Modern Prometheus: editing the human genome with Crispr-Cas9
Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as we...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge University Press
2018
|
| Ausgabe: | Revised and updated edition |
| Schlagworte: | |
| Online-Zugang: | BSB01 FHN01 UER01 URL des Erstveröffentlichers |
| Zusammenfassung: | Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. Ultimately, Kozubek places the debate in its historical and scientific context to consider both what drives scientific discovery and the implications of the 'commodification' of life |
| Beschreibung: | Title from publisher's bibliographic system (viewed on 24 Apr 2018) |
| Beschreibung: | 1 Online-Ressource (xxvi, 451 Seiten) |
| DOI: | 10.1017/9781108597104 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV045083771 | ||
| 003 | DE-604 | ||
| 005 | 20190226 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 180711s2018 |||| o||u| ||||||eng d | ||
| 020 | |z 9781108597104 |9 9781108597104 | ||
| 024 | 7 | |a 10.1017/9781108597104 |2 doi | |
| 035 | |a (ZDB-20-CBO)CR9781108597104 | ||
| 035 | |a (OCoLC)1035626837 | ||
| 035 | |a (DE-599)BVBBV045083771 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-29 |a DE-92 |a DE-11 | ||
| 082 | 0 | |a 572.8/77 | |
| 084 | |a WG 1600 |0 (DE-625)148493: |2 rvk | ||
| 084 | |a WG 3450 |0 (DE-625)148549: |2 rvk | ||
| 084 | |a WG 7000 |0 (DE-625)148612: |2 rvk | ||
| 100 | 1 | |a Kozubek, Jim |e Verfasser |0 (DE-588)1119335051 |4 aut | |
| 245 | 1 | 0 | |a Modern Prometheus |b editing the human genome with Crispr-Cas9 |c Jim Kozubek |
| 250 | |a Revised and updated edition | ||
| 264 | 1 | |a Cambridge |b Cambridge University Press |c 2018 | |
| 300 | |a 1 Online-Ressource (xxvi, 451 Seiten) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Title from publisher's bibliographic system (viewed on 24 Apr 2018) | ||
| 520 | |a Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. Ultimately, Kozubek places the debate in its historical and scientific context to consider both what drives scientific discovery and the implications of the 'commodification' of life | ||
| 650 | 4 | |a Gene targeting | |
| 650 | 4 | |a Genomes | |
| 650 | 4 | |a CRISPR-associated protein 9 | |
| 650 | 0 | 7 | |a CRISPR/Cas-Methode |0 (DE-588)1116100770 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Genom |0 (DE-588)4156640-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekulare Medizin |0 (DE-588)4543844-4 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Gentechnologie |0 (DE-588)4071722-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Bioethik |0 (DE-588)4006791-9 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Gen-Targeting |0 (DE-588)4294998-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Gentechnologie |0 (DE-588)4071722-7 |D s |
| 689 | 0 | 1 | |a Molekulare Medizin |0 (DE-588)4543844-4 |D s |
| 689 | 0 | 2 | |a Bioethik |0 (DE-588)4006791-9 |D s |
| 689 | 0 | |8 1\p |5 DE-604 | |
| 689 | 1 | 0 | |a Gen-Targeting |0 (DE-588)4294998-1 |D s |
| 689 | 1 | 1 | |a Genom |0 (DE-588)4156640-3 |D s |
| 689 | 1 | 2 | |a CRISPR/Cas-Methode |0 (DE-588)1116100770 |D s |
| 689 | 1 | |8 2\p |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |z 9781108454629 |
| 856 | 4 | 0 | |u https://doi.org/10.1017/9781108597104 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-20-CBO | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-030474684 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 883 | 1 | |8 2\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
| 966 | e | |u https://doi.org/10.1017/9781108597104 |l BSB01 |p ZDB-20-CBO |q BSB_PDA_CBO |x Verlag |3 Volltext | |
| 966 | e | |u https://doi.org/10.1017/9781108597104 |l FHN01 |p ZDB-20-CBO |q FHN_PDA_CBO |x Verlag |3 Volltext | |
| 966 | e | |u https://doi.org/10.1017/9781108597104 |l UER01 |p ZDB-20-CBO |q UER_PDA_CBO_Kauf |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804178701297909760 |
|---|---|
| any_adam_object | |
| author | Kozubek, Jim |
| author_GND | (DE-588)1119335051 |
| author_facet | Kozubek, Jim |
| author_role | aut |
| author_sort | Kozubek, Jim |
| author_variant | j k jk |
| building | Verbundindex |
| bvnumber | BV045083771 |
| classification_rvk | WG 1600 WG 3450 WG 7000 |
