for phytopharmaceuticals |
| title_sort | development of sustained release formulations for phytopharmaceuticals |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1167544803/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030665820&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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