REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit: eine polysomnographische Fall-Kontroll-Studie
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
Köln
2017
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 90, V Blatt Illustrationen 21 cm |
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| adam_text | TABLE OF CONTENTS
GLOSSARY
1.0 BACKGROUND 10
1.1 INTRODUCTION 10
1.1.1 FIRST DESCRIPTION, DIAGNOSIS AND SYMPTOMS OF PARKINSON*S DISEASE
10
1.1.2 NON-MOTOR SYMPTOMS IN I PD 12
1.1.3 BREAK S HYPOTHESIS ON THE ASCENDING DEGENERATION IN IPD 13
1.1.4 SLEEP DISTURBANCES IN PARKINSON*S DISEASE 14
1.1.5 QUESTIONNAIRES ON SLEEP IMPAIRMENT 15
1.1.6 SLEEP: NON-REM AND REM SLEEP 19
1.1.7 PGO-WAVES AND DREAMING 20
1.1.8 REM SLEEP AND IPD 21
1.1.9 REM DENSITY 22
1.1.10 THE EFFECTS OF ANTIDEPRESSANTS ON REM SLEEP 23
1.2 HYPOTHESIS AND PURPOSE OF THE PRESENT STUDY 24
2.0 PATIENTS AND METHODS 26
2.1 DESIGN 26
2.2 POLYSOMNOGRAPHIE STUDY 28
2.2.1 POLYSOMNOGRAPHIE SETTING 28
2.2.2 REM DENSITY IN THE POLYSOMNOGRAPHIC STUDY 30
2.3 NEUROPSYCHOLOGICAL QUESTIONNAIRES 31
2.3.1 THE EPWORTH SLEEPINESS SCALE, THE PARKINSON*S DISEASE SLEEP
SCALE AND THE NONMOTOR SYMPTOMS QUESTIONNAIRE FOR PARKINSON*S
DISEASE 31
2.4 RECRUITMENT PROCEDURE OF IPD PATIENTS 32
2.4.1 EXCLUSION CRITERIA 32
2.5 STATISTICAL ANALYSES 33
3.0 RESULTS 36
3.1 SUBJECTS* CHARACTERISTICS 36
3.1.1 MEDICATION - ANTIDEPRESSANTS 38
3.2 POLYSOMNOGRAPHY CHARACTERISTICS 38
3.2.1 BASIC SLEEP PARAMETERS: TOTAL SLEEP TIME, SLEEP LATENCY, SLEEP
EFFICIENCY REM SLEEP STAGE IN MINUTES AND PERCENTAGE AND REM
LATENCY 38
3.2.2 NUMBER OF OCULAR MOVEMENTS IN REM SLEEP 39
3.2.3 REM DENSITY IN GENERAL 39
3.2.4 REM DENSITY IN CONSECUTIVE REM SLEEP EPISODES 39
3.2.5 NUMBER OF REM SLEEP EPISODES 41
3.2.6 EVOLUTION OF REM DENSITY OVER THE NIGHT 41
3.2.7 MUSCLE ATONIA 42
3.3 POLYSOMNOGRAPHIE ANALYSES 42
3.4 QUESTIONNAIRE-BASED RESULTS 45
3.5 DISTRIBUTION ANALYSIS 47
3.6 CORRELATION ANALYSIS 49
3.6.1 REM DENSITY CORRELATION ANALYSIS 50
3.6.2 CORRELATIONS BETWEEN REM VARIABLES AND SUBJECTIVE SLEEP
IMPAIRMENT 50
3.6.3 NUMBER OF OCULAR MOVEMENTS IN REM SLEEP PER NIGHT 51
3.6.4 EFFECT OF AGE 52
3.6.5 TOTAL SLEEP TIME, SLEEP EFFICIENCY AND SLEEP LATENCY 52
3.6.6 CORRELATIONS WITH THE SCORES OF THE SLEEP QUESTIONNAIRES
CORRELATIONS 53
3.6.7 FURTHER RESULTS 53
4.0 DISCUSSION 54
4.1 SUMMARY OF THE RESULTS 54
4.2 REM DENSITY IN IPD PATIENTS 55
4.3 REM DENSITY IN NEU RODEGENERATIVE OR PSYCHIATRIC DISEASES 59
4.3.1 NEUROPSYCHIATRIC DISEASES WITH INCREASED REM DENSITY 59
4.3.2 NEUROPSYCHIATRIC DISEASES WITH DECREASED REM DENSITY 60
4.4 OTHER OBJECTIVE SLEEP CHANGES IN IPD 61
4.5 SLEEP-QUESTIONNAIRES IN IPD PATIENTS 62
4.6 LIMITATIONS OF THE STUDY 64
4.7 RECOMMENDATIONS FOR FURTHER RESEARCH 66
4.8 CONCLUSION 66
5.0 SUMMARY 68
6.0 ZUSAMMENFASSUNG 70
7.0 REFERENCES 71
8.0 PRELIMINARY PUBLICATIONS 90
9.0 APPENDIX I
9.1 LIST OF TABLES I
9.2 LIST OF FIGURES II
10.0 LEBENSLAUF III
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| spelling | Schroeder, Lynn Abigail Camille 1989- Verfasser (DE-588)1151150932 aut REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie vorglegt von Lynn Abigail Camille Schroeder Köln 2017 90, V Blatt Illustrationen 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Universität zu Köln 2017 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1151660817/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030504672&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schroeder, Lynn Abigail Camille 1989- REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie |
| subject_GND | (DE-588)4113937-9 |
| title | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie |
| title_auth | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie |
| title_exact_search | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie |
| title_full | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie vorglegt von Lynn Abigail Camille Schroeder |
| title_fullStr | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie vorglegt von Lynn Abigail Camille Schroeder |
| title_full_unstemmed | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit eine polysomnographische Fall-Kontroll-Studie vorglegt von Lynn Abigail Camille Schroeder |
| title_short | REM-Dichte im Frühstadium und fortgeschrittenem Stadium der idiopathischen Parkinson-Krankheit |
| title_sort | rem dichte im fruhstadium und fortgeschrittenem stadium der idiopathischen parkinson krankheit eine polysomnographische fall kontroll studie |
| title_sub | eine polysomnographische Fall-Kontroll-Studie |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1151660817/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030504672&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schroederlynnabigailcamille remdichteimfruhstadiumundfortgeschrittenemstadiumderidiopathischenparkinsonkrankheiteinepolysomnographischefallkontrollstudie |
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