| collection | ZDB-20-CBO |
| ctrlnum | (ZDB-20-CBO)CR9781108597104 (OCoLC)1035626837 (DE-599)BVBBV045083771 |
| dewey-full | 572.8/77 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8/77 |
| dewey-search | 572.8/77 |
| dewey-sort | 3572.8 277 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1017/9781108597104 |
| edition | Revised and updated edition |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03705nmm a2200661zc 4500</leader><controlfield tag="001">BV045083771</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20190226 </controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">180711s2018 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="z">9781108597104</subfield><subfield code="9">9781108597104</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1017/9781108597104</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-20-CBO)CR9781108597104</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1035626837</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV045083771</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-11</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.8/77</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 1600</subfield><subfield code="0">(DE-625)148493:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 3450</subfield><subfield code="0">(DE-625)148549:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 7000</subfield><subfield code="0">(DE-625)148612:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kozubek, Jim</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1119335051</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Modern Prometheus</subfield><subfield code="b">editing the human genome with Crispr-Cas9</subfield><subfield code="c">Jim Kozubek</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">Revised and updated edition</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge</subfield><subfield code="b">Cambridge University Press</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (xxvi, 451 Seiten)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Title from publisher's bibliographic system (viewed on 24 Apr 2018)</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. Ultimately, Kozubek places the debate in its historical and scientific context to consider both what drives scientific discovery and the implications of the 'commodification' of life</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gene targeting</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genomes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CRISPR-associated protein 9</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">CRISPR/Cas-Methode</subfield><subfield code="0">(DE-588)1116100770</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Genom</subfield><subfield code="0">(DE-588)4156640-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Molekulare Medizin</subfield><subfield code="0">(DE-588)4543844-4</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gentechnologie</subfield><subfield code="0">(DE-588)4071722-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Bioethik</subfield><subfield code="0">(DE-588)4006791-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gen-Targeting</subfield><subfield code="0">(DE-588)4294998-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Gentechnologie</subfield><subfield code="0">(DE-588)4071722-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Molekulare Medizin</subfield><subfield code="0">(DE-588)4543844-4</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">Bioethik</subfield><subfield code="0">(DE-588)4006791-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="8">1\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Gen-Targeting</subfield><subfield code="0">(DE-588)4294998-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Genom</subfield><subfield code="0">(DE-588)4156640-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">CRISPR/Cas-Methode</subfield><subfield code="0">(DE-588)1116100770</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="8">2\p</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druck-Ausgabe</subfield><subfield code="z">9781108454629</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1017/9781108597104</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-20-CBO</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-030474684</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">2\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1017/9781108597104</subfield><subfield code="l">BSB01</subfield><subfield code="p">ZDB-20-CBO</subfield><subfield code="q">BSB_PDA_CBO</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1017/9781108597104</subfield><subfield code="l">FHN01</subfield><subfield code="p">ZDB-20-CBO</subfield><subfield code="q">FHN_PDA_CBO</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1017/9781108597104</subfield><subfield code="l">UER01</subfield><subfield code="p">ZDB-20-CBO</subfield><subfield code="q">UER_PDA_CBO_Kauf</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV045083771 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:08:09Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030474684 |
| oclc_num | 1035626837 |
| open_access_boolean | |
| owner | DE-12 DE-29 DE-92 DE-11 |
| owner_facet | DE-12 DE-29 DE-92 DE-11 |
| physical | 1 Online-Ressource (xxvi, 451 Seiten) |
| psigel | ZDB-20-CBO ZDB-20-CBO BSB_PDA_CBO ZDB-20-CBO FHN_PDA_CBO ZDB-20-CBO UER_PDA_CBO_Kauf |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Cambridge University Press |
| record_format | marc |
| spelling | Kozubek, Jim Verfasser (DE-588)1119335051 aut Modern Prometheus editing the human genome with Crispr-Cas9 Jim Kozubek Revised and updated edition Cambridge Cambridge University Press 2018 1 Online-Ressource (xxvi, 451 Seiten) txt rdacontent c rdamedia cr rdacarrier Title from publisher's bibliographic system (viewed on 24 Apr 2018) Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. Ultimately, Kozubek places the debate in its historical and scientific context to consider both what drives scientific discovery and the implications of the 'commodification' of life Gene targeting Genomes CRISPR-associated protein 9 CRISPR/Cas-Methode (DE-588)1116100770 gnd rswk-swf Genom (DE-588)4156640-3 gnd rswk-swf Molekulare Medizin (DE-588)4543844-4 gnd rswk-swf Gentechnologie (DE-588)4071722-7 gnd rswk-swf Bioethik (DE-588)4006791-9 gnd rswk-swf Gen-Targeting (DE-588)4294998-1 gnd rswk-swf Gentechnologie (DE-588)4071722-7 s Molekulare Medizin (DE-588)4543844-4 s Bioethik (DE-588)4006791-9 s 1\p DE-604 Gen-Targeting (DE-588)4294998-1 s Genom (DE-588)4156640-3 s CRISPR/Cas-Methode (DE-588)1116100770 s 2\p DE-604 Erscheint auch als Druck-Ausgabe 9781108454629 https://doi.org/10.1017/9781108597104 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Kozubek, Jim Modern Prometheus editing the human genome with Crispr-Cas9 Gene targeting Genomes CRISPR-associated protein 9 CRISPR/Cas-Methode (DE-588)1116100770 gnd Genom (DE-588)4156640-3 gnd Molekulare Medizin (DE-588)4543844-4 gnd Gentechnologie (DE-588)4071722-7 gnd Bioethik (DE-588)4006791-9 gnd Gen-Targeting (DE-588)4294998-1 gnd |
| subject_GND | (DE-588)1116100770 (DE-588)4156640-3 (DE-588)4543844-4 (DE-588)4071722-7 (DE-588)4006791-9 (DE-588)4294998-1 |
| title | Modern Prometheus editing the human genome with Crispr-Cas9 |
| title_auth | Modern Prometheus editing the human genome with Crispr-Cas9 |
| title_exact_search | Modern Prometheus editing the human genome with Crispr-Cas9 |
| title_full | Modern Prometheus editing the human genome with Crispr-Cas9 Jim Kozubek |
| title_fullStr | Modern Prometheus editing the human genome with Crispr-Cas9 Jim Kozubek |
| title_full_unstemmed | Modern Prometheus editing the human genome with Crispr-Cas9 Jim Kozubek |
| title_short | Modern Prometheus |
| title_sort | modern prometheus editing the human genome with crispr cas9 |
| title_sub | editing the human genome with Crispr-Cas9 |
| topic | Gene targeting Genomes CRISPR-associated protein 9 CRISPR/Cas-Methode (DE-588)1116100770 gnd Genom (DE-588)4156640-3 gnd Molekulare Medizin (DE-588)4543844-4 gnd Gentechnologie (DE-588)4071722-7 gnd Bioethik (DE-588)4006791-9 gnd Gen-Targeting (DE-588)4294998-1 gnd |
| topic_facet | Gene targeting Genomes CRISPR-associated protein 9 CRISPR/Cas-Methode Genom Molekulare Medizin Gentechnologie Bioethik Gen-Targeting |
| url | https://doi.org/10.1017/9781108597104 |
| work_keys_str_mv | AT kozubekjim modernprometheuseditingthehumangenomewithcrisprcas9 |